Research Topics
Species | K W SimpsonSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Detail Information
Publications
Localization of Helicobacter spp. in the fundic mucosa of laboratory Beagle dogs: an ultrastructural studyAnna Lanzoni
Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, 20133 Milano, Italy
Vet Res 42:42. 2011..felis in the fundic mucosa of Beagle dogs, and their intracellular localization in parietal cells and macrophages suggests novel pathogenic scenarios for the development of immune response and maintenance of chronic gastritis in dogs...
Helicobacter felis infection in dogs: effect on gastric structure and functionK W Simpson
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Pathol 36:237-48. 1999..These findings suggest that H. felis may not be a gastric pathogen in dogs. However, the density of colonization and limited duration of infection should be considered when interpreting these findings...
Influence of Enterococcus faecium SF68 probiotic on giardiasis in dogsK W Simpson
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
J Vet Intern Med 23:476-81. 2009..Treatment with the probiotic Enterococcus faecium SF68 has been shown to stimulate mucosal and systemic immunity in a variety of animal models and in young dogs, and to reduce giardial cyst and antigen shedding in rodents...- Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogsKenneth W Simpson
Department of Clinical Sciences, College of Veterinary Medicine, VMC2001, Cornell University, Ithaca, New York 14853, USA
Infect Immun 74:4778-92. 2006..E. coli strains associated with GCB and Crohn's disease have an adherent and invasive phenotype and novel multilocus sequence types and resemble E. coli associated with extraintestinal disease in phylogeny and virulence gene profile... - Pitfalls and progress in the diagnosis and management of canine inflammatory bowel diseaseKenneth W Simpson
Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, VMC2001, Ithaca, NY 14853, USA
Vet Clin North Am Small Anim Pract 41:381-98. 2011.... - Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal diseaseK W Simpson
Department of Clinical Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Vet Intern Med 15:26-32. 2001..However, the relationship of subnormal serum cobalamin concentrations to cobalamin deficiency and the effect of cobalamin deficiency on cats remain to be determined... - Helicobacter felis infection is associated with lymphoid follicular hyperplasia and mild gastritis but normal gastric secretory function in catsK W Simpson
College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Infect Immun 68:779-90. 2000..These findings indicate that H. felis infection in cats induces lymphoid follicular hyperplasia, mild gastritis, and seroconversion, but is associated with normal gastric secretory function... - Gastric function in dogs with naturally acquired gastric Helicobacter spp. infectionK W Simpson
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Vet Intern Med 13:507-15. 1999..infection and that treatment with amoxicillin, metronidazole, and famotidine causes suppression rather than eradication of gastric Helicobacter spp. in dogs... - Helicobacter spp. infection in cats: evaluation of the humoral immune response and prevalence of gastric Helicobacter sppD Strauss-Ayali
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Microbiol 79:253-65. 2001..suggests substantial antigenic homology between different Helicobacter spp. The higher degree of inflammation in infected than uninfected cats, supports a role for Helicobacter as a cause of gastritis in cats... - Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and functionK W Simpson
College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA
Helicobacter 6:1-14. 2001..The upregulation of IL-8 in infected cats was independent of cagA and picB. Our findings argue against a direct acid-suppressing effect of H. pylori on the gastric secretory-axis in chronically infected cats... - Fluorescence in situ hybridization confirms clearance of visible Helicobacter spp. associated with gastritis in dogs and catsA E Jergens
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
J Vet Intern Med 23:16-23. 2009..in the pathogenesis of canine and feline gastritis are inconclusive. Furthermore, data evaluating the effectiveness of medical therapy for eradication of Helicobacter infection are limited... - Comparison of 4 Giardia diagnostic tests in diagnosis of naturally acquired canine chronic subclinical giardiasisM Rishniw
Department of Clinical Sciences, VMC 2001, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
J Vet Intern Med 24:293-7. 2010..The performance of Giardia diagnostic tests that detect either cysts or fecal antigens has not been thoroughly examined... - Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infectionC E Egan
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Mucosal Immunol 4:658-70. 2011..Our data provide valuable new insights into the mechanisms of intestinal inflammation, findings that have important implications for understanding human inflammatory bowel disease... - The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel diseaseS Janeczko
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Microbiol 128:178-93. 2008..These data establish that the density and composition of the mucosal flora is related to the presence and severity of intestinal inflammation in cats and suggest that mucosal bacteria are involved in the etiopathogenesis of feline IBD... - Antimicrobial resistance impacts clinical outcome of granulomatous colitis in boxer dogsM Craven
College of Veterinary Medicine, VMC 2001, Cornell University, Ithaca, NY 14853 9655, USA
J Vet Intern Med 24:819-24. 2010..Escherichia coli have recently been identified within the colonic mucosa of Boxer dogs with granulomatous colitis (GC). Eradication of invasive E. coli is associated with clinical and histological remission... - Equine stomachs harbor an abundant and diverse mucosal microbiotaG A Perkins
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Appl Environ Microbiol 78:2522-32. 2012..present in the glandular region of the stomach. The equine stomach harbors an abundant and diverse mucosal microbiota that varies by individual... - Association of Helicobacter with cholangiohepatitis in catsAndrea Greiter-Wilke
College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Vet Intern Med 20:822-7. 2006..Deoxyribonucleic acid sequences of hepatic Helicobacter species were distinct from those found in the stomach and are broadly consistent with those identified in cat intestine and bile, and hepatobiliary disease in people and rodents... - Search for Borrelia burgdorferi in kidneys of dogs with suspected "Lyme nephritis"T A Hutton
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
J Vet Intern Med 22:860-5. 2008..quot;Lyme nephritis" is a poorly characterized condition associated with proteinuria and often fatal renal failure in dogs with serological evidence of infection with Borrelia burgdorferi... - Fluorescence in-situ hybridization for the identification of bacterial species in archival heart valve sections of canine bacterial endocarditisB G Kornreich
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, USA
J Comp Pathol 146:298-307. 2012..FISH identified Streptococcus spp. and/or Staphylococcus spp. in all of these cases, but Bartonella spp. were not identified... - Glomerular filtration rate and renal volume in dogs with congenital portosystemic vascular anomalies before and after surgical ligationT A Deppe
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
J Vet Intern Med 13:465-71. 1999..Knowledge of changes in GFR associated with PSVA ligation may prove helpful in the anesthetic, drug, and dietary management of affected dogs... - Association between granulomatous colitis in French Bulldogs and invasive Escherichia coli and response to fluoroquinolone antimicrobialsA C Manchester
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Vet Intern Med 27:56-61. 2013..French Bulldogs develop a form of granulomatous colitis (GC) with histopathological resemblance to GC of Boxer dogs (GCB). GCB is associated with mucosally invasive Escherichia coli whose eradication correlates with clinical remission... - CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infectionC E Egan
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Mucosal Immunol 2:527-35. 2009..These results for the first time show a role for intraepithelial T lymphocytes in pathogenesis of ileitis triggered by a microbial pathogen... - Evaluation of "Helicobacter heilmannii" subtypes in the gastric mucosas of cats and dogsSimon L Priestnall
College of Veterinary Medicine, Cornell University, Ithaca, New York 14851, USA
J Clin Microbiol 42:2144-51. 2004..heilmannii" bacteria that are distinct from type 1 and from "H. suis." As "H. heilmannii" type 1 predominates in people, the zoonotic risk posed by dogs and cats is likely small... - Feline pancreatitisK W Simpson
College of Veterinary Medicine, Cornell University, Ithica NY, USA
J Feline Med Surg 4:183-4. 2002 - Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileumMartin Baumgart
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
ISME J 1:403-18. 2007..coli is involved in the etiopathogenesis to Crohn's disease involving the ileum... - Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomasOliver A Garden
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Vet Intern Med 19:168-76. 2005..111In-pentetreotide scintigraphy is a useful diagnostic adjunct to the clinical evaluation of the insulinoma patient, but is unable to localize the tumor in some cases... - Expression of leptospiral immunoglobulin-like protein by Leptospira interrogans and evaluation of its diagnostic potential in a kinetic ELISARaghavan U M Palaniappan
College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Med Microbiol 53:975-84. 2004..These findings suggest that recombinant antigen to the conserved region of LigA and LigB can differentiate between vaccinated and naturally infected animals... - Cloning and characterization of an outer membrane protein (Lip18) from Helicobacter bizzozeroniiJiaqian Zhu
College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
DNA Seq 14:87-94. 2003..The Lip18 was localized into the outer membrane of the bacteria. Immunoblot analysis of serum samples from a dog and cat naturally infected with Helicobacter spp was able to recognize the purified recombinant Lip18... - Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogansRaghavan U M Palaniappan
College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Infect Immun 70:5924-30. 2002..LigA is the first leptospiral protein described to have 12 tandem repeats and is also the first to be expressed only during infection. Thus, LigA may have value in serodiagnosis or as a protective immunogen in novel vaccines... - Quantitative analysis of inflammatory and immune responses in dogs with gastritis and their relationship to Helicobacter spp. infectionBo Wiinberg
Royal Veterinary and Agricultural University, Frederiksberg, Denmark
J Vet Intern Med 19:4-14. 2005..No significant associations between Helicobacter infection and proinflammatory cytokine expression, severity of gastritis, or differences in the pathogenicity of different Helicobacter spp. were found... - A simple method for the production of bacterial controls for immunohistochemistry and fluorescent in situ hybridizationCamilla Recordati
Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, Milano, Italy
J Mol Histol 39:459-62. 2008..The sandwich is an effective and simple method to prepare bacterial histological controls fixed and processed in the same way as the diagnostic tissues... - Detection of Helicobacter spp. DNA in the oral cavity of dogsCamilla Recordati
Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, Milano, Italy
Vet Microbiol 119:346-51. 2007..These findings support the possibility of oral-oral transmission between dogs and that the canine oral cavity may act as source of non-pylori Helicobacter spp. infection for humans...
Research Grants
- Helicobacter pylori: Pathogenesis and VirulenceKenneth Simpson; Fiscal Year: 2005....