Scott Falci

Summary

Affiliation: Craig Rehabilitation Hospital
Location: Englewood, CO, USA
Summary:
Dr. Falci is a graduate of Georgetown University in Washington, D.C. and completed his neurosurgical residency at Georgetown in 1992. He received his undergraduate training at Princeton University, Princeton, N.J. Dr. Falci initiated and designed the First Transplantation of Embryonic Nerve Cells for Spinal Cord Injury Project at Craig Center for Spinal Cord Research in collaboration with the Spinalis SCI Research Unit, Karolinska Institute, Huddinge University Hospital, Stockholm, and the department of Neurosurgery, University of Uppsala in Sweden. (J. of Neurotrauma, Vol. 14, No. 11, November, 1997)

Specialties include: surgical treatment for posttraumatic spinal cord tethering, postraumatic syringomyelia, posttraumatic neuropathic pain, spinal deformities, spasticity, as well as research in neuropathic pain and stem cell development for spinal cord injury

Current research includes: Neurochemical and Histopathologic Analysis of the Dorsal Root Entry Zone in Spinal Cord Injured Patients with Central Deafferentation Pain, Animal Modeling of neuropathic pain in spinal cord injury, Development of Human Clinical Trial for Administration of Embryonic Stem Cells in Spinal Cord Injury, and Use of Human Embryonic Stem Cells in Restoration of Neurologic Function in Spinal Cord Injured Rats.

Publications

  1. ncbi In-vitro and in-vivo studies of human axillary odour and the cutaneous microflora
    P J Rennie
    Department of Microbiology, Leeds, U K
    Br J Dermatol 124:596-602. 1991
  2. doi Markers of pluripotency and differentiation in human neural precursor cells derived from embryonic stem cells and CNS tissue
    M Sundberg
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cell Transplant 20:177-91. 2011
  3. doi A phase 2 autologous cellular therapy trial in patients with acute, complete spinal cord injury: pragmatics, recruitment, and demographics
    L A T Jones
    Proneuron Biotechnologies, Englewood, CO, USA
    Spinal Cord 48:798-807. 2010
  4. doi Posttraumatic spinal cord tethering and syringomyelia: surgical treatment and long-term outcome
    Scott P Falci
    Department of Neurosurgery, Craig Hospital, Englewood, Colorado 80113, USA
    J Neurosurg Spine 11:445-60. 2009
  5. doi Human neural stem cells and astrocytes, but not neurons, suppress an allogeneic lymphocyte response
    Elisabet Akesson
    Department of Neurobiology, Division of Neurodegeneration, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm, Sweden
    Stem Cell Res 2:56-67. 2009
  6. doi Human neural precursor cells continue to proliferate and exhibit low cell death after transplantation to the injured rat spinal cord
    Mia Emgard
    Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Geriatric Clinic Res Lab, Novum level 5, Stockholm, Sweden
    Brain Res 1278:15-26. 2009
  7. pmc Neuroimaging in traumatic spinal cord injury: an evidence-based review for clinical practice and research
    Daniel Lammertse
    Department of Physical Medicine and Rehabilitation, Univeristy of Colorado Denver Health Science Center, Denver Cororado, USA
    J Spinal Cord Med 30:205-14. 2007
  8. ncbi Long-term culture and neuronal survival after intraspinal transplantation of human spinal cord-derived neurospheres
    Elisabet Akesson
    Karolinska Institutet, Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Novum, S 141 86 Stockholm, Sweden
    Physiol Behav 92:60-6. 2007
  9. ncbi Late human cytomegalovirus (HCMV) proteins inhibit differentiation of human neural precursor cells into astrocytes
    Jenny Odeberg
    Karolinska Institutet, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital in Solna, Stockholm, Sweden
    J Neurosci Res 85:583-93. 2007
  10. pmc Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells
    Jenny Odeberg
    Neurotec Department, Division of Neurodegeneration and Neuroinflammation, Novum floor 5, SE 141 86 Stockholm, Sweden
    J Virol 80:8929-39. 2006

Collaborators

Detail Information

Publications19

  1. ncbi In-vitro and in-vivo studies of human axillary odour and the cutaneous microflora
    P J Rennie
    Department of Microbiology, Leeds, U K
    Br J Dermatol 124:596-602. 1991
    ..Underarm odour was produced exclusively by aerobic coryneform bacteria. Of aerobic coryneforms, 71.4% were odour producers and these were identified as Corynebacterium xerosis...
  2. doi Markers of pluripotency and differentiation in human neural precursor cells derived from embryonic stem cells and CNS tissue
    M Sundberg
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cell Transplant 20:177-91. 2011
    ..Our data show that transplantation to the subcutaneous tissue or the testes of immunodeficient mice is not a reliable method for evaluation of the tumor risk of remaining pluripotent cells in grafts...
  3. doi A phase 2 autologous cellular therapy trial in patients with acute, complete spinal cord injury: pragmatics, recruitment, and demographics
    L A T Jones
    Proneuron Biotechnologies, Englewood, CO, USA
    Spinal Cord 48:798-807. 2010
    ..Post hoc analysis from a randomized controlled cellular therapy trial in acute, complete spinal cord injury (SCI)...
  4. doi Posttraumatic spinal cord tethering and syringomyelia: surgical treatment and long-term outcome
    Scott P Falci
    Department of Neurosurgery, Craig Hospital, Englewood, Colorado 80113, USA
    J Neurosurg Spine 11:445-60. 2009
    ..Both objective and subjective long-term outcomes were evaluated. To the authors' knowledge, this is the first series of this size correlating long-term patient perception of outcome with long-term objective outcome analyses...
  5. doi Human neural stem cells and astrocytes, but not neurons, suppress an allogeneic lymphocyte response
    Elisabet Akesson
    Department of Neurobiology, Division of Neurodegeneration, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm, Sweden
    Stem Cell Res 2:56-67. 2009
    ..Thus, human NSCs and their derived astrocytes do not initiate, but instead suppress, an allogeneic response, while they cannot block a graft rejection in a xenogeneic setting...
  6. doi Human neural precursor cells continue to proliferate and exhibit low cell death after transplantation to the injured rat spinal cord
    Mia Emgard
    Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Geriatric Clinic Res Lab, Novum level 5, Stockholm, Sweden
    Brain Res 1278:15-26. 2009
    ....
  7. pmc Neuroimaging in traumatic spinal cord injury: an evidence-based review for clinical practice and research
    Daniel Lammertse
    Department of Physical Medicine and Rehabilitation, Univeristy of Colorado Denver Health Science Center, Denver Cororado, USA
    J Spinal Cord Med 30:205-14. 2007
    ..To perform an evidence-based review of the literature on neuroimaging techniques utilized in spinal cord injury clinical practice and research...
  8. ncbi Long-term culture and neuronal survival after intraspinal transplantation of human spinal cord-derived neurospheres
    Elisabet Akesson
    Karolinska Institutet, Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Novum, S 141 86 Stockholm, Sweden
    Physiol Behav 92:60-6. 2007
    ....
  9. ncbi Late human cytomegalovirus (HCMV) proteins inhibit differentiation of human neural precursor cells into astrocytes
    Jenny Odeberg
    Karolinska Institutet, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital in Solna, Stockholm, Sweden
    J Neurosci Res 85:583-93. 2007
    ..Clearly, HCMV can reduce the capacity of NPCs to differentiate into astrocytes and this effect may provide part of the explanation for the abnormalities in brain development associated with congenital HCMV infection...
  10. pmc Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells
    Jenny Odeberg
    Neurotec Department, Division of Neurodegeneration and Neuroinflammation, Novum floor 5, SE 141 86 Stockholm, Sweden
    J Virol 80:8929-39. 2006
    ..These findings indicate that HCMV has the capacity to reduce the ability of human NPCs to differentiate into neurons, which may offer one explanation for the abnormalities in brain development associated with congenital HCMV infection...
  11. ncbi Cellular composition of long-term human spinal cord- and forebrain-derived neurosphere cultures
    Jing Hua Piao
    Neurotec Department, Division of Neurodegeneration and Neuroinflammation, Karolinska Institutet, Stockholm, Sweden
    J Neurosci Res 84:471-82. 2006
    ..This could in turn imply that human spinal cord and forebrain NPCs present different repair potentials in in vivo settings...
  12. ncbi Low immunogenicity of in vitro-expanded human neural cells despite high MHC expression
    Jenny Odeberg
    Neurotec Department, Division of Experimental Geriatrics, Karolinska Institutet, Karolinska University Hospital, KFC, 4th Floor, Novum, SE 141 86 Stockholm, Sweden
    J Neuroimmunol 161:1-11. 2005
    ..Taken together, these results suggest a low immunogenicity of these cultured human neural cells despite HLA incompatibility and high HLA expression...
  13. ncbi Dorsal root entry zone microcoagulation for spinal cord injury-related central pain: operative intramedullary electrophysiological guidance and clinical outcome
    Scott Falci
    Department of Neurosurgery, Physical Medicine and Rehabilitation, Craig Hospital, Englewood, Colorado, USA
    J Neurosurg 97:193-200. 2002
    ..Additionally, electrical data were used to determine if the spinal cord could be somatotopically mapped with regard to this pain of central origin...
  14. ncbi Solid human embryonic spinal cord xenografts in acute and chronic spinal cord cavities: a morphological and functional study
    E Akesson
    Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, S-141 86, Sweden
    Exp Neurol 170:305-16. 2001
    ..In conclusion, solid human embryonic spinal cord tissue transplanted to a cavity in the adult injured spinal cord results in beneficial morphological effects in both the acute and chronic spinal cord lesion...
  15. ncbi MHC antigen expression in human first trimester spinal cord with implications for clinical transplantation procedures
    E Akesson
    Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, KFC 4th floor, S 141 86, Novum, Sweden
    J Neuroimmunol 111:210-4. 2000
    ..In conclusion, we report non-immunogenic expression of HLA antigens in the human first trimester spinal cord...
  16. ncbi Surgical treatment of posttraumatic cystic and tethered spinal cords
    S P Falci
    Department of Neurosurgery, Craig Hospital, Denver, Colorado, USA
    J Spinal Cord Med 22:173-81. 1999
    ..Of this latter group, 64.3% regained a lost function, 62.5% saw improvement in spasticity, 55.6% had substantial improvement in neurogenic pain, and 95.8% felt that surgery prevented further neurologic deterioration...
  17. ncbi Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: first clinical attempt
    S Falci
    Department of Neurosurgery, Craig Hospital, Denver, Colorado, USA
    J Neurotrauma 14:875-84. 1997
    ..The grafts are well visualized by MRI to the 7-month postoperative follow-up and cyst obliteration is seen in the region where the grafts were placed...
  18. ncbi The diagnosis and treatment of pediatric lumbar spine injuries caused by rear seat lap belts
    D L Johnson
    Department of Neurosurgery, George Washington University, Washington, District of Columbia
    Neurosurgery 26:434-41. 1990
    ..Rear seat lap belts are better than no restraints, but the addition of a shoulder restraint is strongly advocated to reduce lumbar spine injury...
  19. pmc Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy
    Alexander M Benison
    Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309 0345, USA
    J Neurosci 31:6317-28. 2011
    ..In addition, using electrophysiological techniques, we reveal a corticospinal loop that could be the anatomical source of the influence of CGIC on allodynia...