Hazel Szeto

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis
    Shaoyi Liu
    Dept of Pharmacology, Weill Cornell Medical College, 1300 York Ave, New York, NY 10021
    Am J Physiol Renal Physiol 306:F970-80. 2014
  2. ncbi request reprint Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Antioxid Redox Signal 10:601-19. 2008
  3. ncbi request reprint Development of mitochondria-targeted aromatic-cationic peptides for neurodegenerative diseases
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    Ann N Y Acad Sci 1147:112-21. 2008
  4. ncbi request reprint Dynorphin and the hypothalamo-pituitary-adrenal axis during fetal development
    Hazel H Szeto
    Department of Pharmacology, LC 405, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Life Sci 73:749-58. 2003
  5. ncbi request reprint Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Pharmacol Exp Ther 305:696-702. 2003
  6. ncbi request reprint Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide
    Kesheng Zhao
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Pharmacol Exp Ther 304:425-32. 2003
  7. pmc Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury
    Hazel H Szeto
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021, USA
    J Am Soc Nephrol 22:1041-52. 2011
  8. doi request reprint Novel therapies targeting inner mitochondrial membrane--from discovery to clinical development
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Pharm Res 28:2669-79. 2011
  9. pmc Cell-permeable, mitochondrial-targeted, peptide antioxidants
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    AAPS J 8:E277-83. 2006
  10. pmc Mitochondria-targeted peptide antioxidants: novel neuroprotective agents
    Hazel H Szeto
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    AAPS J 8:E521-31. 2006

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis
    Shaoyi Liu
    Dept of Pharmacology, Weill Cornell Medical College, 1300 York Ave, New York, NY 10021
    Am J Physiol Renal Physiol 306:F970-80. 2014
    ..These results suggest that mitochondria protection represents an upstream target for pharmacological intervention in microvascular rarefaction and fibrosis. ..
  2. ncbi request reprint Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Antioxid Redox Signal 10:601-19. 2008
    ..The pharmacology of the SS peptides in models of ischemia-reperfusion will be the focus of this review...
  3. ncbi request reprint Development of mitochondria-targeted aromatic-cationic peptides for neurodegenerative diseases
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    Ann N Y Acad Sci 1147:112-21. 2008
    ..These peptides can readily penetrate the blood-brain barrier and have demonstrated efficacy in animal models of Parkinson's disease and amyotrophic lateral sclerosis...
  4. ncbi request reprint Dynorphin and the hypothalamo-pituitary-adrenal axis during fetal development
    Hazel H Szeto
    Department of Pharmacology, LC 405, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Life Sci 73:749-58. 2003
    ..It is likely that the two mechanisms may respond to different stress stimuli and play a different role during development...
  5. ncbi request reprint Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Pharmacol Exp Ther 305:696-702. 2003
    ..These data suggest that i.t. [Dmt(1)]DALDA causes the release of dynorphin and [Met(5)]enkephalin-like substances that act at kappa and delta receptors, respectively, to contribute to the extraordinary potency of [Dmt(1)]DALDA...
  6. ncbi request reprint Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide
    Kesheng Zhao
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Pharmacol Exp Ther 304:425-32. 2003
    ..These data show transcellular translocation of a highly polar 3+ charge tetrapeptide and suggest that [Dmt1]DALDA may not only distribute across the blood-brain barrier but also it may even have reasonable oral absorption...
  7. pmc Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury
    Hazel H Szeto
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021, USA
    J Am Soc Nephrol 22:1041-52. 2011
    ..SS-31 holds promise for the prevention and treatment of acute kidney injury...
  8. doi request reprint Novel therapies targeting inner mitochondrial membrane--from discovery to clinical development
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Pharm Res 28:2669-79. 2011
    ..These compounds have the potential to be a paradigm-shifting approach to the treatment of mitochondrial dysfunction, which underlies many common diseases, including cardiorenal, neurologic, and metabolic disorders...
  9. pmc Cell-permeable, mitochondrial-targeted, peptide antioxidants
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    AAPS J 8:E277-83. 2006
    ..Although peptides have often been considered to be poor drug candidates, these small peptides have excellent "druggable" properties, making them promising agents for many diseases with unmet needs...
  10. pmc Mitochondria-targeted peptide antioxidants: novel neuroprotective agents
    Hazel H Szeto
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    AAPS J 8:E521-31. 2006
    ....
  11. ncbi request reprint Fluorescent dyes alter intracellular targeting and function of cell-penetrating tetrapeptides
    Hazel H Szeto
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    FASEB J 19:118-20. 2005
    ....
  12. ncbi request reprint Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
    Kesheng Zhao
    Departments of Pharmacology and Biochemistry, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    J Biol Chem 279:34682-90. 2004
    ..These IMM-targeted antioxidants may be very beneficial in the treatment of aging and diseases associated with oxidative stress...
  13. ncbi request reprint A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36
    Sunghee Cho
    Burke Medical Research Institute, White Plains, New York 10605, USA
    J Biol Chem 282:4634-42. 2007
    ..These in vivo and in vitro studies indicate that the down-regulation of CD36 by novel class antioxidant peptides may be a useful strategy to treat ischemic stroke victims...
  14. ncbi request reprint Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines
    Kesheng Zhao
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Biochem Pharmacol 70:1796-806. 2005
    ..SS-31 represents a novel platform of mitochondria-targeted antioxidants with broad therapeutic potential...
  15. ncbi request reprint Potent mitochondria-targeted peptides reduce myocardial infarction in rats
    Janghyun Cho
    Department of Medicine, St Carollo Hospital, Suncheon City, Seoul Medical Center, Seoul, Korea, and Department of Pharmacology, Weill Cornell Medical College, New York, New York 10025, USA
    Coron Artery Dis 18:215-20. 2007
    ..We subsequently showed that this peptide targeted mitochondria and can scavenge reactive oxygen species. The objective of this study was to determine the role of opioid versus antioxidant activity in cardioprotection...
  16. ncbi request reprint Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function
    Dolca A Thomas
    Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital Weill Cornell, New York, NY, USA
    J Am Soc Nephrol 18:213-22. 2007
    ..Because SS-31 was effective with "extended" islet donors, it is hypothesized that the antioxidant SS-31 may serve to increase the pool of eligible organ donors...
  17. ncbi request reprint Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at mu, delta, and kappa opioid receptors
    Guo Min Zhao
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    J Pharmacol Exp Ther 307:947-54. 2003
    ..The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors...
  18. ncbi request reprint Profound spinal tolerance after repeated exposure to a highly selective mu-opioid peptide agonist: role of delta-opioid receptors
    Guo Min Zhao
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Pharmacol Exp Ther 302:188-96. 2002
    ..These results suggest that agonist activation of delta-receptors is not necessary for the development of opioid tolerance; however, delta-receptors play a modulatory role in the maintenance of the tolerant state...
  19. ncbi request reprint Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis
    Susanne Petri
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    J Neurochem 98:1141-8. 2006
    ..This further enhances the concept that pharmacological modification of oxidative stress is a therapeutic option for the treatment of ALS...
  20. pmc A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction
    Yasunori Mizuguchi
    Institute for Pediatric Urology, Department of Urology, Weill Medical College, 1300 York Ave, Box 94, New York, NY 10021, USA
    Am J Physiol Renal Physiol 295:F1545-53. 2008
    ..The mechanism by which protection is afforded requires further studies both in vitro and in vivo...
  21. pmc Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
    Lichuan Yang
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    Antioxid Redox Signal 11:2095-104. 2009
    ..These findings provide strong evidence that these neuroprotective peptides, which target both mitochondrial dysfunction and oxidative damage, are a promising approach for the treatment of PD...
  22. ncbi request reprint Site and mechanism of action of dynorphin A-(1-13) and N-methyl-D-aspartate on ACTH release in fetal sheep
    Laura Nardo
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Physiol Endocrinol Metab 282:E1301-7. 2002
    ....
  23. pmc Cytoplasmic vacuolization responses to cytopathic bovine viral diarrhoea virus
    ALEXANDER V BIRK
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Virus Res 132:76-85. 2008
    ....
  24. ncbi request reprint Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology
    Alex V Birk
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Lab Clin Med 139:116-24. 2002
    ....
  25. ncbi request reprint A highly potent peptide analgesic that protects against ischemia-reperfusion-induced myocardial stunning
    Dunli Wu
    Department of Pharmacology, Joan and Sanford I Weill Medical College, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Physiol Heart Circ Physiol 283:H783-91. 2002
    ..These findings suggest that [Dmt(1)]DALDA is a potent analgesic that may be useful for myocardial stunning resulting from cardiac interventions or myocardial ischemia...
  26. ncbi request reprint Role of extracellular ATP metabolism in regulation of platelet reactivity
    Alex V Birk
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Lab Clin Med 140:166-75. 2002
    ..The presence of both endothelial CD39 and plasma nucleotidase appears to be important in the maintenance of normal hemostasis and prevention of excessive platelet responsiveness...
  27. ncbi request reprint Interaction between ATP and catecholamines in stimulation of platelet aggregation
    Alex V Birk
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Physiol Heart Circ Physiol 284:H619-25. 2003
    ..This synergistic interaction between ATP and norepinephrine in stimulating platelet aggregation may have significant clinical implications and suggests a prothrombotic role for ATP in stress...
  28. pmc A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia
    Ivone Gomes
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 101:5135-9. 2004
    ..Thus, heterodimeric associations between mu-delta opioid receptors can be used as a model for the development of novel combination therapies for the treatment of chronic pain and other pathologies...
  29. ncbi request reprint Highly potent fluorescent analogues of the opioid peptide [Dmt1] DALDA
    Irena Berezowska
    Laboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Peptides 24:1195-200. 2003
    ....
  30. ncbi request reprint Quantitative analysis of [Dmt(1)]DALDA in ovine plasma by capillary liquid chromatography-nanospray ion-trap mass spectrometry
    Haibao Wan
    Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, TN 38163, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 803:83-90. 2004
    ..The MS/MS detection sensitivity for [Dmt(1)]DALDA was 625 amol. A calibration curve was constructed, and quantitative analysis was performed on a series of ovine plasma samples...
  31. ncbi request reprint Antiviral activity of geneticin against bovine viral diarrhoea virus
    ALEXANDER V BIRK
    Institute of Hepatitis and Viral Research, Doylestown, PA 18902, USA
    Antivir Chem Chemother 19:33-40. 2008
    ..This precludes testing 6418's own antiviral activities against those viruses. Here, we report antiviral activity of 6418 against BVDV...
  32. ncbi request reprint Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?
    Matthew Whiteman
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Universities of Exeter and Plymouth, St Luke s Campus, Exeter, Devon, England
    Antioxid Redox Signal 10:641-50. 2008
    ..Our study highlights the potential application of mitochondria-specific targeted antioxidants for the prevention of cellular dysfunction and cell death under conditions of chlorinative stress, as occurs during chronic inflammation...
  33. ncbi request reprint Differential respiratory effects of [Dmt1]DALDA and morphine in mice
    Megumi Shimoyama
    Department of Autonomic Physiology, Chiba University Graduate School of Medicine, Chuo Ku, Chiba 260 8670, Japan
    Eur J Pharmacol 511:199-206. 2005
    ..Thus dDAL likely reduces the sensitivity of the peripheral chemoreflex loop through a non-opioid action...
  34. ncbi request reprint Design of peptide oxytocin antagonists with strikingly higher affinities and selectivities for the human oxytocin receptor than atosiban
    Maurice Manning
    Department of Biochemistry and Cancer Biology, Medical College of Ohio, Toledo, OH 43614, USA
    J Pept Sci 11:593-608. 2005
    ..These OT antagonists are thus promising candidates for development as potential new tocolytic agents...
  35. ncbi request reprint Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8
    Ana Pena
    Institut de Genomique Fonctionnelle, CNRS UMR 5203 INSERM U 661, Universite Montpellier I et II, 34094 Montpellier Cedex 05, France
    J Med Chem 50:835-47. 2007
    ..These selective V1b agonists are promising new tools for studies of the role of the V1b receptor in the rat...
  36. ncbi request reprint Design and synthesis of potent, highly selective vasopressin hypotensive agonists
    Stoytcho Stoev
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, 43614 5804, USA
    J Pept Sci 12:592-604. 2006
    ..Some of these new hypotensive peptides may be of value as research tools for studies on the complex cardiovascular actions of VP and may lead to the development of a new class of antihypertensive agents...

Research Grants4

  1. Cell-Permeable Peptides for Mitochondrial Protection
    Hazel Szeto; Fiscal Year: 2005
    ..Potential collaborators for the animal studies have already been identified. ..
  2. PHARMACOKINETICS AND FETAL EXPOSURE TO NARCOTICS
    Hazel Szeto; Fiscal Year: 2002
    ..The proposed studies will provide new information on the functional roles of opiate receptor subtypes in the fetus, and should be helpful in the design of better analgesics for perinatal use. ..
  3. Mitoprotective and antioxidant peptides for DM treatment
    Hazel Szeto; Fiscal Year: 2005
    ..abstract_text> ..
  4. Mitoprotective and antioxidant peptides for DM treatment
    Hazel Szeto; Fiscal Year: 2006
    ..abstract_text> ..