Xian Ming Chen


Affiliation: Creighton University
Country: USA


  1. Wang Y, Shen Y, Liu H, Yin J, Zhang X, Gong A, et al. Induction of Inflammatory Responses in Splenocytes by Exosomes Released from Intestinal Epithelial Cells following Cryptosporidium parvum Infection. Infect Immun. 2019;: pubmed publisher
    ..parvum infection can activate immune cells through shuttling various effector molecules, a process that may be relevant to host systemic responses to Cryptosporidium infection. ..
  2. Li M, Gong A, Zhang X, Wang Y, Mathy N, Martins G, et al. Induction of a Long Noncoding RNA Transcript, NR_045064, Promotes Defense Gene Transcription and Facilitates Intestinal Epithelial Cell Responses against Cryptosporidium Infection. J Immunol. 2018;201:3630-3640 pubmed publisher
    ..Our data demonstrate that lncRNAs, such as NR_045064, play a role in regulating epithelial defense against microbial infection. ..
  3. Ma S, Ming Z, Gong A, Wang Y, Chen X, Hu G, et al. A long noncoding RNA, lincRNA-Tnfaip3, acts as a coregulator of NF-κB to modulate inflammatory gene transcription in mouse macrophages. FASEB J. 2017;31:1215-1225 pubmed publisher
    ..Gong, A.-Y., Wang, Y., Chen, X., Hu, G., Zhou, R., Shibata, A., Swanson, P. C., Chen, X.-M. A long noncoding RNA, LincRNA-Tnfaip3, acts as a coregulator of NF-κB to modulate inflammatory gene transcription in mouse macrophages. ..
  4. Ming Z, Gong A, Wang Y, Zhang X, Li M, Dolata C, et al. Trans-suppression of defense DEFB1 gene in intestinal epithelial cells following Cryptosporidium parvum infection is associated with host delivery of parasite Cdg7_FLc_1000 RNA. Parasitol Res. 2018;117:831-840 pubmed publisher
    ..parvum infection involves host delivery of parasite Cdg7_FLc_1000 RNA, a process that may be relevant to the epithelial defense evasion by C. parvum at the early stage of infection. ..
  5. Ming Z, Gong A, Wang Y, Zhang X, Li M, Li Y, et al. Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA. Int J Parasitol. 2018;48:423-431 pubmed publisher
    ..parvum infection through PRDM1-mediated H3K9 methylation in the CDH3 gene locus, whereas Cdg7_FLc_1000 induces trans-suppression of the host LOXL4 gene through H3K9/H3K27 methylation-independent mechanisms. ..
  6. Zhao G, Gong A, Wang Y, Zhang X, Li M, Mathy N, et al. Nuclear delivery of parasite Cdg2_FLc_0220 RNA transcript to epithelial cells during Cryptosporidium parvum infection modulates host gene transcription. Vet Parasitol. 2018;251:27-33 pubmed publisher
    ..parvum Cdg2_FLc_0220 RNA transcript in infected epithelial cells modulates the transcription of host genes, contributing to the alterations in the gene expression profile in host epithelial cells during C. parvum infection. ..
  7. Gong A, Eischeid A, Xiao J, Zhao J, Chen D, Wang Z, et al. miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells. BMC Cancer. 2012;12:492 pubmed publisher
    ..PCAF is upregulated in cultured PCa cells, and upregulation of PCAF is associated with the downregulation of miR-17-5p. Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells. ..
  8. Tong Q, Gong A, Zhang X, Lin C, Ma S, Chen J, et al. LincRNA-Cox2 modulates TNF-α-induced transcription of Il12b gene in intestinal epithelial cells through regulation of Mi-2/NuRD-mediated epigenetic histone modifications. FASEB J. 2016;30:1187-97 pubmed publisher
    ..Thus, our data demonstrate a novel mechanism of epigenetic modulation by lincRNA-Cox2 on Il12b transcription, supporting an important role for lincRNAs in the regulation of intestinal epithelial inflammatory responses. ..
  9. Chen X, Splinter P, O Hara S, Larusso N. A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem. 2007;282:28929-38 pubmed
    ..parvum infection. Furthermore, the data raise the possibility that micro-RNA-mediated post-transcriptional pathways may be critical to host-cell regulatory responses to microbial infection in general. ..

More Information


  1. Chen X, O Hara S, Larusso N. The immunobiology of cholangiocytes. Immunol Cell Biol. 2008;86:497-505 pubmed publisher
    ..Thus, cholangiocytes are actively involved in mucosal immunity of the biliary system and represent a fine-tuned, integral component of liver immunity...
  2. Zhang X, Gong A, Wang Y, Chen X, Lim S, Dolata C, et al. Cryptosporidium parvum infection attenuates the ex vivo propagation of murine intestinal enteroids. Physiol Rep. 2016;4: pubmed publisher
  3. Mathy N, Chen X. Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses. J Biol Chem. 2017;292:12375-12382 pubmed publisher
    ..Better understanding of lncRNA regulation of inflammation will provide novel targets for the development of new therapeutic strategies. ..