KENDALL SMITH

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, New York, USA
    PLoS ONE 3:e1581. 2008
  2. pmc Edward jenner and the small pox vaccine
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College of Cornell University New York, NY, USA
    Front Immunol 2:21. 2011
  3. pmc Louis pasteur, the father of immunology?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:68. 2012
  4. pmc Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Cornell Medical College New York, NY, USA
    Front Immunol 3:102. 2012
  5. pmc Toward a molecular understanding of adaptive immunity: a chronology - part II
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:364. 2012
  6. pmc Toward a molecular understanding of adaptive immunity: a chronology, part I
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:369. 2012
  7. pmc Smallpox: can we still learn from the journey to eradication?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, USA
    Indian J Med Res 137:895-9. 2013
  8. ncbi request reprint To cure chronic HIV infection, a new therapeutic strategy is needed
    K A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Curr Opin Immunol 13:617-24. 2001
  9. ncbi request reprint The quantal theory of immunity
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Cell Res 16:11-9. 2006
  10. ncbi request reprint Low-dose daily interleukin-2 immunotherapy: accelerating immune restoration and expanding HIV-specific T-cell immunity without toxicity
    K A Smith
    Division of Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    AIDS 15:S28-35. 2001

Research Grants

  1. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 1999
  2. New Strategies to Prevent Death from Influenza
    KENDALL SMITH; Fiscal Year: 2007
  3. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2006
  4. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2005
  5. INTERLEUKIN 2 IMMUNOTHERAPY FOR HCV INFECTION
    KENDALL SMITH; Fiscal Year: 2004
  6. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2004
  7. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2003
  8. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2003
  9. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2002
  10. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2002

Collaborators

  • Genoveffa Franchini
  • EDWARD J WHERRY
  • A Kinter
  • Zoran Popmihajlov
  • Janos Nacsa
  • Elzbieta Tryniszewska
  • Deborah J Stauber
  • David Venzon
  • Marcin Moniuszko
  • Joseph N Blattman
  • Heather Morgan
  • Zoie Milligan
  • Dong Xu
  • Ian A Wilson
  • Erik W Debler
  • Patricia A Horton
  • Wen Po Tsai
  • Anna Hryniewicz
  • Yvette Edghill-Smith
  • Jason M Grayson
  • Susan M Kaech
  • Rafi Ahmed
  • Mark G Lewis
  • David Montefiori
  • Robyn Washington Parks
  • Peter Silvera
  • Jim Tartaglia
  • Zdenek Hel

Detail Information

Publications31

  1. pmc Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, New York, USA
    PLoS ONE 3:e1581. 2008
    ....
  2. pmc Edward jenner and the small pox vaccine
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College of Cornell University New York, NY, USA
    Front Immunol 2:21. 2011
    ..Also, the vaccine that Jenner used, which decreased the prevalence of Small Pox worldwide in his own time, and later was used to eradicate Small Pox altogether, is discussed in light of recent data...
  3. pmc Louis pasteur, the father of immunology?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:68. 2012
    ..This review chronicles Pasteur's remarkable metamorphosis from organic chemist to microbiologist to immunologist, and from basic science to medicine...
  4. pmc Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Cornell Medical College New York, NY, USA
    Front Immunol 3:102. 2012
    ....
  5. pmc Toward a molecular understanding of adaptive immunity: a chronology - part II
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:364. 2012
    ..Thus, adaptive immunity receives antigen-specific activation signals from the environment and turns them into antigen non-specific endogenous action signals...
  6. pmc Toward a molecular understanding of adaptive immunity: a chronology, part I
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:369. 2012
    ..This review is the first part of a chronology of our evolution toward a molecular understanding of adaptive immunity...
  7. pmc Smallpox: can we still learn from the journey to eradication?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, USA
    Indian J Med Res 137:895-9. 2013
    ..Accordingly vaccinia itself, and not modified replication incompetent vaccina, is the hope for use as a vector in the eradication of additional pathogenic microbes from the globe...
  8. ncbi request reprint To cure chronic HIV infection, a new therapeutic strategy is needed
    K A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Curr Opin Immunol 13:617-24. 2001
    ....
  9. ncbi request reprint The quantal theory of immunity
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Cell Res 16:11-9. 2006
    ....
  10. ncbi request reprint Low-dose daily interleukin-2 immunotherapy: accelerating immune restoration and expanding HIV-specific T-cell immunity without toxicity
    K A Smith
    Division of Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    AIDS 15:S28-35. 2001
    ..At least two signals are required to promote the proliferative expansion and function of antiviral effector lymphocytes, HIV antigens and IL-2...
  11. pmc Following the cytokine signaling pathway to leukemogenesis: a chronology
    Kendall A Smith
    Department of Medicine, Weill Medical College, Cornell University, New York, New York 10065, USA
    J Clin Invest 118:3564-73. 2008
    ..Based on the paradigm established by these data, it is inescapable that going forward, investigators will operate under the hypothesis that transformation of additional cells and tissues will have a similar pathogenesis...
  12. ncbi request reprint The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response
    Kendall A Smith
    Department of Medicine, The Division of Immunology, Weill Medical College, Cornell University, New York, NY, USA
    Immunol Rev 224:124-40. 2008
    ..In contrast, we found no evidence that FOXP3(+) cells actively suppress IL-2 expression, thereby failing to support the notion that such cells regulate potential effector cells...
  13. ncbi request reprint Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
    Joseph N Blattman
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Med 9:540-7. 2003
    ..Thus, timing of IL-2 administration and differentiation status of the T cell are critical parameters in designing IL-2 therapies...
  14. ncbi request reprint Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251
    Janos Nacsa
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 174:1913-21. 2005
    ..Thus, we conclude that the decrease in virus-specific CD4+ T cell response may be due to IL-2-promoted redistribution of cells from the circulation, or due to Ag-induced cell death, rather than suppression by a T regulatory population...
  15. ncbi request reprint Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy
    Elzbieta Tryniszewska
    Basic Research Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 169:5347-57. 2002
    ..These data provide the proof of concept that therapeutic vaccination before cessation of ART may be a feasible approach in the clinical management of HIV-1 infection...
  16. pmc Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
    Deborah J Stauber
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2788-93. 2006
    ..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes...
  17. ncbi request reprint New strategies to combat HIV: augmenting antiviral immunity
    Kendall A Smith
    Division of Immunology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, USA
    AIDS Read 13:365-9, 382. 2003

Research Grants13

  1. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 1999
    ..abstract_text> ..
  2. New Strategies to Prevent Death from Influenza
    KENDALL SMITH; Fiscal Year: 2007
    ..If successful, this research effort will provide the foundation for the development of a universal approach to the prevention and treatment of one of the world's most dangerous microbes, one that kills hundreds of thousands yearly. ..
  3. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2006
    ..Thus, this project is designed to determine the capacity of IBTs to control HIV, and to develop laboratory assays that are predictive of effective HIV immunty. ..
  4. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2005
    ..Thus, this project is designed to determine the capacity of IBTs to control HIV, and to develop laboratory assays that are predictive of effective HIV immunty. ..
  5. INTERLEUKIN 2 IMMUNOTHERAPY FOR HCV INFECTION
    KENDALL SMITH; Fiscal Year: 2004
    ..This approach should prove beneficial in improving the proportion of patients who recover from HCV infection, and as well, introduce immunologic tests that may be predictive of responsiveness to therapy. ..
  6. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2004
    ..Thus, this project is designed to determine the capacity of IBTs to control HIV, and to develop laboratory assays that are predictive of effective HIV immunty. ..
  7. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2003
    ..abstract_text> ..
  8. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2003
    ..Thus, this project is designed to determine the capacity of IBTs to control HIV, and to develop laboratory assays that are predictive of effective HIV immunty. ..
  9. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2002
    ..abstract_text> ..
  10. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2002
    ..Thus, this project is designed to determine the capacity of IBTs to control HIV, and to develop laboratory assays that are predictive of effective HIV immunty. ..
  11. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  12. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2000
    ..abstract_text> ..