Anthony Sauve

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells
    Tianle Yang
    Department of Pharmacology, Weill Medical College of Cornell University, Manhattan, NY 10021, USA
    J Med Chem 50:6458-61. 2007
  2. pmc Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase
    Jarrod B French
    Department of Pharmacology, Weill Cornell College of Medicine, 1300 York Avenue LC216, New York, New York 10065, USA
    Biochemistry 47:10227-39. 2008
  3. doi request reprint Sirtuins: NAD(+)-dependent deacetylase mechanism and regulation
    Anthony A Sauve
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, United States
    Curr Opin Chem Biol 16:535-43. 2012
  4. doi request reprint NAD+ and vitamin B3: from metabolism to therapies
    Anthony A Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Pharmacol Exp Ther 324:883-93. 2008
  5. ncbi request reprint The biochemistry of sirtuins
    Anthony A Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Annu Rev Biochem 75:435-65. 2006
  6. pmc Sirtuin chemical mechanisms
    Anthony A Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Biochim Biophys Acta 1804:1591-603. 2010
  7. ncbi request reprint Pharmaceutical strategies for activating sirtuins
    Anthony A Sauve
    Weill Medical College of Cornell University, New York, NY 10065, USA
    Curr Pharm Des 15:45-56. 2009
  8. doi request reprint Vitamin B3, the nicotinamide adenine dinucleotides and aging
    Ping Xu
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue LC216, New York, NY 10065, USA
    Mech Ageing Dev 131:287-98. 2010
  9. pmc Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches
    Yana Cen
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
    J Am Chem Soc 132:12286-98. 2010
  10. ncbi request reprint Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006

Research Grants

  1. Sir2 regulation and chemical modulation
    Anthony Sauve; Fiscal Year: 2007
  2. Sir2 regulation and chemical modulation
    Anthony A Sauve; Fiscal Year: 2010

Collaborators

  • Vern L Schramm
  • Jun Wang
  • C Wolberger
  • David A Sinclair
  • Vilhelm A Bohr
  • CHARLES M BRENNER
  • Michael W McBurney
  • Tianle Yang
  • Yana Cen
  • Maofu Fu
  • Ping Xu
  • Y Cen
  • Marcella Fulco
  • Jarrod B French
  • Hongying Yang
  • Wolfram Tempel
  • Weiping Qin
  • Andrew A Quong
  • Wei Gu
  • Fang Wang
  • Richard G Pestell
  • Toula Bouras
  • Jessica N Falco
  • D Y Youn
  • Dou Yeon Youn
  • Vittorio Sartorelli
  • Eric P Hoffman
  • Po Zhao
  • Joseph A Baur
  • Rafael De Cabo
  • Marzena Wojcik
  • Hee Won Park
  • Katrina L Bogan
  • Peter Belenky
  • Dudley W Lamming
  • Wael M Rabeh
  • Anthony Rosenzweig
  • Evelyn Perez
  • Juan J Carmona
  • Takashi Matsui
  • Lyudmila Nedyalkova
  • Nadja C Souza-Pinto
  • Heather F Seidle
  • Noel Yan Ki Chan
  • Michael J Powell
  • Joseph T Rodgers
  • Zhong Zhao
  • Xuanmao Jiao
  • Giulio M Pasinetti
  • Xiaofang Wu
  • Meenakshisundaram Thiyagarajan
  • Donal MacGrogan
  • Junichi Sadoshima
  • Maria Laura Avantaggiati
  • Haiteng Deng
  • Lap Ho
  • Richard Pestell
  • Steven Pedrini
  • Timothy G Pestell
  • Wei Zhao
  • Chenguang Wang
  • Manran Liu
  • Linghong Chen
  • Pere Puigserver
  • Xueping Zhang
  • Nagarajan Pattabiraman
  • Samuel Gandy
  • Neil D Perkins
  • Ronald T Hay

Detail Information

Publications24

  1. ncbi request reprint Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells
    Tianle Yang
    Department of Pharmacology, Weill Medical College of Cornell University, Manhattan, NY 10021, USA
    J Med Chem 50:6458-61. 2007
    ..2-2.7-fold in several mammalian cell lines. These findings establish bioavailability and potent effects of these nucleosides in stimulating the increase of NAD+ concentrations in mammalian cells...
  2. pmc Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase
    Jarrod B French
    Department of Pharmacology, Weill Cornell College of Medicine, 1300 York Avenue LC216, New York, New York 10065, USA
    Biochemistry 47:10227-39. 2008
    ..These findings also illustrate the potential utility of nicotinamide as a probe for mechanisms of sirtuin-catalyzed ADP-ribosyl transfer...
  3. doi request reprint Sirtuins: NAD(+)-dependent deacetylase mechanism and regulation
    Anthony A Sauve
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, United States
    Curr Opin Chem Biol 16:535-43. 2012
    ..Novel new directions include chemical probes to study sirtuins in cells, and the discovery of novel post-translational modifications besides acetyl, such as succinyl and malonyl, that are regulated by sirtuins...
  4. doi request reprint NAD+ and vitamin B3: from metabolism to therapies
    Anthony A Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Pharmacol Exp Ther 324:883-93. 2008
    ....
  5. ncbi request reprint The biochemistry of sirtuins
    Anthony A Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Annu Rev Biochem 75:435-65. 2006
    ..The biological, chemical, and structural characteristics of these unusual enzymes are discussed in this review...
  6. pmc Sirtuin chemical mechanisms
    Anthony A Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Biochim Biophys Acta 1804:1591-603. 2010
    ..This review broadly surveys the chemistries and chemical mechanisms of these enzymes...
  7. ncbi request reprint Pharmaceutical strategies for activating sirtuins
    Anthony A Sauve
    Weill Medical College of Cornell University, New York, NY 10065, USA
    Curr Pharm Des 15:45-56. 2009
    ..Efficacies and shortcomings of the various approaches are also discussed...
  8. doi request reprint Vitamin B3, the nicotinamide adenine dinucleotides and aging
    Ping Xu
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue LC216, New York, NY 10065, USA
    Mech Ageing Dev 131:287-98. 2010
    ..We consider how metabolism, specifically connected with Vitamin B3 and the nicotinamide adenine dinucleotides and their derivatives, occupies a central place in the aging processes of mammals...
  9. pmc Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches
    Yana Cen
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
    J Am Chem Soc 132:12286-98. 2010
    ..A concerted yet highly asynchronous substitution mechanism forms the ADPR-peptidylimidate intermediate of the sirtuin deacetylation reaction...
  10. ncbi request reprint Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
  11. pmc NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity
    Tianle Yang
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY, USA
    AAPS J 8:E632-43. 2006
    ....
  12. ncbi request reprint Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications
    Y Cen
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Curr Med Chem 18:1919-35. 2011
    ..Finally, this review updates research on pharmacologic sirtuin activation and allostery on sirtuins and considers new developments for detection and isolation of sirtuins in complex mixtures...
  13. pmc Mechanism-based affinity capture of sirtuins
    Yana Cen
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Org Biomol Chem 9:987-93. 2011
    ..Finally, we demonstrate the ability to simultaneously detect multiple sirtuin isoforms in reaction mixtures with this methodology, establishing proof of concept tools for chemical studies of sirtuins in complex biological samples...
  14. pmc Diastereocontrolled electrophilic fluorinations of 2-deoxyribonolactone: syntheses of all corresponding 2-deoxy-2-fluorolactones and 2'-deoxy-2'-fluoro-NAD+s
    Yana Cen
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
    J Org Chem 74:5779-89. 2009
    ..The fluorinated NAD(+)s are anticipated to be useful for studying a variety of cellular metabolic and signaling processes...
  15. ncbi request reprint SIRT1 and endocrine signaling
    Tianle Yang
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, LC 216, New York, NY 10021, USA
    Trends Endocrinol Metab 17:186-91. 2006
    ....
  16. ncbi request reprint Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
    Anthony A Sauve
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:9249-56. 2003
    ..Sir2 intermediate. These findings suggest a strategy for increasing Sir2 enzyme catalytic activity in vivo by inhibition of chemical exchange but not deacetylation...
  17. ncbi request reprint Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition
    Anthony A Sauve
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Cell 17:595-601. 2005
    ..Thus, a nicotinamide antagonist is a Sir2 agonist in vitro and in vivo...
  18. ncbi request reprint SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates
    Anthony A Sauve
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave F304, Bronx, NY 10461, USA
    Curr Med Chem 11:807-26. 2004
    ..The present review describes the current knowledge of the Sir2 reaction, the reaction mechanism and the regulation of Sir2...
  19. ncbi request reprint SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
    Toula Bouras
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington, DC 20057, USA
    J Biol Chem 280:10264-76. 2005
    ..Because p300 is a limiting transcriptional cofactor, deacetylation and repression of p300 by SIRT1 may serve an important integration point during metabolism and cellular differentiation...
  20. pmc Nicotinamide riboside kinase structures reveal new pathways to NAD+
    Wolfram Tempel
    Structural Genomics Consortium and Department of Pharmacology, University of Toronto, Toronto, Canada
    PLoS Biol 5:e263. 2007
    ..Additionally, nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage. Thus, crystal structures of Nrk1 led to the identification of new pathways to NAD+...
  21. pmc Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
    Marcella Fulco
    Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Dev Cell 14:661-73. 2008
    ..These experiments reveal that AMPK, Nampt, and SIRT1 are the molecular components of a functional signaling pathway that allows skeletal muscle cells to sense and react to nutrient availability...
  22. pmc Hormonal control of androgen receptor function through SIRT1
    Maofu Fu
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Cell Biol 26:8122-35. 2006
    ..DHT-induced prostate cancer cellular contact-independent growth is also blocked by SIRT1, providing a direct functional link between the AR, which is a critical determinant of progression of human prostate cancer, and the sirtuins...
  23. pmc Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
    Hongying Yang
    Department of Pathology, Paul F Glenn Laboratories, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 130:1095-107. 2007
    ..We discuss the relevance of these findings to understanding how nutrition modulates physiology and to the evolution of apoptosis...
  24. ncbi request reprint Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases
    Anthony A Sauve
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:5694-705. 2003
    ..Substrate complexes, even in catalytically cycling equilibrium mixtures, do not reveal similar distortions...

Research Grants6

  1. Sir2 regulation and chemical modulation
    Anthony Sauve; Fiscal Year: 2007
    ....
  2. Sir2 regulation and chemical modulation
    Anthony A Sauve; Fiscal Year: 2010
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