John J Savarese

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium
    John J Savarese
    Department of Anesthesiology, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA
    Anesthesiology 100:835-45. 2004
  2. doi request reprint Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011
    John J Savarese
    Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Anesthesiology 113:58-73. 2010
  3. doi request reprint Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs
    Paul M Heerdt
    Departments of Anesthesiology of Pharmacology, Weill Medical College of Cornell University, New York, New York, USA
    Anesthesiology 112:910-6. 2010
  4. ncbi request reprint Clinical pharmacology of GW280430A in humans
    Matthew R Belmont
    Department of Anesthesiology, New York Presbyterian Weill Medical Cornell Medical Center, New York, New York 10021, USA
    Anesthesiology 100:768-73. 2004
  5. doi request reprint Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology
    Hiroshi Sunaga
    Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York, USA
    Anesthesiology 112:900-9. 2010
  6. pmc Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs
    Hiroshi Sunaga
    Department of Anesthesiology, Weill Cornell Medical College, New York, New York, USA
    Anesthesiology 112:892-9. 2010
  7. ncbi request reprint Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium
    Takahiro Suzuki
    Department of Anesthesiology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, USA
    Can J Anaesth 50:879-85. 2003
  8. ncbi request reprint Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs
    Paul M Heerdt
    Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Anesthesiology 100:846-51. 2004
  9. doi request reprint Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles
    Paul M Heerdt
    Department of Anesthesiology, Weill Medical College of Cornell University, USA
    J Pharmacol Toxicol Methods 64:111-8. 2011
  10. ncbi request reprint Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys
    Eric E Boros
    GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA
    J Med Chem 46:2502-15. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium
    John J Savarese
    Department of Anesthesiology, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, New York 10021, USA
    Anesthesiology 100:835-45. 2004
    ..The neuromuscular, cardiovascular, and autonomic pharmacology of GW280430A is compared herein with that of mivacurium...
  2. doi request reprint Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011
    John J Savarese
    Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Anesthesiology 113:58-73. 2010
    ..Two new analogues of gantacurium (CW 002 and CW 011) have been synthesized to undergo slower L-cysteine adduction, yielding intermediate duration. L-cysteine adduction to and antagonism of these novel agents is further defined herein...
  3. doi request reprint Pharmacodynamics and cardiopulmonary side effects of CW002, a cysteine-reversible neuromuscular blocking drug in dogs
    Paul M Heerdt
    Departments of Anesthesiology of Pharmacology, Weill Medical College of Cornell University, New York, New York, USA
    Anesthesiology 112:910-6. 2010
    ..CW002 is a novel neuromuscular blocking drug with a duration dependent on the rate of cysteine adduction to the molecule. The current study characterized the pharmacodynamics and cardiopulmonary side effects of CW002 in dogs...
  4. ncbi request reprint Clinical pharmacology of GW280430A in humans
    Matthew R Belmont
    Department of Anesthesiology, New York Presbyterian Weill Medical Cornell Medical Center, New York, New York 10021, USA
    Anesthesiology 100:768-73. 2004
    ..GW280430A showed a promising pharmacodynamic profile in preclinical work and a wide margin of safety and so was selected for study in humans...
  5. doi request reprint Cysteine reversal of the novel neuromuscular blocking drug CW002 in dogs: pharmacodynamics, acute cardiovascular effects, and preliminary toxicology
    Hiroshi Sunaga
    Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York, USA
    Anesthesiology 112:900-9. 2010
    ..This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs...
  6. pmc Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs
    Hiroshi Sunaga
    Department of Anesthesiology, Weill Cornell Medical College, New York, New York, USA
    Anesthesiology 112:892-9. 2010
    ..We questioned whether two new members of a bisquaternary nondepolarizing muscle relaxant family, gantacurium and CW002, demonstrated detrimental effects of airway muscarinic receptors using an in vivo model in guinea pig airways...
  7. ncbi request reprint Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium
    Takahiro Suzuki
    Department of Anesthesiology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, USA
    Can J Anaesth 50:879-85. 2003
    ..To examine the efficacy of antagonism of rapacuronium-, mivacurium-, rocuronium- and cisatracurium-induced neuromuscular block at the laryngeal adductors (LA)...
  8. ncbi request reprint Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs
    Paul M Heerdt
    Department of Anesthesiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Anesthesiology 100:846-51. 2004
    ..This investigation determined the cardiopulmonary side effects of a novel nondepolarizing neuromuscular blocking drug with an ultrashort duration of action in anesthetized male beagles...
  9. doi request reprint Noninvasive cardiac output monitoring with bioreactance as an alternative to invasive instrumentation for preclinical drug evaluation in beagles
    Paul M Heerdt
    Department of Anesthesiology, Weill Medical College of Cornell University, USA
    J Pharmacol Toxicol Methods 64:111-8. 2011
    ..The present study was designed to test the hypothesis that NICOM flow measurements can accurately measure CO and detect acute drug-induced changes in aortic blood flow (AoQ)≥10% in beagles...
  10. ncbi request reprint Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys
    Eric E Boros
    GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA
    J Med Chem 46:2502-15. 2003
    ..The NMB properties of 24a in rhesus monkeys led to its clinical evaluation as a possible alternative to succinylcholine...