K W Simpson

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease
    Melanie Craven
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e41594. 2012
  2. pmc Localization of Helicobacter spp. in the fundic mucosa of laboratory Beagle dogs: an ultrastructural study
    Anna Lanzoni
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, 20133 Milano, Italy
    Vet Res 42:42. 2011
  3. ncbi request reprint Helicobacter felis infection in dogs: effect on gastric structure and function
    K W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Vet Pathol 36:237-48. 1999
  4. pmc Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs
    Kenneth W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, VMC2001, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 74:4778-92. 2006
  5. doi request reprint Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease
    Kenneth W Simpson
    Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, VMC2001, Ithaca, NY 14853, USA
    Vet Clin North Am Small Anim Pract 41:381-98. 2011
  6. ncbi request reprint Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease
    K W Simpson
    Department of Clinical Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Intern Med 15:26-32. 2001
  7. pmc Helicobacter felis infection is associated with lymphoid follicular hyperplasia and mild gastritis but normal gastric secretory function in cats
    K W Simpson
    College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 68:779-90. 2000
  8. ncbi request reprint Gastric function in dogs with naturally acquired gastric Helicobacter spp. infection
    K W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Intern Med 13:507-15. 1999
  9. doi request reprint Influence of Enterococcus faecium SF68 probiotic on giardiasis in dogs
    K W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Vet Intern Med 23:476-81. 2009
  10. ncbi request reprint Helicobacter spp. infection in cats: evaluation of the humoral immune response and prevalence of gastric Helicobacter spp
    D Strauss-Ayali
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Microbiol 79:253-65. 2001

Research Grants

  1. Helicobacter pylori: Pathogenesis and Virulence
    Kenneth Simpson; Fiscal Year: 2005

Collaborators

Detail Information

Publications34

  1. pmc Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease
    Melanie Craven
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e41594. 2012
    ..We sought to examine the dynamics of the relationship between inflammation, the ileal microbiome, and host genetics in murine models of ileitis...
  2. pmc Localization of Helicobacter spp. in the fundic mucosa of laboratory Beagle dogs: an ultrastructural study
    Anna Lanzoni
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, 20133 Milano, Italy
    Vet Res 42:42. 2011
    ..felis in the fundic mucosa of Beagle dogs, and their intracellular localization in parietal cells and macrophages suggests novel pathogenic scenarios for the development of immune response and maintenance of chronic gastritis in dogs...
  3. ncbi request reprint Helicobacter felis infection in dogs: effect on gastric structure and function
    K W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Vet Pathol 36:237-48. 1999
    ..These findings suggest that H. felis may not be a gastric pathogen in dogs. However, the density of colonization and limited duration of infection should be considered when interpreting these findings...
  4. pmc Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs
    Kenneth W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, VMC2001, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 74:4778-92. 2006
    ..E. coli strains associated with GCB and Crohn's disease have an adherent and invasive phenotype and novel multilocus sequence types and resemble E. coli associated with extraintestinal disease in phylogeny and virulence gene profile...
  5. doi request reprint Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease
    Kenneth W Simpson
    Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, VMC2001, Ithaca, NY 14853, USA
    Vet Clin North Am Small Anim Pract 41:381-98. 2011
    ....
  6. ncbi request reprint Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease
    K W Simpson
    Department of Clinical Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Intern Med 15:26-32. 2001
    ..However, the relationship of subnormal serum cobalamin concentrations to cobalamin deficiency and the effect of cobalamin deficiency on cats remain to be determined...
  7. pmc Helicobacter felis infection is associated with lymphoid follicular hyperplasia and mild gastritis but normal gastric secretory function in cats
    K W Simpson
    College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 68:779-90. 2000
    ..These findings indicate that H. felis infection in cats induces lymphoid follicular hyperplasia, mild gastritis, and seroconversion, but is associated with normal gastric secretory function...
  8. ncbi request reprint Gastric function in dogs with naturally acquired gastric Helicobacter spp. infection
    K W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Intern Med 13:507-15. 1999
    ..infection and that treatment with amoxicillin, metronidazole, and famotidine causes suppression rather than eradication of gastric Helicobacter spp. in dogs...
  9. doi request reprint Influence of Enterococcus faecium SF68 probiotic on giardiasis in dogs
    K W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Vet Intern Med 23:476-81. 2009
    ..Treatment with the probiotic Enterococcus faecium SF68 has been shown to stimulate mucosal and systemic immunity in a variety of animal models and in young dogs, and to reduce giardial cyst and antigen shedding in rodents...
  10. ncbi request reprint Helicobacter spp. infection in cats: evaluation of the humoral immune response and prevalence of gastric Helicobacter spp
    D Strauss-Ayali
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Microbiol 79:253-65. 2001
    ..suggests substantial antigenic homology between different Helicobacter spp. The higher degree of inflammation in infected than uninfected cats, supports a role for Helicobacter as a cause of gastritis in cats...
  11. ncbi request reprint Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and function
    K W Simpson
    College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA
    Helicobacter 6:1-14. 2001
    ..The upregulation of IL-8 in infected cats was independent of cagA and picB. Our findings argue against a direct acid-suppressing effect of H. pylori on the gastric secretory-axis in chronically infected cats...
  12. doi request reprint Comparison of 4 Giardia diagnostic tests in diagnosis of naturally acquired canine chronic subclinical giardiasis
    M Rishniw
    Department of Clinical Sciences, VMC 2001, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Vet Intern Med 24:293-7. 2010
    ..The performance of Giardia diagnostic tests that detect either cysts or fecal antigens has not been thoroughly examined...
  13. pmc Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection
    C E Egan
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Mucosal Immunol 4:658-70. 2011
    ..Our data provide valuable new insights into the mechanisms of intestinal inflammation, findings that have important implications for understanding human inflammatory bowel disease...
  14. ncbi request reprint The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease
    S Janeczko
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Microbiol 128:178-93. 2008
    ..These data establish that the density and composition of the mucosal flora is related to the presence and severity of intestinal inflammation in cats and suggest that mucosal bacteria are involved in the etiopathogenesis of feline IBD...
  15. doi request reprint Antimicrobial resistance impacts clinical outcome of granulomatous colitis in boxer dogs
    M Craven
    College of Veterinary Medicine, VMC 2001, Cornell University, Ithaca, NY 14853 9655, USA
    J Vet Intern Med 24:819-24. 2010
    ..Escherichia coli have recently been identified within the colonic mucosa of Boxer dogs with granulomatous colitis (GC). Eradication of invasive E. coli is associated with clinical and histological remission...
  16. doi request reprint Fluorescence in situ hybridization confirms clearance of visible Helicobacter spp. associated with gastritis in dogs and cats
    A E Jergens
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
    J Vet Intern Med 23:16-23. 2009
    ..in the pathogenesis of canine and feline gastritis are inconclusive. Furthermore, data evaluating the effectiveness of medical therapy for eradication of Helicobacter infection are limited...
  17. doi request reprint Association between granulomatous colitis in French Bulldogs and invasive Escherichia coli and response to fluoroquinolone antimicrobials
    A C Manchester
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Intern Med 27:56-61. 2013
    ..French Bulldogs develop a form of granulomatous colitis (GC) with histopathological resemblance to GC of Boxer dogs (GCB). GCB is associated with mucosally invasive Escherichia coli whose eradication correlates with clinical remission...
  18. pmc Equine stomachs harbor an abundant and diverse mucosal microbiota
    G A Perkins
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Appl Environ Microbiol 78:2522-32. 2012
    ..present in the glandular region of the stomach. The equine stomach harbors an abundant and diverse mucosal microbiota that varies by individual...
  19. ncbi request reprint Association of Helicobacter with cholangiohepatitis in cats
    Andrea Greiter-Wilke
    College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Intern Med 20:822-7. 2006
    ..Deoxyribonucleic acid sequences of hepatic Helicobacter species were distinct from those found in the stomach and are broadly consistent with those identified in cat intestine and bile, and hepatobiliary disease in people and rodents...
  20. doi request reprint Search for Borrelia burgdorferi in kidneys of dogs with suspected "Lyme nephritis"
    T A Hutton
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    J Vet Intern Med 22:860-5. 2008
    ..Lyme nephritis" is a poorly characterized condition associated with proteinuria and often fatal renal failure in dogs with serological evidence of infection with Borrelia burgdorferi...
  21. pmc CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection
    C E Egan
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Mucosal Immunol 2:527-35. 2009
    ..These results for the first time show a role for intraepithelial T lymphocytes in pathogenesis of ileitis triggered by a microbial pathogen...
  22. doi request reprint Fluorescence in-situ hybridization for the identification of bacterial species in archival heart valve sections of canine bacterial endocarditis
    B G Kornreich
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, USA
    J Comp Pathol 146:298-307. 2012
    ..FISH identified Streptococcus spp. and/or Staphylococcus spp. in all of these cases, but Bartonella spp. were not identified...
  23. ncbi request reprint Glomerular filtration rate and renal volume in dogs with congenital portosystemic vascular anomalies before and after surgical ligation
    T A Deppe
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    J Vet Intern Med 13:465-71. 1999
    ..Knowledge of changes in GFR associated with PSVA ligation may prove helpful in the anesthetic, drug, and dietary management of affected dogs...
  24. pmc Evaluation of "Helicobacter heilmannii" subtypes in the gastric mucosas of cats and dogs
    Simon L Priestnall
    College of Veterinary Medicine, Cornell University, Ithaca, New York 14851, USA
    J Clin Microbiol 42:2144-51. 2004
    ..heilmannii" bacteria that are distinct from type 1 and from "H. suis." As "H. heilmannii" type 1 predominates in people, the zoonotic risk posed by dogs and cats is likely small...
  25. doi request reprint The relationship of serum cobalamin to methylmalonic acid concentrations and clinical variables in cats
    P Worhunsky
    College of Veterinary Medicine, Cornell University, Ithaca, NY
    J Vet Intern Med 27:1056-63. 2013
    ..Serum cobalamin concentration [CBL] suggests CBL deficiency in cats but serum methylmalonic acid concentration [MMA] more accurately indicates CBL deficiency...
  26. ncbi request reprint Feline pancreatitis
    K W Simpson
    College of Veterinary Medicine, Cornell University, Ithica NY, USA
    J Feline Med Surg 4:183-4. 2002
  27. ncbi request reprint Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum
    Martin Baumgart
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    ISME J 1:403-18. 2007
    ..coli is involved in the etiopathogenesis to Crohn's disease involving the ileum...
  28. ncbi request reprint Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas
    Oliver A Garden
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Intern Med 19:168-76. 2005
    ..111In-pentetreotide scintigraphy is a useful diagnostic adjunct to the clinical evaluation of the insulinoma patient, but is unable to localize the tumor in some cases...
  29. pmc Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogans
    Raghavan U M Palaniappan
    College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 70:5924-30. 2002
    ..LigA is the first leptospiral protein described to have 12 tandem repeats and is also the first to be expressed only during infection. Thus, LigA may have value in serodiagnosis or as a protective immunogen in novel vaccines...
  30. ncbi request reprint Cloning and characterization of an outer membrane protein (Lip18) from Helicobacter bizzozeronii
    Jiaqian Zhu
    College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    DNA Seq 14:87-94. 2003
    ..The Lip18 was localized into the outer membrane of the bacteria. Immunoblot analysis of serum samples from a dog and cat naturally infected with Helicobacter spp was able to recognize the purified recombinant Lip18...
  31. ncbi request reprint Expression of leptospiral immunoglobulin-like protein by Leptospira interrogans and evaluation of its diagnostic potential in a kinetic ELISA
    Raghavan U M Palaniappan
    College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Med Microbiol 53:975-84. 2004
    ..These findings suggest that recombinant antigen to the conserved region of LigA and LigB can differentiate between vaccinated and naturally infected animals...
  32. ncbi request reprint Quantitative analysis of inflammatory and immune responses in dogs with gastritis and their relationship to Helicobacter spp. infection
    Bo Wiinberg
    Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Vet Intern Med 19:4-14. 2005
    ..No significant associations between Helicobacter infection and proinflammatory cytokine expression, severity of gastritis, or differences in the pathogenicity of different Helicobacter spp. were found...
  33. ncbi request reprint Detection of Helicobacter spp. DNA in the oral cavity of dogs
    Camilla Recordati
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, Milano, Italy
    Vet Microbiol 119:346-51. 2007
    ..These findings support the possibility of oral-oral transmission between dogs and that the canine oral cavity may act as source of non-pylori Helicobacter spp. infection for humans...
  34. doi request reprint A simple method for the production of bacterial controls for immunohistochemistry and fluorescent in situ hybridization
    Camilla Recordati
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, Milano, Italy
    J Mol Histol 39:459-62. 2008
    ..The sandwich is an effective and simple method to prepare bacterial histological controls fixed and processed in the same way as the diagnostic tissues...

Research Grants1

  1. Helicobacter pylori: Pathogenesis and Virulence
    Kenneth Simpson; Fiscal Year: 2005
    ....