MARC WEKSLER

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Evolution of B-cell clonal expansions with age
    Paul Szabo
    Division of Geriatrics and Gerontology, Weill Medical College of Cornell University, NY 10021, USA
    Cell Immunol 231:158-67. 2004
  2. doi request reprint The epidemic of distraction
    Marc E Weksler
    Division of Geriatric Medicin, Department of Medicine, Weill Cornell Medical Center, New York, NY 10065, USA
    Gerontology 58:385-90. 2012
  3. doi request reprint Alzheimer's disease and Down's syndrome: treating two paths to dementia
    Marc E Weksler
    Department of Medicine, Weill Cornell Medical College, NY, USA
    Autoimmun Rev 12:670-3. 2013
  4. pmc Age matters:  Young T lymphocytes offer better protection from myeloma proliferation
    Alexander F Glick
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Immun Ageing 10:5. 2013
  5. doi request reprint Immune therapy for age-related diseases
    Marc E Weksler
    Department of Medicine, Weill Cornell Medical College, NY 10065, USA
    Trends Immunol 30:344-50. 2009
  6. ncbi request reprint The immune system, amyloid-beta peptide, and Alzheimer's disease
    Marc E Weksler
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Immunol Rev 205:244-56. 2005
  7. ncbi request reprint [The streets of Paris: the "Alexis Carrel issue"]
    Marc E Weksler
    Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Med Sci (Paris) 20:707-9. 2004
  8. ncbi request reprint Naming streets for physicians: "l'affaire Carrel"
    Marc E Weksler
    Institut Pasteur, Paris
    Perspect Biol Med 47:67-73. 2004
  9. ncbi request reprint Changes in the B-cell repertoire with age
    M E Weksler
    Division of Geriatrics and Gerontology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Vaccine 18:1624-8. 2000
  10. ncbi request reprint Oligoclonal expansions of antigen-specific CD8+ T cells in aged mice
    David N Posnett
    Weill Medical College, Cornell University, Immunology Program, Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 987:274-9. 2003

Research Grants

  1. IMMUNOBIOLOGY OF AGING
    MARC WEKSLER; Fiscal Year: 2003
  2. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Evolution of B-cell clonal expansions with age
    Paul Szabo
    Division of Geriatrics and Gerontology, Weill Medical College of Cornell University, NY 10021, USA
    Cell Immunol 231:158-67. 2004
    ....
  2. doi request reprint The epidemic of distraction
    Marc E Weksler
    Division of Geriatric Medicin, Department of Medicine, Weill Cornell Medical Center, New York, NY 10065, USA
    Gerontology 58:385-90. 2012
    ..New approaches to information gathering can foster creativity if cognitive overload is avoided...
  3. doi request reprint Alzheimer's disease and Down's syndrome: treating two paths to dementia
    Marc E Weksler
    Department of Medicine, Weill Cornell Medical College, NY, USA
    Autoimmun Rev 12:670-3. 2013
    ..It follows, therefore, that the therapy of AD and DS should reflect a different balance between the dominant agent that inhibits the synthesis of Abeta in the brain in AD and increase the clearance of Abeta from the cerebrospinal DS...
  4. pmc Age matters:  Young T lymphocytes offer better protection from myeloma proliferation
    Alexander F Glick
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Immun Ageing 10:5. 2013
    ..The incidence and growth of cancer has been reported to increase with age and/or impaired T lymphocyte function...
  5. doi request reprint Immune therapy for age-related diseases
    Marc E Weksler
    Department of Medicine, Weill Cornell Medical College, NY 10065, USA
    Trends Immunol 30:344-50. 2009
    ..Indeed, recent clinical studies have already demonstrated that vaccination can reduce the incidence of shingles and might prove effective in patients with Alzheimer's disease and artherosclerotic cardiovascular disease...
  6. ncbi request reprint The immune system, amyloid-beta peptide, and Alzheimer's disease
    Marc E Weksler
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Immunol Rev 205:244-56. 2005
    ..We review the relationship between the immune system, amyloid-beta peptide, and Alzheimer's disease and the progress made in applying immunotherapy to patients with Alzheimer's disease...
  7. ncbi request reprint [The streets of Paris: the "Alexis Carrel issue"]
    Marc E Weksler
    Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Med Sci (Paris) 20:707-9. 2004
  8. ncbi request reprint Naming streets for physicians: "l'affaire Carrel"
    Marc E Weksler
    Institut Pasteur, Paris
    Perspect Biol Med 47:67-73. 2004
    ..Paris has recently followed the lead of other French cities and has voted to remove Carrel's name from its streets...
  9. ncbi request reprint Changes in the B-cell repertoire with age
    M E Weksler
    Division of Geriatrics and Gerontology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Vaccine 18:1624-8. 2000
    ..Many of these changes can be traced to an impaired capacity of T cells to support isotype switching and somatic mutation in the periphery and the generation of a diverse B-cell repertoire from bone marrow B-cell precursors...
  10. ncbi request reprint Oligoclonal expansions of antigen-specific CD8+ T cells in aged mice
    David N Posnett
    Weill Medical College, Cornell University, Immunology Program, Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 987:274-9. 2003
    ..The TCE appear to be inefficient as they are often anergic. As a result an occasional peritoneal or splenic tumor may arise in old mice...
  11. ncbi request reprint Tumor antigen drives a persistent oligoclonal expansion of CD8+ T cells in aged mice
    Fang Li
    Immunology Program, Graduate School of Medical Sciences, Weil Medical College of Cornell University, New York, NY 10021, USA
    Eur J Immunol 32:1650-8. 2002
    ..This induced tumor antigen-specific response may represent a model for the spontaneous TCE observed with aging and demonstrates that the CD8 response to a defined peptide/MHC antigen is indeed more oligoclonal in old mice...
  12. doi request reprint Natural human antibodies to amyloid beta peptide
    Paul Szabo
    Department of Neurology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Autoimmun Rev 7:415-20. 2008
    ..This neuro-protective effect may reflect the therapeutic potential of the natural anti-Abeta antibodies found in IVIg for the treatment of patients with AD...
  13. ncbi request reprint The effect of age on B cell development and humoral immunity
    Marc E Weksler
    Weill Medical College, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Springer Semin Immunopathol 24:35-52. 2002
  14. ncbi request reprint Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals
    Marc E Weksler
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Exp Gerontol 37:943-8. 2002
    ..The lower titer of serum anti-Abeta42 peptide antibodies in AD patients may reflect the reported specific impairment of helper T cell activity for B cells that produce anti-amyloid-beta42 peptide antibodies in APP-transgenic mice...
  15. doi request reprint Measurement of anti-beta amyloid antibodies in human blood
    Paul Szabo
    Department of Neurology and Neurosciences, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neuroimmunol 227:167-74. 2010
    ....
  16. ncbi request reprint Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice
    Paul Szabo
    Division of Geriatrics and Gerontology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Immunol 222:78-87. 2003
    ..These data are consistent with the view that impaired V to DJ rearrangement contributes to the decreased levels of bone marrow Pre-B cells as well as the decreased levels of transitional B cells in the periphery...
  17. doi request reprint 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
    Norman R Relkin
    Department of Neurology, the Weill Cornell Medical College, New York, NY, USA
    Neurobiol Aging 30:1728-36. 2009
    ..J. Neurol. Neurosurg. Psychiatry 75, 1472-1474] from a 6-month trial of IVIg in 5 AD patients and justify further studies of IVIg for treatment of AD...
  18. ncbi request reprint Autoantibody-catalyzed hydrolysis of amyloid beta peptide
    Hiroaki Taguchi
    Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 283:4714-22. 2008
    ..Our results suggest that catalytic IgM autoantibodies can help clear Abeta, and they open the possibility of using catalytic Abs for AD immunotherapy...
  19. pmc Catalytic antibodies to amyloid beta peptide in defense against Alzheimer disease
    Hiroaki Taguchi
    Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA
    Autoimmun Rev 7:391-7. 2008
    ..Reduced Abeta aggregation and neurotoxicity attributable to the catalytic function were evident. These findings provide a foundation for development of catalytic Igs for AD immunotherapy...
  20. ncbi request reprint Do age-associated changes in 'physiologic' autoantibodies contribute to infection, atherosclerosis, and Alzheimer's disease?
    Marc E Weksler
    Institut Pasteur, 34 rue du Docteur Roux, Paris 75015, France
    Exp Gerontol 37:971-9. 2002
    ..In contrast, low levels of autoantibodies to oxidised low-density lipoproteins or to the amyloid beta peptide may contribute to the increased risk of developing atherosclerosis of Alzheimer's disease, respectively...
  21. ncbi request reprint Antibodies as defensive enzymes
    Sudhir Paul
    Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, MSB 2 250, 6431 Fannin, Houston, TX 77030, USA
    Springer Semin Immunopathol 26:485-503. 2005
    ....

Research Grants5

  1. IMMUNOBIOLOGY OF AGING
    MARC WEKSLER; Fiscal Year: 2003
    ..The influence of anti-influenza T cell clones on the immune system of young and old mice as well as the function of the anti- influenza TCR T cell clone in young and old mice will be studied. ..
  2. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
    ..abstract_text> ..