DEVENDRA AGRAWAL

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi request reprint Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model
    D K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int Immunopharmacol 1:2081-9. 2001
  2. ncbi request reprint Autophagy of vascular smooth muscle cells in atherosclerotic lesions
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Autophagy 3:63-4. 2007
  3. pmc Insulin-like growth factor-1 induces phosphorylation of PI3K-Akt/PKB to potentiate proliferation of smooth muscle cells in human saphenous vein
    Guanghong Jia
    Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA
    Exp Mol Pathol 89:20-6. 2010
  4. ncbi request reprint Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug
    D K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Expert Opin Investig Drugs 10:547-60. 2001
  5. ncbi request reprint Allergic airway inflammation
    Devendra K Agrawal
    Departments of Biomedical Sciences, Medicine, and Medical Microbiology and Immunology, Creighton University School of Medicine, CRISS I Room 131, 2500 California Plaza, Omaha, NE 68178, USA
    Curr Allergy Asthma Rep 5:142-8. 2005
  6. pmc Pathogenesis of allergic airway inflammation
    Devendra K Agrawal
    Center for Clinical and Translational Science, Creighton University School of Medicine, Criss II, Room 510, Omaha, NE 68178, USA
    Curr Allergy Asthma Rep 10:39-48. 2010
  7. ncbi request reprint Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma
    Devendra K Agrawal
    Medical Microbiology and Immunology and Biomedical Sciences, Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int Immunopharmacol 4:127-38. 2004
  8. ncbi request reprint Controlling cytokine signaling by constitutive inhibitors
    Kriti Rakesh
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Biochem Pharmacol 70:649-57. 2005
  9. ncbi request reprint Interaction of suplatast tosilate (IPD) with chloride channels in human blood eosinophils: a potential mechanism underlying its anti-allergic and anti-asthmatic effects
    D K Agrawal
    Creighton University School of Medicine, Omaha, NE 68178, USA
    Clin Exp Allergy 38:305-12. 2008
  10. ncbi request reprint Anti-inflammatory properties of desloratadine
    D K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Clin Exp Allergy 34:1342-8. 2004

Collaborators

  • J E Talmadge
  • Sudhir Agrawal
  • Uwe A Wittel
  • Xiang Wang
  • Ming Zhang
  • Gang Cheng
  • Chad K Oh
  • Guanghong Jia
  • Halvor S McGee
  • Zhifei Shao
  • Amit K Mitra
  • Arpita S Bharadwaj
  • Jehad H Edwan
  • Deepak M Gangahar
  • Toluwalope O Makinde
  • Richard F Murphy
  • Toluwalope Makinde
  • Kriti Rakesh
  • Kristopher D Krueger
  • Gaurav K Gupta
  • Benjamin Moore
  • Saumya Pandey
  • Bharti R Chaudhari
  • Todd R Allen
  • Abdo I Berro
  • Daniel Abraha
  • Arpita Bharadwaj
  • William J Hunter
  • Matthew H Kim
  • Michael T Hopfenspirger
  • Arthur L Stallworth
  • Lindsey Lorence
  • Tanupriya Agrawal
  • Hideo Yagita
  • Againdra K Bewtra
  • Krish Soundararajan
  • Michael G Del Core
  • Seong H Cho
  • Jae M Park
  • Greg A Perry
  • Greg Perry
  • Michael G DelCore

Detail Information

Publications53

  1. ncbi request reprint Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model
    D K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int Immunopharmacol 1:2081-9. 2001
    ..However, there was no change in BAL fluid IL-4 and serum IgE levels. These data suggest that FL treatment prevents ovalbumin-induced asthma in the mouse and may provide a useful adjuvant in the treatment of human asthma...
  2. ncbi request reprint Autophagy of vascular smooth muscle cells in atherosclerotic lesions
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Autophagy 3:63-4. 2007
    ..Understanding the underlying cellular and molecular mechanisms of autophagy can provide key insights into the cell death machinery of atherosclerotic diseases...
  3. pmc Insulin-like growth factor-1 induces phosphorylation of PI3K-Akt/PKB to potentiate proliferation of smooth muscle cells in human saphenous vein
    Guanghong Jia
    Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA
    Exp Mol Pathol 89:20-6. 2010
    ..This, at least in part, could explain the greater propensity of the SV conduits than the IMA to undergo intimal hyperplasia following CABG...
  4. ncbi request reprint Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug
    D K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Expert Opin Investig Drugs 10:547-60. 2001
    ..Desloratadine also provides significant relief of SAR symptoms in patients with co-existing asthma and is effective in the treatment of chronic idiopathic urticaria. Desloratadine improves quality of life and is well-tolerated...
  5. ncbi request reprint Allergic airway inflammation
    Devendra K Agrawal
    Departments of Biomedical Sciences, Medicine, and Medical Microbiology and Immunology, Creighton University School of Medicine, CRISS I Room 131, 2500 California Plaza, Omaha, NE 68178, USA
    Curr Allergy Asthma Rep 5:142-8. 2005
    ....
  6. pmc Pathogenesis of allergic airway inflammation
    Devendra K Agrawal
    Center for Clinical and Translational Science, Creighton University School of Medicine, Criss II, Room 510, Omaha, NE 68178, USA
    Curr Allergy Asthma Rep 10:39-48. 2010
    ..In this review, we discuss the current information on the pathogenesis of allergic airway inflammation and potential immunotherapy, which could be beneficial in the treatment of airway inflammation, allergy, and asthma...
  7. ncbi request reprint Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma
    Devendra K Agrawal
    Medical Microbiology and Immunology and Biomedical Sciences, Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int Immunopharmacol 4:127-38. 2004
    ..These data suggest that the treatment with these novel IMOs prevents OVA-induced allergic airway inflammation and AHR in asthma in the mouse and may provide a useful agent in the treatment of human asthma...
  8. ncbi request reprint Controlling cytokine signaling by constitutive inhibitors
    Kriti Rakesh
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Biochem Pharmacol 70:649-57. 2005
    ..This review throws light on the mechanisms of action of these regulators as being evolved by the latest researches...
  9. ncbi request reprint Interaction of suplatast tosilate (IPD) with chloride channels in human blood eosinophils: a potential mechanism underlying its anti-allergic and anti-asthmatic effects
    D K Agrawal
    Creighton University School of Medicine, Omaha, NE 68178, USA
    Clin Exp Allergy 38:305-12. 2008
    ..Because blood and tissue eosinophilia are hallmarks of bronchial asthma, in this study we examined the role of chloride channels in the underlying effects of suplatast tosilate (IPD), an anti-allergic drug, in human blood eosinophils...
  10. ncbi request reprint Anti-inflammatory properties of desloratadine
    D K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Clin Exp Allergy 34:1342-8. 2004
    ..Allergic rhinitis (AR) is associated with robust infiltration of immune cells and mediators that may contribute to clinical manifestations of the disease...
  11. pmc Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma
    Halvor S McGee
    Center for Clinical and Translational Science, Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Am J Respir Crit Care Med 180:211-25. 2009
    ..T-regulatory cells (Tregs) are potent immunomodulators in allergic asthma...
  12. ncbi request reprint Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation
    Jehad H Edwan
    Department of Medical Microbiology and Immunology, and Center for Allergy, Asthma, and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Immunol 172:5016-23. 2004
    ..These data suggest that Flt3-L can reverse allergic airway inflammation and associated changes in pulmonary functions in murine asthma model...
  13. pmc Programmed Death-1 antibody blocks therapeutic effects of T-regulatory cells in cockroach antigen-induced allergic asthma
    Halvor S McGee
    Department of Biomedical Sciences, Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Respir Cell Mol Biol 43:432-42. 2010
    ..g., inducible costimulatory molecule [ICOS] or CTLA-4) have been shown to play a role in Treg-mediated suppression...
  14. pmc Fms-like tyrosine kinase 3 ligand increases a lung DC subset with regulatory properties in allergic airway inflammation
    Zhifei Shao
    Department of Biomedical Sciences, Creighton University of School of Medicine, Omaha, NE 68178, USA
    J Allergy Clin Immunol 123:917-924.e2. 2009
    ..Administration of Fms-like tyrosine kinase 3 (Flt3) ligand prevents and reverses allergic airway inflammation and airway hyperresponsiveness in a mouse model. However, the underlying mechanisms are unclear...
  15. ncbi request reprint Airway hyperresponsiveness, late allergic response, and eosinophilia are reversed with mycobacterial antigens in ovalbumin-presensitized mice
    Michael T Hopfenspirger
    Center for Allergy, Asthma, and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    J Immunol 168:2516-22. 2002
    ..These data suggest that mycobacterial Ags (BCG>>M. vaccae) are effective in attenuating allergic airway inflammation and associated changes in pulmonary functions in an allergen-presensitized state...
  16. pmc Regulation of cell cycle entry by PTEN in smooth muscle cell proliferation of human coronary artery bypass conduits
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Cell Mol Med 13:547-54. 2009
    ..Therefore, overexpression of PTEN possibly by means of gene therapy could be a viable option in regulating the cell cycle in SV SMCs in the treatment of vein graft disease...
  17. ncbi request reprint Treatment with Flt3 ligand plasmid reverses allergic airway inflammation in ovalbumin-sensitized and -challenged mice
    Jehad H Edwan
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, CRISS I Room 131, 2500 California Plaza, Omaha, NE 68178, USA
    Int Immunopharmacol 5:345-57. 2005
    ..05). Total BALF cellularity, eosinophiles counts and BALF IL-5 levels were also reduced (P<0.01). pUMVC3-hFLex treatment can reverse established experimental asthma and might provide a novel approach for treating asthma...
  18. pmc Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice
    Halvor S McGee
    Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Am J Respir Cell Mol Biol 43:520-9. 2010
    ....
  19. ncbi request reprint Flt3-ligand plasmid prevents the development of pathophysiological features of chronic asthma in a mouse model
    Jehad H Edwan
    Department of Biomedical Sciences, Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 37:147-59. 2007
    ..These results suggest that pUMVC3-hFLex treatment can prevent the development of airway remodeling and maintain airway protection in chronic experimental asthma model, and might provide a novel approach for treating chronic asthma...
  20. doi request reprint Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation
    Zhifei Shao
    Department of Biomedical Sciences, Creighton University of School of Medicine, Omaha, NE 68178, USA
    J Immunol 183:7531-8. 2009
    ..In conclusion, Flt3L-generated lung immunogenic CD11c(low)CD11b(high) DCs have a less mature phenotype, impaired Ag uptake, and impaired migration to draining lymph nodes...
  21. ncbi request reprint TH2 cells in the pathogenesis of airway remodeling: regulatory T cells a plausible panacea for asthma
    Halvor S McGee
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 35:219-32. 2006
    ..The development of this specialized subset of T cells is an enigma, but their understanding will provide a plausible panacea for asthma...
  22. pmc Temporal PTEN inactivation causes proliferation of saphenous vein smooth muscle cells of human CABG conduits
    Amit K Mitra
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Cell Mol Med 13:177-87. 2009
    ..Therefore, modulation of the PI3K-AKT/PKB pathway via PTEN might be a novel and effective strategy in combating SV graft failure following CABG...
  23. ncbi request reprint Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Immunol Cell Biol 84:422-9. 2006
    ..The different expression and activity of cell cycle regulatory proteins could be responsible for apoptosis of VSMC and destabilization of atherosclerotic plaques...
  24. doi request reprint CpG oligodeoxynucleotides as TLR9 agonists: therapeutic application in allergy and asthma
    Gaurav K Gupta
    Center for Clinical and Translational Science, Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    BioDrugs 24:225-35. 2010
    ..In this review, we discuss the therapeutic application of CpG ODNs in allergy and asthma. CpG ODNs may be used alone or as an adjuvant to immunotherapy to treat these disorders...
  25. ncbi request reprint Dendritic cells in allergic airway inflammation
    Arpita S Bharadwaj
    Department of Medical Microbiology, Creighton University School of Medicine, Criss II, Room 510, California Plaza, Omaha, NE 68178, USA
    Can J Physiol Pharmacol 85:686-99. 2007
    ..Effects of various therapeutic agents to modulate the function of lung myeloid DCs have been discussed...
  26. pmc Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Mol Cell Cardiol 44:882-90. 2008
    ..These data demonstrate the role of Cx43 in the proliferation and migration of human saphenous vein SMCs and angiotensin II-induced Cx43 expression via mitogen-activated protein kinases (MAPK)-AP-1 signaling pathway...
  27. pmc Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice
    Halvor S McGee
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Respir Cell Mol Biol 42:331-40. 2010
    ..Flt3-L could be a therapeutic strategy for the management and prevention of allergic asthma...
  28. ncbi request reprint Interaction of tgf-beta with immune cells in airway disease
    Benjamin Moore
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Curr Mol Med 8:427-36. 2008
    ..TGF-beta-induced signaling pathways, especially those in different cell types in asthma, COPD, or CF, may provide potential therapeutic targets for the treatment of some of the most devastating airway diseases...
  29. ncbi request reprint The regulatory role of TGF-beta in airway remodeling in asthma
    Toluwalope Makinde
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Cell Biol 85:348-56. 2007
    ..Reduction of TGF-beta production and control of TGF-beta effects would be beneficial in the development of therapeutic intervention for airway remodeling in chronic asthma...
  30. pmc Flt3 ligand generates morphologically distinct semimature dendritic cells in ovalbumin-sensitized mice
    Arpita S Bharadwaj
    Department of Medical Microbiology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Exp Mol Pathol 83:17-24. 2007
    ....
  31. ncbi request reprint Cytokines and growth factors involved in apoptosis and proliferation of vascular smooth muscle cells
    Kriti Rakesh
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, United States
    Int Immunopharmacol 5:1487-506. 2005
    ..A number of these studies, focusing on activation of inflammatory cells and the roles of chemokines, cytokines and growth factors, are addressed in this review...
  32. ncbi request reprint (S)-Albuterol activates pro-constrictory and pro-inflammatory pathways in human bronchial smooth muscle cells
    Devendra K Agrawal
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Allergy Clin Immunol 113:503-10. 2004
    ..Pro-constrictory and proinflammatory properties of (S)-albuterol have been widely reported both under in vivo and in vitro conditions. However, underlying mechanisms are unclear...
  33. ncbi request reprint Increased expression and activation of CD30 induce apoptosis in human blood eosinophils
    Abdo I Berro
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Immunol 173:2174-83. 2004
    ..This research will help in furthering our understanding of eosinophil apoptosis and therefore might contribute to the development of better therapeutic modalities in the treatment and/or cure of allergic inflammation in bronchial asthma...
  34. ncbi request reprint Insulin-like growth factor-I receptors in atherosclerotic plaques of symptomatic and asymptomatic patients with carotid stenosis: effect of IL-12 and IFN-gamma
    Guanghong Jia
    Department of Biomedical Science, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Am J Physiol Heart Circ Physiol 292:H1051-7. 2007
    ..These data suggest that the decreased expression of IGF-IR mRNA and increased expression of IGFBP-3 in carotid plaques of symptomatic patients could be due to atheroma-associated cytokines and this could result in plaque instability...
  35. pmc Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells
    Gang Cheng
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Cardiovasc Res 73:198-207. 2007
    ..The siRNA approach was used to support the role of ClC-2, a member of the volume-regulated Cl- channel family, in cell proliferation of VSMCs...
  36. ncbi request reprint Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling
    Toluwalope Makinde
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Curr Mol Med 6:831-41. 2006
    ..This paper reviews individual and combined roles of VEGF and Ang-1. The potential therapeutic applications involving these factors are also discussed...
  37. ncbi request reprint Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Surg Res 142:137-42. 2007
    ..It is our hypothesis that increased connexin43 expression following stimulation of VSMCs with Ang II and IGF-1 contributes to more proliferation in saphenous vein (SV) than in the internal mammary artery (IMA)...
  38. ncbi request reprint Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells
    Kristopher D Krueger
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int Immunopharmacol 3:1751-9. 2003
    ..Studies utilizing this system may prove useful in understanding the apoptotic response of VSMCs in the arterial wall...
  39. pmc Calcium-activated potassium channel KCa3.1 in lung dendritic cell migration
    Zhifei Shao
    Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Respir Cell Mol Biol 45:962-8. 2011
    ..1 with TRAM-34 impaired CCL19/CCL21-induced transmigration. In conclusion, KCa3.1 expression in lung DCs is up-regulated by OVA sensitization in both lung DC subsets, and KCa3.1 is involved in lung DC migration to lymphatic chemokines...
  40. pmc Increased expression of angiopoietins and Tie2 in the lungs of chronic asthmatic mice
    Toluwalope O Makinde
    Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Respir Cell Mol Biol 44:384-93. 2011
    ..In conclusion, increased expression of Tie2 and Ang2 in allergic airway epithelium and alveolar macrophages correlates with the severity of airway remodeling...
  41. ncbi request reprint Immunomodulation in asthma: a distant dream or a close reality?
    Arpita Bharadwaj
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int Immunopharmacol 4:495-511. 2004
    ..All these agents have been shown to be promising and could serve as an alternative approach to the treatment of asthma and maybe other allergic diseases...
  42. ncbi request reprint Effect of interleukin-1beta and tumor necrosis factor-alpha on the expression of G-proteins in CD4+ T-cells of atopic asthmatic subjects
    Matthew H Kim
    Center for Allergy, Asthma and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Asthma 39:441-8. 2002
    ....
  43. ncbi request reprint Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49
    Uwe A Wittel
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochem Biophys Res Commun 329:168-76. 2005
    ..In animal studies, the radiolabeled sc(Fv)(2)-AngII construct exhibited similar uptake and a more homogeneous distribution within the tumor as compared to sc(Fv)(2)...
  44. ncbi request reprint Chloride channel expression and functional diversity in the immune cells of allergic diseases
    Gang Cheng
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Curr Mol Med 8:401-7. 2008
    ..Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease...
  45. ncbi request reprint Evidence that insulin-like growth factor-1 requires protein kinase C-epsilon, PI3-kinase and mitogen-activated protein kinase pathways to protect human vascular smooth muscle cells from apoptosis
    Todd R Allen
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Immunol Cell Biol 83:651-67. 2005
    ..These results indicate for the first time that IGF-1 can protect human VSMC via multiple signals, including PKC-epsilon, PI3-K and mitogen-activated protein kinase pathways...
  46. ncbi request reprint Cells, cytokines and cellular immunity in the pathogenesis of fibroproliferative vasculopathies
    Amit K Mitra
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Can J Physiol Pharmacol 83:701-15. 2005
    ..New light on the 'old' problems will help us to devise newer and better therapeutic strategies to combat these clinical entities...
  47. ncbi request reprint Immunobiology of Toll-like receptors: emerging trends
    Saumya Pandey
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Immunol Cell Biol 84:333-41. 2006
    ..In this review, we have discussed the immunobiology of TLR and emphasize significant advances made within the ever-expanding field of TLR that provide intriguing insights efficacious in unravelling the complexities associated with TLR...
  48. ncbi request reprint Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Immunol Cell Biol 84:448-54. 2006
    ..These findings suggest that the expression of autophagy genes can be influenced by IGF-1 and TNF-alpha through c-jun N-terminal kinase or Akt pathways and autophagy might be involved in the regulation of plaque stability...
  49. ncbi request reprint Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells
    Gang Cheng
    Department of Biomedical Sciences, Creighton Univ School of Medicine, CRISS II Rm 510, 2500 California Plaza, Omaha, NE 68178, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1339-47. 2007
    ..TGF-beta1-induced cell apoptosis was suppressed in Bcl-2-transfected HBECs. Our data demonstrate that CLC-3-like voltage-gated chloride channels play a critical role in TGF-beta-induced apoptosis of human airway epithelial cells...
  50. ncbi request reprint Transcription factors in the control of dendritic cell life cycle
    Arpita S Bharadwaj
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 37:79-96. 2007
    ..This review will discuss the various transcription factors and signaling pathways involved in each stage of the life cycle of DCs...
  51. ncbi request reprint Following the TRAIL to apoptosis
    Bharti R Chaudhari
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 35:249-62. 2006
    ..Analogs of TRAIL could have therapeutical applications for asthma. TRAIL is also seen as the basis for a "miracle" drug for cancer because of its ability to selectively kill cancer cells...
  52. ncbi request reprint (S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model
    Daniel Abraha
    Division of Allergy and Immunology, Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles, Torrance, CA 90509, USA
    Int Arch Allergy Immunol 133:380-8. 2004
    ..We thus hypothesized that (S,S)-formoterol promotes asthma by enhancing IL-4 production in mast cells of the asthmatic airway...
  53. ncbi request reprint Decoding IgE Fc receptors
    Ming Zhang
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Res 37:1-16. 2007
    ..A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively...

Research Grants23

  1. SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN CORONARY ARTERY BYPASS GRAFTS
    DEVENDRA AGRAWAL; Fiscal Year: 2009
    ..The information obtained from this study should provide an opportunity to formulate superior therapeutic approaches. ..
  2. SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN CORONARY ARTERY BYPASS GRAFTS
    Devendra K Agrawal; Fiscal Year: 2010
    ..The information obtained from this study should provide an opportunity to formulate superior therapeutic approaches. ..
  3. TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILS
    Devendra K Agrawal; Fiscal Year: 2010
    ..The information obtained from this study should provide an opportunity to formulate superior therapeutic approaches in chronic asthma. ..
  4. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    Devendra K Agrawal; Fiscal Year: 2010
    ..Such investigations would provide unique insights to the pathophysiologic process of neurological diseases associated with the rupture of atherosclerotic plaques and the means to prevent the disease in patients with carotid stenosis. ..
  5. TGF-BETA, CHLORIDE CHANNELS AND APOPTOSIS OF AIRWAY EPITHELIAL CELLS
    Devendra K Agrawal; Fiscal Year: 2010
    ..Such investigations would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease. ..
  6. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    DEVENDRA AGRAWAL; Fiscal Year: 2007
    ..A better understanding of the pathophysiology of carotid stenosis and regulatory role of IGF-1 receptors in the stability of plaques will provide opportunities to develop a more precise and cost-effective treatment. ..
  7. FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA
    DEVENDRA AGRAWAL; Fiscal Year: 2007
    ..As KO mice may have pre-existing compensatory mechanisms, we will also undertake studies examining the therapeutic activity of FL in animals given neutralizing antibodies to IL-12 during allergic airway inflammation. ..
  8. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    Devendra K Agrawal; Fiscal Year: 2011
    ..Such investigations would provide unique insights to the pathophysiologic process of neurological diseases associated with the rupture of atherosclerotic plaques and the means to prevent the disease in patients with carotid stenosis. ..