M Suthanthiran

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint The importance of genetic polymorphisms in renal transplantation
    M Suthanthiran
    Department of Transplantation Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
    Curr Opin Urol 10:71-5. 2000
  2. pmc Epidemiology of BK virus in renal allograft recipients: independent risk factors for BK virus replication
    Darshana Dadhania
    Division of Nephrology and Hypertension, Department of Medicine, New York Presbyterian Weill Cornell Medical Center, New York, NY, USA
    Transplantation 86:521-8. 2008
  3. pmc Urinary-cell mRNA profile and acute cellular rejection in kidney allografts
    Manikkam Suthanthiran
    Weill Cornell Medical College, New York, NY, USA
    N Engl J Med 369:20-31. 2013
  4. pmc Post-transplantation malignancy: a cell autonomous mechanism with implications for therapy
    Manikkam Suthanthiran
    Division of Nephrology and Department of Transplantation Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA
    Trans Am Clin Climatol Assoc 120:369-88. 2009
  5. ncbi request reprint Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine
    Ruchuang Ding
    Division of Nephrology, Departments of Medicine and Transplantation Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
    Transplantation 74:987-94. 2002
  6. ncbi request reprint Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine
    B Li
    Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 344:947-54. 2001
  7. ncbi request reprint Transforming growth factor-beta 1 hyperexpression in African American end-stage renal disease patients
    M Suthanthiran
    Department of Transplantation Medicine and Extracorporeal Therapy, New York City Department of Health, New York, USA
    Kidney Int 53:639-44. 1998
  8. ncbi request reprint Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes
    Daniel J Boffa
    The Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Immunol 222:105-15. 2003
  9. ncbi request reprint Hypertension-induced organ damage in African Americans: transforming growth factor-beta(1) excess as a mechanism for increased prevalence
    P August
    Divisions of Nephrology and Hypertension, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Curr Hypertens Rep 2:184-91. 2000
  10. ncbi request reprint Optimization of RNA yield, purity and mRNA copy number by treatment of urine cell pellets with RNAlater
    M Medeiros
    Weill Medical College of Cornell University, New York, NY, USA
    J Immunol Methods 279:135-42. 2003

Research Grants

  1. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2004
  2. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2004
  3. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2005
  4. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2005
  5. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2006
  6. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2006
  7. FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant Outcomes
    Manikkam Suthanthiran; Fiscal Year: 2007
  8. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2007
  9. FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant Outcomes
    Manikkam Suthanthiran; Fiscal Year: 2009
  10. FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant Outcomes
    Manikkam Suthanthiran; Fiscal Year: 2010

Collaborators

Detail Information

Publications32

  1. ncbi request reprint The importance of genetic polymorphisms in renal transplantation
    M Suthanthiran
    Department of Transplantation Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
    Curr Opin Urol 10:71-5. 2000
    ..These nucleotide sequence variations, polymorphisms located in genes contributing to immune repertory and in genes responsible for drug metabolism, are excellent candidates for the differential clinical phenotype...
  2. pmc Epidemiology of BK virus in renal allograft recipients: independent risk factors for BK virus replication
    Darshana Dadhania
    Division of Nephrology and Hypertension, Department of Medicine, New York Presbyterian Weill Cornell Medical Center, New York, NY, USA
    Transplantation 86:521-8. 2008
    ..Identification of risk factors for BK virus (BKV) replication may improve transplant outcome. We investigated the impact of immunosuppressive drugs on the prevalence of BKV replication in recipients of human renal allografts...
  3. pmc Urinary-cell mRNA profile and acute cellular rejection in kidney allografts
    Manikkam Suthanthiran
    Weill Cornell Medical College, New York, NY, USA
    N Engl J Med 369:20-31. 2013
    ..The standard test for the diagnosis of acute rejection in kidney transplants is the renal biopsy. Noninvasive tests would be preferable...
  4. pmc Post-transplantation malignancy: a cell autonomous mechanism with implications for therapy
    Manikkam Suthanthiran
    Division of Nephrology and Department of Transplantation Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA
    Trans Am Clin Climatol Assoc 120:369-88. 2009
    ..Our studies, in addition to demonstrating a cell autonomous mechanism for tumor progression, advance TGF-beta blockade as an anti-tumor strategy...
  5. ncbi request reprint Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine
    Ruchuang Ding
    Division of Nephrology, Departments of Medicine and Transplantation Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
    Transplantation 74:987-94. 2002
    ..Its diagnosis is contingent on the invasive procedure of allograft biopsy. A noninvasive diagnostic test for BKV nephritis could improve clinical outcome...
  6. ncbi request reprint Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine
    B Li
    Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 344:947-54. 2001
    ..CONCLUSIONS: Measurement of mRNA encoding cytotoxic proteins in urinary cells offers a noninvasive means of diagnosing acute rejection of renal allografts...
  7. ncbi request reprint Transforming growth factor-beta 1 hyperexpression in African American end-stage renal disease patients
    M Suthanthiran
    Department of Transplantation Medicine and Extracorporeal Therapy, New York City Department of Health, New York, USA
    Kidney Int 53:639-44. 1998
    ....
  8. ncbi request reprint Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes
    Daniel J Boffa
    The Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Immunol 222:105-15. 2003
    ..Taken together, our study supports a unique and non-redundant role for c-Rel in dendritic cell costimulatory capacity...
  9. ncbi request reprint Hypertension-induced organ damage in African Americans: transforming growth factor-beta(1) excess as a mechanism for increased prevalence
    P August
    Divisions of Nephrology and Hypertension, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Curr Hypertens Rep 2:184-91. 2000
    ....
  10. ncbi request reprint Optimization of RNA yield, purity and mRNA copy number by treatment of urine cell pellets with RNAlater
    M Medeiros
    Weill Medical College of Cornell University, New York, NY, USA
    J Immunol Methods 279:135-42. 2003
    ..RNAlater, an RNA stabilization solution, has been reported to optimize RNA isolation from tumor tissues stored at room temperature and from pigment-rich ocular tissues...
  11. ncbi request reprint Enforced c-REL deficiency prolongs survival of islet allografts1
    Hua Yang
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Transplantation 74:291-8. 2002
    ..Whether c-Rel, a lymphoid-predominant member of the NF-kappaB/Rel family, is essential for transplantation immunity is not known...
  12. ncbi request reprint Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function
    Dolca A Thomas
    Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital Weill Cornell, New York, NY, USA
    J Am Soc Nephrol 18:213-22. 2007
    ..Because SS-31 was effective with "extended" islet donors, it is hypothesized that the antioxidant SS-31 may serve to increase the pool of eligible organ donors...
  13. ncbi request reprint Messenger RNA for FOXP3 in the urine of renal-allograft recipients
    Thangamani Muthukumar
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 353:2342-51. 2005
    ..The outcome of renal transplantation after an episode of acute rejection is difficult to predict, even with an allograft biopsy...
  14. ncbi request reprint Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK VP1 virus in urine
    Ruchuang Ding
    Transplantation 76:446. 2003
  15. pmc HLA-mismatched renal transplantation without maintenance immunosuppression
    Tatsuo Kawai
    Transplantation Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, USA
    N Engl J Med 358:353-61. 2008
    ....
  16. ncbi request reprint CD103 mRNA levels in urinary cells predict acute rejection of renal allografts
    Ruchuang Ding
    2 Division of Nephrology, Department of Medicine, Department of Transplantation Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY
    Transplantation 75:1307-12. 2003
    ..Because intratubular localization of mononuclear cells is a feature of acute cellular rejection of renal allografts, we explored the hypothesis that CD103 messenger (m)RNA levels in urinary cells predict acute rejection...
  17. ncbi request reprint The natural history, risk factors and outcomes of polyomavirus BK-associated nephropathy after renal transplantation
    Hans H Hirsch
    University of Basel, Switzerland
    Nat Clin Pract Nephrol 2:240-1. 2006
  18. ncbi request reprint Transcriptional profiling to assess the clinical status of kidney transplants
    Terry B Strom
    Medicine and Surgery, Transplant Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Nat Clin Pract Nephrol 2:116-7. 2006
  19. pmc Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells
    Xunrong Luo
    Division of Nephrology, Department of Medicine, and the Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 104:2821-6. 2007
    ....
  20. ncbi request reprint Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts
    Hua Yang
    Division of Nephrology and Hypertension, Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
    Transplantation 83:1643-7. 2007
    ..We investigated the hypothesis that Foxp3+ cells are an integral component of antiallograft immunity but are dominated by pathogenic effectors...
  21. ncbi request reprint Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations
    Hans H Hirsch
    Transplantation Virology, Institute for Medical Microbiology and Div Infectious Diseases, Universitatsspital Basel, Switzerland
    Transplantation 79:1277-86. 2005
    ..25-0.33 mg/kg intravenously biweekly) without probenicid should be considered for refractory cases. Retransplantation after renal allograft loss to PVAN remains a treatment option for patients clearing polyomavirus replication...
  22. ncbi request reprint Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice
    Xunrong Luo
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Transplantation 79:1091-6. 2005
    ....
  23. ncbi request reprint Rapamycin is an effective inhibitor of human renal cancer metastasis
    Fu L Luan
    Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital New York, New York, USA
    Kidney Int 63:917-26. 2003
    ..Rapamycin is an effective inhibitor of human renal cancer metastasis...
  24. ncbi request reprint Molecular signatures of urinary cells distinguish acute rejection of renal allografts from urinary tract infection
    Darshana Dadhania
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, USA
    Transplantation 75:1752-4. 2003
    ..0001). We conclude that bacterial UTI is unlikely to confound AR diagnosis made by measurement of granzyme B mRNA levels in urinary cells...
  25. ncbi request reprint Serine proteinase inhibitor-9, an endogenous blocker of granzyme B/perforin lytic pathway, is hyperexpressed during acute rejection of renal allografts
    Thangamani Muthukumar
    Division of Nephrology, Department of Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, NY, USA
    Transplantation 75:1565-70. 2003
    ..Because PI-9 can protect CTL from its own fatal arsenal and potentially enhance the vitality of CTL, we examined whether PI-9 levels correlate with the severity of rejection as well as predict subsequent graft function...
  26. ncbi request reprint Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression
    Mary Maluccio
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Transplantation 76:597-602. 2003
    ..Transforming growth factor (TGF)-beta(1) has been associated with tumor invasion and metastasis, and we have implicated cyclosporine-associated TGF-beta(1) hyperexpression in tumor progression in mice...
  27. ncbi request reprint Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer
    Daniel J Boffa
    Department of Medicine and Transplantation Medicine, Division of Nephrology, The New York Presbyterian Hospital, Weill Cornell Medical Center, New York, USA
    Clin Cancer Res 10:293-300. 2004
    ..Lung cancer has a dismal prognosis and comprises 5.5% of post-transplant malignancies. We explored whether rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer (NSCLC)...
  28. ncbi request reprint Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy
    Fu L Luan
    Department of Transplantation Medicine, New York Presbyterian Hospital, New York, NY 10021, USA
    Transplantation 73:1565-72. 2002
    ..In this study, we investigated the effect of rapamycin on tumor progression, in the presence and absence of cyclosporine...
  29. ncbi request reprint Correlation between interleukin-15 and granzyme B expression and acute lung allograft rejection
    Ruili Shi
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transpl Immunol 12:103-8. 2004
    ..1 fg/microg). These data indicate that IL-15 secreted by activated alveolar macrophages and granzyme B secreted by activated CD8+ cytotoxic T lymphocytes play important roles in the process of acute lung allograft rejection...
  30. ncbi request reprint Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine
    Ravi Raju Tatapudi
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Kidney Int 65:2390-7. 2004
    ....
  31. ncbi request reprint Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection
    Katja Kotsch
    Institute of Medical Immunology, Universitätsmedizin Charité, Humboldt University, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Transplantation 77:1866-75. 2004
    ..A noninvasive diagnostic test for predicting aRx could improve the management and outcome. The recently described measurement of urinary mRNA expression offers a new noninvasive approach...
  32. ncbi request reprint Noninvasive diagnosis of acute rejection of solid organ transplants
    Choli Hartono
    The Rogosin Institute, New York Presbyterian Hospital, New York, NY 10021, USA
    Front Biosci 9:145-53. 2004
    ..Thus, there is an urgent need for specific and sensitive noninvasive biomarkers of acute rejection. Herein, we review noninvasive strategies for the diagnosis of acute rejection of solid organ transplants...

Research Grants29

  1. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2004
    ..abstract_text> ..
  2. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2004
    ..abstract_text> ..
  3. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2005
    ..abstract_text> ..
  4. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2005
    ..abstract_text> ..
  5. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2006
    ..abstract_text> ..
  6. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2006
    ..abstract_text> ..
  7. FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant Outcomes
    Manikkam Suthanthiran; Fiscal Year: 2007
    ....
  8. Noninvasive diagnosis of BKV nephropathy
    Manikkam Suthanthiran; Fiscal Year: 2007
    ..abstract_text> ..
  9. FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant Outcomes
    Manikkam Suthanthiran; Fiscal Year: 2009
    ..abstract_text> ..
  10. FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant Outcomes
    Manikkam Suthanthiran; Fiscal Year: 2010
    ..abstract_text> ..
  11. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2003
    ..abstract_text> ..
  12. Gene Therapy for Islet Cell Transplantation
    Manikkam Suthanthiran; Fiscal Year: 2002
    ..g., perforin) and proinflammatory cytokines (e.g., interferon-gamma) while stimulating the expression of mRNA encoding anti-inflammatory cytokines (e.g., interleukin-4). ..
  13. TGF-BETA1 AND EXCESS RENAL DISEASE IN AFRICAN AMERICANS
    Manikkam Suthanthiran; Fiscal Year: 2002
    ..Children (stratified by race) with focal and segmental glomerulosclerosis (FSGS) demonstrated by biopsy will be compared to children with non-immunologic renal disease. ..
  14. CYCLOSPORINE, TGF BETA1 AND IMMUNOSUPPRESSION
    Manikkam Suthanthiran; Fiscal Year: 1999
    ..Finally, the effect of cyclosporine-induced TGF-b hyperexpression will be examined in vitro on CTL and NK cell cytolytic activity, as well as on the expression of cytotoxic attack molecules and immunoregulatory cytokines. ..
  15. TGF-BETA1 AND EXCESS RENAL DISEASE IN AFRICAN AMERICANS
    Manikkam Suthanthiran; Fiscal Year: 1999
    ..Children (stratified by race) with focal and segmental glomerulosclerosis (FSGS) demonstrated by biopsy will be compared to children with non-immunologic renal disease. ..
  16. CYCLOSPORINE: MECHANISMS OF IMMUNOSUPPRESSIVE ACTION
    Manikkam Suthanthiran; Fiscal Year: 1991
    ....
  17. CYCLOSPORINE--MECHANISMS OF IMMUNOSUPPRESSIVE ACTION
    Manikkam Suthanthiran; Fiscal Year: 1992
    ....
  18. CYCLOSPORINE: MECHANISMS OF IMMUNOSUPPRESSIVE ACTION
    Manikkam Suthanthiran; Fiscal Year: 1993
    ....
  19. CYCLOSPORINE, TGF BETA1, AND IMMUNOSUPPRESSION
    Manikkam Suthanthiran; Fiscal Year: 2000
    ....
  20. TGF-BETA1 AND EXCESS RENAL DISEASE IN AFRICAN AMERICANS
    Manikkam Suthanthiran; Fiscal Year: 2000
    ..Children (stratified by race) with focal and segmental glomerulosclerosis (FSGS) demonstrated by biopsy will be compared to children with non-immunologic renal disease. ..
  21. CYCLOSPORINE, TGF BETA1, AND IMMUNOSUPPRESSION
    Manikkam Suthanthiran; Fiscal Year: 2001
    ....
  22. TGF-BETA1 AND EXCESS RENAL DISEASE IN AFRICAN AMERICANS
    Manikkam Suthanthiran; Fiscal Year: 2001
    ..Children (stratified by race) with focal and segmental glomerulosclerosis (FSGS) demonstrated by biopsy will be compared to children with non-immunologic renal disease. ..
  23. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2002
    ..abstract_text> ..
  24. CYCLOSPORINE, TGF BETA1, AND IMMUNOSUPPRESSION
    Manikkam Suthanthiran; Fiscal Year: 2002
    ....
  25. FoxP3 Regulatory Network mRNA Profiles and Human Renal Transplant Outcomes
    Manikkam Suthanthiran; Fiscal Year: 2009
    ..abstract_text> ..