Research Topics
Genomes and GenesSpecies | R J TodhunterSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritisRory J Todhunter
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 64:418-24. 2003....- Quantitative trait loci for hip dysplasia in a cross-breed canine pedigreeRory J Todhunter
Department of Clinical Sciences, Box 32 College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Mamm Genome 16:720-30. 2005..Successful detection of QTL was due to the cross-breed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools... - An outcrossed canine pedigree for linkage analysis of hip dysplasiaR J Todhunter
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Hered 90:83-92. 1999..Although dogs in the backcross generation that were three-quarter greyhound had a broad range of hip laxity, a protective effect of the greyhound QTLs for good osseous conformation has mitigated thus far against subluxation and CHD... - Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigreeR J Todhunter
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
J Hered 94:39-48. 2003..When combined with previous power and quantitative genetic analyses, these estimates indicate that this pedigree is informative for QTL mapping of hip dysplasia traits... - Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome-wide screening for hip dysplasia in a crossbreed pedigreeR G Mateescu
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, NY 14853, USA
J Hered 96:847-53. 2005.... - Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritisG Lust
James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 62:1711-5. 2001..Thus, the DLS method might be useful for early identification of dogs with hip dysplasia... - Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogsG Lust
James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Am Vet Med Assoc 219:1242-6. 2001..However, the DLS score had higher sensitivity, indicating that there were fewer false-negative results... - Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigreeLaurel Hays
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 68:35-41. 2007..To evaluate the quantitative inheritance of secondary hip joint osteoarthritis in a canine pedigree... - Technical note: Use of marker-based relationships with multiple-trait derivative-free restricted maximal likelihoodZ Zhang
Institute for Genetic Diversity, Cornell University, Ithaca, NY 14853, USA
J Anim Sci 85:881-5. 2007..The strategy behind this modification and its design is described. An application is illustrated in a QTL association study for canine hip dysplasia... - Keratan sulfate as a marker of articular cartilage catabolism and joint treatment in poniesR J Todhunter
James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
Am J Vet Res 54:1007-16. 1993..Synovial fluid from medicated joints of nonexercised ponies had significantly (P < 0.05) lower KS concentration than did synovial fluid from nonmedicated joints of nonexercised ponies.(ABSTRACT TRUNCATED AT 250 WORDS).. - Corticosteroids alter the differentiated phenotype of articular chondrocytesS L Fubini
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Orthop Res 19:688-95. 2001..Decreased and altered chondrocyte expression of matrix proteins likely contributes to the pathogenesis of corticosteroid-induced cartilage degeneration... 
Prognostic factors affecting survival of 507 horses with joint disease: (1983 to 1990)S L Fubini
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Can J Vet Res 63:253-60. 1999..Sixty-four (60%) of these became sound; the odds increased if the horse was not severely lame at admission or was hospitalized for > 1 d. Risk factors and prognosis differed by age-use group among horses seen at our hospital...- Effect of early postnatal body weight on femoral head ossification onset and hip osteoarthritis in a canine model of developmental dysplasia of the hipWendy S Vanden Berg-Foels
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
Pediatr Res 60:549-54. 2006..These results support the hypothesis that increased birth weight is sufficient to alter the course of hip development and result in measurable degenerative changes at adulthood... - Assessment of bone mineral density of the femoral head in dogs with early osteoarthritisHeather J Chalmers
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 67:796-800. 2006.... - Magnetic resonance imaging of subarticular bone marrow lesions in dogs with stifle lamenessKevin R Winegardner
Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
Vet Radiol Ultrasound 48:312-7. 2007..High-signal STIR lesions may be a common sign in naturally acquired canine stifle disease, but the pathogenesis, prognostic and diagnostic values need further investigation... - Mixed linear model approach adapted for genome-wide association studiesZhiwu Zhang
Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
Nat Genet 42:355-60. 2010..We have made these methods available within an implementation of the software program TASSEL... - Increased MIG-6 mRNA transcripts in osteoarthritic cartilageRaluca G Mateescu
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, NY 14853, USA
Biochem Biophys Res Commun 332:482-6. 2005..This is the first report associating MIG-6 with OA. Additional studies will determine what role MIG-6 has in the origin of cartilage degeneration... - The potential and limitations of cartilage-specific (V+C)(-) fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluidMichele A Steffey
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Osteoarthritis Cartilage 12:818-25. 2004..However, the wide range of values obtained limits the diagnostic value for any one individual. Joint effusions obscure the total amount of biomarkers in affected synovial joints... - Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected GreyhoundsStuart Bliss
Department of Clinical Sciences, College of Agricultural and Life Sciences, Cornell University, Ithica, NY 14853, USA
Am J Vet Res 63:1029-35. 2002..Phenotypic differences exist among founder dogs of each breed and their crosses. This pedigree should be useful for identification of quantitative trait loci underlying the dysplastic phenotype... - Thoracolumbar spinal cord compression due to vertebral process degenerative joint disease in a family of Shiloh Shepherd dogsJohn J McDonnell
Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA
J Vet Intern Med 17:530-7. 2003..The DJD could have been caused by a primary vertebral malformation or an injury to the processes at a young age causing malarticulation... - Slow-acting, disease-modifying osteoarthritis agentsP S McNamara
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Vet Clin North Am Small Anim Pract 27:863-81. 1997..Until more evidence becomes available, the use of tetracyclines as therapeutic agents for OA should be considered investigational... - Evaluation of multiple radiographic predictors of cartilage lesions in the hip joints of eight-month-old dogsRory J Todhunter
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 64:1472-8. 2003..CONCLUSIONS AND CLINICAL RELEVANCE: A combination of the DLS score and Norberg angle was the best predictor of radiographic measures in 8-month-old dogs to determine whether a dog would have normal or osteoarthritic hip joints... - Genes in canine articular cartilage that respond to mechanical injury: gene expression studies with Affymetrix canine GeneChipN Burton-Wurster
Baker Institute for Animal Health, Cornell University, Ithaca, NY 14853, USA niw
J Hered 96:821-8. 2005..Deficiencies in the current annotation of the canine chip are discussed. Gene expression studies with the Affymetrix canine GeneChip are potentially valuable, but await more complete annotation... - Complex population structure in African village dogs and its implications for inferring dog domestication historyAdam R Boyko
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 106:13903-8. 2009..Surprisingly, we find similar mtDNA haplotype diversity in African and East Asian village dogs, potentially calling into question the hypothesis of an East Asian origin for dog domestication... - Usefulness, completeness, and accuracy of Web sites providing information on osteoarthritis in dogsCarl T Jehn
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
J Am Vet Med Assoc 223:1272-5. 2003..Although most of the sites conveyed some conventional information with reasonable accuracy, the information was incomplete, of minimal use, and often considered counterproductive... 
Estimation of heritabilities, genetic correlations, and breeding values of four traits that collectively define hip dysplasia in dogsZhiwu Zhang
Institute for Genomic Diversity, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
Am J Vet Res 70:483-92. 2009....- Development and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogsMarta G P Castelhano
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Am Vet Med Assoc 234:75-80. 2009..The most important feature of a DNA archive is accurate identification or exclusion of diseases in each animal. Such archives will be complimentary resources to tissue banks that are currently available... - In vitro biomechanical comparison of limited contat dynamic compression plate and locking compression plateA Z Aguila
College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Vet Comp Orthop Traumatol 18:220-6. 2005..0024) than the LCP. Based on the similar performance with loading, the locking compression plate is a good alternative implant for unstable diaphyseal femoral fracture repair in dogs... - Acceleration and balance in trotting dogsD V Lee
College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Exp Biol 202:3565-73. 1999..Vertical forces exerted by the forelimb and hindlimb resist this pitching moment, providing stability during fore-aft acceleration and deceleration... - Effect of dorsal hip loading, sedation, and general anesthesia on the dorsolateral subluxation score in dogsRory J Todhunter
Departments of Clinical Sciences and Population Medicine and Diagnostic Sciences and the James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Surg 32:196-205. 2003.... - Use of a centrifugation-based, point-of-care device for production of canine autologous bone marrow and platelet concentratesMichael S Thoesen
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 67:1655-61. 2006..9%). CONCLUSIONS AND CLINICAL RELEVANCE: Bone marrow-derived cell and platelet-rich concentrates may form bone if delivered in an engineered graft, thus decreasing the need for cancellous bone grafts... - Identification of quantitative trait loci for osteoarthritis of hip joints in dogsRaluca G Mateescu
Department of Animal Science, College of Agricultural Sciences and Natural Resources, Oklahoma State University, Stillwater, OK 74078, USA
Am J Vet Res 69:1294-300. 2008..To identify quantitative trait loci (QTL) associated with osteoarthritis (OA) of hip joints of dogs by use of a whole-genome microsatellite scan... - A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasiaTian Liu
Department of Statistics, University of Florida, Gainesville, FL 32611, USA
Genomics 90:276-84. 2007..The detected iQTL provide important candidate regions for fine-mapping of imprinted genes and for studying their structure and function in the control of complex traits... - The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigreeXiang-Yang Lou
Department of Statistics, 533 McCarty Hall C, University of Florida, Gainesville, Florida 32611, USA
Mamm Genome 14:555-64. 2003..This study supports the appropriateness of linkage disequilibrium analysis to detect and map quantitative trait loci underlying complex traits in dogs... - Modeling extent and distribution of zygotic disequilibrium: implications for a multigenerational canine pedigreeTian Liu
Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
Genetics 174:439-53. 2006..The results from this study provide scientific guidance about the determination of the number of markers used for whole-genome association studies... - Linkage and segregation analysis of black and brindle coat color in domestic dogsJulie A Kerns
Department of Genetics, Stanford University, Stanford, California 94035, USA
Genetics 176:1679-89. 2007..These findings suggest a molecular model for a new component of the melanocortin signaling pathway and reveal how coat-color patterns and pigmentary diversity have been shaped by recent selection...