Bik Kwoon Tye

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Novel features of ARS selection in budding yeast Lachancea kluyveri
    Ivan Liachko
    School of Mathematics and Statistics, University of Sydney, Sydney, Australia
    BMC Genomics 12:633. 2011
  2. pmc Computational detection of significant variation in binding affinity across two sets of sequences with application to the analysis of replication origins in yeast
    Uri Keich
    Department of Computer Science, Cornell University, Ithaca, NY 14853, USA
    BMC Bioinformatics 9:372. 2008
  3. ncbi request reprint Dual functional regulators coordinate DNA replication and gene expression in proliferating cells
    Bik K Tye
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Front Biosci 9:2548-55. 2004
  4. ncbi request reprint The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts
    B K Tye
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    J Biol Chem 275:34833-6. 2000
  5. pmc The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication
    S I Gibson
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Mol Cell Biol 10:5707-20. 1990
  6. pmc Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
    L Homesley
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    Genes Dev 14:913-26. 2000
  7. pmc A comprehensive genome-wide map of autonomously replicating sequences in a naive genome
    Ivan Liachko
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 6:e1000946. 2010
  8. pmc A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae
    A M Merchant
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Mol Cell Biol 17:3261-71. 1997
  9. pmc Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
    M Lei
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Genes Dev 11:3365-74. 1997
  10. ncbi request reprint Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function
    H Yan
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Genes Dev 5:944-57. 1991

Collaborators

  • Uri Keich
  • Anand Bhaskar
  • H Yan
  • A Sugino
  • R T Surosky
  • Ivan Liachko
  • Chanmi Lee
  • M Lei
  • Shau Chee Claire Chung
  • Y Kawasaki
  • Katherine Cox
  • Gina Kang
  • Emi Tanaka
  • Maki Inada
  • Jasmine Barrow
  • Lindsay Hallas
  • Lu Yang
  • Arael Seher
  • Heather Pace
  • Eugene Cha
  • L Homesley
  • Roxane Bouten
  • Zvi Kelman
  • Y Chen
  • A M Merchant
  • T Christensen
  • S Sawyer
  • M Kihara
  • M R Young
  • S Passmore
  • S I Gibson
  • R Elble
  • G T Maine
  • C Christ

Detail Information

Publications16

  1. pmc Novel features of ARS selection in budding yeast Lachancea kluyveri
    Ivan Liachko
    School of Mathematics and Statistics, University of Sydney, Sydney, Australia
    BMC Genomics 12:633. 2011
    ..This lack of understanding is largely due to the vast evolutionary distances between model organisms in which origins have been examined...
  2. pmc Computational detection of significant variation in binding affinity across two sets of sequences with application to the analysis of replication origins in yeast
    Uri Keich
    Department of Computer Science, Cornell University, Ithaca, NY 14853, USA
    BMC Bioinformatics 9:372. 2008
    ....
  3. ncbi request reprint Dual functional regulators coordinate DNA replication and gene expression in proliferating cells
    Bik K Tye
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Front Biosci 9:2548-55. 2004
    ..Emerging examples in eukaryotes are the growth responsive transcription factor E2f, the MADS domain combinatorial transcription factor Mcm1, and a subunit of the MCM2-7 helicase, Mcm7...
  4. ncbi request reprint The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts
    B K Tye
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    J Biol Chem 275:34833-6. 2000
  5. pmc The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication
    S I Gibson
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Mol Cell Biol 10:5707-20. 1990
    ..The phenotype exhibited by the mcm3 mutant is very similar to that of mcm2, suggesting that the Mcm2 and Mcm3 protein may play interacting roles in DNA replication...
  6. pmc Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
    L Homesley
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    Genes Dev 14:913-26. 2000
    ..These results suggest that Mcm10, like Mcm7, is a critical component of the prereplication chromatin and that interaction between Mcm10 and Mcm7 is required for proper replication initiation and prompt release of origin-bound factors...
  7. pmc A comprehensive genome-wide map of autonomously replicating sequences in a naive genome
    Ivan Liachko
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 6:e1000946. 2010
    ..cerevisiae. Comparative genomic analysis shows that ARSs in K. lactis and S. cerevisiae preferentially localize to non-syntenic intergenic regions, linking ARSs with loci of accelerated evolutionary change...
  8. pmc A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae
    A M Merchant
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Mol Cell Biol 17:3261-71. 1997
    ..This novel phenotype suggests a unique role for the Mcm10 protein in the initiation of DNA synthesis at replication origins...
  9. pmc Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
    M Lei
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Genes Dev 11:3365-74. 1997
    ..Taken together, our data suggest that phosphorylation of Mcm2 and probably other members of the Mcm2-7 proteins by Cdc7-Dbf4 at the G1-to-S phase transition is a critical step in the initiation of DNA synthesis at replication origins...
  10. ncbi request reprint Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function
    H Yan
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Genes Dev 5:944-57. 1991
    ..cerevisiae, and Nda4 and Cdc21 of Schizosaccharomyces pombe. The phenotypes of mutants defective in these proteins suggest that they belong to a protein family involved in the early steps of DNA replication...
  11. pmc Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae
    M Lei
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Cell Biol 16:5081-90. 1996
    ..These results together suggest that a significant molar excess of Mcm proteins relative to replication origins is required for the proper initiation of all replication origins...
  12. pmc The yeast Mcm1 protein is regulated posttranscriptionally by the flux of glycolysis
    Y Chen
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Cell Biol 15:4631-9. 1995
    ....
  13. ncbi request reprint MCM proteins in DNA replication
    B K Tye
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853 2703, USA
    Annu Rev Biochem 68:649-86. 1999
    ..Orchestration of the functional interactions between the MCM2-7 proteins and other components of the prereplication complex by cell cycle-dependent protein kinases results in initiation of DNA synthesis once every cell cycle...
  14. ncbi request reprint Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MAT alpha cells
    S Passmore
    Section of Biochemistry, Molecular and Cell Biology Cornell University, Ithaca, NY 14853
    J Mol Biol 204:593-606. 1988
    ....
  15. ncbi request reprint A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes
    S Passmore
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Genes Dev 3:921-35. 1989
    ..We have shown that MCM1 binds to the human c-fos SRE in vitro and, like other MCEs, the c-fos SRE exhibits MCM1-mediated upstream activating sequence (UAS) activity in vivo...
  16. pmc Alternative mechanisms for coordinating polymerase alpha and MCM helicase
    Chanmi Lee
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Cell Biol 30:423-35. 2010
    ....

Research Grants21

  1. INTERACTIONS OF THE MCM PROTEINS AT REPLICATION ORIGINS
    Bik Kwoon Tye; Fiscal Year: 2002
    ..Through understanding of normal cellular processes that regulate DNA replication, it may be possible to elucidate the molecular basis for abnormalities or defects that lead to the disease state in cancer cells. ..
  2. Regulation of Replication Origin Usage in Saccharomyces cerevisiae
    Bik Kwoon Tye; Fiscal Year: 2007
    ..Therefore, understanding the regulation of DNA replication is central to the study of the etiology of all genetic diseases rooted in genome instability including trisomy and cancer. ..
  3. YEAST TRANSCRIPTION FACTOR INVOLVED IN DNA REPLICATION
    Bik Kwoon Tye; Fiscal Year: 1993
    ..3) We will look for additional ABPs that would bind to the 5' side of the ARS consensus sequence...
  4. Regulation of Replication Origin Usage in Saccharomyces cerevisiae
    Bik Kwoon Tye; Fiscal Year: 2009
    ..Therefore, understanding the regulation of DNA replication is central to the study of the etiology of all genetic diseases rooted in genome instability including trisomy and cancer. ..