D G Russell

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis
    Clare V Smith
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 278:1735-43. 2003
  2. ncbi request reprint New ways to arrest phagosome maturation
    David G Russell
    Nat Cell Biol 9:357-9. 2007
  3. ncbi request reprint Lysosomal ubiquitin and the demise of Mycobacterium tuberculosis
    Georgiana E Purdy
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Microbiol 9:2768-74. 2007
  4. ncbi request reprint Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosis
    Henry C Mwandumba
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Box 30096, Blantyre 3, Malawi
    Tuberculosis (Edinb) 88:58-63. 2008
  5. pmc Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell
    Shumin Tan
    Cornell University, College of Veterinary Medicine, Department of Microbiology and Immunology, Ithaca, New York, United States of America
    PLoS Pathog 9:e1003282. 2013
  6. pmc Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival
    Susanne Homolka
    Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
    PLoS Pathog 6:e1000988. 2010
  7. doi request reprint Trp'ing tuberculosis
    David G Russell
    Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Electronic address
    Cell 155:1209-10. 2013
  8. pmc The evolutionary pressures that have molded Mycobacterium tuberculosis into an infectious adjuvant
    David G Russell
    Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States
    Curr Opin Microbiol 16:78-84. 2013
  9. ncbi request reprint Who puts the tubercle in tuberculosis?
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Microbiol 5:39-47. 2007
  10. doi request reprint Staphylococcus and the healing power of pus
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Host Microbe 3:115-6. 2008

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis
    Clare V Smith
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 278:1735-43. 2003
    ..7-A resolution. Coenzyme A binds in a bent conformation, and the details of its interactions are described, together with implications on the enzyme mechanism...
  2. ncbi request reprint New ways to arrest phagosome maturation
    David G Russell
    Nat Cell Biol 9:357-9. 2007
  3. ncbi request reprint Lysosomal ubiquitin and the demise of Mycobacterium tuberculosis
    Georgiana E Purdy
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Microbiol 9:2768-74. 2007
    ..Recent data indicate that the antimycobacterial mechanism of the lysosome is due in part to the action of ubiquitin-derived peptides...
  4. ncbi request reprint Association between sputum smear status and local immune responses at the site of disease in HIV-infected patients with pulmonary tuberculosis
    Henry C Mwandumba
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Box 30096, Blantyre 3, Malawi
    Tuberculosis (Edinb) 88:58-63. 2008
    ..The local immune responses may affect the clinical presentation of active pulmonary TB in HIV-infected patients...
  5. pmc Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell
    Shumin Tan
    Cornell University, College of Veterinary Medicine, Department of Microbiology and Immunology, Ithaca, New York, United States of America
    PLoS Pathog 9:e1003282. 2013
    ..Our study establishes Cl⁻ and pH as linked environmental cues for Mtb, and illustrates the utility of reporter bacterial strains for the study of Mtb-host interactions in vivo...
  6. pmc Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates: delineation of conserved core and lineage-specific transcriptomes during intracellular survival
    Susanne Homolka
    Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
    PLoS Pathog 6:e1000988. 2010
    ..This study affords new insights into the genetic information that M. tuberculosis has conserved under selective pressure during its long-term interactions with its human host...
  7. doi request reprint Trp'ing tuberculosis
    David G Russell
    Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Electronic address
    Cell 155:1209-10. 2013
    ..Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-dependent drug target for tuberculosis...
  8. pmc The evolutionary pressures that have molded Mycobacterium tuberculosis into an infectious adjuvant
    David G Russell
    Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States
    Curr Opin Microbiol 16:78-84. 2013
    ..However, growth on host lipids places metabolic stresses on Mtb, which has evolved to incorporate potentially harmful metabolic intermediates into the very cell wall lipids that induce the remodeling of the host tissue response...
  9. ncbi request reprint Who puts the tubercle in tuberculosis?
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Microbiol 5:39-47. 2007
    ..But what is the role of the TB bacillus in the progression of the granuloma? This Review explores how Mycobacterium tuberculosis influences granuloma formation and maintenance, and ensures the spread of the disease...
  10. doi request reprint Staphylococcus and the healing power of pus
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Host Microbe 3:115-6. 2008
    ..As manganese is an essential cofactor for several enzymes in S. aureus, this impacts bacterial growth and the bacterium's ability to withstand oxidative stress...
  11. ncbi request reprint The kinetics of phagosome maturation as a function of phagosome/lysosome fusion and acquisition of hydrolytic activity
    Robin M Yates
    Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Traffic 6:413-20. 2005
    ..The fluorescence profiles of all three assays are modulated by known inhibitors of phagosome maturation, demonstrating the veracity, sensitivity and versatility of the assays...
  12. pmc Foamy macrophages and the progression of the human tuberculosis granuloma
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Nat Immunol 10:943-8. 2009
    ..The foamy macrophage seems to be a key participant in both sustaining persistent bacteria and contributing to the tissue pathology that leads to cavitation and the release of infectious bacilli...
  13. ncbi request reprint Highlighting the parallels between human and bovine tuberculosis
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Med Educ 30:140-2. 2003
  14. pmc Tuberculosis: what we don't know can, and does, hurt us
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Science 328:852-6. 2010
    ..Here we focus on the biology of the host-pathogen interaction and discuss new and evolving strategies for intervention...
  15. pmc Mycobacterium tuberculosis and the intimate discourse of a chronic infection
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Immunol Rev 240:252-68. 2011
    ..This damage reflects the pathogen's ability to subvert the host's innate and acquired immune responses to its own nefarious ends...
  16. pmc Mycobacterium and the coat of many lipids
    David G Russell
    Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 158:421-6. 2002
    ..The molecules play key roles in the induction and maintenance of the granuloma, a tissue response that limits bacterial spread yet ensures persistence of the infection...
  17. ncbi request reprint Mycobacterium tuberculosis: here today, and here tomorrow
    D G Russell
    Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Mol Cell Biol 2:569-77. 2001
    ..As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control...
  18. ncbi request reprint TLR signalling and phagosome maturation: an alternative viewpoint
    David G Russell
    Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Microbiol 9:849-50. 2007
  19. ncbi request reprint Interaction of Mycobacterium avium-containing phagosomes with the antigen presentation pathway
    H J Ullrich
    College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 Department of Microbiology, Washington University, St Louis, MO 63110, USA
    J Immunol 165:6073-80. 2000
    ....
  20. ncbi request reprint Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues
    Kyle H Rohde
    Cornell University, College of Veterinary Medicine, Department of Microbiology and Immunology, Ithaca, NY 14853, USA
    Cell Host Microbe 2:352-64. 2007
    ..Finally, there are marked species-specific differences in the response of Mtb and M. bovis BCG to intraphagosomal cues...
  21. pmc Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
    Sylvie Alonso
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 104:6031-6. 2007
    ..The accumulation of ubiquitinated proteins in the autophagolysosome provides one possible mechanism behind the antimicrobial activities observed for a range of pathogens in autophagous host cells...
  22. ncbi request reprint Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial components
    Elizabeth R Rhoades
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Tuberculosis (Edinb) 85:159-76. 2005
    ..We submit that the matrix model presents pertinent features of the murine granulomatous response that will prove to be an adaptable method for study of this complex response...
  23. ncbi request reprint Macrophage activation downregulates the degradative capacity of the phagosome
    Robin M Yates
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14863, USA
    Traffic 8:241-50. 2007
    ..The data are consistent with limiting proteolysis in the early phagosome to maximize epitope generation and antigen presentation while sequestering the degradative capacity in the late phagolysosome...
  24. ncbi request reprint Kinetics of phosphatidylinositol-3-phosphate acquisition differ between IgG bead-containing phagosomes and Mycobacterium tuberculosis-containing phagosomes
    Georgiana E Purdy
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Microbiol 7:1627-34. 2005
    ..Given the role these lipids play in the regulation of phagosome maturation these findings have implications with respect to the mechanisms behind the arrest of phagosome maturation...
  25. ncbi request reprint Phagosome maturation proceeds independently of stimulation of toll-like receptors 2 and 4
    Robin M Yates
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Immunity 23:409-17. 2005
    ..The results demonstrate that the rate of maturation of phagosomes proceeds independently of TLR signaling pathways...
  26. pmc Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosome
    Robin M Yates
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Methods Mol Biol 445:311-25. 2008
    ..The assays are described as population-based methodologies utilizing a spectrofluorometer but, alternatively, can be adapted readily to confocal-based technologies for single phagosomal measurements...
  27. ncbi request reprint Mycobacterial persistence: adaptation to a changing environment
    K Honer zu Bentrup
    Dept of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Trends Microbiol 9:597-605. 2001
    ..The characterization of these gene products and their role in bacterial metabolism and physiology is starting to provide insights into the mechanisms that M. tuberculosis has evolved to adopt its highly successful mode of pathogenicity...
  28. pmc Transcriptional responses of Mycobacterium tuberculosis to lung surfactant
    Ute Schwab
    Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    Microb Pathog 46:185-93. 2009
    ....
  29. ncbi request reprint Ubiquitin trafficking to the lysosome: keeping the house tidy and getting rid of unwanted guests
    Georgiana E Purdy
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Autophagy 3:399-401. 2007
    ..We discuss the possible role(s) that the multivesicular body (MVB), the late endosome and the autophagosome may play in trafficking of ubiquitinated proteins to the lysosome...
  30. pmc Intraphagosomal measurement of the magnitude and duration of the oxidative burst
    Brian C VanderVen
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Traffic 10:372-8. 2009
    ..Additionally, the extent and rate of macrophage phagosomal substrate oxidation were subject to immunomodulation by activation with lipopolysaccharide and/or interferon-gamma...
  31. pmc Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides
    Georgiana E Purdy
    Department of Microbiology and Immunology, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
    Mol Microbiol 73:844-57. 2009
    ..We conclude that Ub2 targets mycobacterial membranes and that reduced membrane permeability provides mycobacteria intrinsic resistance against antimicrobial compounds including bactericidal ubiquitin-derived peptides...
  32. doi request reprint Equine bronchial epithelial cells differentiate into ciliated and mucus producing cells in vitro
    Ute E Schwab
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    In Vitro Cell Dev Biol Anim 46:102-6. 2010
    ..Furthermore, the demonstration of the two major gel-forming mucin species, Muc5ac and Muc5b, in our bronchial epithelial cell culture system validates this method for studies of respiratory tract disease of the horse...
  33. ncbi request reprint In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guérin is due principally to trehalose mycolates
    Rachel E Geisel
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 174:5007-15. 2005
    ..These results demonstrate that the trehalose mycolates, particularly trehalose dimycolate, are the most bioactive lipids in the BCG extract, inducing a proinflammatory cascade that influences granuloma formation...
  34. pmc The macrophage marches on its phagosome: dynamic assays of phagosome function
    David G Russell
    David G Russell and Brian C VanderVen are at the Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Immunol 9:594-600. 2009
    ..These assays provide functional insights into how the phagosome fulfils its diverse roles in homeostasis and in innate and adaptive immune responses...
  35. pmc Recording phagosome maturation through the real-time, spectrofluorometric measurement of hydrolytic activities
    Robin M Yates
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Methods Mol Biol 531:157-71. 2009
    ..These assays, however, can be expanded to high-throughput or single cell formats. In addition, this approach can be applied to measure a wide variety of phagosomal hydrolytic properties with the design of suitable fluorogenic substrates...
  36. doi request reprint Quantification of Mycobacterium avium subsp. paratuberculosis (MAP) survival in monocyte-derived macrophages
    Rebecca M Mitchell
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Immunol Immunopathol 139:73-8. 2011
    ..In summary, real-time PCR assays provided a more accurate and precise method for evaluating intracellular growth dynamics when comparing strains of MAP...
  37. pmc Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs
    Kenneth W Simpson
    Department of Clinical Sciences, College of Veterinary Medicine, VMC2001, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 74:4778-92. 2006
    ..E. coli strains associated with GCB and Crohn's disease have an adherent and invasive phenotype and novel multilocus sequence types and resemble E. coli associated with extraintestinal disease in phylogeny and virulence gene profile...
  38. ncbi request reprint Identification and macrophage-activating activity of glycolipids released from intracellular Mycobacterium bovis BCG
    E Rhoades
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Mol Microbiol 48:875-88. 2003
    ....
  39. pmc Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
    Mi Jeong Kim
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    EMBO Mol Med 2:258-74. 2010
    ..These results provide molecular and biochemical evidence that the development of the human TB granuloma to caseation correlates with pathogen-mediated dysregulation of host lipid metabolism...
  40. pmc Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infection
    Kaori Sakamoto
    Department of Pathology, College of Veterinary Medicine, 501 D W Brooks Dr, University of Georgia, Athens, GA 30602 7388, USA
    Infect Immun 78:1004-11. 2010
    ..In this model, fibrin(ogen) was not required for cell recruitment, cytokine response, or response to infection, but it promoted granulation tissue formation and suppressed leukocyte necrosis...
  41. ncbi request reprint Mycobacterium tuberculosis and the environment within the phagosome
    Kyle Rohde
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Immunol Rev 219:37-54. 2007
    ..These approaches represent our ongoing attempts to unravel the discourse that takes place between the pathogen and its host cell...
  42. pmc Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation
    Kevin Pethe
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
    Proc Natl Acad Sci U S A 101:13642-7. 2004
    ..In addition to clarifying the processes active in modulation of phagosome biogenesis by M. tuberculosis, this screen may be applicable to other pathogens that restrict the maturation of their phagosome...
  43. pmc Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages
    Brian C VanderVen
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Cytometry A 77:751-60. 2010
    ..This process enabled us to identify a new structural class of pyrazole-methanone compounds that directly inhibit lysosomal and lipoprotein lipase activity...
  44. pmc Genetic toggling of alkaline phosphatase folding reveals signal peptides for all major modes of transport across the inner membrane of bacteria
    Matthew Marrichi
    School of Chemical and Biomolecular Engineering, Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 283:35223-35. 2008
    ....
  45. ncbi request reprint pckA-deficient Mycobacterium bovis BCG shows attenuated virulence in mice and in macrophages
    Keyi Liu
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Microbiology 149:1829-35. 2003
    ..Whether its role is in the gluconeogenic pathway for carbohydrate formation or in the conversion of PEP to OAA to maintain the TCA cycle remains to be determined...
  46. ncbi request reprint M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs)
    Roisin M Owens
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14053, USA
    Mol Microbiol 60:1152-63. 2006
    ..tuberculosis derived diacylglycerol. Targeted deletion of the rv2252 gene resulted in disruption of the production of certain higher order PIM species, suggesting a role for Rv2252 in the biosynthetic pathway of PI, a PIM precursor...
  47. pmc Mycobacterium tuberculosis wears what it eats
    David G Russell
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Host Microbe 8:68-76. 2010
    ..Understanding these environments, and the stresses that they place on M. tuberculosis, should provide insights invaluable for the development of new chemo- and immunotherapeutic strategies...
  48. ncbi request reprint Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system
    Dirk Wagner
    Kuzell Institute for Arthritis and Infectious Diseases, San Francisco, CA 94115, USA
    J Immunol 174:1491-500. 2005
    ..tuberculosis vacuoles exhibited retarded acquisition of iron compared with phagosomes with wild-type M. tuberculosis. This is a unique approach to define the environmental conditions within the pathogen-containing compartment...
  49. ncbi request reprint Vesicle size influences the trafficking, processing, and presentation of antigens in lipid vesicles
    James M Brewer
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    J Immunol 173:6143-50. 2004
    ..We conclude that the ability of phagocytosed, particulate Ag to target early phagosomes results in more efficient Ag presentation...
  50. ncbi request reprint Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 4:167-76. 2002
    ..Infection of macrophages from gal-3-deficient mice indicated that the protein did not play a role in infection in vitro. In contrast, infection of gal-3-deficient mice revealed a reduced capacity to clear late but not early infection...
  51. ncbi request reprint Toll-like receptors and phagosome maturation
    David G Russell
    Nat Immunol 8:217; author reply 217-8. 2007
  52. ncbi request reprint Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant function
    Zhengdong Wang
    Department of Pediatrics, University of Rochester School of Medicine, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Tuberculosis (Edinb) 88:178-86. 2008
    ....
  53. ncbi request reprint Mycobacterium tuberculosis resides in nonacidified vacuoles in endocytically competent alveolar macrophages from patients with tuberculosis and HIV infection
    Henry C Mwandumba
    Malawi Liverpool Wellcome Trust Clinical Research Program, College of Medicine, Blantyre, Malawi
    J Immunol 172:4592-8. 2004
    ..This confirms, for the first time in humans with tuberculosis and HIV, the conclusions from previous animal and in vitro studies...
  54. ncbi request reprint The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence
    Farahnaz Movahedzadeh
    Department of Pathology and Infectious Diseases, Royal Veterinary College, London, UK
    Mol Microbiol 51:1003-14. 2004
    ....
  55. ncbi request reprint Phagosomes, fatty acids and tuberculosis
    David G Russell
    Nat Cell Biol 5:776-8. 2003
  56. pmc Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Guérin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. I. PIMs and lyso-PIMs
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 18:466-78. 2007
    ..The combined structural information from the MS(2) and MS(3) product-ion spectra permit the complex structures of PIMs that consist of various isomers to be unveiled in detail...
  57. ncbi request reprint Structural characterization of cardiolipin by tandem quadrupole and multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 16:491-504. 2005
    ..The applications of the above methods in the differentiation of cardiolipin isomers and in the identification of complex cardiolipin species consisting of multiple molecular structures are also demonstrated...
  58. ncbi request reprint Alveolar macrophages from HIV-infected patients with pulmonary tuberculosis retain the capacity to respond to stimulation by lipopolysaccharide
    Henry C Mwandumba
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre 3, Malawi
    Microbes Infect 9:1053-60. 2007
    ..704 pg/g, p=0.03 for IL-8). We concluded that AM from HIV-infected patients with pulmonary TB produced and released inflammatory cytokines in vivo and retained their innate ability to respond to stimulation by LPS...
  59. pmc Structural characterization of phosphatidyl-myo-inositol mannosides from Mycobacterium bovis Bacillus Calmette Gúerin by multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization. II. Monoacyl- and diacyl-PIMs
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 18:479-92. 2007
    ..bovis Bacillus Calmette Guérin...

Research Grants40

  1. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2007
    ..We propose to identify the receptor(s) involved and elucidate their cellular and tissue distribution, and the signaling pathways through which they operate. ..
  2. Restoration of alveolar macrophage function in HIV patients: A clinical study.
    David G Russell; Fiscal Year: 2010
    ....
  3. FLAGELLAR POCKET OF LEISHMANIA
    David Russell; Fiscal Year: 2000
    ..abstract_text> ..
  4. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2005
    ..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
  5. Cell Biology of Mycobacterium tuberculosis Infection
    David Russell; Fiscal Year: 2006
    ..Preliminary characterization of this fraction suggests that the activity co-purifies with cathepsins S and B. We intend to identify the active component and characterize the mechanism that leads to bacterial death. ..
  6. Development of a Novel Strategy of Adjuvant Discovery
    David Russell; Fiscal Year: 2006
    ..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
  7. Cell Biology of Mycobacterium tuberculosis Infection
    David Russell; Fiscal Year: 2007
    ..Preliminary characterization of this fraction suggests that the activity co-purifies with cathepsins S and B. We intend to identify the active component and characterize the mechanism that leads to bacterial death. ..
  8. Environmental cues and responses in tuberculosis
    David Russell; Fiscal Year: 2007
    ....
  9. Development of a Novel Strategy of Adjuvant Discovery
    David Russell; Fiscal Year: 2007
    ..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
  10. Zeiss LSM510 Meta Confocal Microscope
    David Russell; Fiscal Year: 2007
    ..These data will extend ongoing, NIH-funded programs for identification of new drug targets, vaccines and adjuvants. ..
  11. Enviromental cues and responses in tuberculosis
    David Russell; Fiscal Year: 2009
    ..abstract_text> ..
  12. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2009
    ..We propose to identify the receptor(s) involved and elucidate their cellular and tissue distribution, and the signaling pathways through which they operate. ..
  13. Cell Biology of Mycobacterium tuberculosis Infection
    David Russell; Fiscal Year: 2004
    ..Preliminary characterization of this fraction suggests that the activity co-purifies with cathepsins S and B. We intend to identify the active component and characterize the mechanism that leads to bacterial death. ..
  14. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2004
    ..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
  15. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2001
    ..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
  16. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2001
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
  17. FLAGELLAR POCKET OF LEISHMANIA
    David Russell; Fiscal Year: 2001
    ..abstract_text> ..
  18. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2003
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
  19. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2004
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
  20. Metabolism of M. tuberculosis: New Targets for MDR TB
    David Russell; Fiscal Year: 2004
    ..abstract_text> ..
  21. Cell Biology of Mycobacterium tuberculosis Infection
    David Russell; Fiscal Year: 2003
    ..Preliminary characterization of this fraction suggests that the activity co-purifies with cathepsins S and B. We intend to identify the active component and characterize the mechanism that leads to bacterial death. ..
  22. Development of a Novel Strategy of Adjuvant Discovery
    David Russell; Fiscal Year: 2009
    ..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
  23. Cell Biology of Mycobacterium tuberculosis Infection
    David Russell; Fiscal Year: 2005
    ..Preliminary characterization of this fraction suggests that the activity co-purifies with cathepsins S and B. We intend to identify the active component and characterize the mechanism that leads to bacterial death. ..
  24. Development of a cell-based HTS for compounds with activity against tuberculosis
    David Russell; Fiscal Year: 2009
    ..tuberculosis, which can then be used to develop new drugs or combinations of drugs to more effectively treat this disease. ..
  25. Enviromental cues and responses in tuberculosis
    David G Russell; Fiscal Year: 2010
    ..abstract_text> ..
  26. Development of a cell-based HTS for compounds with activity against tuberculosis
    David G Russell; Fiscal Year: 2010
    ..tuberculosis, which can then be used to develop new drugs or combinations of drugs to more effectively treat this disease. ..
  27. Cell Biology of Mycobacterium tuberculosis Infection
    David G Russell; Fiscal Year: 2010
    ..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
  28. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David G Russell; Fiscal Year: 2010
    ..We propose to identify the receptor(s) involved and elucidate their cellular and tissue distribution, and the signaling pathways through which they operate. ..
  29. Cell Biology of Mycobacterium tuberculosis Infection
    David Russell; Fiscal Year: 2009
    ..tuberculosis. We propose determining how the bacterium's metabolism is realigned to access these carbon sources. ..
  30. Enviromental cues and responses in tuberculosis
    David Russell; Fiscal Year: 2006
    ....
  31. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2003
    ..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
  32. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2006
    ..We propose to identify the receptor(s) involved and elucidate their cellular and tissue distribution, and the signaling pathways through which they operate. ..
  33. THE ROLE OF THE GRANULOMA IN M. TUBERCULOSIS INFECTIONS
    David Russell; Fiscal Year: 2002
    ..The BAL cells will also be examined in cell migration assays based on the result from the murine granuloma model described in aim # 2...
  34. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2002
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
  35. Development of a Novel Strategy of Adjuvant Discovery
    David Russell; Fiscal Year: 2005
    ..It is anticipated that this final aim will develop into a new grant application that will enable us to test the effectiveness of a range of microbial products for their efficacy as adjuvants. ..
  36. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2000
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..
  37. Development of a cell-based HTS for compounds with activity against tuberculosis
    David Russell; Fiscal Year: 2009
    ..tuberculosis, which can then be used to develop new drugs or combinations of drugs to more effectively treat this disease. ..