Affiliation: Cornell University
Subbaramaiah K, Iyengar N, Morrow M, Elemento O, Zhou X, Dannenberg A. Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection. J Biol Chem. 2019;294:361-371 pubmed publisher
..These findings suggest that reduced SIRT1-mediated deacetylation of HIF-1α contributes to the elevated levels of aromatase in breast tissues of obese women. ..
Subbaramaiah K, Cole P, Dannenberg A. Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. Cancer Res. 2002;62:2522-30 pubmed
..Taken together, these results show that small molecules can block the activation of COX-2 transcription by distinct mechanisms. ..
Subbaramaiah K, Yoshimatsu K, Scherl E, Das K, Glazier K, Golijanin D, et al
. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. J Biol Chem. 2004;279:12647-58 pubmed
..Moreover, TNF-alpha induced mPGES-1 by stimulating PC-PLC --> PKC --> NO --> cGMP --> PKG signal transduction pathway. ..
Subbaramaiah K, Howe L, Bhardwaj P, Du B, Gravaghi C, Yantiss R, et al
. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011;4:329-46 pubmed publisher
..The presence of CLS may be a biomarker of increased breast cancer risk or poor prognosis. ..
Subbaramaiah K, Dannenberg A. Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange. Cancer Res. 2007;67:3976-85 pubmed
..To our knowledge, this study also provides the first evidence that NCoR can function as a repressor of COX-2 gene expression. ..
Subbaramaiah K, Benezra R, Hudis C, Dannenberg A. Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. J Biol Chem. 2008;283:33955-68 pubmed publisher
..These findings provide new insights into the relationship between COX-2 and Id-1 and their potential role in metastasis. ..
Subbaramaiah K, Morris P, Zhou X, Morrow M, Du B, Giri D, et al
. Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2012;2:356-65 pubmed publisher
..These findings help to explain the link among obesity, low-grade chronic inflammation, and breast cancer with important clinical implications...
Subbaramaiah K, Howe L, Zhou X, Yang P, Hudis C, Kopelovich L, et al
. Pioglitazone, a PPAR? agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1. Cancer Prev Res (Phila). 2012;5:1183-94 pubmed publisher
..PPAR? agonists may have a role in reducing the risk of hormone-dependent breast cancer in obese postmenopausal women. ..
Subbaramaiah K, Brown K, Zahid H, Balmus G, Weiss R, Herbert B, et al
. Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells. J Biol Chem. 2016;291:16011-23 pubmed publisher
..PKM2 and HIF-1? were shown to co-localize in the nucleus of stromal cells of LFS breast tissue. Taken together, our results show that the Aha1-Hsp90-PKM2/HIF-1? axis mediates the induction of aromatase in LFS. ..