Steven Witkin

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Gelsolin down-regulates lipopolysaccharide-induced intraamniotic tumor necrosis factor-alpha production in the midtrimester of pregnancy
    Devrim Sezen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 200:191.e1-4. 2009
  2. ncbi Fatty acid composition of mid-trimester amniotic fluid in women of different ethnicities
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Matern Fetal Neonatal Med 25:818-21. 2012
  3. ncbi Complexities of the uniquely human vagina
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY 10065, USA
    Sci Transl Med 4:132fs11. 2012
  4. ncbi The safe motherhood referral system to reduce cesarean sections and perinatal mortality - a cross-sectional study [1995-2006]
    Marilza V C Rudge
    Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University UNESP, Brazil
    Reprod Health 8:34. 2011
  5. ncbi Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1beta and interleukin-1 receptor antagonist and pregnancy outcome
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 E 68th Street, Box 35, New York, NY 10021, USA
    Am J Obstet Gynecol 189:1413-7. 2003
  6. ncbi Bacterial flora of the female genital tract: function and immune regulation
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York 10021, USA
    Best Pract Res Clin Obstet Gynaecol 21:347-54. 2007
  7. ncbi Unique alterations in infection-induced immune activation during pregnancy
    S S Witkin
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10065, USA
    BJOG 118:145-53. 2011
  8. ncbi Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide
    Steven S Witkin
    Department of Obstetrics and Gynecology, Division of Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
    FEMS Immunol Med Microbiol 61:153-8. 2011
  9. ncbi An altered immunity hypothesis for the development of symptomatic bacterial vaginosis
    Steven S Witkin
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Infect Dis 44:554-7. 2007
  10. ncbi Influence of mid-trimester amniotic fluid on endogenous and lipopolysaccharide-mediated responses of mononuclear lymphoid cells
    Steven S Witkin
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, NY 10065, USA
    Am J Reprod Immunol 67:28-33. 2012

Research Grants

  1. Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*
    Steven Witkin; Fiscal Year: 2005

Collaborators

Detail Information

Publications74

  1. ncbi Gelsolin down-regulates lipopolysaccharide-induced intraamniotic tumor necrosis factor-alpha production in the midtrimester of pregnancy
    Devrim Sezen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 200:191.e1-4. 2009
    ..The purpose of this study was to identify gelsolin in midtrimester amniotic fluid and evaluate its interaction with lipopolysaccharide (LPS)...
  2. ncbi Fatty acid composition of mid-trimester amniotic fluid in women of different ethnicities
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Matern Fetal Neonatal Med 25:818-21. 2012
    ..To determine whether the fatty acid composition of mid-trimester amniotic fluid differs by ethnicity and pregnancy outcome...
  3. ncbi Complexities of the uniquely human vagina
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY 10065, USA
    Sci Transl Med 4:132fs11. 2012
    ..The vaginal microbiome in healthy women changes over short periods of time, differs among individuals, and varies in its response to sexual intercourse...
  4. ncbi The safe motherhood referral system to reduce cesarean sections and perinatal mortality - a cross-sectional study [1995-2006]
    Marilza V C Rudge
    Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University UNESP, Brazil
    Reprod Health 8:34. 2011
    ..In 2000, the eight Millennium Development Goals (MDGs) set targets for reducing child mortality and improving maternal health by 2015...
  5. ncbi Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1beta and interleukin-1 receptor antagonist and pregnancy outcome
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 E 68th Street, Box 35, New York, NY 10021, USA
    Am J Obstet Gynecol 189:1413-7. 2003
    ..The relationship among the IL-1ra genotype of the fetus, concentrations of IL-1beta and IL-1ra in second-trimester amniotic fluid, and pregnancy outcome was determined...
  6. ncbi Bacterial flora of the female genital tract: function and immune regulation
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York 10021, USA
    Best Pract Res Clin Obstet Gynaecol 21:347-54. 2007
    ..Recognition leads to pro-inflammatory cytokine production and antigen-specific immunity. Local production of IgG and IgA antibodies can also be initiated in the endocervix and vagina in response to infection...
  7. ncbi Unique alterations in infection-induced immune activation during pregnancy
    S S Witkin
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10065, USA
    BJOG 118:145-53. 2011
    ..Immune responses to infection are uniquely regulated during gestation to allow for antimicrobial defence and tissue repair, whilst preventing damage to developing fetal organs or the triggering of preterm labour...
  8. ncbi Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide
    Steven S Witkin
    Department of Obstetrics and Gynecology, Division of Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
    FEMS Immunol Med Microbiol 61:153-8. 2011
    ....
  9. ncbi An altered immunity hypothesis for the development of symptomatic bacterial vaginosis
    Steven S Witkin
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Infect Dis 44:554-7. 2007
    ..A deficit in vaginal mannose-binding lectin concentrations would further decrease the capacity for microbial killing and increase the likelihood of bacterial migration from the vagina to the upper genital tract...
  10. ncbi Influence of mid-trimester amniotic fluid on endogenous and lipopolysaccharide-mediated responses of mononuclear lymphoid cells
    Steven S Witkin
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, NY 10065, USA
    Am J Reprod Immunol 67:28-33. 2012
    ....
  11. ncbi Genetic polymorphism in an inflammasome component, cervical mycoplasma detection and female infertility in women undergoing in vitro fertilization
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10065, USA
    J Reprod Immunol 84:171-5. 2010
    ..7% as opposed to 19.5% in those negative for this infection (p<0.0001). We conclude that the CIAS1 7unit repeat polymorphism increases the likelihood of mycoplasma infection-associated female infertility...
  12. ncbi Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome
    Ahinoam Lev-Sagie
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Am J Obstet Gynecol 200:303.e1-6. 2009
    ..Patients with vulvar vestibulitis syndrome (VVS) and control subjects were tested for a polymorphism in the gene coding for the NALP3 component of inflammasomes, cytoplasmic structures regulating interleukin (IL)-1beta production...
  13. ncbi Fetal interleukin-1 receptor antagonist gene polymorphism, intra-amniotic interleukin-1beta levels, and history of spontaneous abortion
    Sriram C Perni
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Obstet Gynecol 191:1318-23. 2004
    ..The purpose of this study was to determine whether fetal carriage of specific alleles of the polymorphic interleukin-1 receptor antagonist gene is associated with variations in intra-amniotic cytokine levels and previous pregnancy outcomes...
  14. ncbi Mycoplasma hominis in mid-trimester amniotic fluid: relation to pregnancy outcome
    Daniel P Nguyen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Perinat Med 32:323-6. 2004
    ..CONCLUSIONS: Detection of M. hominis in second-trimester amniotic fluids can identify women at increased risk for subsequent preterm labor and delivery...
  15. ncbi Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women
    Mehmet R Genc
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Obstet Gynecol Reprod Biol 116:152-6. 2004
    ....
  16. ncbi Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome
    Stefan Gerber
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 515 East 71st Street, New York, NY 10021, USA
    Eur J Obstet Gynecol Reprod Biol 107:74-7. 2003
    ..The relation between this syndrome and a polymorphism at position +3953 in the interleukin-1beta gene was examined. Allele 2 of this gene has been associated with increased pro-inflammatory immunity...
  17. ncbi Interleukin-1 receptor antagonist gene polymorphism, vaginal interleukin-1 receptor antagonist concentrations, and vaginal ureaplasma urealyticum colonization in pregnant women
    Parrin T Barton
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Infect Immun 71:271-4. 2003
    ..Pregnant women who are colonized with U. urealyticum during the first trimester have elevated vaginal IL-1ra concentrations and a higher prevalence of the IL-1RN*2 homozygote genotype than do noncolonized women...
  18. ncbi Antibody to the Chlamydia trachomatis 60 kDa heat shock protein in follicular fluid and in vitro fertilization outcome
    Sharon Jakus
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
    Am J Reprod Immunol 59:85-9. 2008
    ..The association between 60 kDa Chlamydia trachomatis heat shock protein (CHSP60) antibodies and the etiology and outcomes of in vitro fertilization (IVF) outcomes is not well known...
  19. ncbi Differential vaginal expression of interleukin-1 system cytokines in the presence of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women
    Kunihiko Doh
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Infect Dis Obstet Gynecol 12:79-85. 2004
    ..06). CONCLUSION: M. hominis colonization in healthy pregnant women is associated with localized pro-inflammatory immune activation, while U. urealyticum colonization is associated with immune suppression...
  20. ncbi Interleukin-1 receptor antagonist gene polymorphism and multifetal pregnancy outcome
    Robin B Kalish
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Am J Obstet Gynecol 189:911-4. 2003
    ..The purpose of this study was to determine whether interleukin-1 receptor antagonist and/or interleukin-1beta gene polymorphisms influence multifetal pregnancy outcome...
  21. ncbi Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome
    Katherine D Schoyer
    Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 88:139-44. 2007
    ..To evaluate serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) levels during stimulation in polycystic ovary syndrome (PCOS) and control populations as factors predictive of IVF outcome...
  22. ncbi Antibodies to the 70 kDa heat shock protein in midtrimester amniotic fluid and intraamniotic immunity
    Shari E Gelber
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, NY 10021, USA
    Am J Obstet Gynecol 197:278.e1-4. 2007
    ..The association between intraamniotic hsp70 IgG concentrations and intraamniotic immune responses were evaluated...
  23. ncbi TNFA-308G>A polymorphism influences the TNF-alpha response to altered vaginal flora
    Mehmet R Genc
    Brigham and Women s Hospital, Harvard Medical School, Department of Obstetrics and Gynecology, Boston, MA 02446, USA
    Eur J Obstet Gynecol Reprod Biol 134:188-91. 2007
    ..To investigate the association between a tumor necrosis factor-alpha (TNF-alpha) gene polymorphism, vaginal TNF-alpha level, and microbial flora in pregnant women...
  24. ncbi Vaginal nitric oxide in pregnant women with bacterial vaginosis
    Mehmet R Genc
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Reprod Immunol 56:86-90. 2006
    ..To evaluate vaginal nitric oxide (NO) production in response to alterations in the vaginal microbial flora...
  25. ncbi Are you a lumper or a splitter?
    William J Ledger
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, J 130, New York, NY 10021, USA
    Am J Obstet Gynecol 195:1205-9. 2006
    ..Utilization of more complete information provides the basis for more specific and individualized therapeutic interventions...
  26. ncbi Influence of interleukin-1 receptor antagonist gene polymorphism on disease
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Infect Dis 34:204-9. 2002
    ....
  27. ncbi Extracellular 70-kd heat shock protein in mid-trimester amniotic fluid and its effect on cytokine production by ex vivo-cultured amniotic fluid cells
    Claudel Jean-Pierre
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 194:694-8. 2006
    ..We hypothesized that 70-kd heat shock protein in mid-trimester amniotic fluid might regulate local immune system activation...
  28. ncbi Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery
    Stefan Gerber
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Infect Dis 187:518-21. 2003
    ..7%) than did the negative women (2.7%; P=.0008). PCR testing of second-trimester amniotic fluid for U. urealyticum can identify women at risk for subsequent preterm labor and delivery...
  29. ncbi Endogenous adenosine down-modulates mid-trimester intraamniotic tumor necrosis factor-alpha production
    Uma Perni
    Department of Obstetrics and Gynecology, New York Hospital Medical Center of Queens, New York, NY, USA
    Am J Reprod Immunol 62:232-7. 2009
    ..To determine whether adenosine in amniotic fluid down-regulates pro-inflammatory cytokine production...
  30. ncbi Differential characterization of women with vulvar vestibulitis syndrome
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 187:589-94. 2002
    ..We differentiated women with vulvar vestibulitis syndrome into subgroups on the basis of the time of symptom onset, a history of recurrent vulvovaginal candidiasis, and the interleukin-1 receptor antagonist gene polymorphism...
  31. ncbi Chlamydia trachomatis in subfertile women undergoing uterine instrumentation: an alternative to direct microbial testing or prophylactic antibiotic treatment
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 515 East 71st St, New York 10021, USA
    Hum Reprod 17:1938-41. 2002
    ..Screening for both cervical IgA antibodies to C. trachomatis and serum IgG anti-chlamydial hsp60 appears to provide the best indication as to which women may be harbouring C. trachomatis...
  32. ncbi Prevalence of cervical human papillomavirus in women undergoing in vitro fertilization and association with outcome
    Steven D Spandorfer
    The Center for Reproductive Medicine and Infertility, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
    Fertil Steril 86:765-7. 2006
    ..0%) of 106 patients undergoing treatment for IVF. Human papillomavirus-positive women had a decreased pregnancy rate (4 of 17, 23.5%) as compared with HPV-negative women (51 of 89, 57.0%; P<.02)...
  33. ncbi Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism
    Oksana Babula
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 198:101.e1-4. 2008
    ..We evaluated whether women with vulvar vestibulitis syndrome (VVS) could be subdivided on the basis of genotyping the polymorphic mannose-binding lectin (MBL) gene...
  34. ncbi Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis
    Ahinoam Lev-Sagie
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Am J Obstet Gynecol 201:206.e1-5. 2009
    ..We evaluated whether vaginal concentrations of hyaluronan were altered in women with recurrent vulvovaginal candidiasis (RVVC)...
  35. ncbi Mycoplasma hominis and Ureaplasma urealyticum in midtrimester amniotic fluid: association with amniotic fluid cytokine levels and pregnancy outcome
    Sriram C Perni
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Obstet Gynecol 191:1382-6. 2004
    ..The association between the detection of Mycoplasma hominis or Ureaplasma urealyticum in midtrimester amniotic fluid and amniotic fluid cytokine concentrations and subsequent pregnancy outcome were examined...
  36. ncbi Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women
    Oksana Babula
    Department of Obstetric and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Infect Dis 37:733-7. 2003
    ..Reduced vaginal MBL levels and an increased occurrence of the polymorphism were present in women with RVVC...
  37. ncbi Immunological aspects of genital chlamydia infections
    Steven S Witkin
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, Box 35, New York, New York 10021, USA
    Best Pract Res Clin Obstet Gynaecol 16:865-74. 2002
    ..Detection and treatment of a recently acquired infection can prevent development of h-hsp60 autoantibodies and tubal occlusion, preserve fertility, and prevent complications such as ectopic pregnancy...
  38. ncbi Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women
    Daniel P Nguyen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Obstet Gynecol 104:293-300. 2004
    ..Differences in allelic carriage of immune system-related genes among white, black, and Hispanic pregnant women living in New York City and Boston were evaluated...
  39. ncbi Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery
    Mehmet R Genc
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, USA
    Am J Obstet Gynecol 187:157-63. 2002
    ..We examined the association between preterm delivery and polymorphisms at position +3953 of the interleukin-1 beta gene (IL1B+3953) and in intron 2 of the interleukin-1 receptor antagonist gene (IL1RN)...
  40. ncbi Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome
    Stefan Gerber
    Department of Obstetrics and Gynecology, Division of Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 186:696-700. 2002
    ..62 ng/mL; P <.0001). CONCLUSION: A relative inability to down-regulate proinflammatory interleukin-1 beta activity by interleukin-1 receptor antagonist may contribute to the pathophysiologic features of vulvar vestibulitis syndrome...
  41. ncbi A deficiency in interferon-alpha production in women with vulvar vestibulitis
    Stefan Gerber
    Department of Obstetrics and Gynecology, Division of Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 186:361-4. 2002
    ..There was no relation between interleukin-1 receptor antagonist genotype and interferon-alpha production. CONCLUSION: An inability to produce interferon-alpha may contribute to chronic vestibular inflammation in some women...
  42. ncbi Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis
    Oksana Babula
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Infect Dis 40:1258-62. 2005
    ..Associations between this polymorphism and recurrent vulvovaginal candidiasis (RVVC), as well as vaginal concentrations of IL-4 and the anticandidal compounds nitric oxide (NO) and mannose binding lectin (MBL), were evaluated...
  43. ncbi Association of a maternal CD14 -159 gene polymorphism with preterm premature rupture of membranes and spontaneous preterm birth in multi-fetal pregnancies
    Robin B Kalish
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
    J Reprod Immunol 70:109-17. 2006
    ..Thus, an enhanced maternal pro-inflammatory immune response to LPS may increase susceptibility to PPROM in multi-fetal pregnancies...
  44. ncbi Hyaluronan modulates pro-inflammatory immune activity in the mid-trimester amniotic cavity
    Devrim Sezen
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10065, USA
    J Reprod Immunol 82:89-93. 2009
    ..In conclusion, intraamniotic HA levels are elevated in pregnancies at risk for adverse outcome and HA may be a component of the fetal response to immune alterations that threaten gestation...
  45. ncbi Differential expression of immune system-related components in midtrimester amniotic fluid from singleton and twin pregnancies
    Sriram C Perni
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 193:942-6. 2005
    ..We investigated differences between singleton and twin gestations in immune mediators in midtrimester amniotic fluid...
  46. ncbi Clara cell protein 16 concentration in mid-trimester amniotic fluid: association with fetal gender, fetal G>A +38 CC16 gene polymorphism and pregnancy outcome
    Sriram C Perni
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, Box 35, NY 10021, USA
    J Reprod Immunol 68:85-90. 2005
    ..01). We conclude that mid-trimester intraamniotic CC16 concentrations vary by gender, ethnicity and fetal CC16 gene polymorphism. Elevated CC16 levels are predictive of subsequent development of PPROM...
  47. ncbi Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract
    Iara Moreno Linhares
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, 525 East 68th Street, P O Box 35, New York, NY 10065, USA
    Cell Stress Chaperones 15:467-73. 2010
    ..Production of cross-reacting antibodies and cell-mediated immunity to the human hsp60 is detrimental to subsequent pregnancy outcome and may also possibly increase susceptibility to atherosclerosis, autoimmune disorders, or malignancies...
  48. ncbi An interleukin-23 binding protein in mid-trimester amniotic fluid
    Catherine Herway
    Department of Obstetrics and Gynecology, New York Hospital Queens Medical Center, New York, NY, USA
    Am J Reprod Immunol 62:308-13. 2009
    ..The binding of mid-trimester amniotic fluid to cytokines was evaluated...
  49. ncbi Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery
    Daniel W Skupski
    Department of Obstetrics and Gynecology, New York Hospital Queens, New York, NY, USA
    Am J Obstet Gynecol 199:296.e1-5. 2008
    ..The interval between induction and delivery may change in association with different polymorphisms in genes regulating inflammation...
  50. ncbi Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms
    Oksana Babula
    Department of Obstetrics and Gynecology, Division of Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
    Am J Obstet Gynecol 190:663-7. 2004
    ..CONCLUSION: A subset of women with vulvar vestibulitis syndrome are sensitized to seminal fluid, and an allergic reaction to seminal fluid may be associated with the initiation and persistence of their symptoms...
  51. ncbi Interleukin-4 and -10 gene polymorphisms and spontaneous preterm birth in multifetal gestations
    Robin B Kalish
    Department of Obstetrics and Gynecology, the Divisions of Maternal Fetal Medicine and Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
    Am J Obstet Gynecol 190:702-6. 2004
    ..The purpose of this study was to determine the relationship between maternal and fetal carriage of different alleles of interleukin-4 and -10 genes and pregnancy outcome in multifetal gestations...
  52. ncbi Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model
    Michael G Gravett
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
    Am J Obstet Gynecol 197:518.e1-8. 2007
    ..The purpose of this study was to determine whether treatment with ampicillin together with dexamethasone and indomethacin delays preterm birth that is induced by intraamniotic group B Streptococcus in a nonhuman primate model...
  53. ncbi Ex vivo cytokine production by whole mid-trimester amniotic fluid
    Devrim Sezen
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Reprod Immunol 78:22-7. 2008
    ..Immune mediator production by ex vivo amniotic fluid culture differs from that present in amniotic fluid supernatants and may provide a more accurate indication of the immune potential of the intraamniotic environment...
  54. ncbi Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome
    Oksana Babula
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 191:762-6. 2004
    ..In this study, we determined whether vulvar vestibulitis syndrome, a disorder of unknown etiology, was associated with an altered distribution of MBL alleles...
  55. ncbi Beta2-adrenergic receptor gene polymorphisms and pregnancy outcome
    Kunihiko Doh
    Division of Immunology and Infectious Diseases, Weill Medical College of Cornell University, New York, New York 10021, U S A
    J Perinat Med 32:413-7. 2004
    ..The association between alleles at two loci of the polymorphic beta2-adrenergic receptor (beta2AR) gene and pregnancy outcome was determined...
  56. ncbi Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes
    Robin B Kalish
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, New York Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Obstet Gynecol 191:1368-74. 2004
    ..The purpose of this study was to determine the relationship between preterm premature rupture of membranes, tumor necrosis factor-alpha, and heat shock protein-70 gene polymorphisms in multifetal gestations...
  57. ncbi Fetal polymorphisms in anti-inflammatory cytokine and beta-adrenergic receptor genes associated with placental pathological lesions
    Alexandros D Polydorides
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York10021, USA
    Int J Gynecol Pathol 27:79-85. 2008
    ..Carriage of these alleles may render the fetus more susceptible to the adverse consequences of infection and inflammation...
  58. ncbi Prenatal diagnosis of congenital cytomegalovirus infection by detection of immunoglobulin M antibodies to the 70-kd heat shock protein in fetal serum
    Stefan Gerber
    Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 515 East 71st Street, New York, NY 10021, USA
    Am J Obstet Gynecol 187:955-9. 2002
    ..CONCLUSION: The anti-70-kd heat shock protein immunoglobulin M assay may be of value in the assessment of fetal cytomegalovirus infection in pregnant women with a primary cytomegalovirus infection...
  59. ncbi Hyaluronan in follicular fluid and embryo implantation following in vitro fertilization and embryo transfer
    Arthur Babayan
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, Box 35, New York, NY 10065, USA
    J Assist Reprod Genet 25:473-6. 2008
    ..To determine whether the concentration of hyaluronan (HA) in follicular fluid predicts implantation success following embryo transfer...
  60. ncbi Maternal serum vascular endothelial growth factor levels in early ectopic and intrauterine pregnancies after in vitro fertilization treatment
    Sozos J Fasouliotis
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 305 East 70th Street, New York, NY 10021, USA
    Fertil Steril 82:309-13. 2004
    ....
  61. ncbi A single nucleotide A>G polymorphism at position -670 in the Fas gene promoter: relationship to preterm premature rupture of fetal membranes in multifetal pregnancies
    Robin B Kalish
    Division of Meternal Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Obstet Gynecol 192:208-12. 2005
    ..The relationship between a polymorphism at position -670 in the Fas gene (TNFRSF6) and preterm premature rupture of membranes (PPROM) in multifetal pregnancies was examined...
  62. ncbi A fetal cyclooxygenase-2 gene polymorphism is associated with placental malperfusion
    Alexandros D Polydorides
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, New York, New York, USA
    Int J Gynecol Pathol 26:284-90. 2007
    ..Thus, a fetal polymorphism in the COX-2 gene influences the occurrence of placental malperfusion and ischemia, which may be of sufficient severity to promote or allow the development of IUGR...
  63. ncbi Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60-kDa heat shock protein is associated with decreased spontaneous fertility rate in ectopic pregnant women treated by salpingectomy
    Istvan Sziller
    First Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Am J Reprod Immunol 59:99-104. 2008
    ..This prospective study was aimed to evaluate whether non-invasive clinical and serologic parameters of tubal disease are predictive for subsequent spontaneous conception and pregnancy outcome after first episode of ectopic pregnancy (EP)...
  64. ncbi Association between vaginal 70-kd heat shock protein, interleukin-1 receptor antagonist, and microbial flora in mid trimester pregnant women
    Mehmet R Genc
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Am J Obstet Gynecol 192:916-21. 2005
    ..This study investigated the association among the inducible 70-kd heat shock protein, cytokines, and microbial flora in the vagina in mid trimester pregnant women and subsequent preterm delivery...
  65. ncbi Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model
    Drew W Sadowsky
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR, USA
    Am J Obstet Gynecol 195:1578-89. 2006
    ..The purpose of this study was to determine the relative contributions of individual proinflammatory cytokines and chemokines to the triggering of preterm labor...
  66. ncbi Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth
    Mehmet R Genc
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 191:1324-30. 2004
    ....
  67. ncbi Association between fetal interleukin-1 receptor antagonist gene polymorphism and unexplained fetal death
    Stefan Gerber
    Department of Obstetrics and Gynecology, Institute of Pathology, Lausanne, Switzerland
    Am J Obstet Gynecol 193:1472-7. 2005
    ..The gene coding for IL-1ra (IL1RN) is polymorphic. We hypothesized that fetal possession of a specific allele, IL-1RN*2, associated with increased proinflammatory responses, may increase susceptibility to intrauterine fetal death...
  68. ncbi Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis
    Paulo C Giraldo
    Department of Gynecology and Obstetrics, The State University of Campinas, School of Medical Sciences, Sao Paulo, Brazil
    Obstet Gynecol 109:1123-8. 2007
    ..To evaluate associations between polymorphisms in the gene coding for mannose-binding lectin (MBL) and the diagnosis of acute or recurrent vulvovaginal candidiasis and bacterial vaginosis..
  69. ncbi Dexamethasone or interleukin-10 blocks interleukin-1beta-induced uterine contractions in pregnant rhesus monkeys
    Drew W Sadowsky
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Oregon Health Sciences University, Portland, OR 97201, USA
    Am J Obstet Gynecol 188:252-63. 2003
    ..Dexamethasone and interleukin-10 are likely to be useful adjuncts in the treatment of preterm labor that is associated with inflammation or infection...
  70. ncbi Detection of candida by polymerase chain reaction vs microscopy and culture in women diagnosed as recurrent vulvovaginal cases
    Per Anders Mardh
    Department of Obstetrics, Lund University Hospital, SE 221 85 Lund, Sweden
    Int J STD AIDS 14:753-6. 2003
    ..Thus reliance only on microscopy, culture or PCR may lead to inaccurate results...
  71. ncbi A disproportionate increase in IL-1beta over IL-1ra in the cervicovaginal secretions of pregnant women with altered vaginal microflora correlates with preterm birth
    Mehmet R Genc
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Obstet Gynecol 190:1191-7. 2004
    ..Study design Vaginal samples collected at 18 to 22 weeks' gestation from 207 women were analyzed to study qualitative and quantitative microbiologic aspects of vaginal microflora and IL-1beta and IL-1ra concentrations...
  72. ncbi Human papillomavirus in the oral mucosa of women with genital human papillomavirus lesions
    Paulo Giraldo
    Department of Gynecology and Obstetrics, Department of Clinical Pathology, The State University of Campinas, School of Medical Sciences, CEP 13092 160 Campinas, Sao Paulo, Brazil
    Eur J Obstet Gynecol Reprod Biol 126:104-6. 2006
    ..Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases worldwide. We determined the frequency of HPV in the oral cavity of women with and without genital HPV lesions...
  73. ncbi An A > G polymorphism at position -670 in the Fas (TNFRSF6) gene in pregnant women with pre-eclampsia and intrauterine growth restriction
    Istvan Sziller
    First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary
    Mol Hum Reprod 11:207-10. 2005
    ..Maternal possession of the TNFRSF6-670*G increases the risk for pre-eclampsia and pre-eclampsia-associated IUGR in women who deliver at < 37 weeks...
  74. ncbi Fetal MMP2/MMP9 polymorphisms and intrauterine growth restriction risk
    Sandrine Gremlich
    Department of Gynecology and Obstetrics, CHUV Hospital, Av Pierre Decker 2, 1011 Lausanne, Switzerland
    J Reprod Immunol 74:143-51. 2007
    ..We conclude that fetal MMP2 -1306 single nucleotide polymorphism (SNP) is associated with an increased risk for IUGR, but not MMP9 -1562 SNP nor MMP9 microsatellite...

Research Grants5

  1. Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*
    Steven Witkin; Fiscal Year: 2005
    ..Identification of genetic factors in mothers or their neonates that influence susceptibility to preterm labor and fetal morbidity in different racial groups will aid in development of improved protocols for monitoring and treatment...