M P Wajnrajch

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Evaluation of growth and hormonal status in patients referred to the International Fanconi Anemia Registry
    M P Wajnrajch
    Department of Pediatrics and Children s Clinical Research Center, New York Presbyterian Hospital Cornell University Medical Center, New York, New York 10021, USA
    Pediatrics 107:744-54. 2001
  2. ncbi Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor
    Michael P Wajnrajch
    Division of Pediatric Endocrinology, Department of Pediatrics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Med Genet A 120:77-83. 2003
  3. ncbi Genetic disorders of human growth
    Michael P Wajnrajch
    Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Pediatr Endocrinol Metab 15:701-14. 2002
  4. ncbi Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse
    M P Wajnrajch
    Children s Clinical Research Center, New York Hospital Cornell Medical Center, New York 10021, USA
    Nat Genet 12:88-90. 1996
  5. ncbi Congenital hypopituitarism as a cause of undetectable estriol levels in the maternal triple-marker screen
    I Marshall
    Division of Pediatric Endocrinology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Endocrinol Metab 88:4144-8. 2003
  6. ncbi Heritable disorders of pituitary development
    J S Parks
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 84:4362-70. 1999
  7. ncbi Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor
    Karen Lin-Su
    Division of Pediatric Endocrinology, Weill Medical College of Cornell University, New York, USA
    Rev Endocr Metab Disord 3:313-23. 2002
  8. ncbi Variable phenotypes in familial isolated growth hormone deficiency caused by a G6664A mutation in the GH-1 gene
    Ora Hess
    Faculty of Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Clin Endocrinol Metab 92:4387-93. 2007
  9. ncbi Effect of different growth hormone (GH) mutants on the regulation of GH-receptor gene transcription in a human hepatoma cell line
    Johnny Deladoey
    Department of Paediatrics, Division of Paediatric Endocrinology, Inselspital, CH 3010 Bern, Switzerland
    Eur J Endocrinol 146:573-81. 2002
  10. ncbi Physiological and pathological growth hormone secretion
    Michael P Wajnrajch
    Pfizer Inc, New York, NY 10017, USA
    J Pediatr Endocrinol Metab 18:325-38. 2005

Research Grants

  1. Molecular Pathophysiology of Human Growth Disorders
    MICHAEL WAJNRAJCH; Fiscal Year: 2002

Collaborators

Detail Information

Publications14

  1. ncbi Evaluation of growth and hormonal status in patients referred to the International Fanconi Anemia Registry
    M P Wajnrajch
    Department of Pediatrics and Children s Clinical Research Center, New York Presbyterian Hospital Cornell University Medical Center, New York, New York 10021, USA
    Pediatrics 107:744-54. 2001
    ....
  2. ncbi Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor
    Michael P Wajnrajch
    Division of Pediatric Endocrinology, Department of Pediatrics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Med Genet A 120:77-83. 2003
    ..5 centimorgan (cM) region around GHRHR on chromosome 7p15. We conclude that the affected individuals share a common ancestor, and we use the association with linked markers to estimate the age of this unique mutation...
  3. ncbi Genetic disorders of human growth
    Michael P Wajnrajch
    Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Pediatr Endocrinol Metab 15:701-14. 2002
    ..What is becoming increasingly clear is the role of genetics in determining stature. This review discusses the most clinically relevant factors, with an emphasis on ontogeny, genetic inheritance, and clinical presentation...
  4. ncbi Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse
    M P Wajnrajch
    Children s Clinical Research Center, New York Hospital Cornell Medical Center, New York 10021, USA
    Nat Genet 12:88-90. 1996
  5. ncbi Congenital hypopituitarism as a cause of undetectable estriol levels in the maternal triple-marker screen
    I Marshall
    Division of Pediatric Endocrinology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Endocrinol Metab 88:4144-8. 2003
    ..Therefore, it is essential that physicians be familiar with the various etiologies, perform the appropriate antenatal evaluation to determine the specific cause, and closely monitor both mother and child ante- and postnatally...
  6. ncbi Heritable disorders of pituitary development
    J S Parks
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 84:4362-70. 1999
    ..Homozygosity for inactivating mutations of HESX1 produces a complex phenotype that resembles septo-optic dysplasia. Much more needs to be learned about the role of HESX1 mutations in other forms of hypopituitarism...
  7. ncbi Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor
    Karen Lin-Su
    Division of Pediatric Endocrinology, Weill Medical College of Cornell University, New York, USA
    Rev Endocr Metab Disord 3:313-23. 2002
  8. ncbi Variable phenotypes in familial isolated growth hormone deficiency caused by a G6664A mutation in the GH-1 gene
    Ora Hess
    Faculty of Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    J Clin Endocrinol Metab 92:4387-93. 2007
    ..G to A transition at position 6,664 (G6664A) in human GH-1 results in the substitution of arginine by histidine at position 183 (R183H) of the GH molecule and causes familial isolated GH deficiency type II (IGHD II)...
  9. ncbi Effect of different growth hormone (GH) mutants on the regulation of GH-receptor gene transcription in a human hepatoma cell line
    Johnny Deladoey
    Department of Paediatrics, Division of Paediatric Endocrinology, Inselspital, CH 3010 Bern, Switzerland
    Eur J Endocrinol 146:573-81. 2002
    ..The aim of this study was to assess the bioactivity of this R183H mutant GH in comparison with both other GH variants and the 22-kDa GH in terms of GH-receptor gene regulation...
  10. ncbi Physiological and pathological growth hormone secretion
    Michael P Wajnrajch
    Pfizer Inc, New York, NY 10017, USA
    J Pediatr Endocrinol Metab 18:325-38. 2005
    ..Inferences made from comprehensive evaluations of the GH axis in Fanconi's anemia provide unique insight into general GH pathophysiology...
  11. ncbi Limited efficacy of growth hormone (GH) during transition of GH-deficient patients from adolescence to adulthood: a phase III multicenter, double-blind, randomized two-year trial
    Nelly Mauras
    Division of Endocrinology, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 90:3946-55. 2005
    ..Treatment of GH-deficient adolescents in transition to adulthood remains challenging...
  12. ncbi Treatment of acromegaly with pegvisomant during pregnancy: maternal and fetal effects
    Susan Riddle Brian
    Department of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 92:3374-7. 2007
    ..Our objective was to describe the first case of the successful use of pegvisomant during pregnancy in a woman with acromegaly...
  13. pmc Gender of pediatric recombinant human growth hormone recipients in the United States and globally
    Adda Grimberg
    Division of Pediatric Endocrinology, The Children s Hospital of Philadelphia, Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    J Clin Endocrinol Metab 93:2050-6. 2008
    ..With rhGH entering its third decade, we sought to examine U.S. gender-based treatment patterns and how these patterns compare with that of other countries...
  14. ncbi Predictors of first-year growth response to a fixed-dose growth hormone treatment in children born small for gestational age: results of an open-label, multicenter trial in the United States
    Robert Rapaport
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pediatr Endocrinol Metab 21:411-22. 2008
    ..The GH dose was the major predictor of first year growth response...

Research Grants1

  1. Molecular Pathophysiology of Human Growth Disorders
    MICHAEL WAJNRAJCH; Fiscal Year: 2002
    ....