T B Casale

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi request reprint Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils
    Henry Lin
    Division of Allergy Immunology, Department of Medicine, Creighton University, Omaha, Neb, USA
    J Allergy Clin Immunol 113:297-302. 2004
  2. doi request reprint Asthma: imaging of the smaller airways
    Thomas B Casale
    Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:13-4. 2003
  3. ncbi request reprint Clinical implications of the allergic rhinitis-asthma link
    Thomas B Casale
    Department of Medicine, Creighton University, Omaha, Nebraska, USA
    Am J Med Sci 327:127-38. 2004
  4. doi request reprint The pathophysiology of small airway inflammation in asthma
    Thomas B Casale
    Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:7-12. 2003
  5. ncbi request reprint Introduction
    Thomas B Casale
    Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:5-6. 2003
  6. doi request reprint Nasal carbon dioxide for the symptomatic treatment of perennial allergic rhinitis
    Thomas B Casale
    Division of Allergy and Immunology, Creighton University, Omaha, Nebraska, USA
    Ann Allergy Asthma Immunol 107:364-70. 2011
  7. doi request reprint Immunomodulators for allergic respiratory disorders
    Thomas B Casale
    Department of Medicine, Division of Allergy Immunology, Creighton University, Omaha, NE 68131, USA
    J Allergy Clin Immunol 121:288-96; quiz 297-8. 2008
  8. ncbi request reprint Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis
    Thomas B Casale
    Creighton University School of Medicine, Omaha, NE 68131, USA
    J Allergy Clin Immunol 117:134-40. 2006
  9. ncbi request reprint Intranasal noninhaled carbon dioxide for the symptomatic treatment of seasonal allergic rhinitis
    Thomas B Casale
    Division of Allergy and Immunology, Department of Medicine, Creighton University, Omaha, NE 68131, USA
    J Allergy Clin Immunol 121:105-9. 2008
  10. ncbi request reprint Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis
    Thomas B Casale
    Division of Allergy and Immunology, Department of Internal Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 97:454-6. 2006

Detail Information

Publications51

  1. ncbi request reprint Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils
    Henry Lin
    Division of Allergy Immunology, Department of Medicine, Creighton University, Omaha, Neb, USA
    J Allergy Clin Immunol 113:297-302. 2004
    ..Omalizumab is a monoclonal anti-IgE antibody that is effective for the treatment of allergic respiratory disorders; however, its onset of action is unknown...
  2. doi request reprint Asthma: imaging of the smaller airways
    Thomas B Casale
    Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:13-4. 2003
    ..Assessment of air trapping in small airways may have diagnostic value, distinguishing those patients who are likely to experience frequent asthmatic exacerbations...
  3. ncbi request reprint Clinical implications of the allergic rhinitis-asthma link
    Thomas B Casale
    Department of Medicine, Creighton University, Omaha, Nebraska, USA
    Am J Med Sci 327:127-38. 2004
    ..The roles of various therapies for dually afflicted patients are evaluated, including topical corticosteroids, antihistamines, leukotriene modifiers, anti-immunoglobulin E monoclonal antibody, theophylline, and immunotherapy...
  4. doi request reprint The pathophysiology of small airway inflammation in asthma
    Thomas B Casale
    Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:7-12. 2003
    ..Inflammatory activity in the distal lung of patients may actually exceed that of the large airways. Anatomic changes in small airways are prominent in cases of fatal asthma...
  5. ncbi request reprint Introduction
    Thomas B Casale
    Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:5-6. 2003
    ..Corticosteroids delivered by the inhaled route have fulfilled that purpose, and they continue as the mainstay of controller therapy for persistent asthma.1...
  6. doi request reprint Nasal carbon dioxide for the symptomatic treatment of perennial allergic rhinitis
    Thomas B Casale
    Division of Allergy and Immunology, Creighton University, Omaha, Nebraska, USA
    Ann Allergy Asthma Immunol 107:364-70. 2011
    ..Brief nasal carbon dioxide insufflation has previously been shown to provide rapid relief of the symptoms of allergic rhinitis...
  7. doi request reprint Immunomodulators for allergic respiratory disorders
    Thomas B Casale
    Department of Medicine, Division of Allergy Immunology, Creighton University, Omaha, NE 68131, USA
    J Allergy Clin Immunol 121:288-96; quiz 297-8. 2008
    ..The goal of this review is to summarize the data from human clinical trials with immunomodulators, discussing the rationale for their use, efficacy results, and putative adverse events associated with them...
  8. ncbi request reprint Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis
    Thomas B Casale
    Creighton University School of Medicine, Omaha, NE 68131, USA
    J Allergy Clin Immunol 117:134-40. 2006
    ..Rush immunotherapy (RIT) presents an attractive alternative to standard immunotherapy. However, RIT carries a much greater risk of acute allergic reactions, including anaphylaxis...
  9. ncbi request reprint Intranasal noninhaled carbon dioxide for the symptomatic treatment of seasonal allergic rhinitis
    Thomas B Casale
    Division of Allergy and Immunology, Department of Medicine, Creighton University, Omaha, NE 68131, USA
    J Allergy Clin Immunol 121:105-9. 2008
    ..Intranasal CO2 might inhibit trigeminal neuronal activation and suppress the release of calcitonin gene-related peptide...
  10. ncbi request reprint Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis
    Thomas B Casale
    Division of Allergy and Immunology, Department of Internal Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 97:454-6. 2006
    ..CRX-675 is an aqueous formulation of a toll-like receptor 4 agonist and an inducer of TH1 responses. Studies in allergic dogs showed that pretreatment with CRX-675 reduced nasal congestion induced by allergen challenge...
  11. doi request reprint Small airway asthma therapy, challenges, and the future
    Thomas B Casale
    Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:15-20. 2003
    ..By extending the delivery of this medication to the peripheral lung and by increasing the efficiency of lung targeting, these new corticosteroid formulations provide more effective treatment at reduced drug doses...
  12. ncbi request reprint Budesonide Turbuhaler delivered once daily improves health-related quality of life and maintains improvements with a stepped-down dose in adults with mild to moderate asthma
    Thomas B Casale
    Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 90:323-30. 2003
    ..Budesonide inhalation powder administered via Turbuhaler (budesonide Turbuhaler, AstraZeneca LP, Wilmington, DE) is proven efficacious and safe in the treatment of mild to severe asthma...
  13. doi request reprint Recommendations for appropriate sublingual immunotherapy clinical trials
    Thomas B Casale
    Creighton University, Omaha, Neb 68131, USA
    J Allergy Clin Immunol 124:665-70. 2009
    ....
  14. ncbi request reprint Clinical importance of identifying immunoglobulin E-mediated disease in patients with asthma
    Thomas B Casale
    Allergy Immunology, Creighton University, Omaha, Nebraska, USA
    Clin Cornerstone 9:20-9. 2009
    ..These data also suggest that when clinicians participate in education about the role of IgE in asthma and begin testing their patients for allergy, the recognition of allergies among patients with asthma dramatically increases...
  15. ncbi request reprint Anti-immunoglobulin E (omalizumab) therapy in seasonal allergic rhinitis
    T B Casale
    Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    Am J Respir Crit Care Med 164:S18-21. 2001
    ..With adequate dosing, nasal and ocular symptoms are significantly reduced, and quality of life is significantly improved. Omalizumab is safe and well tolerated and can be safely readministered in subsequent pollen seasons...
  16. ncbi request reprint Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patients
    T B Casale
    Department of Medicine Creighton University, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 87:379-85. 2001
    ..Suppression of the hypothalamic-pituitary-adrenal (HPA) axis, a potential systemic effect of inhaled corticosteroid therapy, can be quantified by monitoring serum, urinary, and salivary cortisol levels...
  17. ncbi request reprint Effect of omalizumab on symptoms of seasonal allergic rhinitis: a randomized controlled trial
    T B Casale
    Department of Medicine, Creighton University, Omaha, NE, USA
    JAMA 286:2956-67. 2001
    ..A recombinant humanized monoclonal anti-IgE antibody (omalizumab) forms complexes with free IgE, blocking its interaction with mast cells and basophils and lowering free IgE levels in the circulation...
  18. doi request reprint Future forms of immunotherapy
    Thomas B Casale
    Division of Allergy Immunology, Creighton University, Omaha, Neb 68131, USA
    J Allergy Clin Immunol 127:8-15; quiz 16-7. 2011
    ..One thing is clear: the next century of immunotherapy will be vastly different from today's current standard of care...
  19. ncbi request reprint First do no harm: managing antihistamine impairment in patients with allergic rhinitis
    Thomas B Casale
    Creighton University, School of Medicine, Omaha, NE 68131, USA
    J Allergy Clin Immunol 111:S835-42. 2003
    ..In addition, further epidemiologic studies on the effects of antihistamines should be performed...
  20. ncbi request reprint Allergy immunotherapy for primary care physicians
    Jeffrey R Stokes
    Creighton University, Division of Allergy Immunology, Department of Medicine, Omaha, Neb 68131, USA
    Am J Med 119:820-3. 2006
    ..Even with newer therapies on the horizon, allergen immunotherapy will continue to have an important role in the treatment of allergic diseases...
  21. ncbi request reprint Anti-immunoglobulin E monoclonal antibody administered with immunotherapy
    Kevin W Parks
    Division of Allergy and Immunology, Department of Internal Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Allergy Asthma Proc 27:S33-6. 2006
    ..Results thus far provide the opportunity to develop strategies using omalizumab pretreatment to enhance the safety and efficacy of allergen-immunotherapy to treat a wide variety of allergic diseases...
  22. doi request reprint The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  23. ncbi request reprint Rationale for new treatments aimed at IgE immunomodulation
    Jeffrey Stokes
    Division of Allergy Immunology, Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 93:212-7; quiz 217-9, 271. 2004
    ..To review potential or current therapies that decrease IgE synthesis or effects...
  24. doi request reprint Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine
    Douglas H Jones
    Division of Allergy, Asthma, and Immunology, Creighton University Medical Center, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 100:452-6. 2008
    ..Second- and third-generation histamine1-antihistamines are generally devoid of these adverse effects but are typically not used because of a perceived slower onset of action...
  25. pmc Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial
    Lee E Morrow
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Creighton University School of Medicine, Omaha, Nebraska, USA
    Am J Respir Crit Care Med 182:1058-64. 2010
    ..It is unknown whether probiotic modification of the upper aerodigestive flora can reduce nosocomial infections...
  26. ncbi request reprint Omalizumab in asthma: approval and postapproval experience
    Dean T Chiang
    Division of Allergy and Immunology, Creighton University Medical Center, Omaha, NE, USA
    Clin Rev Allergy Immunol 29:3-16. 2005
    ..Postmarketing surveillance has shown omalizumab to be a relatively safe and well-tolerated medication...
  27. ncbi request reprint A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroids
    Harold S Nelson
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Pharmacol 42:319-26. 2002
    ..Because it is noninvasive, salivary cortisol measurement offers distinct advantages as a screening method for detecting pronounced HPA axis suppression in asthma patients receiving corticosteroid therapy...
  28. ncbi request reprint Ragweed skin test responsiveness correlates with specific immunoglobulin E levels
    Jeffrey Stokes
    Division of Allergy lmmunology, Department of Medicine, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
    Allergy Asthma Proc 26:103-7. 2005
    ..Skin test responsiveness to ragweed correlated with in vitro ragweed-specific IgE levels, but these tests are not equivalent indicators of the degree of IgE-mediated sensitivity...
  29. ncbi request reprint Efficacy of montelukast during the allergy season in patients with chronic asthma and seasonal aeroallergen sensitivity
    William W Busse
    Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Ann Allergy Asthma Immunol 96:60-8. 2006
    ..Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluated in the subpopulation of asthmatic patients with seasonal asthma symptoms...
  30. doi request reprint Time-dependent effects of inhaled corticosteroids on lung function, bronchial hyperresponsiveness, and airway inflammation in asthma
    Vinay Mehta
    Allergy, Asthma and Immunology Associates, PC, Lincoln, Nebraska, USA
    Ann Allergy Asthma Immunol 103:31-7. 2009
    ..Exhaled nitric oxide (F(ENO)) and exhaled breath condensate (EBC) are noninvasive markers that directly measure airway inflammation and may potentially be useful in assessing asthma control and response to therapy...
  31. ncbi request reprint Anti-IgE therapy
    Jaine Brownell
    Division of Allergy and Immunology, Department of Medicine, Creighton University School of Medicine, 601 North 30th Street Suite 5850 Omaha, NE 68131, USA
    Immunol Allergy Clin North Am 24:551-68, v. 2004
    ..The primary mechanism of action of anti-IgE therapy is the reduction in serum levels of IgE and FcepsilonRI expression on mast cells and basophils...
  32. doi request reprint Safety and efficacy of olopatadine hydrochloride nasal spray 0.6% in pediatric subjects with allergic rhinitis
    William E Berger
    Department of Pediatrics, Division of Allergy and Immunology, University of California, Irvine, California, USA
    Allergy Asthma Proc 30:612-23. 2009
    ..In subjects 6 to <12 years of age, OLO was superior to vehicle in the treatment of SAR. In subjects 2 to <12 years of age, OLO had an overall low rate of AEs and low systemic exposure...
  33. ncbi request reprint Experience with monoclonal antibodies in allergic mediated disease: seasonal allergic rhinitis
    T B Casale
    Creighton University, Omaha, Nebraska 68231, USA
    J Allergy Clin Immunol 108:S84-8. 2001
    ..Furthermore, subcutaneous or intravenous administration of omalizumab does not invoke the generation of anti-omalizumab antibodies. Thus, omalizumab represents a novel agent that should assist in the treatment of allergic rhinitis...
  34. ncbi request reprint Pediatric allergic rhinitis: treatment
    Lien Lai
    Department of Medicine, Creighton University Medical Center, 601 North 30th Street, Suite 5850, Omaha, NE 68131 USA
    Immunol Allergy Clin North Am 25:283-99, vi. 2005
    ..Immunotherapy generally is reserved for patients unresponsive to therapy or unable to take medications...
  35. ncbi request reprint Omalizumab in the treatment of allergic respiratory disease
    Justin Clark
    Division of Allergy and Immunology, Creighton University, Omaha, Nebraska, USA
    J Asthma 43:87-93. 2006
  36. doi request reprint Expression and function of a novel variant of estrogen receptor-α36 in murine airways
    Shuping Jia
    Department of Medicine, Creighton University Medical Center, Omaha, NE 68131, USA
    Am J Respir Cell Mol Biol 45:1084-9. 2011
    ..The identification and localization of specific estrogen receptor subtypes in the lung could lead to newer therapeutic avenues aimed at addressing sex differences of asthma susceptibility...
  37. doi request reprint The role of vitamin D in asthma
    Manbir S Sandhu
    Creighton University, Department of Medicine, Division of Allergy and Immunology, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 105:191-9; quiz 200-2, 217. 2010
    ..To review the current literature on vitamin D and asthma, discussing the possible roles of vitamin D on asthma pathogenesis and the potential consequences of vitamin D deficiency...
  38. ncbi request reprint Treatment of allergic asthma
    Henry Lin
    Division of Allergy Immunology, Department of Medicine, Creighton University, Omaha, Nebraska, USA
    Am J Med 113:8S-16S. 2002
    ..In patients with asthma and concomitant allergic rhinitis, antihistamines may be useful as adjunctive therapy...
  39. ncbi request reprint Managing impairment in patients with allergic rhinitis
    Jeffrey Stokes
    Division of Allergy Immunology, Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Allergy Asthma Proc 27:12-6. 2006
    ..Second-generation antihistamines are the preferred medication when antihistamines are necessary...
  40. ncbi request reprint Necrotizing pneumonia with a questionable lung mass in a 59-year-old man
    Jaine Brownell
    Department of Medicine, Division of Allergy and Immunology, Creighton University Medical Center, Omaha, Nebraska 68131, USA
    Ann Allergy Asthma Immunol 96:116-21. 2006
  41. ncbi request reprint Omalizumab: an effective anti-IgE treatment for allergic asthma and rhinitis
    Thomas B Casale
    Medical Information Department, Prous Science, Provença 388, 08025 Barcelona, Spain
    Drugs Today (Barc) 40:367-76. 2004
    ..Omalizumab has a good safety profile, with only mild to intermediate drug-related adverse events...
  42. ncbi request reprint Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen binding
    Sven Klunker
    Upper Respiratory Medicine, Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, United Kingdom
    J Allergy Clin Immunol 120:688-95. 2007
    ..One proposed mechanism of immunotherapy is to induce regulatory antibodies that inhibit facilitated antigen presentation...
  43. ncbi request reprint Omalizumab treatment downregulates dendritic cell FcepsilonRI expression
    Calman Prussin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 112:1147-54. 2003
    ..Although the downregulation of basophil FcepsilonRI during anti-IgE therapy with omalizumab is well documented, its effect on FcepsilonRI expression by DCs has not been reported...
  44. ncbi request reprint Efficacy and safety of clemastine-pseudoephedrine-acetaminophen versus pseudoephedrine-acetaminophen in the treatment of seasonal allergic rhinitis in a 1-day, placebo-controlled park study
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, San Diego, California, USA
    Ann Allergy Asthma Immunol 90:79-86. 2003
    ..Patients with allergic rhinitis have a wide range of symptoms that are often treated with oral combination products that contain antihistamines, decongestants, and analgesics...
  45. ncbi request reprint Sublingual immunotherapy and subcutaneous immunotherapy: issues in the United States
    Paul A Greenberger
    J Allergy Clin Immunol 120:1466-8. 2007
  46. doi request reprint Guidelines for treatment of pediatric asthma
    Thomas B Casale
    JAMA 299:2855; author reply 2855. 2008
  47. ncbi request reprint Next generation antihistamines: therapeutic rationale, accomplishments and advances
    John J Oppenheimer
    University of Medicine and Dentistry, Pulmonary and Allergy Associates, New Jersey Medical School, 101 Madison Avenue, Morristown, NJ 07960 7305 USA
    Expert Opin Investig Drugs 11:807-17. 2002
    ..The clinical benefit of these newer oral antihistamines will clearly help improve the quality of life of patients with chronic allergies...
  48. pmc Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normal
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Respir Cell Mol Biol 37:424-30. 2007
    ..The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma...
  49. ncbi request reprint Identifying and managing rhinitis and its subtypes: allergic and nonallergic components--a consensus report and materials from the Respiratory & Allergic Disease Foundation
    Mervat Nassef
    Curr Med Res Opin 22:2541-8. 2006
    ..CONCLUSION: The use of these clinical practice tools may improve the management of rhinitis by helping clinicians to identify both the allergic and nonallergic components of a patient's disease and choose an appropriate treatment...
  50. ncbi request reprint Asthma quality-of-care measures using administrative data: relationships to subsequent exacerbations in multiple databases
    Michael Schatz
    American Academy of Allergy, Asthma and Immunology and American College of Allergy, Asthma and Immunology Joint Quality Measures Task Force, USA
    Ann Allergy Asthma Immunol 101:235-9. 2008
  51. ncbi request reprint Status of immunotherapy: current and future
    Thomas B Casale
    J Allergy Clin Immunol 113:1036-9. 2004