Sandra J Shin

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67
    Sandra J Shin
    Department of Pathology and Laboratory Medicine Starr 1009, New York Presbyterian Hospital Weill Medical College of Cornell University, 525 E 68th St, New York, NY 10021, USA
    Arch Pathol Lab Med 131:538-44. 2007
  2. doi Florid lobular carcinoma in situ: molecular profiling and comparison to classic lobular carcinoma in situ and pleomorphic lobular carcinoma in situ
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065 Electronic address
    Hum Pathol 44:1998-2009. 2013
  3. ncbi Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Int J Surg Pathol 14:279-84. 2006
  4. doi Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY 10065, USA
    Am J Surg Pathol 33:496-504. 2009
  5. ncbi Immunocytochemistry and fluorescence in situ hybridization in HER-2/neu status in cell block preparations
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Acta Cytol 51:552-7. 2007
  6. ncbi Bilateral presentation of fibroadenoma with digital fibroma-like inclusions in the male breast
    Sandra J Shin
    Department of Pathology and Laboratory Medicine Starr 1009, New York Presbyterian Hospital Weill Medical College of Cornell University, 525 E 68th St, New York, NY 10021, USA
    Arch Pathol Lab Med 131:1126-9. 2007
  7. ncbi Mammary presentation of adult-type "juvenile" xanthogranuloma
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Starr 1028, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Surg Pathol 29:827-31. 2005
  8. ncbi Carcinoma arising from preexisting pregnancy-like and cystic hypersecretory hyperplasia lesions of the breast: a clinicopathologic study of 9 patients
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 28:789-93. 2004
  9. doi Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites
    Paula S Ginter
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA Electronic address
    Hum Pathol 45:709-16. 2014
  10. doi Accurately assessing her-2/neu status in needle core biopsies of breast cancer patients in the era of neoadjuvant therapy: emerging questions and considerations addressed
    Timothy D'Alfonso
    Department of Pathology and Laboratory Medicine Starr, Weill Cornell Medical Center, New York, NY 10065, USA
    Am J Surg Pathol 34:575-81. 2010

Collaborators

Detail Information

Publications42

  1. ncbi Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67
    Sandra J Shin
    Department of Pathology and Laboratory Medicine Starr 1009, New York Presbyterian Hospital Weill Medical College of Cornell University, 525 E 68th St, New York, NY 10021, USA
    Arch Pathol Lab Med 131:538-44. 2007
    ..Ki-67 expression has been used as an adjunct to distinguish between benign and malignant lesions exhibiting histologic overlap at various anatomic sites...
  2. doi Florid lobular carcinoma in situ: molecular profiling and comparison to classic lobular carcinoma in situ and pleomorphic lobular carcinoma in situ
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065 Electronic address
    Hum Pathol 44:1998-2009. 2013
    ..This may explain the greater frequency of concurrent invasive carcinoma in florid lobular carcinoma in situ compared with classic lobular carcinoma in situ. ..
  3. ncbi Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Int J Surg Pathol 14:279-84. 2006
    ....
  4. doi Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY 10065, USA
    Am J Surg Pathol 33:496-504. 2009
    ..This result implicates MGA as a nonobligate precursor for the development of intraductal and invasive ductal carcinoma...
  5. ncbi Immunocytochemistry and fluorescence in situ hybridization in HER-2/neu status in cell block preparations
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Acta Cytol 51:552-7. 2007
    ..However, the utility of cytologic cell block material in determining HER-2/neu status has not been reported and is the subject of this study...
  6. ncbi Bilateral presentation of fibroadenoma with digital fibroma-like inclusions in the male breast
    Sandra J Shin
    Department of Pathology and Laboratory Medicine Starr 1009, New York Presbyterian Hospital Weill Medical College of Cornell University, 525 E 68th St, New York, NY 10021, USA
    Arch Pathol Lab Med 131:1126-9. 2007
    ..To the best of our knowledge, this is the first reported case of bilaterally occurring fibroadenomas in the male breast, one of which also contained digital fibroma-like inclusions, a second unreported phenomenon...
  7. ncbi Mammary presentation of adult-type "juvenile" xanthogranuloma
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Starr 1028, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Surg Pathol 29:827-31. 2005
    ..With the aid of immunohistochemical stains and appropriate clinical history, the correct diagnosis of extracutaneous adult JXG manifesting as a spindle cell xanthogranuloma can be made...
  8. ncbi Carcinoma arising from preexisting pregnancy-like and cystic hypersecretory hyperplasia lesions of the breast: a clinicopathologic study of 9 patients
    Sandra J Shin
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 28:789-93. 2004
    ..DCIS, usually micropapillary or cystic hypersecretory types, and rarely invasive carcinoma can arise in this setting. Affected patients are typically younger than those with more common types of breast carcinoma...
  9. doi Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites
    Paula S Ginter
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA Electronic address
    Hum Pathol 45:709-16. 2014
    ..MYC protein expression in AS can be helpful in certain diagnostic scenarios in the breast but not in other sites. ..
  10. doi Accurately assessing her-2/neu status in needle core biopsies of breast cancer patients in the era of neoadjuvant therapy: emerging questions and considerations addressed
    Timothy D'Alfonso
    Department of Pathology and Laboratory Medicine Starr, Weill Cornell Medical Center, New York, NY 10065, USA
    Am J Surg Pathol 34:575-81. 2010
    ....
  11. doi Clonal relationship between closely approximated low-grade ductal and lobular lesions in the breast: a molecular study of 10 cases
    Patrick L Wagner
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Am J Clin Pathol 132:871-6. 2009
    ..Instead, these traditionally segregated classes of breast cancer may, in fact, share common precursor lesions...
  12. pmc CT-X antigen expression in human breast cancer
    Anita Grigoriadis
    Ludwig Institute for Cancer Research, 605 Third Avenue, New York, NY 10158, USA
    Proc Natl Acad Sci U S A 106:13493-8. 2009
    ..Because of the limited therapeutic options for ER-negative breast cancers, vaccines based on CT-X antigens might prove to be useful...
  13. doi Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer
    Yao Tseng Chen
    Departments of Pathology and Surgery, Weill Cornell Medical College, New York, NY 10065, USA
    Int J Cancer 124:2893-8. 2009
    ..In summary, the expression frequency and characteristics of CT45 expression are similar to other CT cancer vaccine targets currently in clinical trials, e.g., NY-ESO-1 and MAGE-A, suggesting CT45 as a potentially useful cancer target...
  14. doi MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065 Electronic address
    Hum Pathol 45:2270-80. 2014
    ..This study is the first to confirm the presence of MYB rearrangement in SBACC. Additional validation with long-term follow-up is needed to determine the relationship, if any, between MYB-NFIB gene fusion and clinical outcome. ..
  15. ncbi Sentinel lymph node biopsy is a reliable method for lymph node evaluation in neoadjuvant chemotherapy-treated patients with breast cancer
    Starr B Koslow
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Cornell Medical College, New York, New York, USA
    Am Surg 80:171-7. 2014
    ..6%). Successful SLN mapping in patients who have undergone neoadjuvant chemotherapy is highly accurate with a low false-negative rate even in patients who have a PCR. ..
  16. doi Pathologic upgrade rates on subsequent excision when lobular carcinoma in situ is the primary diagnosis in the needle core biopsy with special attention to the radiographic target
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Arch Pathol Lab Med 137:927-35. 2013
    ..Lobular carcinoma in situ (LCIS) as the primary pathologic diagnosis in a needle core biopsy is an infrequent finding, and the management of patients in this setting is controversial...
  17. doi Phosphohistone H3 expression correlates with manual mitotic counts and aids in identification of "hot spots" in fibroepithelial tumors of the breast
    Paula S Ginter
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065 Electronic address
    Hum Pathol 49:90-8. 2016
    ..Although H&E-determined counts remain the criterion standard for assessing mitotic activity in FETs, PHH3 may be a useful adjunctive tool in some cases and is helpful in identifying mitotic hot spots. ..
  18. doi Cystic hypersecretory (in situ) carcinoma of the breast: a clinicopathologic and immunohistochemical characterization of 10 cases with clinical follow-up
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY
    Am J Surg Pathol 38:45-53. 2014
    ..Negative or discontinuous reactivity with myoepithelial markers may be seen, despite its in situ nature. CHC usually behaves in a nonaggressive manner as was seen in our patients who were all free from disease at last follow-up...
  19. ncbi Recurrent breast carcinoma arising in a transverse rectus abdominis myocutaneous flap
    Sun M Chung
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Arch Pathol Lab Med 128:1157-60. 2004
    ..We report an additional 2 cases of breast carcinoma recurring within the myocutaneous flap, both of which exhibited uncommon histologic features not previously reported...
  20. ncbi Excisional biopsy should be performed if lobular carcinoma in situ is seen on needle core biopsy
    Sandra J Shin
    Department of Pathology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York 10021, USA
    Arch Pathol Lab Med 126:697-701. 2002
    ..The management of patients with a primary diagnosis of LCIS or ALH on needle core biopsy is uncertain. Recommendations include excisional biopsy, tamoxifen citrate therapy, mammographic surveillance, or a combination of these approaches...
  21. doi The minimal carcinoma triple stain is superior to commercially available multiplex immunohistochemical stains: breast triple stain and LC/DC breast cocktail
    Paula S Ginter
    From the Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY
    Am J Clin Pathol 144:869-79. 2015
    ....
  22. pmc Aberrant E-cadherin staining patterns in invasive mammary carcinoma
    Malini Harigopal
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY, USA
    World J Surg Oncol 3:73. 2005
    ..The molecular "signature" of mammary lobular carcinomas is the loss of E-cadherin protein expression as evidenced by immunohistochemistry, whereas ductal carcinomas are typically E-cadherin positive...
  23. doi Expression of p40 and laminin 332 in metaplastic spindle cell carcinoma of the breast compared with other malignant spindle cell tumours
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA
    J Clin Pathol 68:516-21. 2015
    ....
  24. doi Elucidating encounters of atypical ductal hyperplasia arising in gynaecomastia
    Justin M Wells
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Cornell Medical College, New York, NY, USA
    Histopathology 66:398-408. 2015
    ..Atypical ductal hyperplasia (ADH) rarely arises in gynaecomastia. We set out to understand more clearly the clinical, histological and immunohistochemical features of ADH in this setting...
  25. pmc XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
    Xi Chen
    1 Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA 2 Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
    Nature 508:103-7. 2014
    ..Our findings reveal a key function for the XBP1 branch of the UPR in TNBC and indicate that targeting this pathway may offer alternative treatment strategies for this aggressive subtype of breast cancer...
  26. doi BreastPRS is a gene expression assay that stratifies intermediate-risk Oncotype DX patients into high- or low-risk for disease recurrence
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medical College, 525 East 68th Street, Starr 1031E, New York, NY 10065, USA
    Breast Cancer Res Treat 139:705-15. 2013
    ..BreastPRS recurrence score is comparable with Oncotype DX and can reclassify Oncotype DX intermediate-risk patients into two groups with significant differences in RFS. Further studies are needed to validate these findings. ..
  27. doi The diagnostic utility of the minimal carcinoma triple stain in breast carcinomas
    Dara S Ross
    Dept of Pathology and Laboratory Medicine, The New York Presbyterian Hospital Weill Cornell Medical College, New York, NY 10065, USA
    Am J Clin Pathol 139:62-70. 2013
    ..The Minimal Carcinoma Triple Stain offers an accurate and tissue-conserving method to diagnose small, morphologically problematic foci of breast carcinoma while ideally leaving more tissue for additional adjunctive studies...
  28. ncbi A 65-year-old woman with a "hemorrhoid". Fibroadenoma of the anogenital region
    Garron J Solomon
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
    Arch Pathol Lab Med 130:e30-2. 2006
  29. ncbi Primary carcinoid tumor of the prostate with concurrent adenocarcinoma: a case report
    Julien E Ghannoum
    Department of Oral and Maxillofacial Pathology, New York Hospital of Queens, New York, USA
    Int J Surg Pathol 12:167-70. 2004
    ..Owing to the relatively minute size of the carcinoid, the possibility that this tumor will impact negatively on the patient's overall prognosis is not anticipated...
  30. doi Bcl-xL promotes metastasis independent of its anti-apoptotic activity
    Soyoung Choi
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065, USA
    Nat Commun 7:10384. 2016
    ..Consistent with these findings, we detect nuclear Bcl-xL in human metastatic panNETs. Taken together, the metastatic function of Bcl-xL is independent of its anti-apoptotic activity and its residence in the mitochondria. ..
  31. pmc Axl receptor tyrosine kinase expression in breast cancer
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA
    J Clin Pathol 67:690-6. 2014
    ....
  32. doi Prostate-specific membrane antigen expression in tumor-associated vasculature of breast cancers
    Alla Gabriella Wernicke
    Department of Radiation Oncology, Stich Radiation Center, Weill Cornell Medical College, New York, NY, USA
    APMIS 122:482-9. 2014
    ..Further studies are needed to evaluate whether PSMA has diagnostic and/or potential therapeutic value. ..
  33. doi Impact of oncotype DX recurrence score in the management of breast cancer cases
    Michaela T Nguyen
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Cornell Medical College, New York, NY
    Clin Breast Cancer 14:182-90. 2014
    ..A popular assay, Oncotype DX (Genomic Health), stratifies node-negative breast cancer patients into groups that are at low, intermediate, or high risk for distant recurrence and guides decisions about adjuvant chemotherapy utilization...
  34. ncbi Prepubertal gynecomastia with lobular differentiation
    Malini Harigopal
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Breast J 11:48-51. 2005
    ..This exceptional example of prepubertal gynecomastia with lobular differentiation has been previously reported only four times in the literature. We report a fifth patient, as well as the youngest, with this unusual histologic finding...
  35. ncbi Solid variant of mammary adenoid cystic carcinoma with basaloid features: a study of nine cases
    Sandra J Shin
    Department of Pathology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 26:413-20. 2002
    ..Systemic adjuvant treatment would be prudent when axillary nodal metastases are present. Breast-conserving surgery with radiation is an option if negative margins can be achieved because this appears to be a unicentric form of carcinoma...
  36. doi Advocating Nonsurgical Management of Patients With Small, Incidental Radial Scars at the Time of Needle Core Biopsy: A Study of 77 Cases
    Cathleen Matrai
    From the Departments of Pathology and Laboratory Medicine Drs Matrai, D Alfonso, and Shin, Breast Surgery Drs Pharmer and Simmons, and Radiology Division of Women s Imaging Dr Drotman, Weill Cornell Medical College, New York, New York Drs Matrai and D Alfonso contributed equally to this study
    Arch Pathol Lab Med 139:1137-42. 2015
    ..Radial scars are benign sclerosing lesions that are routinely excised when diagnosed in a needle core biopsy. Optimal management for patients with incidental and small (≤5 mm) radial scars is uncertain...
  37. doi Small Glandular Proliferations of the Breast
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital Weill Cornell Medical College, New York, NY, USA
    Surg Pathol Clin 5:591-643. 2012
    ..The similarities and differences among these lesions in their clinicopathologic features, radiologic findings, and immunohistochemical profiles are emphasizesd. ..
  38. pmc ZNF365 promotes stability of fragile sites and telomeres
    Yuqing Zhang
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA
    Cancer Discov 3:798-811. 2013
    ..Thus, the p53-ZNF365 axis contributes to genomic stability in the setting of telomere dysfunction. ..
  39. doi An algorithmic approach to spindle cell lesions of the breast
    Sonal Varma
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Adv Anat Pathol 20:95-109. 2013
    ..Finally, we provide short summaries of the most commonly encountered mammary spindle cell lesions...
  40. doi Intramuscular lipoma arising within the pectoralis major muscle presenting as a radiographically detected breast mass
    Timothy M D'Alfonso
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, New York, USA
    Arch Pathol Lab Med 135:1061-3. 2011
    ..However, when the tumor is posteriorly located and appears to involve the pectoralis muscle, the diagnostic possibility of intramuscular lipoma should be entertained...
  41. ncbi Erythema nodosum secondary to aromatase inhibitor use in breast cancer patients: case reports and review of the literature
    Komal Jhaveri
    Division of Hematology Oncology, Department of Internal Medicine, Weill Cornell Medical College, New York, NY, 10021, USA
    Breast Cancer Res Treat 106:315-8. 2007
    ..To date, erythema nodosum (EN) has not been reported as a dermatologic side effect of AI's. Here, we report three cases of EN which developed in postmenopausal breast cancer patients on AI's...
  42. ncbi Reduced lecithin:retinol acyltransferase expression in human breast cancer
    Marni Sheren-Manoff
    Division of Hematology and Medical Oncology, New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY 10021, USA
    Int J Oncol 29:1193-9. 2006
    ..Furthermore, normal human breast epithelium exhibits intense LRAT staining, indicating a major role for LRAT in human breast physiology...