Research Topics
Species | B WagnerSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Live-attenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV)Cristina T Rosas
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
Virus Res 125:69-78. 2007..From the results, we concluded that the EHV-1 vectored virus is able to express the WNV structural proteins and that vaccination of horses results in the induction of WNV E-protein-specific IgG(T), IgGb, and neutralizing antibodies...
The EGF receptor is required for efficient liver regenerationAnuradha Natarajan
Department of Dermatology, Division of Immunology, Allergy, and Infectious Diseases, and Institute for Cancer Research, Department of Medicine 1, Vienna Competence Center, Medical University of Vienna, Lazarettgasse 19, A 1090 Vienna, Austria
Proc Natl Acad Sci U S A 104:17081-6. 2007..Our studies demonstrate that EGFR is a critical regulator of hepatocyte proliferation in the initial phases of liver regeneration...
Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horsesBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 132:53-61. 2009..Because many clinically healthy horses developed skin reactions to this allergen, sensitization results are useful to diagnose Culicoides-induced allergy only in horses with allergic conditions...- Development of a multiplex assay for the detection of antibodies to Borrelia burgdorferi in horses and its validation using Bayesian and conventional statistical methodsBettina Wagner
Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, USA
Vet Immunol Immunopathol 144:374-81. 2011..Multiplex analysis is a valuable quantitative tool that simultaneously detects antibodies indicative for natural infection with and/or vaccination against the Lyme pathogen... - Antibodies to Borrelia burgdorferi OspA, OspC, OspF, and C6 antigens as markers for early and late infection in dogsBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Clin Vaccine Immunol 19:527-35. 2012..burgdorferi Osp antigens and C6 reflect their differential expression during infection. They provide valuable tools to determine the stage of infection, treatment outcomes, and vaccination status in dogs... - Dogs and horses with antibodies to outer-surface protein C as on-time sentinels for ticks infected with Borrelia burgdorferi in New York State in 2011B Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Electronic address
Prev Vet Med 107:275-9. 2012..burgdorferi by geographic region. We recommend that both dogs and horses be part of such a passive surveillance system... - Monoclonal antibodies to equine CD23 identify the low-affinity receptor for IgE on subpopulations of IgM+ and IgG1+ B-cells in horsesBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 146:125-34. 2012..The new anti-CD23 mAbs provide valuable reagents to further analyze the roles of CD23 during immune responses of the horse in health and disease... - Immunological correlates of vaccination and infection for equine herpesvirus 1Laura B Goodman
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Clin Vaccine Immunol 19:235-41. 2012..Since these parameters can be assessed in a high-throughput manner, they may prove useful in screening future vaccine candidates and assessing levels of protection... - Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutantGisela Soboll Hussey
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W, Drake Rd, Fort Collins, Colorado 80523, USA
Vet Res 42:23. 2011.... - A monoclonal antibody to equine interleukin-4Bettina Wagner
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 110:363-7. 2006..In conclusion, the new mAb detects equine IL-4 and can be used for intracellular staining and ELISA to measure this important cytokine... - Occurrence of IgE in foals: evidence for transfer of maternal IgE by the colostrum and late onset of endogenous IgE production in the horseBettina Wagner
James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 110:269-78. 2006.... - Immunoglobulins and immunoglobulin genes of the horseBettina Wagner
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Dev Comp Immunol 30:155-64. 2006..The IGHC region contains eleven constant heavy chain genes, seven of which are gamma heavy chain genes. It is suggested that all seven genes encoding IgG isotypes are expressed and have distinct functions in equine immune responses... - Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgEBettina Wagner
Immunology Unit, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, Germany
Vet Immunol Immunopathol 92:45-60. 2003..The stained leukocytes from adult horses could be enriched by magnetic cell sorting and contained 32% basophils, 53% monocytes and/or large lymphocytes, 13% small lymphocytes and 2% eosinophils... - IgE and IgG antibodies in skin allergy of the horseBettina Wagner
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Res 37:813-25. 2006..The data also suggest that IgG(T) can bind to skin mast cells and might contribute to clinical allergy... - Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horsesBettina Wagner
Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 127:242-8. 2009..In the future, the assay can also be expanded by adding bead assays for other equine cytokines and chemokines to the existing platform... - A histamine release assay to identify sensitization to Culicoides allergens in horses with skin hypersensitivityBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 126:302-8. 2008.... - Monoclonal antibodies to equine interferon-alpha (IFN-alpha): new tools to neutralize IFN-activity and to detect secreted IFN-alphaBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 125:315-25. 2008..Overall, the data showed that the new anti-equine IFN-alpha mAbs are valuable tools to detect native IFN-alpha for further characterization of the early innate immune response and anti-viral immunity in horses... - Characterization of monoclonal antibodies to equine interleukin-10 and detection of T regulatory 1 cells in horsesBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 122:57-64. 2008..In summary, the new mAbs to equine IL-10 detected native equine IL-10 by ELISA and flow cytometry and can be used for further characterization of this important regulatory cytokine in horses... - Horse cytokine/IgG fusion proteins--mammalian expression of biologically active cytokines and a system to verify antibody specificity to equine cytokinesBettina Wagner
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 105:1-14. 2005.... - Evolution of the six horse IGHG genes and corresponding immunoglobulin gamma heavy chainsBettina Wagner
Immunology Unit, School of Veterinary Medicine, Hannover, Germany
Immunogenetics 54:353-64. 2002..In addition, various segmental exchanges were found between the horse IGHG genes, which might be the result of unequal crossing over and/or gene conversion events during the evolution of the six horse IGHG genes... - IgE in horses: occurrence in health and diseaseBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 132:21-30. 2009..New IgE-specific tools and technologies are likely to uncover additional aspects of IgE-mediated mechanisms in equine health and disease... - Characterization of the horse (Equus caballus) IGHA geneBettina Wagner
James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
Immunogenetics 55:552-60. 2003..The same species also cluster together in a phylogenetic tree of the IGHA coding regions of various mammals, whereas rodent, rabbit, marsupial and monotreme IGHA genes each build a separate cluster... - Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strainsBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Immunol Immunopathol 143:116-24. 2011..The ability of this EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4... - A fluorescent bead-based multiplex assay for the simultaneous detection of antibodies to B. burgdorferi outer surface proteins in canine serumB Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 140:190-8. 2011..burgdorferi OspA, OspC and OspF antigens and distinguishes between antibodies that originated from vaccination or natural exposure to B. burgdorferi... - Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foalsBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Res 41:47. 2010.... - Induction of interleukin-4 production in neonatal IgE+ cells after crosslinking of maternal IgEBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Dev Comp Immunol 34:436-44. 2010..In conclusion, stimulation via maternal IgE antibodies mediated innate IL-4 production in neonatal basophils which might provide a paragenetic mechanism to promote the development of adaptive T-cell responses in the neonate after birth... - Monoclonal antibodies to equine IgM improve the sensitivity of West Nile virus-specific IgM detection in horsesBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 122:46-56. 2008..The highest sensitivity was obtained by using the anti-IgM 1-22 mAb to capture IgM from equine serum. In conclusion, the use of monoclonal anti-IgM antibodies can improve the sensitivity of IgM detection in the acute phase of WN disease... - Expression of a 4-(hydroxy-3-nitro-phenyl) acetyl (NP) specific equi-murine IgE antibody that mediates histamine release in vitro and a type I skin reaction in vivoB Wagner
Immunology, School of Veterinary Medicine, Hannover, Germany
Equine Vet J 34:657-65. 2002..This property could be used to investigate IgE-mediated mechanisms for a better understanding of equine type I allergic diseases... - Serum interleukin-6 (IL-6) and IL-10 concentrations in normal and septic neonatal foalsA B Burton
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 132:122-8. 2009..Although the number of animals involved in this study was too small for the identification of a concrete value, the serum IL-6:IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia... - Histamine bronchoprovocation does not affect bronchoalveolar lavage fluid cytology, gene expression and protein concentrations of IL-4, IL-8 and IFN-gammaG A Perkins
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States
Vet Immunol Immunopathol 126:230-5. 2008..IL-4 protein was undetectable in BALF either prior to or following HBP. We conclude that HBP can precede BALF collection performed within 2-4h of the former without affecting selected parameters analysed in the BAL cells or BALF... - Nucleotide sequence and restriction fragment length polymorphisms of the equine Cvarepsilon geneB Wagner
Immunology Unit, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, FRG, Germany
Vet Immunol Immunopathol 82:193-202. 2001..Polymorphism of the IgE heavy chain constant region gene, as described here, might well impose genetic variability on the effector functions of equine IgE predisposition to allergic diseases in horses... - Cloning and functional characterization of recombinant equine P-selectinJin Xu
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706 1102, USA
Vet Immunol Immunopathol 116:115-30. 2007..The ePsel-IgG chimera can be a useful as a reagent for further studies on the role of equine P-selectin and signal transduction in inflammatory events in horse... - Some immune parameters in carp cyprinus Carpio susceptible and resistant to the haemoflagellate Trypanoplasma borreliJ P Scharsack
Fish Disease Research Unit, School of Veterinary Medicine, Hannover, Hannover, Germany
Dis Aquat Organ 60:41-8. 2004..Whether this is decisive for a T. borreli-specific and successful immune response is discussed... - Organization of the equine immunoglobulin constant heavy chain genes. I. c epsilon and c alpha genesB Wagner
Immunology Unit, Hannover School of Veterinary Medicine, Germany
Vet Immunol Immunopathol 60:1-13. 1997..The relative location of the c epsilon and c alpha genes 3' of the equine c mu and c gamma genes was determined by restriction analysis of equi-murine heterohybridomas... - Effects of in vitro exposure to hay dust on expression of interleukin-17, -23, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells isolated from horses chronically affected with recurrent airway diseaseDorothy M Ainsworth
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 68:1361-9. 2007.... - Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cellsDorothy M Ainsworth
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Immunol Immunopathol 96:83-91. 2003.... - A comparison of intradermal testing and detection of allergen-specific immunoglobulin E in serum by enzyme-linked immunosorbent assay in horses affected with skin hypersensitivityErin E Morgan
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 120:160-7. 2007..The reliable diagnosis of allergens in equine skin hypersensitivity is essential to improve allergen-specific treatments, such as hyposensitization, or the development of allergy vaccines... - Effects of in vitro exposure to hay dust on expression of interleukin-23, -17, -8, and -1beta and chemokine (C-X-C motif) ligand 2 by pulmonary mononuclear cells from horses susceptible to recurrent airway obstructionClaudia L Reyner
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 70:1277-83. 2009.... - Time-dependent alterations in gene expression of interleukin-8 in the bronchial epithelium of horses with recurrent airway obstructionDorothy M Ainsworth
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 67:669-77. 2006..CONCLUSIONS AND CLINICAL RELEVANCE: Epithelial-derived IL-8 may promote airway neutrophilia, but the inciting stimulus is unlikely to be IL-17 because upregulation of this gene is subsequent to that of IL-8 in epithelial cells... - Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expressionChristine L Wimer
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 140:266-74. 2011..The data also implies that different EHV-1 strains have varying effects on all five chemokines, with the nuropathogenic strain, Ab4, having the greatest suppressive potential... - Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1)Laura B Goodman
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vaccine 24:3636-45. 2006.... - Organization of the equine immunoglobulin heavy chain constant region genes; III. Alignment of c mu, c gamma, c epsilon and c alpha genesB Wagner
Immunology Unit, Hannover School of Veterinary Medicine, Germany
Immunobiology 199:105-18. 1998..For three of the c gamma genes the corresponding IgG isotypes could be identified as IgGa for c gamma 1, IgG(T) for c gamma 3 and IgGb for c gamma 4... - The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horseBettina Wagner
Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
J Immunol 173:3230-42. 2004..Fluorescence in situ hybridization was used to localize the IGHC region to Equus caballus (ECA) 24qter, the horse chromosome corresponding to human chromosome 14, where the human IGH locus is found... - Perturbation of the small intestine microbial ecology by streptomycin alters pathology in a Salmonella enterica serovar typhimurium murine model of infectionCherilyn D Garner
Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853, USA
Infect Immun 77:2691-702. 2009..Together these results provide a better understanding of the ileal environment in the mouse and the changes that occur upon streptomycin treatment... - Identification of equine P-selectin glycoprotein ligand-1 (CD162)Jin Xu
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, 53706 1102, USA
Mamm Genome 16:66-71. 2005..The greatest homologies between species exist in the transmembrane domain and cytoplasmic tail while substantial differences exist in the extracellular domain... - Comparison of TGF-beta 1 concentrations in bronchoalveolar fluid of horses affected with heaves and of normal controlsIsabelle Desjardins
Departement de Sciences Cliniques, Faculte de Medecine Veterinaire, University de Montreal, St. Hyacinthe, Canada J2S 7C6
Vet Immunol Immunopathol 101:133-41. 2004..Other studies are necessary for a better definition of the role of this cytokine within the lung, as our study does not establish a causal relationship between TGF-beta1 and the pathophysiology of heaves in the horse... - Equine immunology: offspring of the serum horseFalko Steinbach
Institute of Virology, FU Berlin, , 14195 Berlin, Germany
Trends Immunol 23:223-5. 2002 - Reduced incidence of insect-bite hypersensitivity in Icelandic horses is associated with a down-regulation of interleukin-4 by interleukin-10 and transforming growth factor-beta1Eman Hamza
Institute of Veterinary Virology, Vetsuisse Faculty, University of Bern, Laenggassstrasse 122, CH 3001 Bern, Switzerland
Vet Immunol Immunopathol 122:65-75. 2008..It is suggested that in this naturally occurring IgE-mediated allergy, IL-10 and TGF-beta1 have a role in the down-regulation of IL-4-induced allergen-specific Th2 cells, thereby reducing the incidence of IBH... - The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategiesMelanie J Lewis
Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
Mol Immunol 45:818-27. 2008..The differential effector function capabilities of the subclasses suggest that, for maximum efficacy, equine vaccine strategies should seek to elicit antibody responses of the IgG1, IgG3, IgG4, and IgG7 subclasses... - Early embryonic lethality of mice lacking the essential protein SNEVKlaus Fortschegger
Institute of Applied Microbiology, Muthgasse 18, A 1190 Vienna, Austria
Mol Cell Biol 27:3123-30. 2007..Our experiments demonstrate that the SNEV protein is essential, functionally nonredundant, and indispensable for mouse development... - WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report August 2007, 13th International Congress of Immunology, Rio de Janeiro, BrazilMarie-Paule Lefranc
the international ImMunoGeneTics information system, , 34396 Montpellier Cedex 5, France
Dev Comp Immunol 32:461-3. 2008 - Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter geneMasao Miyagawa
Nuklearmedizinische Klinik und Poliklinik, , Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, , Germany
Eur J Nucl Med Mol Imaging 32:1108-14. 2005..hNIS yielded higher signal intensity and imaging contrast for PET than did HSV1-tk and HSV1-sr39tk. Therefore, this approach may be preferable for the future monitoring of cardiac gene- or cell-based therapy... - Coexpression of herpesviral thymidine kinase reporter gene and VEGF gene for noninvasive monitoring of therapeutic gene transfer: an in vitro evaluationMartina Anton
, , Munich, Germany
J Nucl Med 45:1743-6. 2004..This approach may allow for future in vivo monitoring of cardiac angiogenesis gene therapy... - PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter geneMasao Miyagawa
Nuklearmedizinische Klinik und Poliklinik, , 81675 Munich, Germany
J Nucl Med 45:1917-23. 2004..The results favor (18)F-FHBG with mutant HSV1-sr39tk because of continuous accumulation over time and higher imaging contrast... - Efficient and stable gene transfer of growth factors into chondrogenic cells and primary articular chondrocytes using a VSV.G pseudotyped retroviral vectorStephan Vogt
Department of Orthopaedic and Trauma Surgery, Technical University Munich, Munich, Germany
Biomaterials 29:1242-9. 2008..Gene transfer was very stable over the time period analysed, rendering it a useful tool for future in vitro and in vivo studies on cartilage remodelling...