R J Todhunter

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis
    Rory J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 64:418-24. 2003
  2. pmc Monitoring Hip and Elbow Dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA
    Yali Hou
    Key Laboratory of Agricultural Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 8:e76390. 2013
  3. ncbi request reprint Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree
    R J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Hered 94:39-48. 2003
  4. ncbi request reprint Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree
    Rory J Todhunter
    Department of Clinical Sciences, Box 32 College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Mamm Genome 16:720-30. 2005
  5. ncbi request reprint An outcrossed canine pedigree for linkage analysis of hip dysplasia
    R J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Hered 90:83-92. 1999
  6. ncbi request reprint Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome-wide screening for hip dysplasia in a crossbreed pedigree
    R G Mateescu
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, NY 14853, USA
    J Hered 96:847-53. 2005
  7. ncbi request reprint Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis
    G Lust
    James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 62:1711-5. 2001
  8. ncbi request reprint Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogs
    G Lust
    James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 219:1242-6. 2001
  9. ncbi request reprint Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree
    Laurel Hays
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 68:35-41. 2007
  10. ncbi request reprint Technical note: Use of marker-based relationships with multiple-trait derivative-free restricted maximal likelihood
    Z Zhang
    Institute for Genetic Diversity, Cornell University, Ithaca, NY 14853, USA
    J Anim Sci 85:881-5. 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis
    Rory J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 64:418-24. 2003
    ..To estimate the number of dogs required to find linkage to heritable traits of hip dysplasia in dogs from an experimental pedigree...
  2. pmc Monitoring Hip and Elbow Dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA
    Yali Hou
    Key Laboratory of Agricultural Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 8:e76390. 2013
    ..The weak genetic correlation suggested that selection based on hip scores would also slightly improve elbow scores but it is necessary to allocate effort toward improvement of elbow scores alone. ..
  3. ncbi request reprint Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree
    R J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Hered 94:39-48. 2003
    ..When combined with previous power and quantitative genetic analyses, these estimates indicate that this pedigree is informative for QTL mapping of hip dysplasia traits...
  4. ncbi request reprint Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree
    Rory J Todhunter
    Department of Clinical Sciences, Box 32 College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Mamm Genome 16:720-30. 2005
    ..Successful detection of QTL was due to the cross-breed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools...
  5. ncbi request reprint An outcrossed canine pedigree for linkage analysis of hip dysplasia
    R J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Hered 90:83-92. 1999
    ..Although dogs in the backcross generation that were three-quarter greyhound had a broad range of hip laxity, a protective effect of the greyhound QTLs for good osseous conformation has mitigated thus far against subluxation and CHD...
  6. ncbi request reprint Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome-wide screening for hip dysplasia in a crossbreed pedigree
    R G Mateescu
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, NY 14853, USA
    J Hered 96:847-53. 2005
    ....
  7. ncbi request reprint Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis
    G Lust
    James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 62:1711-5. 2001
    ..Thus, the DLS method might be useful for early identification of dogs with hip dysplasia...
  8. ncbi request reprint Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogs
    G Lust
    James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 219:1242-6. 2001
    ..However, the DLS score had higher sensitivity, indicating that there were fewer false-negative results...
  9. ncbi request reprint Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree
    Laurel Hays
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 68:35-41. 2007
    ..To evaluate the quantitative inheritance of secondary hip joint osteoarthritis in a canine pedigree...
  10. ncbi request reprint Technical note: Use of marker-based relationships with multiple-trait derivative-free restricted maximal likelihood
    Z Zhang
    Institute for Genetic Diversity, Cornell University, Ithaca, NY 14853, USA
    J Anim Sci 85:881-5. 2007
    ..The strategy behind this modification and its design is described. An application is illustrated in a QTL association study for canine hip dysplasia...
  11. ncbi request reprint Keratan sulfate as a marker of articular cartilage catabolism and joint treatment in ponies
    R J Todhunter
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
    Am J Vet Res 54:1007-16. 1993
    ..Synovial fluid from medicated joints of nonexercised ponies had significantly (P < 0.05) lower KS concentration than did synovial fluid from nonmedicated joints of nonexercised ponies.(ABSTRACT TRUNCATED AT 250 WORDS)..
  12. pmc Prognostic factors affecting survival of 507 horses with joint disease: (1983 to 1990)
    S L Fubini
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Can J Vet Res 63:253-60. 1999
    ..Sixty-four (60%) of these became sound; the odds increased if the horse was not severely lame at admission or was hospitalized for > 1 d. Risk factors and prognosis differed by age-use group among horses seen at our hospital...
  13. ncbi request reprint Corticosteroids alter the differentiated phenotype of articular chondrocytes
    S L Fubini
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Orthop Res 19:688-95. 2001
    ..Decreased and altered chondrocyte expression of matrix proteins likely contributes to the pathogenesis of corticosteroid-induced cartilage degeneration...
  14. ncbi request reprint Effect of early postnatal body weight on femoral head ossification onset and hip osteoarthritis in a canine model of developmental dysplasia of the hip
    Wendy S Vanden Berg-Foels
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Pediatr Res 60:549-54. 2006
    ..These results support the hypothesis that increased birth weight is sufficient to alter the course of hip development and result in measurable degenerative changes at adulthood...
  15. ncbi request reprint Assessment of bone mineral density of the femoral head in dogs with early osteoarthritis
    Heather J Chalmers
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 67:796-800. 2006
    ..To compare the bone mineral density (BMD) of the proximal portion of the femur in dogs with and without early osteoarthritis secondary to hip dysplasia...
  16. ncbi request reprint Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds
    Stuart Bliss
    Department of Clinical Sciences, College of Agricultural and Life Sciences, Cornell University, Ithica, NY 14853, USA
    Am J Vet Res 63:1029-35. 2002
    ..To determine the genetic influence on expression of traits associated with canine hip dysplasia...
  17. ncbi request reprint Increased MIG-6 mRNA transcripts in osteoarthritic cartilage
    Raluca G Mateescu
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, NY 14853, USA
    Biochem Biophys Res Commun 332:482-6. 2005
    ..This is the first report associating MIG-6 with OA. Additional studies will determine what role MIG-6 has in the origin of cartilage degeneration...
  18. ncbi request reprint The potential and limitations of cartilage-specific (V+C)(-) fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid
    Michele A Steffey
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Osteoarthritis Cartilage 12:818-25. 2004
    ..To determine if levels of the cartilage-specific (V+C)(-) fibronectin isoform in the synovial fluid is associated with cartilage change during osteoarthritis...
  19. ncbi request reprint Magnetic resonance imaging of subarticular bone marrow lesions in dogs with stifle lameness
    Kevin R Winegardner
    Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
    Vet Radiol Ultrasound 48:312-7. 2007
    ..High-signal STIR lesions may be a common sign in naturally acquired canine stifle disease, but the pathogenesis, prognostic and diagnostic values need further investigation...
  20. pmc Mixed linear model approach adapted for genome-wide association studies
    Zhiwu Zhang
    Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
    Nat Genet 42:355-60. 2010
    ..We have made these methods available within an implementation of the software program TASSEL...
  21. ncbi request reprint Thoracolumbar spinal cord compression due to vertebral process degenerative joint disease in a family of Shiloh Shepherd dogs
    John J McDonnell
    Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA
    J Vet Intern Med 17:530-7. 2003
    ..The DJD could have been caused by a primary vertebral malformation or an injury to the processes at a young age causing malarticulation...
  22. ncbi request reprint Slow-acting, disease-modifying osteoarthritis agents
    P S McNamara
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Vet Clin North Am Small Anim Pract 27:863-81. 1997
    ..Until more evidence becomes available, the use of tetracyclines as therapeutic agents for OA should be considered investigational...
  23. ncbi request reprint Evaluation of multiple radiographic predictors of cartilage lesions in the hip joints of eight-month-old dogs
    Rory J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 64:1472-8. 2003
    ..To determine the radiographic methods that best predict the development of osteoarthritis in the hip joints of a cohort of dogs with hip dysplasia and unaffected dogs...
  24. ncbi request reprint Genes in canine articular cartilage that respond to mechanical injury: gene expression studies with Affymetrix canine GeneChip
    N Burton-Wurster
    Baker Institute for Animal Health, Cornell University, Ithaca, NY 14853, USA niw
    J Hered 96:821-8. 2005
    ..Deficiencies in the current annotation of the canine chip are discussed. Gene expression studies with the Affymetrix canine GeneChip are potentially valuable, but await more complete annotation...
  25. ncbi request reprint Usefulness, completeness, and accuracy of Web sites providing information on osteoarthritis in dogs
    Carl T Jehn
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Am Vet Med Assoc 223:1272-5. 2003
    ..To evaluate the quality of information regarding osteoarthritis (OA) in dogs currently available on the World Wide Web...
  26. pmc Complex population structure in African village dogs and its implications for inferring dog domestication history
    Adam R Boyko
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 106:13903-8. 2009
    ..Surprisingly, we find similar mtDNA haplotype diversity in African and East Asian village dogs, potentially calling into question the hypothesis of an East Asian origin for dog domestication...
  27. doi request reprint Estimation of heritabilities, genetic correlations, and breeding values of four traits that collectively define hip dysplasia in dogs
    Zhiwu Zhang
    Institute for Genomic Diversity, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    Am J Vet Res 70:483-92. 2009
    ....
  28. pmc Development and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogs
    Marta G P Castelhano
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 234:75-80. 2009
    ..The most important feature of a DNA archive is accurate identification or exclusion of diseases in each animal. Such archives will be complimentary resources to tissue banks that are currently available...
  29. ncbi request reprint In vitro biomechanical comparison of limited contat dynamic compression plate and locking compression plate
    A Z Aguila
    College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Vet Comp Orthop Traumatol 18:220-6. 2005
    ..0024) than the LCP. Based on the similar performance with loading, the locking compression plate is a good alternative implant for unstable diaphyseal femoral fracture repair in dogs...
  30. ncbi request reprint Acceleration and balance in trotting dogs
    D V Lee
    College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Exp Biol 202:3565-73. 1999
    ..Vertical forces exerted by the forelimb and hindlimb resist this pitching moment, providing stability during fore-aft acceleration and deceleration...
  31. ncbi request reprint Effect of dorsal hip loading, sedation, and general anesthesia on the dorsolateral subluxation score in dogs
    Rory J Todhunter
    Departments of Clinical Sciences and Population Medicine and Diagnostic Sciences and the James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 32:196-205. 2003
    ..To determine whether dorsal loading of the pelvis and type of chemical restraint affected the dorsolateral subluxation (DLS) score of dog hips. STYDY DESIGN: In vivo testing of diagnostic method...
  32. ncbi request reprint Use of a centrifugation-based, point-of-care device for production of canine autologous bone marrow and platelet concentrates
    Michael S Thoesen
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 67:1655-61. 2006
    ..To analyze a centrifugation-based, point-of-care device that concentrates canine platelets and bone marrow-derived cells...
  33. doi request reprint Identification of quantitative trait loci for osteoarthritis of hip joints in dogs
    Raluca G Mateescu
    Department of Animal Science, College of Agricultural Sciences and Natural Resources, Oklahoma State University, Stillwater, OK 74078, USA
    Am J Vet Res 69:1294-300. 2008
    ..To identify quantitative trait loci (QTL) associated with osteoarthritis (OA) of hip joints of dogs by use of a whole-genome microsatellite scan...
  34. ncbi request reprint A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasia
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genomics 90:276-84. 2007
    ..The detected iQTL provide important candidate regions for fine-mapping of imprinted genes and for studying their structure and function in the control of complex traits...
  35. ncbi request reprint The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree
    Xiang Yang Lou
    Department of Statistics, 533 McCarty Hall C, University of Florida, Gainesville, Florida 32611, USA
    Mamm Genome 14:555-64. 2003
    ..This study supports the appropriateness of linkage disequilibrium analysis to detect and map quantitative trait loci underlying complex traits in dogs...
  36. pmc Modeling extent and distribution of zygotic disequilibrium: implications for a multigenerational canine pedigree
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 174:439-53. 2006
    ..The results from this study provide scientific guidance about the determination of the number of markers used for whole-genome association studies...
  37. pmc Linkage and segregation analysis of black and brindle coat color in domestic dogs
    Julie A Kerns
    Department of Genetics, Stanford University, Stanford, California 94035, USA
    Genetics 176:1679-89. 2007
    ..These findings suggest a molecular model for a new component of the melanocortin signaling pathway and reveal how coat-color patterns and pigmentary diversity have been shaped by recent selection...