Research Topics
Genomes and GenesSpecies | J G ScottSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Cytochromes P450 and insecticide resistanceJ G Scott
Department of Entomology, Cornell University, Ithaca, NY 14853, USA
Insect Biochem Mol Biol 29:757-77. 1999..The importance of these studies for development of effective insecticide resistance management strategies is discussed...- The nicotinic acetylcholine receptor subunits Mdalpha5 and Mdbeta3 on autosome 1 of Musca domestica are not involved in spinosad resistanceJ R Gao
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA
Insect Mol Biol 16:691-701. 2007..This suggests neither Mdalpha5 nor Mdbeta3 is responsible for spinosad resistance in house flies... - House-fly cytochrome P450 CYP6D1: 5' flanking sequences and comparison of allelesJ G Scott
Department of Entomology, Cornell University, Ithaca, NY 14853 0901
Gene 226:347-53. 1999..The possible roles of these sequence differences in regulation of CYP6D1 expression are discussed... 
Transcriptional diversity and allelic variation in nicotinic acetylcholine receptor subunits of the red flour beetle, Tribolium castaneumF D Rinkevich
Department of Entomology, Cornell University, Ithaca, NY 14853 0901, USA
Insect Mol Biol 18:233-42. 2009..Alleles were found for all subunit genes, except Tcasalpha1 and Tcasalpha10. Transcriptional and allelic diversity are discussed with respect to receptor function and potential interactions with insecticides...- Use of isogenic strains indicates CYP9M10 is linked to permethrin resistance in Culex pipiens quinquefasciatusM C Hardstone
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853 0901, USA
Insect Mol Biol 19:717-26. 2010..We conclude that CYP9M10 is linked to permethrin resistance in these strains of C. p. quinquefasciatus, and is likely to be the P450 gene responsible for resistance in these strains... - Increased transcription of CYP6D1 causes cytochrome P450-mediated insecticide resistance in house flyN Liu
Department of Entomology, Cornell University, Ithaca, New York 14853 0901, USA
Insect Biochem Mol Biol 28:531-5. 1998..The increased rate of transcription of CYP6D1 in the resistant strain (LPR) is controlled by two factors: one on autosome 1 and another on autosome 2... - Cloning of two novel P450 cDNAs from German cockroaches, Blattella germanica (L.): CYP6K1 and CYP6J1Z Wen
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853-0901, USA
Insect Mol Biol 10:131-7. 2001..Southern blots suggest the two mRNA bands detected in the Northern blot might be a result of alternative splicing. No signal could be detected at any life stage using the CYP6J1 probe, suggesting that CYP6J1 was expressed at a low level... - Insect cytochromes P450: diversity, insecticide resistance and tolerance to plant toxinsJ G Scott
Department of Entomology, Cornell University, Ithaca, NY 14853 0901, USA
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 121:147-55. 1998..Advances in this area are critical because they will provide important new information about insect physiology, biochemistry and development... - Cytochrome P450s CYP6D3 and CYP6D1 are part of a P450 gene cluster on autosome 1 in the house flyS Kasai
Department of Entomology, Comstock Hall, Cornell University, Ithaca, New York 14853-0901, USA
Insect Mol Biol 10:191-6. 2001..3 kDa. The CYP6D3 protein is most similar to house fly CYP6D1 (78%) and Cyp6D2 (56%) from Drosophila melanogaster. The deduced amino acid sequences of CYP6D3 and CYP6D1 are identical at the Helix I and heme binding regions... - CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella germanica: implications for molecular evolution, expression studies and nomenclature of P450sZ Wen
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853-0901, USA
Gene 272:257-66. 2001..The relative number of P450 pseudogenes in B. germanica is apparently higher than in D. melanogaster. The implications of these results for the molecular evolution, expression studies and nomenclature of P450s are discussed... - A house fly gene homologous to the zinc finger proto-oncogene Gfi-1S Kasai
Department of Entomology, Comstock Hall, Cornell University, Ithaca, New York, 14853-0901, USA
Biochem Biophys Res Commun 283:644-7. 2001..Given that Gfi-1 is highly conserved from insects to vertebrates suggests this may be an important transcription factor in many taxa... - Frequencies of the pyrethroid resistance alleles of Vssc1 and CYP6D1 in house flies from the eastern United StatesF D Rinkevich
Department of Entomology, Comstock Hall, Cornell University, Ithaca, New York 14853-0901, USA
Insect Mol Biol 15:157-67. 2006..Based on this analysis it appears the kdr-his mutation had multiple evolutionary origins, but that the kdr mutation may have had a single origin. The impacts of these findings on resistance management are discussed... - Expression and regulation of CYP6D3 in the house fly, Musca domestica (L.)S Kasai
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853-0901, USA
Insect Biochem Mol Biol 32:1-8. 2001..6 fold) strains. The CYP6D3 5' flanking regions were sequenced from the resistant and susceptible strains. Possible regulatory sequences within this region are discussed... - Cytochromes P450 of insects: the tip of the icebergJ G Scott
Department of Entomology, Comstock Hall, Cornell University, Ithaca, New York, USA
Pest Manag Sci 57:958-67. 2001..Our knowledge continues to expand at a rapid pace, suggesting that the next decade will outpace the last in terms of improving our understanding of the cytochromes P450 of insects... - Monitoring insecticide resistance in house flies (Diptera: Muscidae) from New York dairiesP E Kaufman
Department of Entomology, Cornell University, Ithaca, New York 14853 0999, USA
Pest Manag Sci 57:514-21. 2001..A diagnostic concentration for each insecticide is proposed on the basis of a comparison of our bioassays... - The nicotinic acetylcholine receptor subunit Mdalpha6 from Musca domestica is diversified via post-transcriptional modificationJ R Gao
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA
Insect Mol Biol 16:325-34. 2007..These comparisons indicate that Mdalpha6 is not responsible for spinosad resistance in house flies... - Differences in development, glycogen, and lipid content associated with cytochrome P450-mediated permethrin resistance in Culex pipiens quinquefasciatus (Diptera: Culicidae)M C Hardstone
Department of Entomology, Cornell University, Ithaca, NY 14853, USA
J Med Entomol 47:188-98. 2010.... - Anti-P450lpr antiserum inhibits specific monooxygenase activities in LPR house fly microsomesG D Wheelock
Department of Entomology, Cornell University, Ithaca, New York 14853
J Exp Zool 264:153-8. 1992..These results demonstrate that methoxyresourfin-O-demethylase activity and benzo(a)pyrene hydroxylase activity are characteristic substrates for P450lpr activity in the LPR strain of house fly... - Inhibitors of CYP6D1 in house fly microsomesJ G Scott
Department of Entomology, Cornell University, Ithaca, NY 14853 0901, USA
Insect Biochem Mol Biol 26:645-9. 1996..Isosafrole was shown to be a potent synergist of pyrethroid insecticides in adult house flies... 
Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cellsG G H Lin
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA
Insect Mol Biol 20:87-95. 2011..This represents new functional evidence that Drosophila HR96 and BR-C can act as an activator and repressor, respectively, in regulating PB induced transcription in insects...- A high frequency of male determining factors in male Musca domestica (Diptera: Muscidae) from Ipswich, AustraliaR L Hamm
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA
J Med Entomol 46:169-72. 2009..The high frequency of M, the presence of M on four different linkage groups, and the large number of male genotypes found in this population make it unique relative to other populations of house flies that have been examined... - A case for sequencing the genome of Musca domestica (Diptera: Muscidae)J G Scott
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA
J Med Entomol 46:175-82. 2009..The community of researchers investigating Musca domestica are well prepared and highly motivated to apply genomic analyses to their widely varied research programs... - Use of quantitative real-time polymerase chain reaction to estimate the size of the house-fly Musca domestica genomeJ Gao
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 17853-0901, USA
Insect Mol Biol 15:835-7. 2006.... - The house fly aliesterase gene (MdalphaE7) is not associated with insecticide resistance or P450 expression in three strains of house flyJ G Scott
Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY, USA
Insect Biochem Mol Biol 33:139-44. 2003..The relationship between MdalphaE7 alleles and insecticide resistance is discussed in light of these findings... - Botanical insecticides for controlling agricultural pests: piperamides and the Colorado Potato Beetle Leptinotarsa decemlineata say (Coleoptera: Chrysomelidae)I M Scott
Biology Department, University of Ottawa, Ottawa, Ontario, Canada
Arch Insect Biochem Physiol 54:212-25. 2003..1%. There is also potential for Piper extracts to control insecticide resistant populations in conjunction with other integrated pest management (IPM) strategies used in conventional and organic agriculture...