Kotha Subbaramaiah


Affiliation: Cornell University
Country: USA


  1. Subbaramaiah K, Iyengar N, Morrow M, Elemento O, Zhou X, Dannenberg A. Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection. J Biol Chem. 2019;294:361-371 pubmed publisher
    ..These findings suggest that reduced SIRT1-mediated deacetylation of HIF-1α contributes to the elevated levels of aromatase in breast tissues of obese women. ..
  2. Subbaramaiah K, Cole P, Dannenberg A. Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. Cancer Res. 2002;62:2522-30 pubmed
    ..Taken together, these results show that small molecules can block the activation of COX-2 transcription by distinct mechanisms. ..
  3. Subbaramaiah K, Yoshimatsu K, Scherl E, Das K, Glazier K, Golijanin D, et al. Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. J Biol Chem. 2004;279:12647-58 pubmed
    ..Moreover, TNF-alpha induced mPGES-1 by stimulating PC-PLC --> PKC --> NO --> cGMP --> PKG signal transduction pathway. ..
  4. Subbaramaiah K, Howe L, Bhardwaj P, Du B, Gravaghi C, Yantiss R, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011;4:329-46 pubmed publisher
    ..The presence of CLS may be a biomarker of increased breast cancer risk or poor prognosis. ..
  5. Subbaramaiah K, Dannenberg A. Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange. Cancer Res. 2007;67:3976-85 pubmed
    ..To our knowledge, this study also provides the first evidence that NCoR can function as a repressor of COX-2 gene expression. ..
  6. Subbaramaiah K, Benezra R, Hudis C, Dannenberg A. Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. J Biol Chem. 2008;283:33955-68 pubmed publisher
    ..These findings provide new insights into the relationship between COX-2 and Id-1 and their potential role in metastasis. ..
  7. Subbaramaiah K, Morris P, Zhou X, Morrow M, Du B, Giri D, et al. Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2012;2:356-65 pubmed publisher
    ..These findings help to explain the link among obesity, low-grade chronic inflammation, and breast cancer with important clinical implications...
  8. Subbaramaiah K, Howe L, Zhou X, Yang P, Hudis C, Kopelovich L, et al. Pioglitazone, a PPAR? agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1. Cancer Prev Res (Phila). 2012;5:1183-94 pubmed publisher
    ..PPAR? agonists may have a role in reducing the risk of hormone-dependent breast cancer in obese postmenopausal women. ..
  9. Subbaramaiah K, Brown K, Zahid H, Balmus G, Weiss R, Herbert B, et al. Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells. J Biol Chem. 2016;291:16011-23 pubmed publisher
    ..PKM2 and HIF-1? were shown to co-localize in the nucleus of stromal cells of LFS breast tissue. Taken together, our results show that the Aha1-Hsp90-PKM2/HIF-1? axis mediates the induction of aromatase in LFS. ..