NICHOLAS D contact SCHIFF

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Measurements and models of cerebral function in the severely injured brain
    Nicholas D Schiff
    Laboratory of Cognitive Neuromodulation, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurotrauma 23:1436-49. 2006
  2. ncbi request reprint Disorders of consciousness
    Nicholas D Schiff
    Mayo Clin Proc 82:250-1; author reply 251. 2007
  3. ncbi request reprint Developing prosthetics to treat cognitive disabilities resulting from acquired brain injuries
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Medical College, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Neurol Res 24:116-24. 2002
  4. doi request reprint Central thalamic contributions to arousal regulation and neurological disorders of consciousness
    Nicholas D Schiff
    Laboratory of Cognitive Neuromodulation, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Ann N Y Acad Sci 1129:105-18. 2008
  5. doi request reprint Central thalamic deep brain stimulation for support of forebrain arousal regulation in the minimally conscious state
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA Electronic address
    Handb Clin Neurol 116:295-306. 2013
  6. pmc Gating of attentional effort through the central thalamus
    N D Schiff
    Department of Neurology and Neuroscience, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurophysiol 109:1152-63. 2013
  7. doi request reprint Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, USA
    Ann N Y Acad Sci 1265:56-68. 2012
  8. doi request reprint Pattern classification of volitional functional magnetic resonance imaging responses in patients with severe brain injury
    Jonathan C Bardin
    Department of Neuroscience, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA
    Arch Neurol 69:176-81. 2012
  9. ncbi request reprint Deep brain stimulation and cognition: moving from animal to patient
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    Curr Opin Neurol 20:638-42. 2007
  10. doi request reprint Central thalamic deep-brain stimulation in the severely injured brain: rationale and proposed mechanisms of action
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065, USA
    Ann N Y Acad Sci 1157:101-16. 2009

Research Grants

  1. Mechanisms of recovery following severe brain injury
    Nicholas D Schiff; Fiscal Year: 2010
  2. MULTIDISCIPLINARY ASSESSMENT OF SEVERE BRAIN INJURY
    Nicholas Schiff; Fiscal Year: 2003
  3. INTRALAMINAR THALAMIC INFLUENCES ON VISUAL AWARENESS
    Nicholas Schiff; Fiscal Year: 2004
  4. Mechanisms of recovery following severe brain injury
    Nicholas Schiff; Fiscal Year: 2009
  5. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    NICHOLAS D contact SCHIFF; Fiscal Year: 2010

Detail Information

Publications37

  1. ncbi request reprint Measurements and models of cerebral function in the severely injured brain
    Nicholas D Schiff
    Laboratory of Cognitive Neuromodulation, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurotrauma 23:1436-49. 2006
    ..These findings support developing systematic characterizations of the severely injured brain and suggest that some patients may benefit from improved diagnostic assessments...
  2. ncbi request reprint Disorders of consciousness
    Nicholas D Schiff
    Mayo Clin Proc 82:250-1; author reply 251. 2007
  3. ncbi request reprint Developing prosthetics to treat cognitive disabilities resulting from acquired brain injuries
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Medical College, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Neurol Res 24:116-24. 2002
    ..We discuss the possibilities of linking neuromodulation techniques to underlying neuronal mechanisms underpinning cognitive rehabilitation maneuvers. Ethical considerations surrounding the development of these strategies are reviewed...
  4. doi request reprint Central thalamic contributions to arousal regulation and neurological disorders of consciousness
    Nicholas D Schiff
    Laboratory of Cognitive Neuromodulation, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Ann N Y Acad Sci 1129:105-18. 2008
    ..A model accounting for present therapeutic strategies is proposed...
  5. doi request reprint Central thalamic deep brain stimulation for support of forebrain arousal regulation in the minimally conscious state
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA Electronic address
    Handb Clin Neurol 116:295-306. 2013
    ....
  6. pmc Gating of attentional effort through the central thalamus
    N D Schiff
    Department of Neurology and Neuroscience, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurophysiol 109:1152-63. 2013
    ..Such ongoing fluctuations of central thalamic activity likely reflect a mix of influences, including variations in moment-to-moment levels of motivation, arousal, and availability of cognitive resources...
  7. doi request reprint Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, USA
    Ann N Y Acad Sci 1265:56-68. 2012
    ....
  8. doi request reprint Pattern classification of volitional functional magnetic resonance imaging responses in patients with severe brain injury
    Jonathan C Bardin
    Department of Neuroscience, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA
    Arch Neurol 69:176-81. 2012
    ..Recent neuroimaging investigations have explored the use of mental imagery tasks as proxies for an overt motor response, in which patients are asked to imagine performing a task, such as "Imagine yourself swimming."..
  9. ncbi request reprint Deep brain stimulation and cognition: moving from animal to patient
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    Curr Opin Neurol 20:638-42. 2007
    ..This brief review places a small number of recent studies into a broader historical context and identifies important challenges for further development of this area of research...
  10. doi request reprint Central thalamic deep-brain stimulation in the severely injured brain: rationale and proposed mechanisms of action
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065, USA
    Ann N Y Acad Sci 1157:101-16. 2009
    ....
  11. pmc Recovery of consciousness after brain injury: a mesocircuit hypothesis
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA
    Trends Neurosci 33:1-9. 2010
    ..Measuring evolving changes in underlying brain function and dynamics post-injury and post-treatment frames future investigative work...
  12. doi request reprint Recovery of consciousness after severe brain injury: the role of arousal regulation mechanisms and some speculation on the heart-brain interface
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cleve Clin J Med 77:S27-33. 2010
    ..The article concludes with some observations on the heart-brain interface and future research directions in the context of recovery from severe brain injury...
  13. ncbi request reprint Bringing neuroimaging tools closer to diagnostic use in the severely injured brain
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue Room F610, New York, New York, 10021, USA
    Brain 130:2482-3. 2007
  14. ncbi request reprint Multimodal neuroimaging approaches to disorders of consciousness
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Head Trauma Rehabil 21:388-97. 2006
    ..Although limited in number, available studies already provide important insights into underlying brain mechanisms that may help guide development of such assessment strategies...
  15. ncbi request reprint Modeling the minimally conscious state: measurements of brain function and therapeutic possibilities
    Nicholas D Schiff
    Laboratory of Cognitive Neuromodulation, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue Room F610, NY 10021, USA
    Prog Brain Res 150:473-93. 2005
    ..Several pathophysiological mechanisms that might limit further recovery in MCS patients are considered. Implications for future research directions and possible therapeutic strategies are reviewed...
  16. ncbi request reprint Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Medicine and Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Brain 125:1210-34. 2002
    ..The variations in cerebral metabolism in chronic PVS patients indicate that some cerebral regions can retain partial function in catastrophically injured brains...
  17. pmc Attentional modulation of adaptation in V4
    ANDREW E HUDSON
    Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10021, USA
    Eur J Neurosci 30:151-71. 2009
    ..The phase advance generated by attention of the adapted responses suggests that the attentional gain control operates in some ways like a contrast gain control utilizing a neural measure of contrast to influence dynamics...
  18. ncbi request reprint Conflicts of interest in deep brain stimulation research and the ethics of transparency
    Joseph J Fins
    Division of Medical Ethics, Weill Medical College of Cornell University, Ithaca, NewYork, USA
    J Clin Ethics 21:125-32. 2010
    ..We describe ethical challenges faced in clinical research involving medical devices and offer several cautionary notes about its funding and the interplay of market forces and scientific inquiry and suggest some reforms...
  19. doi request reprint Dynamics of coupled thalamocortical modules
    Jonathan D Drover
    Weill Cornell Medical College of Cornell University, New York, NY, USA
    J Comput Neurosci 28:605-16. 2010
    ..These considerations suggest a role for the reticular nucleus in modulating long distance cortical communication...
  20. doi request reprint MRI of neuronal network structure, function, and plasticity
    Henning U Voss
    Citigroup Biomedical Imaging Center, Weill Cornell Medical College, New York, NY, USA
    Prog Brain Res 175:483-96. 2009
    ..To better understand to which degree resting state patterns reflect neuronal network function, we are comparing network patterns of normal subjects with those having severe brain lesions in a small pilot study...
  21. ncbi request reprint Neurophysiological correlates of persistent vegetative and minimally conscious states
    Erik J Kobylarz
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Neuropsychol Rehabil 15:323-32. 2005
    ..In this review we will assess the various neurophysiological studies currently at our disposal to evaluate and follow the clinical course of patients who have suffered severe brain injuries...
  22. doi request reprint Modulation of arousal regulation with central thalamic deep brain stimulation
    Sudhin A Shah
    Physiology, Biophysics and Systems Biology Department, Weill Cornell Graduate School of Biomedical Sciences, NY, NY 10021, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3314-7. 2009
    ..Results of this preliminary study revealed that CT/DBS can lead to an improvement, a decrement, a mixed or have no effect on behavior...
  23. pmc Possible axonal regrowth in late recovery from the minimally conscious state
    Henning U Voss
    Citigroup Biomedical Imaging Center and Department of Radiology, Weill Medical College of Cornell University, and NeuroOncology Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 116:2005-11. 2006
    ..We propose that axonal regrowth may underlie these findings and provide a biological mechanism for late recovery. Our results are discussed in the context of recent experimental studies that support this inference...
  24. ncbi request reprint Late recovery from the minimally conscious state: ethical and policy implications
    Joseph J Fins
    Division of Medical Ethics, New York Presbyterian Weill Cornell Medical Center, 435 E 70 St, Suite 4 J, New York, NY 10021, USA
    Neurology 68:304-7. 2007
    ..Areas of initial focus would be to define the epidemiology of the minimally conscious state, elucidate mechanisms of recovery, and identify clinically useful diagnostic and prognostic markers that will aid decision making at the bedside...
  25. ncbi request reprint Analysis of perisaccadic field potentials in the occipitotemporal pathway during active vision
    Keith P Purpura
    Department of Neurology and Neuroscience, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    J Neurophysiol 90:3455-78. 2003
    ..The timing and frequency characteristics of these signals suggest that the nature of this perisaccadic modulation varies across the cortex...
  26. doi request reprint Temporal patterning of pulses during deep brain stimulation affects central nervous system arousal
    Amy Wells Quinkert
    Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, New York, NY 10065, United States
    Behav Brain Res 214:377-85. 2010
    ..Our data comprise the first demonstration that the temporal pattern of DBS can be used to elevate its effectiveness, and also point the way toward the use of nonlinear dynamics in the exploration of means to optimize DBS...
  27. pmc Cognitive enhancement with central thalamic electrical stimulation
    Prasad Shirvalkar
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:17007-12. 2006
    ..Taken together, these studies indicate that electrical stimulation of the central thalamus may enhance cognitive performance through neocortical and hippocampal neuronal activation and specific regulation of gene expression...
  28. pmc A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale
    Jason W Bohland
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Comput Biol 5:e1000334. 2009
    ..We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget...
  29. ncbi request reprint Functional imaging of severely brain-injured patients: progress, challenges, and limitations
    Erik J Kobylarz
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Arch Neurol 61:1357-60. 2004
  30. pmc Characterization of trial-to-trial fluctuations in local field potentials recorded in cerebral cortex of awake behaving macaque
    David L Menzer
    Department of Neurology and Neuroscience, Weill Medical College and Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    J Neurosci Methods 186:250-61. 2010
    ..We compare our results with evidence for slow fluctuations in human functional imaging studies and other electrophysiologic studies in nonhuman primates...
  31. pmc Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury
    Jonathan C Bardin
    Department of Neuroscience, Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, NY 10021, USA
    Brain 134:769-82. 2011
    ....
  32. ncbi request reprint Shades of gray: new insights into the vegetative state
    Joseph J Fins
    Hastings Cent Rep 36:8. 2006
  33. pmc How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?
    Steven Laureys
    Cyclotron Research Center and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 19:520-7. 2006
    ..We discuss the problems of evidence-based neurorehabilitation in disorders of consciousness, and recent functional neuroimaging data obtained in the vegetative state and minimally conscious state...
  34. ncbi request reprint The afterlife of Terri Schiavo
    Joseph J Fins
    Hastings Cent Rep 35:8. 2005
  35. ncbi request reprint Another "Awakenings"
    Nicholas D Schiff
    Ann Neurol 62:5-7. 2007
  36. ncbi request reprint Brain function in coma, vegetative state, and related disorders
    Steven Laureys
    Belgian National Funds for Scientific Research Cyclotron Research Center and Department of Neurology, University of Liege, Belgium
    Lancet Neurol 3:537-46. 2004
    ..Neuroimaging techniques remain important tools for clinical research that will extend our understanding of the underlying mechanisms of these disorders...

Research Grants7

  1. Mechanisms of recovery following severe brain injury
    Nicholas D Schiff; Fiscal Year: 2010
    ..Without such studies, these patients will continue to remain categorically excluded from advances in medical diagnostics and therapeutics. ..
  2. MULTIDISCIPLINARY ASSESSMENT OF SEVERE BRAIN INJURY
    Nicholas Schiff; Fiscal Year: 2003
    ..The long-range goal of the studies proposed here is to provide a foundation for rational therapies for chronic cognitive disabilities following complex brain injuries. ..
  3. INTRALAMINAR THALAMIC INFLUENCES ON VISUAL AWARENESS
    Nicholas Schiff; Fiscal Year: 2004
    ..While these are long-range goals, and the studies proposed here do not represent direct investigations of these possibilities, completion of these experiments is necessary and logical step toward these goals. ..
  4. Mechanisms of recovery following severe brain injury
    Nicholas Schiff; Fiscal Year: 2009
    ..Without such studies, these patients will continue to remain categorically excluded from advances in medical diagnostics and therapeutics. ..
  5. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    NICHOLAS D contact SCHIFF; Fiscal Year: 2010
    ....