Kotha Subbaramaiah

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract
    A J Dannenberg
    Department of Medicine, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York 10021, USA
    Ann N Y Acad Sci 952:109-15. 2001
  2. pmc Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, 525 East 68th St, Room F 206, New York, New York 10065, USA
    Cancer Prev Res (Phila) 6:886-97. 2013
  3. pmc Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 5:1183-94. 2012
  4. pmc Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Cancer Discov 2:356-65. 2012
  5. ncbi Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR
    Kotha Subbaramaiah
    Department of Medicine Division of Gastroenterology and Hepatology, New York Presbyterian Hospital, New York, New York 10021, USA
    J Biol Chem 278:37637-47. 2003
  6. ncbi Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University and Strang Cancer Prevention Center, 1300 York Avenue, Room F 203A, New York, NY 10021, USA
    J Biol Chem 279:12647-58. 2004
  7. ncbi Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital Cornell and Strang Cancer Prevention Center, New York, New York 10021, USA
    Cancer Res 62:2522-30. 2002
  8. ncbi Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Cancer Res 67:3976-85. 2007
  9. pmc Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription
    Kotha Subbaramaiah
    Department of Medicine and the Weill Cornell Cancer Center, Weill Cornell Medical College, NY, NY 10065, USA
    J Biol Chem 283:33955-68. 2008
  10. doi The prostaglandin transporter regulates adipogenesis and aromatase transcription
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 4:194-206. 2011

Research Grants

  1. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009

Detail Information

Publications82

  1. ncbi Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract
    A J Dannenberg
    Department of Medicine, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York 10021, USA
    Ann N Y Acad Sci 952:109-15. 2001
    ..Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors...
  2. pmc Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, 525 East 68th St, Room F 206, New York, New York 10065, USA
    Cancer Prev Res (Phila) 6:886-97. 2013
    ..Further investigation in obese women is warranted...
  3. pmc Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 5:1183-94. 2012
    ..PPARγ agonists may have a role in reducing the risk of hormone-dependent breast cancer in obese postmenopausal women...
  4. pmc Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Cancer Discov 2:356-65. 2012
    ..These findings help to explain the link among obesity, low-grade chronic inflammation, and breast cancer with important clinical implications...
  5. ncbi Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR
    Kotha Subbaramaiah
    Department of Medicine Division of Gastroenterology and Hepatology, New York Presbyterian Hospital, New York, New York 10021, USA
    J Biol Chem 278:37637-47. 2003
    ..To the best of our knowledge, this is the first evidence that taxanes can promote stabilization of mRNA in addition to modulating gene transcription...
  6. ncbi Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University and Strang Cancer Prevention Center, 1300 York Avenue, Room F 203A, New York, NY 10021, USA
    J Biol Chem 279:12647-58. 2004
    ..Moreover, TNF-alpha induced mPGES-1 by stimulating PC-PLC --> PKC --> NO --> cGMP --> PKG signal transduction pathway...
  7. ncbi Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital Cornell and Strang Cancer Prevention Center, New York, New York 10021, USA
    Cancer Res 62:2522-30. 2002
    ..Taken together, these results show that small molecules can block the activation of COX-2 transcription by distinct mechanisms...
  8. ncbi Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Cancer Res 67:3976-85. 2007
    ..To our knowledge, this study also provides the first evidence that NCoR can function as a repressor of COX-2 gene expression...
  9. pmc Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription
    Kotha Subbaramaiah
    Department of Medicine and the Weill Cornell Cancer Center, Weill Cornell Medical College, NY, NY 10065, USA
    J Biol Chem 283:33955-68. 2008
    ..These findings provide new insights into the relationship between COX-2 and Id-1 and their potential role in metastasis...
  10. doi The prostaglandin transporter regulates adipogenesis and aromatase transcription
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 4:194-206. 2011
    ..Collectively, these results suggest that PGT modulates adipogenesis and thereby PGE(2)-mediated activation of the cAMP → PKA → CREB pathway leading to altered CYP19 transcription and aromatase activity...
  11. pmc Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland
    Kotha Subbaramaiah
    Department of Medicine and Weill Cornell Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 4:329-46. 2011
    ..The presence of CLS may be a biomarker of increased breast cancer risk or poor prognosis...
  12. ncbi Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300
    K Subbaramaiah
    Department of Medicine, Division of Gastroenterology, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 276:12440-8. 2001
    ..Taken together, these findings are likely to be important for understanding the anti-inflammatory and anti-cancer properties of PPARgamma ligands...
  13. ncbi Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2
    Kentaro Yamaguchi
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:32569-77. 2005
    ..This led, in turn, to reduced expression of several activator protein-1-dependent genes (COX-2, cyclin D1, collagenase-1). These findings provide new insights into the mechanisms underlying the antitumor activity of HDAC inhibitors...
  14. pmc UVR exposure sensitizes keratinocytes to DNA adduct formation
    Sudhir Nair
    Department of Medicine and Weill Cornell Cancer Center, 525 East 68th Street, Room F 206, New York, NY 10065, USA
    Cancer Prev Res (Phila) 2:895-902. 2009
    ..Collectively, these results suggest that sunlight may activate AhR signaling and thereby sensitize cells to PAH-mediated DNA adduct formation. Antagonists of AhR signaling may have a role in the chemoprevention of photocarcinogenesis...
  15. ncbi EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 283:3433-44. 2008
    ..Reciprocal changes in the interaction between BRCA1, p300, and the aromatase promoter I.3/II contributed to the inductive effects of PGE(2)...
  16. ncbi Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis
    Dragan Golijanin
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Clin Cancer Res 10:1024-31. 2004
    ..Because human papillomavirus (HPV) has been linked to the development of penile SCC, a secondary objective was to determine whether COX-2 was overexpressed in SCC arising in an HPV16 transgenic mouse...
  17. pmc Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer
    Patrick G Morris
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Prev Res (Phila) 4:1021-9. 2011
    ..The presence of CLS-B may be a biomarker of increased breast cancer risk or poor prognosis...
  18. pmc Effects of cigarette smoke on the human oral mucosal transcriptome
    Jay O Boyle
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Prev Res (Phila) 3:266-78. 2010
    ....
  19. ncbi Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer
    Nasser K Altorki
    Department of Cardiothoracic Surgery and Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 11:4191-7. 2005
    ..To determine the effect of taxane-based chemotherapy on intratumoral levels of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) in patients with non-small cell lung cancer (NSCLC)...
  20. pmc HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling
    Vikram D Kekatpure
    Department of Medicine and the Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA
    J Biol Chem 284:7436-45. 2009
    ..Given the established link between activation of AhR signaling and xenobiotic metabolism, inhibitors of HDAC6 may alter drug or carcinogen metabolism...
  21. ncbi Bryostatin-1 stimulates the transcription of cyclooxygenase-2: evidence for an activator protein-1-dependent mechanism
    Mariana S De Lorenzo
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 9:5036-43. 2003
    ..Moreover, it will be worthwhile to evaluate whether the addition of a selective COX-2 inhibitor can increase the antitumor activity of bryostatin...
  22. pmc Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid
    Powel H Brown
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Cancer Prev Res (Phila) 1:208-14. 2008
    ..Our data show that simultaneous blockade of COX/prostaglandin signaling and retinoid X receptor-dependent transcription confers potent anticancer efficacy, suggesting a novel avenue for clinical evaluation...
  23. pmc Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation
    Duncan Hughes
    Departments of 1General Surgery, Weill Cornell Medical College, New York University, New York, New York 10065, USA
    Cancer Prev Res (Phila) 1:485-93. 2008
    ..Inhibitors of HSP90 may have a role in chemoprevention in addition to cancer therapy...
  24. ncbi Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands
    Dimitrios Moraitis
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Res 65:664-70. 2005
    ..Moreover, these findings strengthen the rationale for determining whether inhibitors of COX-2 or EGFR tyrosine kinase activity can reduce the risk of tobacco smoke-related malignancies of the aerodigestive tract...
  25. pmc Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes
    Akira Miyaki
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Am J Physiol Gastrointest Liver Physiol 297:G559-66. 2009
    ..These results provide new mechanistic insights into the link between bile acids and gastrointestinal carcinogenesis...
  26. pmc NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer
    Duncan Hughes
    Department of General Surgery, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 1:241-9. 2008
    ..Collectively, these data indicate that 15-PGDH is commonly down-regulated in NSCLC, an effect that contributes to the accumulation of multiple bioactive lipids in NSCLC...
  27. ncbi Microsomal prostaglandin E synthase-1 is overexpressed in head and neck squamous cell carcinoma
    Erik G Cohen
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 9:3425-30. 2003
    ..Additional studies will be needed to determine whether this enzyme is a bona fide target for anticancer therapy...
  28. ncbi Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha
    Taisuke Otani
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 290:G361-8. 2006
    ..The decrease in amounts of 15-PGDH in inflamed mucosa can be explained at least, in part, by TNF-alpha-mediated suppression of 15-PGDH transcription...
  29. ncbi HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism
    Kotha Subbaramaiah
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Cancer Res 66:5504-11. 2006
    ..Collectively, our data indicate that COX-2 is the functional intermediate linking HER-2/neu and aromatase and suggest that inhibitors of PGE(2) synthesis will suppress estrogen biosynthesis in breast tissue...
  30. pmc Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway
    Anna J Duffield-Lillico
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 2:322-9. 2009
    ..Because 5-LO activity and LTE(4) have been suggested to play a role in cardiovascular disease, these results may help to explain the link between use of COX-2 inhibitors and cardiovascular complications...
  31. pmc Elevated levels of urinary prostaglandin e metabolite indicate a poor prognosis in ever smoker head and neck squamous cell carcinoma patients
    Vikram D Kekatpure
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Cancer Prev Res (Phila) 2:957-65. 2009
    ..Possibly, HNSCC patients with high COX-2 activity manifested by elevated urinary PGE-M will benefit from treatment with a COX-2 inhibitor...
  32. ncbi Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription
    K Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital-Cornell, and Anne Fisher Nutrition Center at Strang Cancer Prevention Center, New York, NY
    J Biomol Screen 6:101-10. 2001
    ..Collectively, these results demonstrate the successful development and use of a high throughput reporter gene assay for the identification of a novel inhibitor of COX-2 expression...
  33. pmc Caloric restriction reverses obesity-induced mammary gland inflammation in mice
    Priya Bhardwaj
    Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 6:282-9. 2013
    ..Our results provide a rationale for determining whether weight loss can reverse breast inflammation associated with obesity in women...
  34. ncbi Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments
    Chau T Dang
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 10:4062-7. 2004
    ....
  35. pmc UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression
    Benjamin L Judson
    Department of Medicine and Weill Cornell Cancer Center, 525 East 68th Street, Room F 206, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:1104-11. 2010
    ..Possibly, agents that prevent UVR-mediated downregulation of 15-PGDH will affect the acute or the long-term consequences of UVR exposure, including nonmelanoma skin cancer...
  36. ncbi Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells
    Alex Y Hui
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hepatol 41:251-8. 2004
    ..We assessed the impact of COX-2 inhibition and PGE(2) on the regulation of TGF-beta 1-stimulated matrix synthesis in an immortalized human HSC line, LX-1 and corroborated these findings in primary stellate cells...
  37. ncbi Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 277:18649-57. 2002
    ..The clear relationship between HER-2/neu status and COX-2 expression in human breast tumors suggests that this mechanism is likely to be operative in vivo...
  38. ncbi Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanism
    Manish I Patel
    Department of Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Clin Cancer Res 11:1999-2007. 2005
    ..The primary purpose of this study was to evaluate whether celecoxib or rofecoxib, two widely used selective COX-2 inhibitors, possess COX-2-independent antitumor activity...
  39. ncbi Targeting cyclooxygenase-2 in human neoplasia: rationale and promise
    Andrew J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, NY 10021, USA
    Cancer Cell 4:431-6. 2003
  40. ncbi Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract
    Taghreed Almahmeed
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Carcinogenesis 25:793-9. 2004
  41. pmc Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis
    Arash Mohebati
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Prev Res (Phila) 5:593-602. 2012
    ..Carnosol-mediated inhibition of Hsp90 ATPase activity can help explain the chemopreventive activity of herbs such as Rosemary, which contain this phenolic antioxidant...
  42. ncbi COX-2 inhibition in upper aerodigestive tract tumors
    Nasser K Altorki
    New York Presbyterian Medical Center, 525 East 168th Street, Box 110, New York, NY 10021, USA
    Semin Oncol 31:30-6. 2004
    ....
  43. pmc Levels of prostaglandin E metabolite, the major urinary metabolite of prostaglandin E2, are increased in smokers
    Neil D Gross
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Clin Cancer Res 11:6087-93. 2005
    ..In this study, we investigated whether levels of urinary PGE-M were increased in smokers and in patients with head and neck squamous cell carcinoma (HNSCC)...
  44. ncbi Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes
    Victor de Ledinghen
    Department of Medicine, Strang Cancer Prevention Center, Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 23:73-9. 2002
    ..However, these conditions do render hepatocytes susceptible to COX-2 induction from tumor promoters by post-transcriptional mechanisms...
  45. ncbi Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 62:5405-7. 2002
    ..These results strengthen the rationale for developing clinical trials to determine whether selective Cox-2 inhibitors possess anticancer properties in humans at risk for breast cancer...
  46. ncbi Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism
    Baoheng Du
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Cancer Res 65:5982-8. 2005
    ..The ability of tobacco smoke to induce amphiregulin and thereby enhance DNA synthesis is likely to contribute to the procarcinogenic effects of tobacco smoke...
  47. pmc Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia
    Zeynep H Gümüs
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, Box 75, Room E 509, 1300 York Avenue, New York, NY 10065, USA
    Cancer Prev Res (Phila) 1:100-11. 2008
    ..Moreover, the inductive effects of TS on xenobiotic metabolizing enzymes may help explain the reduced efficacy of chemotherapy, and suggest targets for chemopreventive agents in smokers...
  48. ncbi HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, NY, USA
    Cancer Res 65:10113-9. 2005
    ..This finding may help to explain the reduced risk of breast cancer associated with regular use of nonsteroidal anti-inflammatory drugs...
  49. pmc Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia
    David C Montrose
    Department of Medicine, Weill Cornell Medical College, New York, USA
    Cancer Prev Res (Phila) 5:1358-67. 2012
    ..Collectively, these results provide evidence that metabolomics can be used to detect changes in feces and plasma during azoxymethane-induced colorectal carcinogenesis and thus provide a strong rationale for future studies in humans...
  50. ncbi Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine
    Daniel F Catanzaro
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, 10021, USA
    Cardiovasc Toxicol 7:192-201. 2007
    ..Taken together, these observations suggest that smoking may accelerate atherosclerosis by increasing oxidative stress mediated at least in part via the actions of nicotine...
  51. ncbi Tobacco smoke induces CYP1B1 in the aerodigestive tract
    Jeffrey L Port
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 25:2275-81. 2004
    ..05). Taken together, these results support a role for CYP1B1 in TS-induced carcinogenesis in the aerodigestive tract...
  52. ncbi Cyclooxygenase-2: a target for the prevention and treatment of cancers of the upper digestive tract
    Nasser K Altorki
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, Stang Cancer Prevention Center, New York, N Y, USA
    Prog Exp Tumor Res 37:107-23. 2003
  53. ncbi Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: evidence for an epidermal growth factor receptor dependent mechanism
    Baoheng Du
    Department of Medicine, Joan and Sanford I Weill Medical College of Cornell University, New York, New York, USA
    Cancer Res 67:8966-72. 2007
    ..These findings also strengthen the rationale for determining whether inhibitors of EGFR tyrosine kinase reduce the risk of tobacco smoke-related second primary tumors...
  54. pmc The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels
    Daniel W Fitzgerald
    Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, 440 East 69 Street, New York, NY, USA
    Cancer Prev Res (Phila) 5:34-40. 2012
    ..Drugs that inhibit the synthesis of PGE(2) may prove useful in reducing the risk of cervical cancer or systemic inflammation in HIV-infected women...
  55. ncbi The overexpression of cyclo-oxygenase-2 in chronic periodontitis
    Fan Zhang
    Department of Genetic Medicine, Weill Medical College of Cornell University, New York City, NY 10021, USA
    J Am Dent Assoc 134:861-7. 2003
    ..The objective of this prospective cross-sectional study was to determine if cyclo-oxygenase-2, or COX-2, is overexpressed in the inflamed gingival tissue of patients diagnosed as having moderate-to-severe chronic periodontitis, or CP...
  56. pmc Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis
    Louise R Howe
    Department of Cell and Developmental Biology and Weill Cornell Cancer Center, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA Electronic address
    Prostaglandins Other Lipid Mediat 106:99-105. 2013
    ..Our data identify mPGES-1 as a potential anti-breast cancer target. ..
  57. pmc Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification
    Zhe Hou
    Department of Medicine and Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA
    Carcinogenesis 32:695-702. 2011
    ..IL-1β-dependent induction of COX-2 in breast cancer cells provides a mechanism whereby macrophages contribute to tumor progression and potential therapeutic targets in breast cancer...
  58. pmc Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 133:1869-81. 2007
    ..The molecular mechanisms linking inflammation and colon carcinogenesis are incompletely understood. We tested the hypothesis that Toll-like receptor 4 (TLR4) is involved in tumorigenesis in the setting of chronic inflammation...
  59. ncbi Cyclooxygenase 2: a molecular target for cancer prevention and treatment
    Kotha Subbaramaiah
    Weill Medical College of Cornell University, Dept of Medicine, New York, NY 10021, USA
    Trends Pharmacol Sci 24:96-102. 2003
    ....
  60. ncbi Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer
    K Yoshimatsu
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Cancer Res 7:3971-6. 2001
    ..The mechanisms controlling the expression of these two enzymes are not identical...
  61. ncbi Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer
    K Yoshimatsu
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, New York 10021, USA
    Clin Cancer Res 7:2669-74. 2001
    ..Consistent with prior observations for COX-2, these data suggest that both cellular transformation and cytokines contribute to the up-regulation of mPGES in NSCLC...
  62. ncbi Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk
    Mary Beth Terry
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    JAMA 291:2433-40. 2004
    ..Given the importance of estrogen in the pathogenesis of breast cancer, the ability of aspirin and other NSAIDs to protect against breast cancer could vary according to hormone receptor status...
  63. ncbi Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells
    L R Howe
    Strang Cancer Research Laboratory, The Rockefeller University, New York, New York 10021, USA
    Cancer Res 59:1572-7. 1999
    ..In view of the critical role of cyclooxygenase-2 in intestinal tumorigenesis, cyclooxygenase-2 up-regulation in response to Wnt signaling may contribute to Wnt-induced mammary carcinogenesis...
  64. ncbi Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways
    K Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital Cornell and Strang Cancer Prevention Center, New York, New York 10021, USA
    J Biol Chem 275:14838-45. 2000
    ..Thus, microtubule- or actin-interfering agents stimulated MAPK signaling and activator protein-1 activity. This led, in turn, to induction of COX-2 gene expression via the cyclic AMP response element site in the COX-2 promoter...
  65. ncbi Celecoxib, a selective cyclo-oxygenase-2 inhibitor, enhances the response to preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancer
    N K Altorki
    Department of Cardiothoracic Surgery, Strang Cancer Prevention Center and Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Oncol 21:2645-50. 2003
    ..End points were toxicity, response rates, and measurement of intratumoral levels of prostaglandin E2 (PGE2)...
  66. ncbi Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells
    K Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital Cornell, New York 10021, USA
    Ann N Y Acad Sci 889:214-23. 1999
    ..Phorbol ester-mediated induction of AP-1 activity was blocked by resveratrol. These data are likely to be important for understanding the anticancer and anti-inflammatory properties of resveratrol...
  67. ncbi Cyclooxygenase-2: a target for the prevention and treatment of breast cancer
    L R Howe
    Strang Cancer Research Laboratory, Rockefeller University, Box 231, 1230 York Avenue, New York, New York 10021, USA
    Endocr Relat Cancer 8:97-114. 2001
    ..Clinical trials will be needed to determine whether COX-2 inhibition represents a useful approach to preventing or treating human breast cancer...
  68. ncbi PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2
    L R Howe
    Department of Cell Biology and Anatomy, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 276:20108-15. 2001
    ..Therefore, we speculate that PEA3 factors may contribute to the up-regulation of COX-2 expression resulting from both APC mutation and Wnt1 expression...
  69. ncbi Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer
    A J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, USA
    Lancet Oncol 2:544-51. 2001
    ..Importantly, selective COX 2 inhibitors appear to be safe enough in human beings to allow large-scale clinical testing in healthy people. Several chemoprevention trials using selective COX 2 inhibitors are underway...
  70. pmc Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer
    Louise R Howe
    Authors Affiliations Departments of Cell and Developmental Biology and Medicine, Weill Cornell Medical College and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
    Clin Cancer Res 19:6074-83. 2013
    ..A key future goal is to identify biomarkers that accurately report adipose inflammation, both for identification of at-risk individuals and to assess the efficacy of interventions. Clin Cancer Res; 19(22); 6074-83. ©2013 AACR. ..
  71. ncbi Elevated expression of cyclooxygenase-2 contributes to immune dysfunction in a murine model of trauma
    P J Mackrell
    Departments of Surgery, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY10021, USA
    Surgery 130:826-33. 2001
    ..CONCLUSIONS: These experiments link trauma-induced increases in Cox-2 expression and PGE2 production to reduced immune function. Cox-2 represents a potential pharmacologic target to prevent or reverse trauma-induced immunosuppression...
  72. ncbi Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer
    Derrick T Lin
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Head Neck 24:792-9. 2002
    ..In this review, evidence is presented that inhibition of COX-2 represents a promising strategy to prevent or possibly treat human head and neck cancers...
  73. ncbi Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids
    F Zhang
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Gastroenterology 121:1391-9. 2001
    ..CONCLUSIONS: Reflux of duodenal contents into the esophagus led to increased COX-2 expression and mucosal thickening. Bile acids are likely to contribute to these effects...
  74. ncbi Cyclooxygenase-2 is overexpressed in human cervical cancer
    S Kulkarni
    Department of Medicine, New York Presbyterian Hospital-Cornell, New York 10021, USA
    Clin Cancer Res 7:429-34. 2001
    ..Taken together, these findings suggest that deregulation of the EGF receptor signaling pathway may lead to enhanced COX-2 expression in cervical cancer...
  75. ncbi Thalidomide and its analogues inhibit lipopolysaccharide-mediated Iinduction of cyclooxygenase-2
    J Fujita
    Department of Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Cancer Res 7:3349-55. 2001
    ..A series of structural analogues of thalidomide also inhibited LPS-mediated induction of Cox-2 and PGE(2) synthesis. Taken together, these data provide new insights into the antineoplastic and anti-inflammatory properties of thalidomide...
  76. ncbi Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology
    Andrew S Felts
    ACS Chem Biol 2:479-83. 2007
    ..These compounds serve as useful probes of COX-dependent biology and may represent leads for antidiabetic and anticancer drugs...
  77. ncbi Combined targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways
    Scott M Lippman
    Clin Cancer Res 11:6097-9. 2005
  78. ncbi Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma
    Neil D Gross
    Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Clin Cancer Res 13:5910-7. 2007
    ..This study was carried out to investigate whether c-Jun NH2-terminal kinases (JNK) are potential targets for treating head and neck squamous cell carcinoma (HNSCC)...
  79. ncbi Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention
    Andrew J Dannenberg
    Vanderbilt Ingram Cancer Center, 691 Preston Research Building, 2300 Pierce Avenue, Nashville, TN 37232 6838, USA
    J Clin Oncol 23:254-66. 2005
    ....
  80. ncbi Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice
    Stacy A Blaine
    Department of Pharmacology, University of Colorado Health Science Center, Denver, CO 80262, USA
    Carcinogenesis 26:209-17. 2005
    ..Cyclooxygenase-2 levels were elevated in tumors in both groups. From these studies we conclude that over-expression of mPGES-1 and highly elevated PGE2 production are not sufficient to induce lung tumors...
  81. ncbi NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells
    Yan Yan
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    J Cell Sci 119:2985-94. 2006
    ..These findings suggest that NFAT3/cyclooxygenase-2 act as a link between inflammation and carcinogenesis by being involved in the tumor promotion stage...
  82. pmc Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition
    Andrew S Felts
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University Center for Structural Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Med Chem 51:4911-9. 2008
    ..Taken together, these compounds represent potential leads in the development of novel PPARgamma agonists...

Research Grants4

  1. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009
    ..These studies will enhance our understanding of the mechanistic link between COX-2 and colorectal cancer and potentially assist us in optimizing the use of selective COX-2 inhibitors as therapy. ..