Yuan-Shan Zhu

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells
    Yuan Shan Zhu
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Oncol Rep 10:1633-9. 2003
  2. ncbi Effects of male sex hormones on gender identity, sexual behavior, and cognitive function
    Yuan Shan Zhu
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, NY 10021, USA
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:149-61. 2006
  3. ncbi Receptor isoform and ligand-specific modulation of dihydrotestosterone-induced prostate specific antigen gene expression and prostate tumor cell growth by estrogens
    Yuan Shan Zhu
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, 1300 York Ave, Box 149, New York, NY 10021, USA
    J Androl 26:500-8; discussion 509-10. 2005
  4. ncbi 5alpha-reductase isozymes and androgen actions in the prostate
    Yuan Shan Zhu
    Division of Endocrinology, Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Ann N Y Acad Sci 1155:43-56. 2009
  5. ncbi Inhibition of aberrant androgen receptor induction of prostate specific antigen gene expression, cell proliferation and tumor growth by 17α-estradiol in prostate cancer
    Yaming Qiao
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Urol 185:305-14. 2011
  6. ncbi Androgen-induced prostate-specific antigen gene expression is mediated via dihydrotestosterone in LNCaP cells
    Yuan Shan Zhu
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York, USA
    J Androl 24:681-7. 2003
  7. ncbi 17alpha-estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals
    Yaming Qiao
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Prostate 67:1719-28. 2007
  8. ncbi Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task
    Tracy Butler
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Brain Mapp 28:1206-12. 2007
  9. ncbi Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat
    Li Qun Cai
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Prostate 66:738-48. 2006
  10. ncbi Bone mineral density in the complete androgen insensitivity and 5alpha-reductase-2 deficiency syndromes
    Vivian Sobel
    Division of Endocrinology and Metabolism, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Clin Endocrinol Metab 91:3017-23. 2006

Research Grants

  1. MOLECULAR BASIS OF SEX STEROID ACTION IN PROSTATE CANCER
    Yuan Shan Zhu; Fiscal Year: 2005

Collaborators

  • Lu Wang
  • Ying Huang
  • Hong Pan
  • D A Silbersweig
  • D Voyer
  • B S Schwartz
  • Yi Jiang
  • L Zhang
  • Yan-Wen Duan
  • Julianne Imperato-McGinley
  • Li Qun Cai
  • Yaming Qiao
  • Tracy Butler
  • Li-Qun Cai
  • Yun Yu
  • Vivian Sobel
  • Chen Tan
  • Guo-qiang Chen
  • Juan J Cordero
  • Jingjing Cai
  • Joyce K Cohen
  • Emily Stern
  • Man-Gen Song
  • Hua Yan
  • Judy K Lee
  • Chunyan Weng
  • Yuan Hong
  • Shao Ming Shen
  • Krista M D La Perle
  • Guo Qiang Chen
  • Amy Christine Cunningham-Bussel
  • Li Xia
  • Luke Chang
  • Zhi-Kai Zhang
  • Shao-Ming Shen
  • Julianne L Imperato-McGinley
  • Zhi Kai Zhang
  • Juan Cordero
  • Shen-Meng Gao
  • Ke-Ming Du
  • Zhu Chen
  • Qiong Wang
  • Qian Zhao
  • Zhen-Gang Peng
  • Min Xu
  • Yu-Hong Zhou
  • Ying-Li Wu
  • Cecilia Herrera
  • Iluminada Labour

Detail Information

Publications21

  1. ncbi The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells
    Yuan Shan Zhu
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Oncol Rep 10:1633-9. 2003
    ..These data suggest that ZYD88 is a potential agent for prostate cancer therapy, and deserves further study...
  2. ncbi Effects of male sex hormones on gender identity, sexual behavior, and cognitive function
    Yuan Shan Zhu
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, NY 10021, USA
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:149-61. 2006
    ..The issue of the complex interaction of nature versus nurture is addressed...
  3. ncbi Receptor isoform and ligand-specific modulation of dihydrotestosterone-induced prostate specific antigen gene expression and prostate tumor cell growth by estrogens
    Yuan Shan Zhu
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, 1300 York Ave, Box 149, New York, NY 10021, USA
    J Androl 26:500-8; discussion 509-10. 2005
    ....
  4. ncbi 5alpha-reductase isozymes and androgen actions in the prostate
    Yuan Shan Zhu
    Division of Endocrinology, Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Ann N Y Acad Sci 1155:43-56. 2009
    ..The studies of 5alpha-reductases and androgen actions highlight the importance of 5alpha-reductase isozymes in male sexual differentiation and prostate physiology and pathophysiology...
  5. ncbi Inhibition of aberrant androgen receptor induction of prostate specific antigen gene expression, cell proliferation and tumor growth by 17α-estradiol in prostate cancer
    Yaming Qiao
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Urol 185:305-14. 2011
    ..We determined the effectiveness and mechanism of 17α-estradiol (Sigma®) in blocking aberrant androgen receptor activation due to androgen receptor mutation...
  6. ncbi Androgen-induced prostate-specific antigen gene expression is mediated via dihydrotestosterone in LNCaP cells
    Yuan Shan Zhu
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York, USA
    J Androl 24:681-7. 2003
    ..These results suggest that both 5alpha-reductase isozymes are present and functionally important in prostatic tumor LNCaP cells and that DHT is a major mediator of androgen induction of PSA gene expression in these cells...
  7. ncbi 17alpha-estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals
    Yaming Qiao
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Prostate 67:1719-28. 2007
    ..With the discovery of the estrogen receptor (ER) beta and its presence in prostate tumor cells, evaluation of estrogen analogs with less classic estrogenic activity in prostate cancer therapy is emerging...
  8. ncbi Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task
    Tracy Butler
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Brain Mapp 28:1206-12. 2007
    ..Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing...
  9. ncbi Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat
    Li Qun Cai
    Department of Medicine Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Prostate 66:738-48. 2006
    ..High-fat diet is a major risk factor for prostate cancer. 5alpha-reductases are potential targets of dietary fat...
  10. ncbi Bone mineral density in the complete androgen insensitivity and 5alpha-reductase-2 deficiency syndromes
    Vivian Sobel
    Division of Endocrinology and Metabolism, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Clin Endocrinol Metab 91:3017-23. 2006
    ..CONCLUSIONS: 1) Androgens are of direct importance in the development and/or maintenance of BMD; and 2) testosterone and/or low levels of dihydrotestosterone appear to be sufficient for BMD development and/or maintenance...
  11. ncbi Long-term growth hormone therapy in adulthood results in significant linear growth in siblings with a PROP-1 gene mutation
    Judy K Lee
    Department of Medicine/Endocrinology, Weill Medical College of Cornell University, 1300 York Avenue, Box 149, New York, New York 10021, USA
    J Clin Endocrinol Metab 89:4850-6. 2004
    ..5 cm, respectively. In conclusion, the substantial linear growth in adult siblings with a PROP-1 mutation illustrates that despite an advanced BA, linear growth potential remains in adulthood in the setting of sex steroid deficiency...
  12. ncbi Pancreaticoduodenal arterial rupture and hemoabdomen in ACI/SegHsd rats with polyarteritis nodosa
    Joyce K Cohen
    Tri Institutional Training Program in Laboratory Animal Medicine and Science, Memorial Sloan Kettering Cancer Center, Rockefeller University, New York, NY, USA
    Comp Med 57:370-6. 2007
    ..Although arterial rupture is a known complication of polyarteritis nodosa in humans, this case series is the first to document arterial rupture and hemoabdomen in rats with PAN...
  13. ncbi Sex differences in mental rotation: top-down versus bottom-up processing
    Tracy Butler
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, Box 140, 1300 York Avenue, New York, NY 10021, USA
    Neuroimage 32:445-56. 2006
    ....
  14. ncbi Mutations in CYP11B1 gene: phenotype-genotype correlations
    Yuan-Shan Zhu
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Med Genet A 122:193-200. 2003
    ..Heterozygosity was determined in family members of both probands including parents and siblings. These results indicate that mutations of CYP11B1 in these subjects are responsible for their clinical syndromes...
  15. ncbi Fetal hormones and sexual differentiation
    Vivian Sobel
    Department of Medicine, Weill Medical College of Cornell University, 525 East 68th Street, F-2006, New York, NY 10021, USA
    Obstet Gynecol Clin North Am 31:837-56, x-xi. 2004
    ..Most of the article focuses on the hormones that regulate sexual differentiation and development in utero. The genetic factors that regulate sexual differentiation, which constitute a new and emerging field, also are discussed...
  16. ncbi Androgen stimulates endothelial cell proliferation via an androgen receptor/VEGF/cyclin A-mediated mechanism
    Jingjing Cai
    Department of Medicine Endocrinology, Weill Cornell Medical College, New York, New York 10065, USA
    Am J Physiol Heart Circ Physiol 300:H1210-21. 2011
    ....
  17. ncbi Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells
    Hua Yan
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui-Jin Hospital, Shanghai Jiao-Tong University (SJU-SM, formerly named Shanghai Second Medical University, Shanghai 200025, China
    Haematologica 90:1607-16. 2005
    ..These data provide new insights into the understanding of the mechanisms of the action of As2O3 in the treatment of patients with APL...
  18. ncbi Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms
    Man-Gen Song
    Department of Pathophysiology, Shanghai Institute of, Chong-Qing South Rd, Shanghai 200025, China
    Blood 105:3714-21. 2005
    ..In addition, NSC606985-induced apoptosis by PKCdelta also involves caspase-3-independent mechanisms. Taken together, our results suggest that NSC606985 is a potential agent for the treatment of AML...
  19. ncbi Inhibition of tumor growth and tumor metastasis by a Chinese herbal formula--ZYD88, in an animal model with metastatic Lewis lung carcinoma
    Yan Wen Duan
    Changsha Cihang Research Institute of Materia Medica, Changsha, Hunan 410011, China
    Oncol Rep 17:1391-7. 2007
    ..These results indicate that ZYD88 possesses significant anti-angiogenic, anti-tumor and anti-metastatic effects in this animal model, and warrants further investigation...
  20. ncbi In vivo antitumor activity of ZYD88, a Chinese herbal medicine, in animal models with S180 sarcoma and Ehrlich tumor
    Ying Huang
    Changsha Cihang Research Institute of Materia Medica, Changsha, China
    J Soc Integr Oncol 5:45-9. 2007
    ....
  21. ncbi Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells
    Yun Yu
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Proteome Res 6:3808-18. 2007
    ..Collectively, these discoveries would shed new insights for systematically understanding the mechanisms of the camptothecin-induced apoptosis...

Research Grants1

  1. MOLECULAR BASIS OF SEX STEROID ACTION IN PROSTATE CANCER
    Yuan Shan Zhu; Fiscal Year: 2005
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