Peter N Schlegel

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Evaluation of male infertility
    P N Schlegel
    Department of Urology, James Buchanan Brady Foundation, The New York Presbyterian Hospital Weill Medical College of Cornell University and The Population Council, Center for Biomedical Research, New York, NY 10021, USA
    Minerva Ginecol 61:261-83. 2009
  2. pmc Vasectomy and vasectomy reversal: An update
    Ranjith Ramasamy
    Department of Urology, Presbyterian Hospital, Weill Cornell Medical College, New York, USA
    Indian J Urol 27:92-7. 2011
  3. doi request reprint Alternate indications for varicocele repair: non-obstructive azoospermia, pain, androgen deficiency and progressive testicular dysfunction
    Peter N Schlegel
    Department of Urology, Brady Urology Foundation, Center for Male Reproductive Medicine and Microsurgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York 10021, USA
    Fertil Steril 96:1288-93. 2011
  4. doi request reprint Aromatase inhibitors for male infertility
    Peter N Schlegel
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 98:1359-62. 2012
  5. pmc Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3
    Greg L Christensen
    Andrology and IVF Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA
    BMC Med Genet 7:27. 2006
  6. doi request reprint The role of varicocele repair in nonobstructive azoospermia must be evaluated with controlled trials rather than observational studies
    Peter N Schlegel
    Cornell University Medical Center, New York, New York 10021, USA
    Fertil Steril 95:486. 2011
  7. ncbi request reprint The Y chromosome
    Peter N Schlegel
    Department of Urology, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY, USA
    Reprod Biomed Online 5:22-5. 2002
  8. ncbi request reprint Efficacy and safety of histrelin subdermal implant in patients with advanced prostate cancer
    Peter N Schlegel
    Department of Urology, Weill Medical College of Cornell University, New York, New York, USA
    J Urol 175:1353-8. 2006
  9. ncbi request reprint Causes of azoospermia and their management
    P N Schlegel
    Department of Urology, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Reprod Fertil Dev 16:561-72. 2004
  10. ncbi request reprint Yet another test of sperm chromatin structure
    Peter N Schlegel
    Department of Urology, Weill Medical College, Cornell University, New York, New York 10021, USA
    Fertil Steril 84:854-9. 2005

Collaborators

Detail Information

Publications95

  1. ncbi request reprint Evaluation of male infertility
    P N Schlegel
    Department of Urology, James Buchanan Brady Foundation, The New York Presbyterian Hospital Weill Medical College of Cornell University and The Population Council, Center for Biomedical Research, New York, NY 10021, USA
    Minerva Ginecol 61:261-83. 2009
    ..The first step in evaluation is a thorough history and physical examination with initiation of basic laboratory studies...
  2. pmc Vasectomy and vasectomy reversal: An update
    Ranjith Ramasamy
    Department of Urology, Presbyterian Hospital, Weill Cornell Medical College, New York, USA
    Indian J Urol 27:92-7. 2011
    ..The purpose of this document is to provided a synopsis of the latest techniques used in vasectomy and reversal...
  3. doi request reprint Alternate indications for varicocele repair: non-obstructive azoospermia, pain, androgen deficiency and progressive testicular dysfunction
    Peter N Schlegel
    Department of Urology, Brady Urology Foundation, Center for Male Reproductive Medicine and Microsurgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York 10021, USA
    Fertil Steril 96:1288-93. 2011
    ..Varicocele repair is indicated for infertile men with clinical varicoceles. Some men with scrotal pain, low testosterone, non-obstructive azoospermia, and who are at risk for testicular dysfunction may also benefit from varicocelectomy...
  4. doi request reprint Aromatase inhibitors for male infertility
    Peter N Schlegel
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 98:1359-62. 2012
    ..Side effects have rarely been reported. Randomized controlled trials are needed to define the magnitude of benefit of aromatase inhibitor treatment for infertile men...
  5. pmc Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3
    Greg L Christensen
    Andrology and IVF Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA
    BMC Med Genet 7:27. 2006
    ..Ornithine decarboxylase antizyme 3 (OAZ3) is a testis-specific antizyme paralog and the only antizyme expressed in the mid to late stages of spermatogenesis...
  6. doi request reprint The role of varicocele repair in nonobstructive azoospermia must be evaluated with controlled trials rather than observational studies
    Peter N Schlegel
    Cornell University Medical Center, New York, New York 10021, USA
    Fertil Steril 95:486. 2011
    ..In addition, varicocele repair may optimize sperm production. However, additional studies and evaluation of the role of varicocele repair in men with this condition (nonobstructive azoospermia) are warranted...
  7. ncbi request reprint The Y chromosome
    Peter N Schlegel
    Department of Urology, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY, USA
    Reprod Biomed Online 5:22-5. 2002
    ..Recent advances in our understanding of the organization and function of the Y chromosome are likely to enhance further the role of the Y chromosome in normal spermatogenesis and fertility...
  8. ncbi request reprint Efficacy and safety of histrelin subdermal implant in patients with advanced prostate cancer
    Peter N Schlegel
    Department of Urology, Weill Medical College of Cornell University, New York, New York, USA
    J Urol 175:1353-8. 2006
    ..This open label, multicenter study was done to evaluate the efficacy and safety of the gonadotropin hormone-releasing hormone agonist histrelin acetate administered as a 50 mg subdermal implant in men with advanced prostatic cancer...
  9. ncbi request reprint Causes of azoospermia and their management
    P N Schlegel
    Department of Urology, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Reprod Fertil Dev 16:561-72. 2004
    ..Once sperm are found, pregnancy rates of 20-50% may be obtained at different centres with in vitro fertilisation and intracytoplasmic sperm injection...
  10. ncbi request reprint Yet another test of sperm chromatin structure
    Peter N Schlegel
    Department of Urology, Weill Medical College, Cornell University, New York, New York 10021, USA
    Fertil Steril 84:854-9. 2005
    ..The newly proposed test, Halosperm, may not provide additional information beyond that obtained with existent evaluations...
  11. ncbi request reprint Nonobstructive azoospermia: a revolutionary surgical approach and results
    Peter N Schlegel
    Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York 10021, USA
    Semin Reprod Med 27:165-70. 2009
    ..Its specific application for subsets of men with nonobstructive azoospermia is described...
  12. doi request reprint Interpretation of the semen analysis and initial male factor management
    Peter J Stahl
    Weill Cornell Medical College Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Obstet Gynecol 54:656-65. 2011
    ..Each parameter of the SA is described and management recommendations based upon SA findings are provided. The indications for and interpretation of adjunctive diagnostic testing for male factor subfertility are also discussed...
  13. doi request reprint Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor
    Akanksha Mehta
    Department of Urology, Weill Cornell Medical College, New York, New York Electronic address
    Fertil Steril 100:970-4. 2013
    ..To evaluate surgical sperm retrieval rates in adolescents with Klinefelter syndrome and testosterone replacement therapy (TRT)...
  14. ncbi request reprint Microsurgical denervation of rat spermatic cord: safety and efficacy data
    Melissa A Laudano
    Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA
    BJU Int 113:795-800. 2014
    ..To evaluate structural and functional changes in the rat testis and vas deferens after denervation...
  15. doi request reprint Pilot study of the correlation of multiphoton tomography of ex vivo human testis with histology
    Bobby B Najari
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    J Urol 188:538-43. 2012
    ..We hypothesized that we could accurately characterize seminiferous tubular histology in humans using multiphoton microscopy...
  16. doi request reprint Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience
    Wayland Hsiao
    Weill Cornell Medical College, James Buchanan Brady Foundation, New York, NY 10065, USA
    J Clin Oncol 29:1607-11. 2011
    ..While traditionally considered sterile, men who are azoospermic after chemotherapy can be treated with microdissection testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI)...
  17. doi request reprint Microsurgical rat varicocele model
    Bobby B Najari
    Department of Urology, Weill Cornell Medical College, New York, New York
    J Urol 191:548-53. 2014
    ..We hypothesized that varicocele induction would be more effective if microsurgical ligation of the gonadal venous drainage to the common iliac vein was combined with partial occlusion of the left renal vein...
  18. ncbi request reprint Role of varicocelectomy in men with nonobstructive azoospermia
    Peter N Schlegel
    Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Fertil Steril 81:1585-8. 2004
    ..To evaluate the benefits of varicocelectomy in men with nonobstructive azoospermia...
  19. doi request reprint Role of tissue digestion and extensive sperm search after microdissection testicular sperm extraction
    Ranjith Ramasamy
    Center for Reproductive Medicine, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 96:299-302. 2011
    ..To report the chance of sperm discovery in the laboratory when sperm were not identified in the operating room (OR)...
  20. ncbi request reprint Success of testicular sperm extraction [corrected] and intracytoplasmic sperm injection in men with Klinefelter syndrome
    Jonathan D Schiff
    The James Buchanan Brady Foundation, Department of Urology, and The Center for Reproductive Medicine and Infertility, The New York Weill Cornell Medical Center, and the Population Council, New York, New York 10021, USA
    J Clin Endocrinol Metab 90:6263-7. 2005
    ..The aim of this study was to report the successful fertility treatment of men with Klinefelter syndrome using testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI)...
  21. ncbi request reprint Structural and functional changes to the testis after conventional versus microdissection testicular sperm extraction
    Ranjith Ramasamy
    Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Urology 65:1190-4. 2005
    ..TESE has been performed using the conventional multiple biopsy approach and the more recent microdissection technique...
  22. doi request reprint A novel sorting technology allows for highly efficient selection of sperm without chromatin damage
    Michael G Funaro
    Department of Urology, Weill Cornell Medical College, New York, New York 10065, USA
    Syst Biol Reprod Med 59:172-7. 2013
    ..Further research is needed to determine if the reduction in TUNEL positive sperm using PF-1 will improve in vitro fertilization (IVF) outcomes...
  23. doi request reprint Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction
    Ranjith Ramasamy
    Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 99:372-6. 2013
    ..To evaluate the effect of obesity on the outcome of testicular sperm extraction (TESE) and assisted reproductive technology...
  24. doi request reprint Multiphoton imaging and laser ablation of rodent spermatic cord nerves: potential treatment for patients with chronic orchialgia
    Ranjith Ramasamy
    Department of Urology, Weill Cornell Medical College, New York, NY, USA
    J Urol 187:733-8. 2012
    ..We used multiphoton microscopy, a novel laser imaging technology, to identify and selectively ablate spermatic cord nerves in the rat...
  25. doi request reprint Heat shock factor Y chromosome (HSFY) mRNA level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia
    Peter J Stahl
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 96:303-8. 2011
    ..To evaluate heat shock factor Y chromosome (HSFY) mRNA as a biomarker for the presence of retrievable testicular sperm...
  26. doi request reprint Genetic evaluation of the azoospermic or severely oligozoospermic male
    Peter J Stahl
    Weill Cornell Medical College, New York, USA
    Curr Opin Obstet Gynecol 24:221-8. 2012
    ..The purpose of this review is to provide a contemporary overview of the genetic evaluation of azoospermic or severely oligozoospermic men...
  27. ncbi request reprint Male infertility: evaluation and sperm retrieval
    Peter N Schlegel
    Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Obstet Gynecol 49:55-72. 2006
  28. ncbi request reprint Age does not adversely affect sperm retrieval in men undergoing microdissection testicular sperm extraction
    Ranjith Ramasamy
    Department of Urology, Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York
    Fertil Steril 101:653-5. 2014
    ..To evaluate the effect of male age on the outcome of microdissection testicular sperm extraction (micro-TESE) and assisted reproductive technology...
  29. doi request reprint Role of optimizing testosterone before microdissection testicular sperm extraction in men with nonobstructive azoospermia
    Jennifer E Reifsnyder
    Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10065, USA
    J Urol 188:532-6. 2012
    ..We evaluated the influence of preoperative medical therapy in men with nonobstructive azoospermia before microdissection testicular sperm extraction...
  30. pmc Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia
    Peter J Stahl
    Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital Cornell, New York, NY 10065, USA
    Asian J Androl 14:676-82. 2012
    ..These observations suggest that impairments in CDY2 or HSFY expression could be implicated in the pathogenesis of MA...
  31. ncbi request reprint Uniform testicular maturation arrest: a unique subset of men with nonobstructive azoospermia
    Andrew J Hung
    James Buchanan Brady Urology Foundation, Department of Urology, Center for Male Reproductive Medicine and Microsurgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Urol 178:608-12; discussion 612. 2007
    ....
  32. doi request reprint A decade of experience emphasizes that testing for Y microdeletions is essential in American men with azoospermia and severe oligozoospermia
    Peter J Stahl
    Department of Urology, Weill Cornell Medical College, New York, New York 10065, USA
    Fertil Steril 94:1753-6. 2010
    ..To evaluate the benefit of Y microdeletion testing...
  33. doi request reprint Reassessing reconstruction in the management of obstructive azoospermia: reconstruction or sperm acquisition?
    Richard Lee
    James Buchanan Brady Foundation, Department of Urology, Weill Medical College of Cornell University, 525 E 68th Street, Starr 900, New York, NY 10021, USA
    Urol Clin North Am 35:289-301, x. 2008
    ..When considering sperm retrieval, the impact of in vitro fertilization-related indirect costs, specifically that driven by multiple gestation pregnancies, is significant...
  34. doi request reprint The outcome of intracytoplasmic sperm injection using occasional spermatozoa in the ejaculate of men with spermatogenic failure
    Kristin A Bendikson
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Urol 180:1060-4. 2008
    ..We compared intracytoplasmic sperm injection outcomes following the injection of ejaculated or surgically retrieved spermatozoa from these men...
  35. doi request reprint Successful fertility treatment for Klinefelter's syndrome
    Ranjith Ramasamy
    Center for Reproductive Medicine and Infertility, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York
    J Urol 182:1108-13. 2009
    ..We also analyzed the influence of preoperative hormonal therapy on the sperm retrieval rate...
  36. ncbi request reprint Postmortem sperm retrieval: the effect of instituting guidelines
    Jennifer A Tash
    James Buchanan Brady Urology Foundation, Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, 525 East 68th Street, Starr 900, New York, NY 10021, USA
    J Urol 170:1922-5. 2003
    ..In this study we report the effect of intra-institutional guidelines developed for the permissibility of the procedure on the number of procurement procedures performed...
  37. ncbi request reprint Y chromosome assessment and its implications for the development of ICSI children
    Yukiko Katagiri
    Cornell Institute for Reproductive Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Reprod Biomed Online 8:307-18. 2004
    ..Moreover, DNA extraction and Y deletion assessments of cheek cells provide a non-invasive approach. Inheritance of Yq deletions appears not to affect the psychological and physical development of children derived from ICSI...
  38. doi request reprint Azoospermia due to spermatogenic failure
    Boback M Berookhim
    Department of Urology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Urol Clin North Am 41:97-113. 2014
    ..Finally, future directions of treatment for men with spermatogenic failure are discussed, namely, stem cell and gene therapy. ..
  39. doi request reprint Localization of sperm during microdissection testicular sperm extraction in men with nonobstructive azoospermia
    Ranjith Ramasamy
    Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10065, USA
    J Urol 189:643-6. 2013
    ..We determined the location where sperm were identified during microdissection testicular sperm extraction and characterized the subset of patients for whom complete bilateral exploration was most beneficial...
  40. ncbi request reprint Methylation-specific PCR allows for fast diagnosis of X chromosome disomy and reveals skewed inactivation of the X chromosome in men with Klinefelter syndrome
    Akanksha Mehta
    Department of Urology, Weill Cornell Medical College, 525 E 68th St, Box 580, New York, NY 10021, USA
    J Androl 33:955-62. 2012
    ..Men with KS can have incomplete inactivation of supernumerary X chromosomes. M-PCR is a sensitive, specific, fast, and relatively inexpensive test for the diagnosis of X chromosome disomy...
  41. doi request reprint Indications and strategies for fertility preservation in men
    Peter J Stahl
    James Buchanan Brady Department of Urology, Weill Cornell Medical College, New York, New York, USA
    Clin Obstet Gynecol 53:815-27. 2010
    ..Lastly, emerging options for fertility preservation in prepubertal boys are discussed...
  42. ncbi request reprint Microsurgical inguinal varicocelectomy with and without testicular delivery
    Ranjith Ramasamy
    Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Urology 68:1323-6. 2006
    ..To evaluate the effect of the delivery of testis on semen parameters, serum testosterone, and pregnancy rates after varicocelectomy, performed with and without delivery of the testis...
  43. ncbi request reprint Microdissection testicular sperm extraction: effect of prior biopsy on success of sperm retrieval
    Ranjith Ramasamy
    Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    J Urol 177:1447-9. 2007
    ..We determined the effect of prior biopsies with no sperm seen on the chance of sperm retrieval with microdissection testicular sperm extraction in men with nonobstructive azoospermia...
  44. ncbi request reprint Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism
    Jay D Raman
    James Buchanan Brady Urology Foundation, Department of Urology, Center for Male Reproductive Medicine and Microsurgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
    J Urol 170:1287-90. 2003
    ..We evaluated the results of testicular sperm extraction (TESE) with intracytoplasmic sperm injection (ICSI) in men with nonobstructive azoospermia (NOA) associated with cryptorchidism...
  45. ncbi request reprint SUMO-1, human male germ cell development, and the androgen receptor in the testis of men with normal and abnormal spermatogenesis
    Margarita Vigodner
    Center for Biomedical Research, Population Council, New York, New York, USA
    Am J Physiol Endocrinol Metab 290:E1022-33. 2006
    ..Our data suggest that human testicular SUMO-1 has specific functions in heterochromatin organization, meiotic centromere function, and gene expression...
  46. ncbi request reprint High serum FSH levels in men with nonobstructive azoospermia does not affect success of microdissection testicular sperm extraction
    Ranjith Ramasamy
    Center for Reproductive Medicine and Infertility, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA
    Fertil Steril 92:590-3. 2009
    ..To evaluate the outcomes of microdissection testicular sperm extraction (micro-TESE) in patients with high FSH...
  47. ncbi request reprint Bulbocavernosus muscle area measurement: a novel method to assess androgenic activity
    Ali A Dabaja
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, USA
    Asian J Androl 16:618-22. 2014
    ..01). The number of CAGn in the AR correlates with the area of the BCM. Ultrasound assessment of the BCM is an effective surrogate to evaluate end-organ activity of androgens. The number of CAGn may increase with age. ..
  48. pmc Severe testicular atrophy does not affect the success of microdissection testicular sperm extraction
    Campbell F Bryson
    Center for Reproductive Medicine, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York
    J Urol 191:175-8. 2014
    ..We evaluated the outcomes of microdissection testicular sperm extraction in men with severe testicular atrophy (volume 2 ml or less)...
  49. pmc Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis
    Laurent Vaucher
    Department of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, New York, United States of America Population Council, Center for Biomedical Research, New York, New York, United States of America Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS ONE 9:e92425. 2014
    ..The aim of this study was to evaluate GPER-1 expression in the testis, and its role in estradiol dependent regulation of steroidogenesis in isolated rat Leydig cells and human testis...
  50. doi request reprint Flow cytometric characterization of apoptosis and chromatin damage in spermatozoa
    Howard H Kim
    Departments of Urology and Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Reprod Biomed Online 26:393-5. 2013
    ..These results strongly suggest that the drop in mitochondrial potential precedes changes in membrane phospholipids, and thus suggest apoptotic activation through mitochondrial pathway in human spermatozoa...
  51. doi request reprint A comparison of models for predicting sperm retrieval before microdissection testicular sperm extraction in men with nonobstructive azoospermia
    Ranjith Ramasamy
    Departments of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10065, USA
    J Urol 189:638-42. 2013
    ....
  52. pmc Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men
    Petrice W Brown
    Center for Biomedical Research, Population Council, New York, NY 10065, USA
    Hum Reprod 23:2850-7. 2008
    ..Here, we delineate possible functional roles based on subcellular localization for SUMO-1 and SUMO-2/3...
  53. doi request reprint Diagnosis of the gr/gr Y chromosome microdeletion does not help in the treatment of infertile American men
    Peter J Stahl
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    J Urol 185:233-7. 2011
    ..We evaluated the clinical characteristics of infertile American men with the gr/gr deletion...
  54. ncbi request reprint Intraoperative varicocele anatomy: a microscopic study of the inguinal versus subinguinal approach
    Carin V Hopps
    Center for Male Reproductive Medicine and Microsurgery, Cornell Institute for Reproductive Medicine, The New York Weill Cornell Medical Center, New York 10021, USA
    J Urol 170:2366-70. 2003
    ....
  55. ncbi request reprint Births using sperm retrieved via immediate microdissection of a solitary testis with cancer
    Benjamin B Choi
    Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, USA
    Fertil Steril 84:1508. 2005
    ..To determine the feasibility of achieving births using sperm retrieved from a solitary testis with cancer...
  56. ncbi request reprint A decision analysis of treatments for nonobstructive azoospermia associated with varicocele
    Richard Lee
    James Buchanan Brady Foundation, Department of Urology, Weill Medical College of Cornell University, 525 E 68th St, New York, NY 10021, USA
    Fertil Steril 92:188-96. 2009
    ....
  57. pmc Microdissection testicular sperm extraction: an update
    Ali A Dabaja
    Department of Urology, Male Reproductive Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Asian J Androl 15:35-9. 2013
    ..Furthermore, we will update our overall experience to allow counseling on the prognosis of sperm retrieval for the specific subsets of NOA...
  58. doi request reprint Endocrine manipulation in male infertility
    Howard H Kim
    Department of Urology, Weill Medical College of Cornell University and Cornell Institute for Reproductive Medicine, 525 East 68th Street, New York, NY 10065, USA
    Urol Clin North Am 35:303-18, x. 2008
    ..Although empiric endocrine therapy for idiopathic male infertility has been largely replaced by assisted reproductive techniques, both treatment modalities could play a role, perhaps as combination therapy...
  59. pmc Medical therapy for spermatogenic failure
    Ranjith Ramasamy
    Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA
    Asian J Androl 14:57-60. 2012
    ..Although empiric medical therapy for spermatogenic failure has been largely replaced by assisted reproductive techniques, both treatment modalities could play a role, perhaps as combination therapy...
  60. pmc Full field optical coherence tomography can identify spermatogenesis in a rodent sertoli-cell only model
    Ranjith Ramasamy
    Department of Urology, Weill Cornell Medical College, New York
    J Pathol Inform 3:4. 2012
    ..Furthermore, by using a nonlaser safe light source (150 W halogen lamp) for tissue illumination, it ensures that the sperm extracted for in vitro fertilization are not photo-damaged or mutagenized...
  61. ncbi request reprint AZF microdeletions of the Y chromosome and in vitro fertilization outcome
    Janet M Choi
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
    Fertil Steril 81:337-41. 2004
    ..To determine whether the presence of a Y microdeletion confers any adverse effects on in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) outcome...
  62. ncbi request reprint Rapid disappearance of spermatozoa after vasal occlusion in the dog
    Jonathan D Schiff
    Center for Male Reproductive Medicine and Microsurgery, the James Buchanan Brady Foundation Department of Urology and the Cornell Institute for Reproductive Medicine, Weill Cornell Medical Center, New York, New York 10021, USA
    J Androl 24:361-3. 2003
    ..Therefore, the delayed clearance of spermatozoa from the ejaculate in humans may be due to sperm storage in the seminal vesicles...
  63. ncbi request reprint Adverse effect of paroxetine on sperm
    Cigdem Tanrikut
    James Buchanan Brady Foundation, Department of Urology, Cornell Reproductive Medicine Institute, Weill Medical College of Cornell University, New York, New York 10021, USA
    Fertil Steril 94:1021-6. 2010
    ..To assess the effects of a selective serotonin reuptake inhibitor on semen parameters...
  64. ncbi request reprint Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism
    Darius A Paduch
    Department of Urology, Weill Medical College of Cornell University, 525 East 68th Street, Box 580, New York, NY 10021, USA
    Reprod Biomed Online 10:747-54. 2005
    ..The USP26 gene may be of importance in male reproduction. Mutations in this gene may be associated with male infertility, and may negatively affect testicular function...
  65. doi request reprint Identification of spermatogenesis with multiphoton microscopy: an evaluation in a rodent model
    Ranjith Ramasamy
    Department of Urology, Weill Cornell Medical College, New York, New York, USA
    J Urol 186:2487-92. 2011
    ..Multiphoton microscopy enables label-free immediate visualization of many biological processes in living tissue at subcellular resolution...
  66. doi request reprint Standardization and documentation of varicocele evaluation
    Peter Stahl
    Weill Cornell Medical College, New York, New York, USA
    Curr Opin Urol 21:500-5. 2011
    ..Herein we review the clinical evaluation of varicocele. The prognostic relevance of varicocele grade and venous diameter measured with ultrasound is explored...
  67. doi request reprint An ultrasonically actuated silicon-microprobe-based testicular tubule assay
    Abhishek Ramkumar
    SonicMEMS Laboratory, School of Electrical and Computer Engineering, and the Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    IEEE Trans Biomed Eng 56:2666-74. 2009
    ..This information is important in MP-TESE to distinguish tubules with and without fertile sperm, potentially eliminating the large incision currently required for optical spermatazoa localization...
  68. doi request reprint Duration of microdissection testicular sperm extraction procedures: relationship to sperm retrieval success
    Ranjith Ramasamy
    Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA
    J Urol 185:1394-7. 2011
    ..We evaluated the operative time of microdissection testicular sperm extraction in successful and failed procedures to identify the chance of sperm retrieval during longer microsurgical procedures...
  69. doi request reprint Value of serum antisperm antibodies in diagnosing obstructive azoospermia
    Richard Lee
    The Center for Male Reproductive Medicine and Microsurgery, Department of Urology and Cornell Institute for Reproductive Medicine, New York, New York, USA
    J Urol 181:264-9. 2009
    ..The diagnostic performance of serum antisperm antibody was evaluated as a test for obstructive azoospermia...
  70. doi request reprint Sex disparities in cancer mortality: the risks of being a man in the United States
    Bobby B Najari
    Department of Urology, Weill Cornell Medical College of Cornell University, New York, New York, USA
    J Urol 189:1470-4. 2013
    ..In the United States more men are diagnosed with cancer than women. We quantified the differential mortality rates of nonsex specific cancers between the sexes and compared cancer stage distributions...
  71. ncbi request reprint The diagnosis and treatment of the azoospermic patient in the age of intracytoplasmic sperm injection
    Carin V Hopps
    Department of Urology, Cornell Institute for Reproductive Medicine, The New York Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    Urol Clin North Am 29:895-911. 2002
    ..Just as the possibility of ICSI was thought to be inconceivable several decades ago, the advent of future sentinel discoveries will present the possibility for realization of achievements that now seem incredulous...
  72. ncbi request reprint Men with nonobstructive azoospermia have Leydig cell hypertrophy but not hyperplasia
    Jennifer A Tash
    Department of Urology, New York Presbyterian Hospital Wiell Medical College of Cornell University, New York, NY, USA
    J Urol 168:1068-70. 2002
    ..We determined whether testicular histology in men with spermatogenic failure due to nonobstructive azoospermia shows true Leydig cell hyperplasia...
  73. ncbi request reprint Incidental testicular lesions found during infertility evaluation are usually benign and may be managed conservatively
    John B Eifler
    Brady Urology Foundation, Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York 10021, USA
    J Urol 180:261-4; discussion 265. 2008
    ..We retrospectively reviewed the findings at 1 center in men with ultrasonographically detected testicular lesions found during evaluation of severe male infertility...
  74. ncbi request reprint Chromosome analysis of epididymal and testicular sperm in azoospermic patients undergoing ICSI
    Gianpiero D Palermo
    The Center for Reproductive Medicine and Infertility, Department of Urology, The New York Presbyterian Weill Medical College of Cornell University, 505 East 70th Street, New York, NY 10021, USA
    Hum Reprod 17:570-5. 2002
    ..We quantified the incidence of chromosomal abnormalities in epididymal and testicular sperm retrieved from azoospermic patients undergoing ICSI...
  75. doi request reprint Successful repeat microdissection testicular sperm extraction in men with nonobstructive azoospermia
    Ranjith Ramasamy
    Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10065, USA
    J Urol 185:1027-31. 2011
    ..We studied factors that can predict successful repeat microdissection testicular sperm extraction in men with nonobstructive azoospermia...
  76. ncbi request reprint Antidepressant-associated changes in semen parameters
    Cigdem Tanrikut
    James Buchanan Brady Foundation, Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Urology 69:185.e5-7. 2007
    ..Additional assessment of the potential impact of antidepressant medications on male fertility is warranted...
  77. ncbi request reprint Visualization of GM1 with cholera toxin B in live epididymal versus ejaculated bull, mouse, and human spermatozoa
    Danielle E Buttke
    The James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 74:889-95. 2006
    ..These observations reconcile inconsistencies reported for the localization of GM1 in sperm of different species, and provide evidence for the segregation of GM1 to a stable subdomain in the plasma membrane overlying the acrosome...
  78. ncbi request reprint Histologic effects of testicular sperm extraction on the testicle in men with nonobstructive azoospermia
    J A Tash
    James Buchanan Brady Urology Foundation, Department of Urology, The New York Presbyterian Hospital-Weill Medical College of Cornell University, The Population Council, Center for Biomedical Research, New York, New York, USA
    Urology 57:334-7. 2001
    ..This reflects a potentially adverse local effect of TESE on the testis that may have important clinical consequences for men with nonobstructive azoospermia...
  79. ncbi request reprint Detection of sperm in men with Y chromosome microdeletions of the AZFa, AZFb and AZFc regions
    C V Hopps
    Center for Male Reproductive Medicine and Microsurgery, Cornell Institute for Reproductive Medicine and Department of Urology, New York Weill Cornell Medical Center, 525 East 68th Street, Starr 900, New York, NY 10021, USA
    Hum Reprod 18:1660-5. 2003
    ..Y chromosome microdeletions are associated with severe male factor infertility. In this study, the success rate of testicular sperm retrieval was determined for men with deletions of AZF regions a, b or c...
  80. ncbi request reprint Inflammatory conditions of the male excurrent ductal system. Part II
    Peter T K Chan
    James Buchanan Brady Foundation, Department of Urology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY, USA
    J Androl 23:461-9. 2002
  81. ncbi request reprint Effect of hormonal manipulation on mRNA expression of antioxidant enzymes in the rat testis
    Armand Zini
    James Buchanan Brady Foundation, Department of Urology, New York Hospital Cornell Medical Center and Population Council, Center for Biomedical Research, New York, New York, USA
    J Urol 169:767-71. 2003
    ..We evaluated the effects of ethane dimethane sulfonate, an agent that selectively destroys Leydig cells, and hypophysectomy on CuZn superoxide dismutase, catalase and glutathione peroxidase mRNA levels in the testis...
  82. ncbi request reprint Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells
    Junyang Gong
    Weill Medical College of Cornell University, Department of Urology, Room E 300, Box 23, 1300 York Avenue, New York, New York 10021, USA
    Endocrinology 148:4489-99. 2007
    ..Together, our results demonstrate that CgA can increase PC cell survival through Akt-mediated survivin up-regulation...
  83. ncbi request reprint Testicular sperm extraction combined with intracytoplasmic sperm injection in the treatment of men with persistent azoospermia postchemotherapy
    P T Chan
    James Buchanan Brady Foundation, Department of Urology and Cornell Institute for Reproductive Medicine, New York, New York, USA
    Cancer 92:1632-7. 2001
    ..Despite prolonged nonobstructive azoospermia after undergoing chemotherapy, men no longer should be considered sterile in the era of advanced assisted reproductive techniques...
  84. ncbi request reprint Aromatase inhibitors for male infertility
    Jay D Raman
    Department of Urology, James Buchanan Brady Urology Foundation, Center for Male Reproductive Medicine and Microsurgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
    J Urol 167:624-9. 2002
    ..We evaluated the effect of anastrozole, a more selective aromatase inhibitor, on the hormonal and semen profiles of infertile men with abnormal baseline testosterone-to-estradiol ratios...
  85. ncbi request reprint Nonbacterial pyospermia: a consequence of clomiphene citrate therapy
    G J Matthews
    James Buchanan Brady Foundation, Department of Urology, New York Hospital Cornell University Medical Center, New York, USA
    Int J Fertil Menopausal Stud 40:187-91. 1995
    ..Men over the age of 35 are statistically more likely to develop pyospermia with this therapy. Our results suggest that clomiphene citrate-associated pyospermia has a negative effect on male fertility...
  86. ncbi request reprint A decision analysis of treatments for obstructive azoospermia
    R Lee
    James Buchanan Brady Foundation, Department of Urology, Weill Medical College of Cornell University, 525 E 68th St, Starr 900, New York, NY 10021, USA
    Hum Reprod 23:2043-9. 2008
    ..We examined the cost-effectiveness of these treatments...
  87. ncbi request reprint Evidence of a treatable endocrinopathy in infertile men
    C P Pavlovich
    James Buchanan Brady Urology Foundation and Cornell Institute for Reproductive Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
    J Urol 165:837-41. 2001
    ..We establish whether a subset of infertile men have decreased serum testosterone-to-estradiol ratios and whether this condition can be corrected with an oral aromatase inhibitor...
  88. ncbi request reprint Recombination in men with Klinefelter syndrome
    Joanna Gonsalves
    Department of Physiology, Programs in Human Genetics, Cancer Genetics, and Developmental and Stem Cell Biology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0556, USA
    Reproduction 130:223-9. 2005
    ....
  89. ncbi request reprint Defective recombination in infertile men
    Joanna Gonsalves
    Center for Reproductive Sciences, University of Califonia at San Francisco, San Francisco, CA 94143, USA
    Hum Mol Genet 13:2875-83. 2004
    ....
  90. ncbi request reprint Fresh testicular sperm from men with nonobstructive azoospermia works best for ICSI
    Peter N Schlegel
    Urology 64:1069-71. 2004
  91. doi request reprint "Limited" prostate cancer on biopsy: a note of caution
    Peter N Schlegel
    Cancer 112:966-7. 2008
  92. ncbi request reprint Best practice policies for male infertility
    Ira D Sharlip
    Pan Pacific Urology, University of California, California, San Francisco, USA
    Fertil Steril 77:873-82. 2002
  93. ncbi request reprint Do sperm DNA integrity tests predict pregnancy with in vitro fertilization?
    John A Collins
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Fertil Steril 89:823-31. 2008
    ..To evaluate the predictive value of sperm DNA integrity tests for pregnancy from in vitro fertilization treatment...
  94. ncbi request reprint Screening the SPO11 and EIF5A2 genes in a population of infertile men
    Greg L Christensen
    University of Utah School of Medicine, Salt Lake City, Utah, USA
    Fertil Steril 84:758-60. 2005
    ..Populations of infertile and fertile men were screened for mutations in SPO11 and EIF5A2, two infertility candidate genes. Three heterozygous amino acid changes that might contribute to infertility were identified in the infertile group...
  95. ncbi request reprint Best practice policies for male infertility
    Jonathan P Jarow
    J Urol 167:2138-44. 2002