Beate Schwer

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase
    M Fahad Khalid
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Nucleic Acids Res 33:6349-60. 2005
  2. pmc Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors
    Beate Schwer
    Microbiology and Immunology Department, Weill Cornell Medical College, New York, NY 10065, USA and Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Nucleic Acids Res 41:7485-500. 2013
  3. pmc Punctuation and syntax of the RNA polymerase II CTD code in fission yeast
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:18024-9. 2012
  4. pmc RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans
    Y Pei
    Molecular Biology and Cell Biology Programs, Sloan Kettering Institute, New York, NY 10021, USA
    BMC Microbiol 1:29. 2001
  5. pmc Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 39:6715-28. 2011
  6. ncbi Genetic analysis of poxvirus mRNA cap methyltransferase: suppression of conditional mutations in the stimulatory D12 subunit by second-site mutations in the catalytic D1 subunit
    Beate Schwer
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Virology 352:145-56. 2006
  7. pmc A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Cell 30:743-54. 2008
  8. pmc Characterization of the Schizosaccharomyces pombe Spt5-Spt4 complex
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA
    RNA 15:1241-50. 2009
  9. pmc Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA
    Zhicheng R Qiu
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    RNA 18:1996-2011. 2012
  10. pmc Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing
    Jonathan Chang
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    RNA 16:1018-31. 2010

Collaborators

Detail Information

Publications51

  1. pmc Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase
    M Fahad Khalid
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Nucleic Acids Res 33:6349-60. 2005
    ..Dbr1 sediments as a monomer and requires manganese as the metal cofactor for debranching...
  2. pmc Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors
    Beate Schwer
    Microbiology and Immunology Department, Weill Cornell Medical College, New York, NY 10065, USA and Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Nucleic Acids Res 41:7485-500. 2013
    ..Our results fortify the idea that spliceosome assembly can occur via distinct genetically buffered microscopic pathways involving cross-intron-bridging interactions of the U1 snRNP•5'SS complex with the Mud2•Msl5•BP complex. ..
  3. pmc Punctuation and syntax of the RNA polymerase II CTD code in fission yeast
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:18024-9. 2012
    ..We found that the Ser2-PO(4) mark is independent of Ser5, Pro6, Ser7, and Thr4, whereas the Ser5-PO(4) mark is independent of Ser2, Ser7, and Thr4. These results provide unique insights to the reading and writing of the CTD code...
  4. pmc RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans
    Y Pei
    Molecular Biology and Cell Biology Programs, Sloan Kettering Institute, New York, NY 10021, USA
    BMC Microbiol 1:29. 2001
    ....
  5. pmc Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 39:6715-28. 2011
    ....
  6. ncbi Genetic analysis of poxvirus mRNA cap methyltransferase: suppression of conditional mutations in the stimulatory D12 subunit by second-site mutations in the catalytic D1 subunit
    Beate Schwer
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Virology 352:145-56. 2006
    ....
  7. pmc A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Cell 30:743-54. 2008
    ..Bound to its target RNA, the 3'-->5' helicase acts to disrupt mRNA/U5 snRNP contacts, thereby liberating the mRNA from the spliceosome...
  8. pmc Characterization of the Schizosaccharomyces pombe Spt5-Spt4 complex
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA
    RNA 15:1241-50. 2009
    ..pombe growth, but only when Spt4 was present. Synthetic lethality of the spt5(1-835) spt4Delta double mutant at 34 degrees C suggests that interaction of Spt4 with the central domain of Spt5 overlaps functionally with the Spt5 CTD...
  9. pmc Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA
    Zhicheng R Qiu
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    RNA 18:1996-2011. 2012
    ..These studies reveal a new level of splicing control during meiosis that is governed by nuclear CBC...
  10. pmc Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing
    Jonathan Chang
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    RNA 16:1018-31. 2010
    ..Mud2 mutational effects in the swm2Delta background paralleled those for mud1Delta. The requirements for Mud2 function are apparently more stringent when yeast cells lack TMG caps than when they lack Mud1 or Swm2...
  11. pmc Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function
    Naoko Tanaka
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Biochemistry 45:6510-21. 2006
    ..Optimal ATP hydrolysis requires an RNA cofactor of >or=20 nt. Prp43 is largely indifferent to mutations in its C-terminal segment, which is conserved in the DEAH-box splicing factors Prp2, Prp16, and Prp22...
  12. pmc An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs
    Zhicheng R Qiu
    Molecular Biology Program, Sloan Kettering Institute and Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065 USA
    Nucleic Acids Res 39:5633-46. 2011
    ..Our findings illuminate a new mode of tunable splicing, a reliance on TMG caps for an essential developmental RNA transaction, and three genetically distinct meiotic splicing regulons in budding yeast...
  13. pmc A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast
    Miriam Sansó
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Genet 8:e1002822. 2012
    ..Loss of H2Bub1 disrupts that balance and leads to deranged gene expression and aberrant cell morphologies, revealing a novel function of a conserved, co-transcriptional histone modification...
  14. ncbi Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control
    Yi Pei
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    J Biol Chem 278:7180-8. 2003
    ..This elongation checkpoint may avoid wasteful rounds of transcription of uncapped pre-mRNAs...
  15. pmc Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing
    Anna Aronova
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA
    RNA 13:1437-44. 2007
    ....
  16. ncbi Poxvirus mRNA cap methyltransferase. Bypass of the requirement for the stimulatory subunit by mutations in the catalytic subunit and evidence for intersubunit allostery
    Beate Schwer
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 281:18953-60. 2006
    ....
  17. pmc Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD
    Susanne Schneider
    Graduate Program in Molecular Biology, Weill Cornell Medical College, New York, New York 10065, USA
    Mol Cell Biol 30:2353-64. 2010
    ..Viability of yeast cells bearing both Spt5 CTD T1A and Pol II CTD S2A mutations heralds that the Cdk9 kinase has an essential target other than Spt5 and Pol II CTD-Ser2...
  18. pmc Structure-function analysis of the yeast NAD+-dependent tRNA 2'-phosphotransferase Tpt1
    Rana Sawaya
    Molecular Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    RNA 11:107-13. 2005
    ..These findings attest to the structural and functional conservation of Tpt1-like 2'-phosphotransferases and identify likely constituents of the active site...
  19. pmc How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing
    Shelly Ann James
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    RNA 8:1068-77. 2002
    ..All three proteins are released from the spliceosome after step 2 concomitant with release of mature mRNA...
  20. ncbi Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome
    Arnold Martin
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 277:17743-50. 2002
    ..We show that the lariat-intron is not accessible to debranching by purified Dbr1 when it is held in the T123A-arrested splicing complex. Our results define a new ATP-dependent step of splicing that is catalyzed by Prp43...
  21. pmc TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast
    Laia Viladevall
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 33:738-51. 2009
    ..In vitro, phosphorylation of the CTD by Mcs6 stimulates subsequent phosphorylation by Cdk9. We propose that TFIIH primes the CTD and promotes recruitment of P-TEFb/Pcm1, serving to couple elongation and capping of select pre-mRNAs...
  22. pmc Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe
    Stephane Hausmann
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Nucleic Acids Res 35:1411-20. 2007
    ..Deletion of the pcm1(+) gene was lethal, as were missense mutations in the Pcm1 active site. Thus, whereas m(7)G caps are essential in both S. pombe and S. cerevisiae, m(2,2,7)G caps are not...
  23. pmc Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome
    Naoko Tanaka
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA
    Genes Dev 21:2312-25. 2007
    ..Our results demonstrate for the first time that regulating the motor activity of a DEAH-box protein by an accessory factor is critical for mRNA splicing...
  24. pmc Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo
    Alejandro Ramirez
    Graduate Program in Molecular Biology, Weill Cornell Medical College, New York, New York 10065, USA
    RNA 14:1737-45. 2008
    ....
  25. ncbi Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity
    Sushuang Zheng
    Molecular Biology Program, Sloan Kettering Institute, Weill College of Medicine of Cornell University, New York, New York 10021, USA
    J Biol Chem 281:35904-13. 2006
    ..We find that the sensitivity of Saccharomyces cerevisiae to growth inhibition by sinefungin is diminished when Abd1 is overexpressed. These results highlight cap methylation as a principal target of the antifungal activity of sinefungin...
  26. pmc RNA repair: an antidote to cytotoxic eukaryal RNA damage
    Jayakrishnan Nandakumar
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Mol Cell 31:278-86. 2008
    ..Plant andphage tRNA repair enzymes protect yeast from gamma-toxin because they are able to reverse the damage. Our studies underscore how a ribotoxin exploits an Achilles' heel in the target cell's tRNA repair system...
  27. pmc Structure-function analysis of the kinase-CPD domain of yeast tRNA ligase (Trl1) and requirements for complementation of tRNA splicing by a plant Trl1 homolog
    Li Kai Wang
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Nucleic Acids Res 34:517-27. 2006
    ..The plant ligase, like yeast Trl1 but unlike T4 RNA ligase 1, requires a 2'-PO4 end for tRNA splicing in vivo...
  28. pmc Structure-guided mutational analysis of T4 RNA ligase 1
    Li Kai Wang
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    RNA 12:2126-34. 2006
    ..Moreover, the requirements for sealing exogenous preformed RNA-adenylate are more stringent than are those for sealing the RNA-adenylate intermediate formed in situ during ligation of a 5'-PO4 RNA...
  29. ncbi Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8
    Susanne Schneider
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:8617-26. 2004
    ..These findings suggest a model whereby Prp22 disrupts an RNA/protein or RNA/RNA interaction in the spliceosome that is normally stabilized by Prp8...
  30. pmc Determinants of Nam8-dependent splicing of meiotic pre-mRNAs
    Zhicheng R Qiu
    Sloan Kettering Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 39:3427-45. 2011
    ..Nam8 activity is enfeebled by alanine mutations in the putative RNA binding sites of the RRM2 and RRM3 domains...
  31. pmc Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue
    Zhicheng R Qiu
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    RNA 17:1648-54. 2011
    ..We find that the RRM2 and RRM3 domains, and their putative RNA-binding sites, are essential for yeast sporulation, whereas the leader, tail, and RRM1 modules are not...
  32. ncbi Characterization of the NTPase, RNA-binding, and RNA helicase activities of the DEAH-box splicing factor Prp22
    Naoko Tanaka
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Biochemistry 44:9795-803. 2005
    ..We show that Prp22 can hydrolyze all common NTPs and dNTPs with comparable efficiencies and that Prp22 unwinds RNA duplexes with 3' to 5' directionality...
  33. ncbi Genetic and biochemical analysis of the functional domains of yeast tRNA ligase
    Rana Sawaya
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    J Biol Chem 278:43928-38. 2003
    ..Mutations of the signature histidines of the CPD domain were either lethal (H777A) or conferred a ts growth phenotype (H673A)...
  34. pmc Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase
    Sushuang Zheng
    Molecular Biology Program, Sloan Kettering Institute and Microbiology, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 35:6895-903. 2007
    ..These results are consistent with the proposal that mRNA cap methylation is a principal target of sinefungin's bioactivity...
  35. ncbi Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28
    Beate Schwer
    Microbiology and Immunology Department, Weill Cornell Medical College, New York, NY 10065, USA and Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Nucleic Acids Res 42:4697-711. 2014
    ..YHC1-(1-170) was synthetically lethal with mutations of all components interrogated, with the exception of Nam8. ..
  36. ncbi An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1
    Stephane Hausmann
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Biochemistry 43:7111-20. 2004
    ..We exploit synthetic CTD Ser2-PO(4) and Ser5-PO(4) peptides to define minimized substrates for EcFcp1 and to illuminate the importance of CTD primary structure in Ser2 and Ser5 phosphatase activity...
  37. ncbi Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065
    Proc Natl Acad Sci U S A 111:4185-90. 2014
    ..These results highlight specific cellular gene expression programs that are responsive to distinct CTD cues. ..
  38. pmc Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5
    Jonathan Chang
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Nucleic Acids Res 40:4539-52. 2012
    ..The results suggest a network of important but functionally buffered protein-protein and protein-RNA interactions between the Mud2-Msl5 complex at the branchpoint and the U1 snRNP at the 5' splice site...
  39. pmc The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair
    Li Kai Wang
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    RNA 13:1235-44. 2007
    ..Alanine scanning of the N domain identified Ser103, Leu104, Lys117, and Ser118 as important for pRNA ligation in vitro and tRNA repair in vivo...
  40. pmc Characterization of a mimivirus RNA cap guanine-N2 methyltransferase
    Delphine Benarroch
    Sloan Kettering Institute, New York, New York 10065, USA
    RNA 15:666-74. 2009
    ..Our results hint that DMG caps can satisfy many of the functions of TMG caps in vivo. We speculate that DMG capping of mimivirus mRNAs might favor viral protein synthesis in the infected host...
  41. pmc Deciphering the RNA polymerase II CTD code in fission yeast
    Beate Schwer
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Cell 43:311-8. 2011
    ..This illustrates that a key "letter" in the CTD code can be neutralized by delivering its essential cognate receptor to the transcription complex via an alternative route...
  42. pmc Yeast-based genetic system for functional analysis of poxvirus mRNA cap methyltransferase
    Nayanendu Saha
    Department of Microbiology and Immunology, Weill Medical College of Cornell University Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    J Virol 77:7300-7. 2003
    ..Studies of recombinant proteins show that the lethal vD1-C mutations do not preclude heterodimerization with vD12 but either eliminate or reduce cap methyltransferase activity in vitro...
  43. pmc Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC
    Birthe Meineke
    Sloan Kettering Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 39:687-700. 2011
    ..Comparisons of EcoPrrC activity in a variety of yeast genetic backgrounds, and the rescuing effects of tRNA overexpression, implicate tRNA(Lys(UUU)) as a target of EcoPrrC toxicity in yeast...
  44. ncbi Characterization of dominant-negative mutants of the DEAH-box splicing factors Prp22 and Prp16
    Susanne Schneider
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 277:15452-8. 2002
    ..Comparing the mutational effects in Prp16 and Prp22 highlights common as well as distinct structural requirements for the ATP-dependent steps in pre-mRNA splicing...
  45. pmc A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair
    Birthe Meineke
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    RNA 18:1716-24. 2012
    ..The damage-rescuing ability of tRNA repair systems is lost when PaOrf2 can break tRNA at both sites. These results highlight the logic of a two-incision mechanism of tRNA anticodon damage that evades productive repair by tRNA ligases...
  46. pmc ATP-dependent remodeling of the spliceosome: intragenic suppressors of release-defective mutants of Saccharomyces cerevisiae Prp22
    Eva Campodonico
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Genetics 160:407-15. 2002
    ..Increasing the reaction temperature allows H606A and T637A to effect mRNA release in vitro, but does not restore RNA unwinding by T637A...
  47. pmc Portability and fidelity of RNA-repair systems
    Beate Schwer
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2788-93. 2004
    ....
  48. ncbi How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes
    Selom K Doamekpor
    Structural Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 28:1323-36. 2014
    ..We propose that the state of Thr1 phosphorylation comprises a binary "Spt5 CTD code" that is read by capping enzyme independent of and parallel to its response to the state of the Pol2 CTD. ..
  49. ncbi Tat stimulates cotranscriptional capping of HIV mRNA
    Ya Lin Chiu
    Chemical Biology Program, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 10:585-97. 2002
    ..Our findings implicate capping in an elongation checkpoint critical to HIV gene expression...
  50. ncbi A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II
    Stephanie C Schroeder
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, B121, 4200 East 9th Avenue, Denver, CO 80262 USA
    Mol Cell 13:377-87. 2004
    ..Manipulation of transcription by Abd1 may enhance cotranscriptional capping and also act as a checkpoint to ensure that a nascent transcript has a cap before it can be completed...
  51. pmc Mammalian 2',3' cyclic nucleotide phosphodiesterase (CNP) can function as a tRNA splicing enzyme in vivo
    Beate Schwer
    RNA 14:204-10. 2008
    ....

Research Grants13

  1. Structure-Function Analysis of Spliceosomal ATPases
    Beate Schwer; Fiscal Year: 2010
    ..Defects and in this process can alter the structure and function of a gene product thus lead to disease. Understanding the basic mechanism of mRNA splicing is critical to understand how defects can lead to disease. ..
  2. STRUCTURE/FUNCTION ANALYSIS OF SPLICEOSOMAL ATPASES
    Beate Schwer; Fiscal Year: 2006
    ..abstract_text> ..
  3. STRUCTURE/FUNCTION ANALYSIS OF SPLICEOSOMAL ATPASES
    Beate Schwer; Fiscal Year: 2002
    ..abstract_text> ..
  4. STRUCTURE/FUNCTION ANALYSIS OF SPLICEOSOMAL ATPASES
    Beate Schwer; Fiscal Year: 2000
    ..abstract_text> ..
  5. STRUCTURE/FUNCTION ANALYSIS OF SPLICEOSOMAL ATPASES
    Beate Schwer; Fiscal Year: 1999
    ..abstract_text> ..
  6. STRUCTURE/FUNCTION ANALYSIS OF SPLICEOSOMAL ATPASES
    Beate Schwer; Fiscal Year: 2001
    ..abstract_text> ..
  7. STRUCTURE/FUNCTION ANALYSIS OF SPLICEOSOMAL ATPASES
    Beate Schwer; Fiscal Year: 2003
    ..abstract_text> ..
  8. Structure-Function Analysis of Spliceosomal ATPases
    Beate Schwer; Fiscal Year: 2009
    ..Defects and in this process can alter the structure and function of a gene product thus lead to disease. Understanding the basic mechanism of mRNA splicing is critical to understand how defects can lead to disease. ..