Peter N Schlegel
Affiliation: Cornell University
Schlegel P. Evaluation of male infertility. Minerva Ginecol. 2009;61:261-83 pubmed
..The first step in evaluation is a thorough history and physical examination with initiation of basic laboratory studies...
Halpern J, Schlegel P. Should A Couple with Failed In Vitro Fertilization/Intracytoplasmic Sperm Injection and Increased Sperm DNA Fragmentation Use Testicular Sperm for the Next Cycle?. Eur Urol Focus. 2018;4:299-300 pubmed publisher
..The first step is to reduce sperm DNA fragmentation in ejaculated sperm through lifestyle modifications, antioxidant therapy, or treatment of underlying abnormalities such as infection or varicocele. ..
Hayden R, Flannigan R, Schlegel P. The Role of Lifestyle in Male Infertility: Diet, Physical Activity, and Body Habitus. Curr Urol Rep. 2018;19:56 pubmed publisher
..These observations provide actionable data for the reproductive urologist to better counsel men presenting with infertility. ..
Berookhim B, Palermo G, Zaninovic N, Rosenwaks Z, Schlegel P. Microdissection testicular sperm extraction in men with Sertoli cell-only testicular histology. Fertil Steril. 2014;102:1282-6 pubmed publisher
..Given this finding, the utility of testicular biopsy before microTESE is further questioned. ..
Bernie A, Shah K, Halpern J, Scovell J, Ramasamy R, Robinson B, et al
. Outcomes of microdissection testicular sperm extraction in men with nonobstructive azoospermia due to maturation arrest. Fertil Steril. 2015;104:569-73.e1 pubmed publisher
..Sperm were successfully identified in up to one half of the men with MA after micro-TESE. Among men with MA, late MA seems to be the best predictor of successful sperm retrieval with micro-TESE. ..
Bernie A, Mata D, Ramasamy R, Schlegel P. Comparison of microdissection testicular sperm extraction, conventional testicular sperm extraction, and testicular sperm aspiration for nonobstructive azoospermia: a systematic review and meta-analysis. Fertil Steril. 2015;104:1099-103.e1-3 pubmed publisher
..Sperm retrieval was higher for micro-TESE compared with cTESE and for cTESE compared with TESA. Standardization of reported outcomes as well as combining all available SR data would help to further elucidate the SRs of these procedures. ..
Schlegel P. Causes of azoospermia and their management. Reprod Fertil Dev. 2004;16:561-72 pubmed
..Once sperm are found, pregnancy rates of 20-50% may be obtained at different centres with in vitro fertilisation and intracytoplasmic sperm injection...