Research Topics
| D G RussellSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Detail Information
Publications
Biochemical and structural studies of malate synthase from Mycobacterium tuberculosisClare V Smith
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
J Biol Chem 278:1735-43. 2003..7-A resolution. Coenzyme A binds in a bent conformation, and the details of its interactions are described, together with implications on the enzyme mechanism...- New ways to arrest phagosome maturationDavid G Russell
Nat Cell Biol 9:357-9. 2007 - Lysosomal ubiquitin and the demise of Mycobacterium tuberculosisGeorgiana E Purdy
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Cell Microbiol 9:2768-74. 2007..Recent data indicate that the antimycobacterial mechanism of the lysosome is due in part to the action of ubiquitin-derived peptides... - Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosisHenry C Mwandumba
Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Box 30096, Blantyre 3, Malawi
Tuberculosis (Edinb) 88:58-63. 2008..The local immune responses may affect the clinical presentation of active pulmonary TB in HIV-infected patients... 
The evolutionary pressures that have molded Mycobacterium tuberculosis into an infectious adjuvantDavid G Russell
Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States Electronic address
Curr Opin Microbiol 16:78-84. 2013..However, growth on host lipids places metabolic stresses on Mtb, which has evolved to incorporate potentially harmful metabolic intermediates into the very cell wall lipids that induce the remodeling of the host tissue response...- Staphylococcus and the healing power of pusDavid G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Cell Host Microbe 3:115-6. 2008..As manganese is an essential cofactor for several enzymes in S. aureus, this impacts bacterial growth and the bacterium's ability to withstand oxidative stress... 
Foamy macrophages and the progression of the human tuberculosis granulomaDavid G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Nat Immunol 10:943-8. 2009..The foamy macrophage seems to be a key participant in both sustaining persistent bacteria and contributing to the tissue pathology that leads to cavitation and the release of infectious bacilli...- Highlighting the parallels between human and bovine tuberculosisDavid G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Vet Med Educ 30:140-2. 2003 - The kinetics of phagosome maturation as a function of phagosome/lysosome fusion and acquisition of hydrolytic activityRobin M Yates
Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Traffic 6:413-20. 2005..The fluorescence profiles of all three assays are modulated by known inhibitors of phagosome maturation, demonstrating the veracity, sensitivity and versatility of the assays... - TLR signalling and phagosome maturation: an alternative viewpointDavid G Russell
Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Cell Microbiol 9:849-50. 2007 - Mycobacterium tuberculosis and the intimate discourse of a chronic infectionDavid G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Immunol Rev 240:252-68. 2011..This damage reflects the pathogen's ability to subvert the host's innate and acquired immune responses to its own nefarious ends... - Mycobacterium and the coat of many lipidsDavid G Russell
Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Cell Biol 158:421-6. 2002..The molecules play key roles in the induction and maintenance of the granuloma, a tissue response that limits bacterial spread yet ensures persistence of the infection... - Who puts the tubercle in tuberculosis?David G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Nat Rev Microbiol 5:39-47. 2007..But what is the role of the TB bacillus in the progression of the granuloma? This Review explores how Mycobacterium tuberculosis influences granuloma formation and maintenance, and ensures the spread of the disease... - Mycobacterium tuberculosis: here today, and here tomorrowD G Russell
Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
Nat Rev Mol Cell Biol 2:569-77. 2001..As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control... - Tuberculosis: what we don't know can, and does, hurt usDavid G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Science 328:852-6. 2010..Here we focus on the biology of the host-pathogen interaction and discuss new and evolving strategies for intervention... - Interaction of Mycobacterium avium-containing phagosomes with the antigen presentation pathwayH J Ullrich
College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 Department of Microbiology, Washington University, St Louis, MO 63110, USA
J Immunol 165:6073-80. 2000.... - Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cuesKyle H Rohde
Cornell University, College of Veterinary Medicine, Department of Microbiology and Immunology, Ithaca, NY 14853, USA
Cell Host Microbe 2:352-64. 2007..Finally, there are marked species-specific differences in the response of Mtb and M. bovis BCG to intraphagosomal cues... - Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial componentsElizabeth R Rhoades
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Tuberculosis (Edinb) 85:159-76. 2005..We submit that the matrix model presents pertinent features of the murine granulomatous response that will prove to be an adaptable method for study of this complex response... - Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagySylvie Alonso
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 104:6031-6. 2007..The accumulation of ubiquitinated proteins in the autophagolysosome provides one possible mechanism behind the antimicrobial activities observed for a range of pathogens in autophagous host cells... - Macrophage activation downregulates the degradative capacity of the phagosomeRobin M Yates
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14863, USA
Traffic 8:241-50. 2007..The data are consistent with limiting proteolysis in the early phagosome to maximize epitope generation and antigen presentation while sequestering the degradative capacity in the late phagolysosome... - Phagosome maturation proceeds independently of stimulation of toll-like receptors 2 and 4Robin M Yates
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Immunity 23:409-17. 2005..The results demonstrate that the rate of maturation of phagosomes proceeds independently of TLR signaling pathways... - Kinetics of phosphatidylinositol-3-phosphate acquisition differ between IgG bead-containing phagosomes and Mycobacterium tuberculosis-containing phagosomesGeorgiana E Purdy
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Cell Microbiol 7:1627-34. 2005..Given the role these lipids play in the regulation of phagosome maturation these findings have implications with respect to the mechanisms behind the arrest of phagosome maturation... - Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosomeRobin M Yates
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Methods Mol Biol 445:311-25. 2008..The assays are described as population-based methodologies utilizing a spectrofluorometer but, alternatively, can be adapted readily to confocal-based technologies for single phagosomal measurements... - Mycobacterial persistence: adaptation to a changing environmentK Honer zu Bentrup
Dept of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Trends Microbiol 9:597-605. 2001..The characterization of these gene products and their role in bacterial metabolism and physiology is starting to provide insights into the mechanisms that M. tuberculosis has evolved to adopt its highly successful mode of pathogenicity... - Transcriptional responses of Mycobacterium tuberculosis to lung surfactantUte Schwab
Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
Microb Pathog 46:185-93. 2009.... - Ubiquitin trafficking to the lysosome: keeping the house tidy and getting rid of unwanted guestsGeorgiana E Purdy
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Autophagy 3:399-401. 2007..We discuss the possible role(s) that the multivesicular body (MVB), the late endosome and the autophagosome may play in trafficking of ubiquitinated proteins to the lysosome... - Recording phagosome maturation through the real-time, spectrofluorometric measurement of hydrolytic activitiesRobin M Yates
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Methods Mol Biol 531:157-71. 2009..These assays, however, can be expanded to high-throughput or single cell formats. In addition, this approach can be applied to measure a wide variety of phagosomal hydrolytic properties with the design of suitable fluorogenic substrates... - The macrophage marches on its phagosome: dynamic assays of phagosome functionDavid G Russell
David G Russell and Brian C VanderVen are at the Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Nat Rev Immunol 9:594-600. 2009..These assays provide functional insights into how the phagosome fulfils its diverse roles in homeostasis and in innate and adaptive immune responses... - Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptidesGeorgiana E Purdy
Department of Microbiology and Immunology, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
Mol Microbiol 73:844-57. 2009..We conclude that Ub2 targets mycobacterial membranes and that reduced membrane permeability provides mycobacteria intrinsic resistance against antimicrobial compounds including bactericidal ubiquitin-derived peptides... - Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogsKenneth W Simpson
Department of Clinical Sciences, College of Veterinary Medicine, VMC2001, Cornell University, Ithaca, New York 14853, USA
Infect Immun 74:4778-92. 2006..E. coli strains associated with GCB and Crohn's disease have an adherent and invasive phenotype and novel multilocus sequence types and resemble E. coli associated with extraintestinal disease in phylogeny and virulence gene profile... - Intraphagosomal measurement of the magnitude and duration of the oxidative burstBrian C VanderVen
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Traffic 10:372-8. 2009..Additionally, the extent and rate of macrophage phagosomal substrate oxidation were subject to immunomodulation by activation with lipopolysaccharide and/or interferon-gamma... - In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolatesRachel E Geisel
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunol 174:5007-15. 2005..These results demonstrate that the trehalose mycolates, particularly trehalose dimycolate, are the most bioactive lipids in the BCG extract, inducing a proinflammatory cascade that influences granuloma formation... - Quantification of Mycobacterium avium subsp. paratuberculosis (MAP) survival in monocyte-derived macrophagesRebecca M Mitchell
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 139:73-8. 2011..In summary, real-time PCR assays provided a more accurate and precise method for evaluating intracellular growth dynamics when comparing strains of MAP... - Equine bronchial epithelial cells differentiate into ciliated and mucus producing cells in vitroUte E Schwab
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
In Vitro Cell Dev Biol Anim 46:102-6. 2010..Furthermore, the demonstration of the two major gel-forming mucin species, Muc5ac and Muc5b, in our bronchial epithelial cell culture system validates this method for studies of respiratory tract disease of the horse... - Identification and macrophage-activating activity of glycolipids released from intracellular Mycobacterium bovis BCGE Rhoades
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
Mol Microbiol 48:875-88. 2003.... - Mycobacterium tuberculosis and the environment within the phagosomeKyle Rohde
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Immunol Rev 219:37-54. 2007..These approaches represent our ongoing attempts to unravel the discourse that takes place between the pathogen and its host cell... - Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infectionKaori Sakamoto
Department of Pathology, College of Veterinary Medicine, 501 D W Brooks Dr, University of Georgia, Athens, GA 30602 7388, USA
Infect Immun 78:1004-11. 2010..In this model, fibrin(ogen) was not required for cell recruitment, cytokine response, or response to infection, but it promoted granulation tissue formation and suppressed leukocyte necrosis... - Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolismMi Jeong Kim
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
EMBO Mol Med 2:258-74. 2010..These results provide molecular and biochemical evidence that the development of the human TB granuloma to caseation correlates with pathogen-mediated dysregulation of host lipid metabolism... - Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturationKevin Pethe
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
Proc Natl Acad Sci U S A 101:13642-7. 2004..In addition to clarifying the processes active in modulation of phagosome biogenesis by M. tuberculosis, this screen may be applicable to other pathogens that restrict the maturation of their phagosome... - Genetic toggling of alkaline phosphatase folding reveals signal peptides for all major modes of transport across the inner membrane of bacteriaMatthew Marrichi
School of Chemical and Biomolecular Engineering, Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 283:35223-35. 2008.... - Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophagesBrian C VanderVen
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Cytometry A 77:751-60. 2010..This process enabled us to identify a new structural class of pyrazole-methanone compounds that directly inhibit lysosomal and lipoprotein lipase activity... - pckA-deficient Mycobacterium bovis BCG shows attenuated virulence in mice and in macrophagesKeyi Liu
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Microbiology 149:1829-35. 2003..Whether its role is in the gluconeogenic pathway for carbohydrate formation or in the conversion of PEP to OAA to maintain the TCA cycle remains to be determined... - Mycobacterium tuberculosis wears what it eatsDavid G Russell
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Cell Host Microbe 8:68-76. 2010..Understanding these environments, and the stresses that they place on M. tuberculosis, should provide insights invaluable for the development of new chemo- and immunotherapeutic strategies... - M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs)Roisin M Owens
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14053, USA
Mol Microbiol 60:1152-63. 2006..tuberculosis derived diacylglycerol. Targeted deletion of the rv2252 gene resulted in disruption of the production of certain higher order PIM species, suggesting a role for Rv2252 in the biosynthetic pathway of PI, a PIM precursor... - Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant functionZhengdong Wang
Department of Pediatrics, University of Rochester School of Medicine, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
Tuberculosis (Edinb) 88:178-86. 2008.... - Phagosomes, fatty acids and tuberculosisDavid G Russell
Nat Cell Biol 5:776-8. 2003 - The Mycobacterium tuberculosis ino1 gene is essential for growth and virulenceFarahnaz Movahedzadeh
Department of Pathology and Infectious Diseases, Royal Veterinary College, London, UK
Mol Microbiol 51:1003-14. 2004.... - Mycobacterium tuberculosis resides in nonacidified vacuoles in endocytically competent alveolar macrophages from patients with tuberculosis and HIV infectionHenry C Mwandumba
Malawi-Liverpool-Wellcome Trust Clinical Research Program, College of Medicine, Blantyre, Malawi
J Immunol 172:4592-8. 2004..This confirms, for the first time in humans with tuberculosis and HIV, the conclusions from previous animal and in vitro studies... - Vesicle size influences the trafficking, processing, and presentation of antigens in lipid vesiclesJames M Brewer
Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow G11 6NT, Scotland, UK
J Immunol 173:6143-50. 2004..We conclude that the ability of phagocytosed, particulate Ag to target early phagosomes results in more efficient Ag presentation... - Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal systemDirk Wagner
Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, CA 94115, USA
J Immunol 174:1491-500. 2005..tuberculosis vacuoles exhibited retarded acquisition of iron compared with phagosomes with wild-type M. tuberculosis. This is a unique approach to define the environmental conditions within the pathogen-containing compartment... - Toll-like receptors and phagosome maturationDavid G Russell
Nat Immunol 8:217; author reply 217-8. 2007 - Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomesWandy L Beatty
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Cell Microbiol 4:167-76. 2002..Infection of macrophages from gal-3-deficient mice indicated that the protein did not play a role in infection in vitro. In contrast, infection of gal-3-deficient mice revealed a reduced capacity to clear late but not early infection... - Structural characterization of cardiolipin by tandem quadrupole and multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionizationFong Fu Hsu
Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Mass Spectrom 16:491-504. 2005..The applications of the above methods in the differentiation of cardiolipin isomers and in the identification of complex cardiolipin species consisting of multiple molecular structures are also demonstrated... - Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Gúerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. II. Monoacyl- and diacyl-PIMsFong Fu Hsu
Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Mass Spectrom 18:479-92. 2007..bovis Bacillus Calmette Guérin... - Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guérin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. I. PIMs and lyso-PIMsFong Fu Hsu
Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Mass Spectrom 18:466-78. 2007..The combined structural information from the MS(2) and MS(3) product-ion spectra permit the complex structures of PIMs that consist of various isomers to be unveiled in detail... - Alveolar macrophages from HIV-infected patients with pulmonary tuberculosis retain the capacity to respond to stimulation by lipopolysaccharideHenry C Mwandumba
Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre 3, Malawi
Microbes Infect 9:1053-60. 2007..704 pg/g, p=0.03 for IL-8). We concluded that AM from HIV-infected patients with pulmonary TB produced and released inflammatory cytokines in vivo and retained their innate ability to respond to stimulation by LPS...
Research Grants
- THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONSDavid Russell; Fiscal Year: 2007..We propose to identify the receptor(s) involved and elucidate their cellular and tissue distribution, and the signaling pathways through which they operate. ..
- Restoration of alveolar macrophage function in HIV patients: A clinical study.David G Russell; Fiscal Year: 2010....
- Zeiss LSM510 Meta Confocal MicroscopeDavid Russell; Fiscal Year: 2007..These data will extend ongoing, NIH-funded programs for identification of new drug targets, vaccines and adjuvants. ..
- Development of a Novel Strategy of Adjuvant DiscoveryDavid Russell; Fiscal Year: 2007..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
- Environmental cues and responses in tuberculosisDavid Russell; Fiscal Year: 2007....
- THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONSDavid G Russell; Fiscal Year: 2010..We propose to identify the receptor(s) involved and elucidate their cellular and tissue distribution, and the signaling pathways through which they operate. ..
- Cell Biology of Mycobacterium tuberculosis InfectionDavid G Russell; Fiscal Year: 2010..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
- Development of a cell-based HTS for compounds with activity against tuberculosisDavid G Russell; Fiscal Year: 2010..tuberculosis, which can then be used to develop new drugs or combinations of drugs to more effectively treat this disease. ..
- Enviromental cues and responses in tuberculosisDavid G Russell; Fiscal Year: 2010..abstract_text> ..
- Development of a Novel Strategy of Adjuvant DiscoveryDavid Russell; Fiscal Year: 2009..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
- Cell Biology of Mycobacterium tuberculosis InfectionDavid Russell; Fiscal Year: 2007..Preliminary characterization of this fraction suggests that the activity co-purifies with cathepsins S and B. We intend to identify the active component and characterize the mechanism that leads to bacterial death. ..
- FLAGELLAR POCKET OF LEISHMANIADavid Russell; Fiscal Year: 2001..abstract_text> ..
- GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPPDavid Russell; Fiscal Year: 2004..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
- THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONSDavid Russell; Fiscal Year: 2005..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
- Metabolism of M. tuberculosis: New Targets for MDR TBDavid Russell; Fiscal Year: 2004..abstract_text> ..
- Development of a cell-based HTS for compounds with activity against tuberculosisDavid Russell; Fiscal Year: 2009..tuberculosis, which can then be used to develop new drugs or combinations of drugs to more effectively treat this disease. ..