Research Topics
| G P SmithSummaryAffiliation: Cornell University Country: USA Publications
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Detail Information
Publications
The controls of eating: a shift from nutritional homeostasis to behavioral neuroscienceG P Smith
Bourne Laboratory, New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
Nutrition 16:814-20. 2000..Indirect controls act by modulating the potency of the central effects of the direct controls, and they require the forebrain and its reciprocal connections with the caudal brainstem for their control of eating and meal size...- The evolution of an operant ecologistGerard P Smith
Department of Psychiatry, Weill Medical College of Cornell University and The E W Bourne Laboratory, New York Presbyterian Hospital, White Plains, NY 10605, USA
Appetite 38:166-72. 2002.... - Pavlov and integrative physiologyG P Smith
Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University and E W Bourne Laboratory, New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
Am J Physiol Regul Integr Comp Physiol 279:R743-55. 2000.... 
Modified sham feeding of sweet solutions in women with anorexia nervosaD A Klein
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Physiol Behav 101:132-40. 2010....- Type of negative feedback controlling sucrose ingestion depends on sucrose concentrationJ D Davis
Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
Am J Physiol Regul Integr Comp Physiol 278:R383-9. 2000..When concentrated solutions are ingested, intake is controlled jointly by a direct physiological signal operating in conjunction with a labile one that loses its effectiveness with sham-feeding experience... - Increase in intake with sham feeding experience is concentration dependentJ D Davis
Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University, White Plains, New York 10605, USA
Am J Physiol 277:R565-71. 1999..In contrast, the intake of weak concentrations is limited only by the nonlabile negative feedback signal because the labile signal is missing... - Closing the pylorus decreases the size of large meals in the ratJ D Davis
E W Bourne Behavioral Research Laboratory, New York Hospital Cornell Medical Center, White Plains, NY 10605, USA
Physiol Behav 63:191-6. 1998.... - Gastric negative feedback produced by volume and nutrient during a meal in ratsS Eisen
Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell University, New York 10021, USA
Am J Physiol Regul Integr Comp Physiol 281:R1201-14. 2001..Thus a large volume or rapid rate of gastric infusion decreases intake, and some other aspect of small milk infusions decreases the rate of licking... - The impact of sucrose-derived unconditioned and conditioned negative feedback on the microstructure of ingestive behaviorJ D Davis
Department of Psychiatry, Joan and Sanford I. Weill, Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
Physiol Behav 72:393-402. 2001..It has no effect on the ability to continue a bout of licking once it has begun... - Subdiaphragmatic vagotomy does not attenuate c-Fos induction in the nucleus of the solitary tract after conditioned taste aversion expressionT A Houpt
E W Bourne Behavioral Research Laboratory, Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA
Brain Res 747:85-91. 1997..We conclude that c-FLI induction correlated with CTA expression is not dependent on subdiaphragmatic vagal efferent output or afferent input... - c-Fos induction in the rat nucleus of the solitary tract by intraoral quinine infusion depends on prior contingent pairing of quinine and lithium chlorideT A Houpt
E W Bourne Behavioral Research Laboratory, Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA
Physiol Behav 60:1535-41. 1996..Therefore, the induction of c-FLI in the iNTS during expression of a CTA may be correlated with neuronal processes specific to acquisition and expression of a CTA... - John Davis and the meanings of lickingG P Smith
Weill Medical College of Cornell University, New York Presbyterian Hospital, White Plains 10605, USA
Appetite 36:84-92. 2001..His results remind us that behavior is the basic science of ingestion, important in itself, and essential for the investigation of the neural mechanisms that organize it... - Neuropeptide Y overexpression in the preweanling Zucker (fa/fa) ratT J Kowalski
Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, White Plains 10605, USA
Physiol Behav 67:521-5. 1999..This analysis revealed that preproNPY mRNA hybridization in fa/fa pups was higher than lean littermates as early as P2... - Ovariectomy and estradiol affect postingestive controls of sucrose lickingB J Hrupka
Department of Psychiatry, Cornell University Medical College, White Plains 10605, USA
Physiol Behav 61:243-7. 1997..OVX and EB replacement did appear to affect a postingestive mechanism(s) that is engaged within 2-4 min of meal onset... - Orosensory stimulation is sufficient and postingestive negative feedback is not necessary for neuropeptide Y to increase sucrose intakeA-M Torregrossa
Department of Psychiatry, Weill Medical College of Cornell University, USA
Physiol Behav 87:773-80. 2006..This demonstrates that orosensory sucrose stimulation is sufficient and postingestive negative feedback is not necessary for the orexic effect of NPY under these experimental conditions... - Corticotropin-releasing factor decreases meal size by decreasing cluster number in Koletsky (LA/N) rats with and without a null mutation of the leptin receptorD Kochavi
Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell University, NY, USA
Physiol Behav 74:645-51. 2001..Despite these differences in potency, microstructural analysis revealed that CRF decreased intakes in all three genotypes by decreasing the number of clusters of licking without changing the size of clusters... - Modified sham feeding of sweet solutions in women with and without bulimia nervosaD A Klein
Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
Physiol Behav 96:44-50. 2009..These results support the feasibility of a MSF procedure using artificially sweetened solutions, and the hypothesis that the orosensory stimulation of MSF provokes larger intake in women with BN than controls... - The effect of centrally administered CCK-receptor antagonists on food intake in ratsE S Corp
Department of Psychiatry, Cornell University Medical College, The New York Hospital Cornell Medical Center, White Plains 10605, USA
Physiol Behav 61:823-7. 1997.... - Sham feeding in rats with chronic, reversible gastric fistulasG P Smith
Cornell University Medical College and New York Hospital-Cornell Medical Center, White Plains, New York, USA
Curr Protoc Neurosci . 2001.... - c-fos-like immunoreactivity in the subfornical organ and nucleus of the solitary tract following salt intake by sodium-depleted ratsT A Houpt
Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA
Physiol Behav 63:505-10. 1998..3 M NaCl ingestion. c-FLI in the SFO and NTS may serve as quantifiable markers in the central nervous system of the state of sodium depletion and of ingestive (orosensory and gastrointestinal) sensory stimulation, respectively... - Introduction to the reviews on peptides and the control of food intake and body weightG P Smith
Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University and E W Bourne Laboratory, New York Presbyterian Hospital, White Plains, NY, USA
Neuropeptides 33:323-8. 1999.... - Inhibitory effects on intake of cholecystokinin-8 and cholecystokinin-33 in rats with hepatic proper or common hepatic branch vagal innervationS Eisen
Department of Psychiatry, Weill Medical College of Columbia University, New York-Presbyterian Hospital, Westchester Division, 21 Bloomingdale Rd, White Plains, NY 10605, USA
Am J Physiol Regul Integr Comp Physiol 289:R456-R462. 2005..This suggests that there is an inhibitory interaction between the stimulation of the gastroduodenal and hepatic proper afferent fibers by CCK-33... - Introduction to four papers on Curt Richter and analysis of his scientific practiceGerard P Smith
Department of Psychiatry, Weill Medical College, New York Presbyterian Hospital, Payne Whitney Westchester, White Plains, NY 10605, USA
Appetite 49:347-52. 2007..I conclude that Claude Bernard, Walter Cannon, Francois Magendie, and Maurice Arthus were important for Richter's scientific ideas and values, but it was the joy of research that explains his experimental success for over 60 years... - Gastric preloads of corn oil and mineral oil produce different patterns of increases of c-Fos-like immunoreacitve cells in the brain of 9-12 day-old ratsSara Blumberg
Developmental Psychobiology Laboratory, Department of Psychology and the Gonda Goldschmeid Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel, and Department of Psychiatry, New York Presbyterian Hospital, White Plains, NY 10605, USA
Brain Res 1134:140-7. 2007..This differential pattern of increases of CFLI cells is evidence that the brain discriminates the preabsorptive sensory properties of preloads of corn oil and mineral oil on P9-12... - Cholecystokinin and treatment of meal size: proof of principleGerard P Smith
New York-Presbyterian Hospital, 21 Bloomingdale Road, White Plains, NY 10605, USA
Obesity (Silver Spring) 14:168S-170S. 2006 - Introduction to the reviews on appetiteGerard P Smith
Department of Psychiatry, Weill Medical College of Cornell University, New York-Presbyterian Hospital, White Plains, NY 10605, USA
Philos Trans R Soc Lond B Biol Sci 361:1089-93. 2006 - Ontogeny of ingestive behaviorGerard P Smith
Department of Psychiatry, Weill Medical College of Cornell University, Presbyterian Hospital, 21 Bloomingdale Road, White Plains, New York, New York 10605, USA
Dev Psychobiol 48:345-59. 2006.... - Accumbens dopamine mediates the rewarding effect of orosensory stimulation by sucroseGerard P Smith
Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
Appetite 43:11-3. 2004.... - Oral sucrose stimulation increases accumbens dopamine in the ratAndras Hajnal
Department of Neural and Behavioral Sciences H181, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Am J Physiol Regul Integr Comp Physiol 286:R31-7. 2004..This finding provides new and strong support for accumbens dopamine in the rewarding effect of sucrose... - Increased hypothalamic neuropeptide Y expression in deprived preweanling rats is reversed by intragastric infusion of milkTimothy J Kowalski
E W Bourne Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York Presbyterian Hospital, White Plains, NY 10605, USA
Physiol Behav 75:425-32. 2002..We suggest that the lack of milk is the major cause of increased hypothalamic NPY expression during maternal deprivation in lean Zucker pups... - Cholecystokinin-8 increases Fos-like immunoreactivity in myenteric neurons of the duodenum and jejunum more after intraperitoneal than after intravenous injectionTennille Webb
Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
Neurosci Lett 389:157-62. 2005..v. These data provide immunohistochemical evidence that i.p. administration of CCK-8 is a more potent stimulant of Fos-LI in the neurons of the myenteric plexus of the duodenum and jejunum than i.v. injection... - Decreased hypothalamic concentration of neuropeptide Y correlates with onset of hyperphagia in fa/fa rats on postnatal day 12Andrea M Ster
Department of Psychiatry, E W Bourne Laboratory, Weill Medical College of Cornell University and New York Presbyterian Hospital, White Plains, NY 10605, USA
Physiol Behav 78:517-20. 2003..These results provide further support for the importance of hypothalamic NPY in the phenotypic expression of hyperphagia in the fa/fa pups during the second postnatal week... - Two effects of high-fat diets on the satiating potency of cholecystokinin-8Ann-Marie Torregrossa
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
Physiol Behav 78:19-25. 2003..2). A 60% fat diet increased the potency of CCK-8 because it decreased the threshold dose and increased the dose-response function significantly... - Hypothalamic implants of dilute estradiol fail to reduce feeding in ovariectomized ratsBrian J Hrupka
Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University, New York, College of Cornell, New York, NY, USA
Physiol Behav 77:233-41. 2002..Our results do not support the hypothesis that E(2)'s actions in either the PVN or the MPA are sufficient to account for its inhibitory effects on feeding... - The control of water and sodium chloride intake by postingestional and orosensory stimulation in water-deprived ratsJohn D Davis
Department of Psychiatry, Joan and Sanford I Weill Medical College of Cornell University, Edward W Bourne Laboratory, New York Presbyterian Hospital, 21 Bloomingdale Road, White Plains, NY 10605, USA
Physiol Behav 75:7-14. 2002..Postingestional stimulation, however, played an indirect role by serving as the unconditioned stimulus for the conditioned orosensory control...