Kristen M Drescher

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi request reprint The CVB and etiology of type 1 diabetes
    K M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Curr Top Microbiol Immunol 323:259-74. 2008
  2. ncbi request reprint Being a mouse in a man's world: what TMEV has taught us about human disease
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Front Biosci 13:3775-85. 2008
  3. pmc Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Clin Dev Immunol 2010:170432. 2010
  4. ncbi request reprint Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Criss II, Omaha, NE 68178, USA
    Ann N Y Acad Sci 1103:152-6. 2007
  5. doi request reprint Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Fam Cancer 8:231-9. 2009
  6. pmc Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Criss II, Room 424, Omaha, NE 68178, USA
    Virology 359:233-42. 2007
  7. pmc Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, USA
    J Infect Dis 201:160-9. 2010
  8. pmc Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency
    Toru Kanno
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 80:5637-43. 2006
  9. pmc miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e30772. 2012
  10. ncbi request reprint Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University, Omaha, NE 68178, USA
    Virology 329:381-94. 2004

Detail Information

Publications22

  1. ncbi request reprint The CVB and etiology of type 1 diabetes
    K M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Curr Top Microbiol Immunol 323:259-74. 2008
    ..Although the connection between the CVB and T1D has not been firmly established, significant' evidence supports the role of these pathogens in T1D development...
  2. ncbi request reprint Being a mouse in a man's world: what TMEV has taught us about human disease
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Front Biosci 13:3775-85. 2008
    ..In this review we will present some of the key findings from the TMEV model in the context of human disease...
  3. pmc Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Clin Dev Immunol 2010:170432. 2010
    ..In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers...
  4. ncbi request reprint Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Criss II, Omaha, NE 68178, USA
    Ann N Y Acad Sci 1103:152-6. 2007
    ..A complete understanding of the genesis of the sclerotic plaque may provide insights into enhanced treatment for patients with central nervous system (CNS) demyelination...
  5. doi request reprint Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Fam Cancer 8:231-9. 2009
    ....
  6. pmc Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Criss II, Room 424, Omaha, NE 68178, USA
    Virology 359:233-42. 2007
    ..i., hindlimbs were paralyzed. This new model of virus-induced peripheral demyelination may be used to dissect processes involved in protection of the PNS from viral insult and to study the early phases of lesion development...
  7. pmc Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, USA
    J Infect Dis 201:160-9. 2010
    ..These data suggest a role of miR-513 in regulating B7-H1 expression by cholangiocytes in response to C. parvum infection...
  8. pmc Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency
    Toru Kanno
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    J Virol 80:5637-43. 2006
    ..While any CVB strain may be able to induce T1D in prediabetic NOD mice, T1D onset is linked both to the viral replication rate and infectious dose...
  9. pmc miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e30772. 2012
    ..Moreover, functional manipulation of SMRT altered NF-κB-regulated transactivation of LPS-induced IL-8 expression. These data suggest that miR-16 targets SMRT and modulates NF-κB-regulated transactivation of the IL-8 gene...
  10. ncbi request reprint Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University, Omaha, NE 68178, USA
    Virology 329:381-94. 2004
    ..Together, the results suggest a model for resolving conflicting data regarding the role of CVB in human T1D etiology...
  11. pmc 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart
    Nora M Chapman
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Virology 375:480-91. 2008
    ..This is the first report of these naturally-occurring defective enteroviral genomes in human myocarditis...
  12. ncbi request reprint ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska, USA
    J Neurovirol 8:452-8. 2002
    ..Resistance to demyelination was similar in both groups, indicating that the resulting immune response was sufficient for protection of the spinal cord white matter...
  13. pmc MicroRNAs and Epithelial Immunity
    Jun Liu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska 68178, USA
    Int Rev Immunol 28:139-54. 2009
    ..Increased understanding of the role of microRNAs in epithelial immunoregulation and identification of microRNAs of pathogenetic significance will enhance our understanding of epithelial immunobiology and immunopathology...
  14. pmc Exosomal miRNAs: Biological Properties and Therapeutic Potential
    Guoku Hu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center Omaha, NE, USA
    Front Genet 3:56. 2012
    ..This review briefly summarizes recent advances in the biology, function, and therapeutic potential of exosomal miRNAs...
  15. doi request reprint Enteroviruses and type 1 diabetes
    Steven Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Diabetes Metab Res Rev 27:820-3. 2011
    ....
  16. pmc Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence
    S Tracy
    Enterovirus Research Laboratory, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Virol 76:12097-111. 2002
    ..To the contrary, CVB infections provide significant protection from T1D onset in NOD mice. Possible mechanisms by which this virus-induced protection may occur are discussed...
  17. pmc Effect of creatine, creatinine, and creatine ethyl ester on TLR expression in macrophages
    Korey M Leland
    Department of Medical Microbiology and Immunology, Creighton University Medical School, Omaha, Nebraska, USA
    Int Immunopharmacol 11:1341-7. 2011
    ..Of great interest, CRN--largely considered to be a waste product of the argenine biosynthesis pathway may also have immunosuppressive properties similar to those of CR...
  18. pmc NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, United States of America
    PLoS Pathog 5:e1000681. 2009
    ..parvum infection, a process that may be relevant to the regulation of epithelial anti-microbial defense in general...
  19. ncbi request reprint Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate
    C K Lee
    Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198, USA
    J Gen Virol 86:197-210. 2005
    ..This is the first report characterizing a cloned CVB3 genome from an avirulent strain...
  20. doi request reprint Enteroviruses, type 1 diabetes and hygiene: a complex relationship
    S Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Rev Med Virol 20:106-16. 2010
    ..Viewing T1D in this perspective suggests that potential preventative options could be developed...
  21. ncbi request reprint Interleukin-6 protects anterior horn neurons from lethal virus-induced injury
    Kevin D Pavelko
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosci 23:481-92. 2003
    ..These data support the hypothesis that IL-6 plays a critical role in protecting specific populations of neurons from irreversible injury...
  22. ncbi request reprint Coxsackievirus infections and NOD mice: relevant models of protection from, and induction of, type 1 diabetes
    Steven Tracy
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha NE 68198, USA
    Ann N Y Acad Sci 1103:143-51. 2007
    ..These models expand much of what is known or suspected regarding the etiologic role of HEVs in human T1D...