Andrew H Talal

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients
    Nawal M Boukli
    Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, USA
    Clin Proteomics 9:11. 2012
  2. doi request reprint Assessment of methadone clinic staff attitudes toward hepatitis C evaluation and treatment
    Andrew H Talal
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, USA
    J Subst Abuse Treat 44:115-9. 2013
  3. ncbi request reprint The HCV and HIV coinfected patient: what have we learned about pathophysiology?
    Andrew H Talal
    Weill Medical College of Cornell University, 525 East 68th Street, A354, New York, NY 10021, USA
    Curr Gastroenterol Rep 4:15-22. 2002
  4. ncbi request reprint Opportunistic infections in HIV-infected individuals: hepatitis C virus
    Andrew Talal
    Center for the Study of Hepatitis C and Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Lancet 360:584-6. 2002
  5. ncbi request reprint Pharmacodynamics of PEG-IFN alpha differentiate HIV/HCV coinfected sustained virological responders from nonresponders
    Andrew H Talal
    Department of Medicine and the Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hepatology 43:943-53. 2006
  6. ncbi request reprint Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV
    Andrew H Talal
    Department of Medicine, Weill Medical College of Cornell University, New York City, NY, USA
    J Acquir Immune Defic Syndr 35:103-13. 2004
  7. pmc Randomized trial comparing dose reduction and growth factor supplementation for management of hematological side effects in HIV/hepatitis C virus patients receiving pegylated-interferon and ribavirin
    Andrew H Talal
    Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    J Acquir Immune Defic Syndr 58:261-8. 2011
  8. doi request reprint IL28B polymorphism, pretreatment CXCL10, and HCV RNA levels predict treatment response in racially diverse HIV/HCV coinfected and HCV monoinfected patients
    Marija Zeremski
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10065, USA
    J Acquir Immune Defic Syndr 63:9-16. 2013
  9. pmc Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C
    Marija Zeremski
    Department of Medicine, Division of Gastroenterology and Hepatology, The Center for the Study of Hepatitis C, Weill Cornell Medical College, New York, NY 10065, USA
    Hepatology 48:1440-50. 2008
  10. ncbi request reprint Interferon gamma-inducible protein 10: a predictive marker of successful treatment response in hepatitis C virus/HIV-coinfected patients
    Marija Zeremski
    Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Acquir Immune Defic Syndr 45:262-8. 2007

Research Grants

Collaborators

Detail Information

Publications39

  1. pmc Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients
    Nawal M Boukli
    Department of Microbiology and Immunology, and the Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA, USA
    Clin Proteomics 9:11. 2012
    ..abstract:..
  2. doi request reprint Assessment of methadone clinic staff attitudes toward hepatitis C evaluation and treatment
    Andrew H Talal
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, USA
    J Subst Abuse Treat 44:115-9. 2013
    ..Educational interventions and skill building for staff to confidently engage and support MMTP patients in HCV treatment may be necessary prerequisites for onsite HCV management in MMTPs...
  3. ncbi request reprint The HCV and HIV coinfected patient: what have we learned about pathophysiology?
    Andrew H Talal
    Weill Medical College of Cornell University, 525 East 68th Street, A354, New York, NY 10021, USA
    Curr Gastroenterol Rep 4:15-22. 2002
    ..Also, because several issues concerning HCV are unique to coinfected patients, further research is needed to determine optimal management of HCV in this setting...
  4. ncbi request reprint Opportunistic infections in HIV-infected individuals: hepatitis C virus
    Andrew Talal
    Center for the Study of Hepatitis C and Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Lancet 360:584-6. 2002
  5. ncbi request reprint Pharmacodynamics of PEG-IFN alpha differentiate HIV/HCV coinfected sustained virological responders from nonresponders
    Andrew H Talal
    Department of Medicine and the Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hepatology 43:943-53. 2006
    ..In contrast, pharmacodynamic measurements-namely EC50, the therapeutic quotient, and C(7)/EC50--are different in coinfected SVRs and NRs. These parameters might be useful predictors of treatment outcome during the first month of therapy...
  6. ncbi request reprint Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV
    Andrew H Talal
    Department of Medicine, Weill Medical College of Cornell University, New York City, NY, USA
    J Acquir Immune Defic Syndr 35:103-13. 2004
    ....
  7. pmc Randomized trial comparing dose reduction and growth factor supplementation for management of hematological side effects in HIV/hepatitis C virus patients receiving pegylated-interferon and ribavirin
    Andrew H Talal
    Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    J Acquir Immune Defic Syndr 58:261-8. 2011
    ..Our objective was to compare the effectiveness of intervening with hematologic growth factors versus dose reductions of standard HCV therapy for the management of treatment-induced hematologic disorders...
  8. doi request reprint IL28B polymorphism, pretreatment CXCL10, and HCV RNA levels predict treatment response in racially diverse HIV/HCV coinfected and HCV monoinfected patients
    Marija Zeremski
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY 10065, USA
    J Acquir Immune Defic Syndr 63:9-16. 2013
    ..We sought to develop a score to predict sustained virological response (SVR) in racially diverse HIV/hepatitis C virus (HCV)-coinfected and HCV-monoinfected pegylated interferon/ribavirin-treated patients...
  9. pmc Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C
    Marija Zeremski
    Department of Medicine, Division of Gastroenterology and Hepatology, The Center for the Study of Hepatitis C, Weill Cornell Medical College, New York, NY 10065, USA
    Hepatology 48:1440-50. 2008
    ..Most intrahepatic lymphocytes express the CXCR3 receptor, and the number of CXCR3(+) lymphocytes was increased in patients with advanced necroinflammation...
  10. ncbi request reprint Interferon gamma-inducible protein 10: a predictive marker of successful treatment response in hepatitis C virus/HIV-coinfected patients
    Marija Zeremski
    Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Acquir Immune Defic Syndr 45:262-8. 2007
    ..We undertook this study to determine if IP-10 is a marker of treatment outcome in HCV/HIV-coinfected patients...
  11. ncbi request reprint HIV/hepatitis C virus-coinfected patients with normal alanine aminotransferase levels
    Stevan A Gonzalez
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Department of Medicine, Weill Medical College of Columbia University, 525 East 68th Street, New York, NY 10021, USA
    J Acquir Immune Defic Syndr 41:582-9. 2006
    ..The significance of normal alanine aminotransferase (ALT) levels in patients with HIV/hepatitis C virus (HCV) coinfection is not well understood...
  12. pmc Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Blood 117:5425-37. 2011
    ..Down-regulation of multiple activation pathways may represent a homeostatic mechanism attenuating otherwise uncontrolled stimulation of circulating HCV-containing immune complexes...
  13. ncbi request reprint Intrahepatic CD4+ cell depletion in hepatitis C virus/HIV-coinfected patients
    P Wilfredo Canchis
    Center for the Study of Hepatitis C, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Acquir Immune Defic Syndr 37:1125-31. 2004
    ..09 cell/HPF) and monoinfected patients (0.45 +/- 0.08 cell/HPF). In conclusion, HIV coinfection is associated with fewer portal CD4 cells and increased lobular lymphocyte apoptosis that may impact on the natural history of HCV infection...
  14. doi request reprint Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection
    Marija Zeremski
    Division of Gastroenterology and Hepatology and Center for the Study of Hepatitis C, Weill Cornell Medical College, New York, USA
    J Infect Dis 200:1774-80. 2009
    ..We evaluated the potential of peripheral chemokine levels to discriminate among patients with chronic HCV infection who had different stages of fibrosis...
  15. pmc Determinants of hepatitis C virus treatment completion and efficacy in drug users assessed by meta-analysis
    Rositsa B Dimova
    Weill Cornell Medical College, New York, NY 10065, USA
    Clin Infect Dis 56:806-16. 2013
    ..We assessed the effects of different treatment approaches and services to promote HCV care among DUs as well as demographic and viral characteristics...
  16. pmc Insulin resistance predicts re-treatment failure in an efficacy study of peginterferon-α-2a and ribavirin in HIV/HCV co-infected patients
    Marie Louise C Vachon
    Division of Liver Diseases, Mount Sinai School of Medicine, NY, USA
    J Hepatol 54:41-7. 2011
    ....
  17. pmc Induction of CXCR3- and CCR5-associated chemokines during acute hepatitis C virus infection
    Marija Zeremski
    Center for the Study of Hepatitis C and Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, USA
    J Hepatol 55:545-53. 2011
    ..Characterization of inflammatory mediators, such as chemokines, during acute hepatitis C virus (HCV) infection might shed some light on viral clearance mechanisms...
  18. pmc Identification of substance use and dependence among patients with viral hepatitis
    Colin B Jackson
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Dig Liver Dis 42:650-6. 2010
    ..As drug abuse and addiction have been shown to decrease adherence to treatment of hepatitis C virus (HCV) or HIV, screening for substance use should be standard clinical practice in those undergoing an evaluation for these diseases...
  19. ncbi request reprint Histological findings and clinical characteristics associated with hepatic steatosis in patients coinfected with HIV and hepatitis C virus
    Kristen M Marks
    Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Infect Dis 192:1943-9. 2005
    ..The prevalence and significance of steatosis in patients coinfected with human immunodeficiency virus (HIV) and HCV are not well characterized...
  20. doi request reprint Autoimmune hepatitis in the HIV-infected patient: a therapeutic dilemma
    David W Wan
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA
    AIDS Patient Care STDS 23:407-13. 2009
    ....
  21. pmc CXCL9 and CXCL10 chemokines as predictors of liver fibrosis in a cohort of primarily African-American injection drug users with chronic hepatitis C
    Marija Zeremski
    Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, USA
    J Infect Dis 204:832-6. 2011
    ..0045). Therefore, CXCL10 has potential as a marker of fibrosis progression in African-American HCV-infected patients...
  22. pmc Risk factors for thrombocytopenia in HIV-infected persons in the era of potent antiretroviral therapy
    Kristen M Marks
    Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    J Acquir Immune Defic Syndr 52:595-9. 2009
    ..Before potent antiretroviral therapy, thrombocytopenia was observed frequently. Little is known about risk factors for or severity and consequences of thrombocytopenia since establishment of highly effective therapy for HIV...
  23. ncbi request reprint Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C
    Randy S Longman
    The Rockefeller University, The Cornell Rockefeller Sloan Kettering Tri Institutional MD PhD Program, New York, New York, USA
    J Infect Dis 192:497-503. 2005
    ..These results are encouraging for DC-based HCV immunotherapy trials...
  24. pmc Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia
    Edgar D Charles
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10021, USA
    Blood 111:1344-56. 2008
    ..This study was registered at www.clinicaltrials.gov as NCT00219999...
  25. pmc Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C
    David Butera
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, Box 64, 1230 York Ave, New York, NY 10021, USA
    Blood 106:1175-82. 2005
    ..This observation has implications for understanding the pathogenesis of HCV infection...
  26. ncbi request reprint Understanding the pathogenesis and management of hepatitis B/HIV and hepatitis B/hepatitis C virus coinfection
    Srinivas Cheruvu
    Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, 525 E 68th Street, Box 319, New York, NY 10065, USA
    Clin Liver Dis 11:917-43, ix-x. 2007
    ..In HBV/HCV coinfection HCV usually tends to predominate over HBV. More investigation is needed into the mechanisms by which viral pathogenesis is altered and the optimal treatment modalities for coinfected patients...
  27. ncbi request reprint Changing treatment paradigms: hepatitis C virus in HIV-infected patients
    Jaydeep S Kadam
    Division of Gastroenterology and Hepatology, Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York, New York 10021, USA
    AIDS Patient Care STDS 21:154-68. 2007
    ..In summary, HCV treatment will likely follow the example forged by HIV. In the near future, combinations of different drugs will likely be used simultaneously to result in durable viral suppression...
  28. doi request reprint Hepatitis C virus infection in USA: an estimate of true prevalence
    Eric Chak
    Department of Medicine, University of California, Sylmar, CA, USA
    Liver Int 31:1090-101. 2011
    ..Our most conservative estimates suggest that there are at least 5.2 million persons living with HCV in USA today, approximately 1.9 million of whom were unaccounted for in the NHANES survey...
  29. ncbi request reprint Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein
    P Wilfredo Canchis
    Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York, NY 10021, USA
    Liver Int 24:198-203. 2004
    ..The relationships between HP and necroinflammation, fibrosis, and serum alpha-fetoprotein (AFP) levels in chronic hepatitis C virus (HCV) infection, however, are not well understood...
  30. doi request reprint Depression and Fatigue in Chronic Hepatitis C Patients With and Without HIV Co-Infection
    Mohammad Tavakkoli
    Department of Psychiatry, NY Presbyterian Hospital, Weill Cornell Medical College, New York, NY
    Psychosomatics 54:466-71. 2013
    ..Depression and fatigue are common in chronic hepatitis C (CHC)...
  31. ncbi request reprint Hepatitis C viral kinetics during treatment of hepatitis C virus/HIV coinfected patients
    Marija Zeremski
    Division of Gastroenterology and Hepatology, Department of Medicine, and The Center for the Study of Hepatitis C, Weill Medical College of Cornell University, New York, New York, USA
    Curr Opin HIV AIDS 2:489-95. 2007
    ..We sought to review data on hepatitis C virus kinetics in hepatitis C virus/HIV coinfected patients and to illustrate how viral kinetics might direct therapeutic decisions in these patients...
  32. ncbi request reprint Hepatitis C virus in human immunodeficiency virus-infected individuals: an emerging comorbidity with significant implications
    Stevan A Gonzalez
    Center for the Study of Hepatitis C and Department of Medicine, Weill Medical College of Cornell University, New York, New York10021, USA
    Semin Liver Dis 23:149-66. 2003
    ....
  33. ncbi request reprint Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients
    Jianhua Ni
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10021, USA
    J Immunol 170:3429-39. 2003
    ..Instead, factors other than antigenic stimulation may promote the accumulation of peripheral blood B cells with a naive phenotype in a subset of HCV patients...
  34. ncbi request reprint Dideoxynucleoside analogues should be used cautiously in patients with hepatic steatosis
    Marija Zeremski
    Clin Infect Dis 43:373-6. 2006
  35. pmc Early ribavirin pharmacokinetics, HCV RNA and alanine aminotransferase kinetics in HIV/HCV co-infected patients during treatment with pegylated interferon and ribavirin
    Harel Dahari
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    J Hepatol 47:23-30. 2007
    ..We evaluated whether early ribavirin pharmacokinetics differ comparing hepatitis C/human immunodeficiency virus coinfected sustained virological responders and nonresponders...
  36. ncbi request reprint Modeling viral and drug kinetics: hepatitis C virus treatment with pegylated interferon alfa-2b
    Kimberly A Powers
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
    Semin Liver Dis 23:13-8. 2003
    ..Models incorporating pharmacokinetics are needed to correctly interpret viral load changes and estimate drug effectiveness in treatment protocols using peginterferon alfa-2b...
  37. ncbi request reprint Presence of functional dendritic cells in patients chronically infected with hepatitis C virus
    Randy S Longman
    Institut Pasteur, 25, rue du Dr Roux, Paris, France 75724
    Blood 103:1026-9. 2004
    ..This finding is consistent with clinical and immunologic data that the deficit in the patient's immune repertoire is HCV-specific and suggests that refined models are required for understanding the role of DCs in HCV pathogenesis...
  38. ncbi request reprint Noninvasive markers of hepatic fibrosis: are they ready for prime time in the management of HIV/HCV co-infected patients?
    Marija Zeremski
    J Hepatol 43:2-5. 2005
  39. doi request reprint Noninjection drug use: an under-appreciated risk factor for hepatitis C virus transmission
    Anthony Martinez
    Liver Int 28:757-60. 2008

Research Grants1

  1. VIRAL AND IMMUNE RESPONSE TO THERAPY FOR HIV IN THE GALT
    Andrew Talal; Fiscal Year: 2003
    ..This project amy provide important insights into the amount of time needed to treat HIV- infected individuals and may provide novel approaches by which to monitor therapeutic responses in these individuals. ..