ENRIQUE J RODRIGUEZ BOULAN

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Organization of vesicular trafficking in epithelia
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 6:233-47. 2005
  2. ncbi request reprint Protein sorting in the Golgi complex: shifting paradigms
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, LC 300, 1300 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1744:455-64. 2005
  3. ncbi request reprint Epithelial trafficking: new routes to familiar places
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10021, USA
    Curr Opin Cell Biol 16:436-42. 2004
  4. pmc Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells
    Fanny Jaulin
    Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    Dev Cell 13:511-22. 2007
  5. ncbi request reprint The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane
    Yunbo Gan
    Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Nat Cell Biol 4:605-9. 2002
  6. doi request reprint Clathrin is a key regulator of basolateral polarity
    Sylvie Deborde
    Department of Ophthalmology, Dyson Vision Research Institute, LC 300, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
    Nature 452:719-23. 2008
  7. pmc AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells
    Diego Gravotta
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:1564-9. 2007
  8. pmc LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network
    Susana B Salvarezza
    Margaret Dyson Vision Research Institute and Department of Cell and Developmental Biology, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Mol Biol Cell 20:438-51. 2009
  9. pmc Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells
    David Cohen
    Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13792-7. 2004
  10. pmc Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells
    Fernando Diaz
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:11143-8. 2009

Research Grants

  1. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2009
  2. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2002
  3. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2006
  4. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2005
  5. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
  6. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
  7. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2009
  8. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2007
  9. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2007
  10. Tri-Institutional Training in Vision Research
    Enrique Rodriguez Boulan; Fiscal Year: 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Organization of vesicular trafficking in epithelia
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 6:233-47. 2005
    ..Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking...
  2. ncbi request reprint Protein sorting in the Golgi complex: shifting paradigms
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, LC 300, 1300 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1744:455-64. 2005
    ..Several adaptors are candidates to sort apical and basolateral proteins but only AP1B and AP4 are currently involved. Progress is fast and future work should elucidate many of the open questions...
  3. ncbi request reprint Epithelial trafficking: new routes to familiar places
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10021, USA
    Curr Opin Cell Biol 16:436-42. 2004
    ..A promising area of research is the study of trafficking functions of novel polarity genes identified in Drosophila and Caenorhabditis elegans...
  4. pmc Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells
    Fanny Jaulin
    Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    Dev Cell 13:511-22. 2007
    ..Our results demonstrate that apical protein transport depends on selective microtubule motors and that epithelial cells switch kinesins for post-Golgi transport during acquisition of polarity...
  5. ncbi request reprint The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane
    Yunbo Gan
    Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Nat Cell Biol 4:605-9. 2002
    ..Targeting and recycling assays in LLC-PK1 cells, before and after transfection with mu 1B, and in MDCK cells, which express mu 1B constitutively, suggest that AP1B sorts basolateral proteins post-endocytically...
  6. doi request reprint Clathrin is a key regulator of basolateral polarity
    Sylvie Deborde
    Department of Ophthalmology, Dyson Vision Research Institute, LC 300, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
    Nature 452:719-23. 2008
    ..Our results demonstrate a broad requirement for clathrin in basolateral protein trafficking in epithelial cells...
  7. pmc AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells
    Diego Gravotta
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:1564-9. 2007
    ..TfR utilizes a direct route from Golgi to basolateral membrane that is established as the epithelial monolayer matures...
  8. pmc LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network
    Susana B Salvarezza
    Margaret Dyson Vision Research Institute and Department of Cell and Developmental Biology, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Mol Biol Cell 20:438-51. 2009
    ....
  9. pmc Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells
    David Cohen
    Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13792-7. 2004
    ..To our knowledge, Par-1 is the first gene assigned to this task in epithelial morphogenesis...
  10. pmc Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells
    Fernando Diaz
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:11143-8. 2009
    ....
  11. pmc Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells
    Anne Müsch
    M Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 13:158-68. 2002
    ..These data suggest that Mlgl contributes to apico-basolateral polarity by regulating basolateral exocytosis...
  12. pmc The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epithelium
    Ami A Deora
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 15:4148-65. 2004
    ..This unusual basolateral sorting signal will be useful in unraveling the specialized sorting machinery of RPE cells...
  13. ncbi request reprint Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells
    Geri Kreitzer
    Margaret M Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Nat Cell Biol 5:126-36. 2003
    ....
  14. pmc Itinerant exosomes: emerging roles in cell and tissue polarity
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Trends Cell Biol 18:199-209. 2008
    ..In this review, we discuss new evidence suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues...
  15. ncbi request reprint Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin
    Ting Yu Yeh
    Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Traffic 7:1495-502. 2006
    ..Taken together, these results suggest that the dynein complex disassembles to release cargo due to the specific phosphorylation of Tctex-1 at the S82 residue and that this process is critical for the apical delivery of membrane cargoes...
  16. ncbi request reprint Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis
    Jeffrey P Greenfield
    Fisher Center for Research on Alzheimer s Disease and Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 277:12128-36. 2002
    ..These results suggest a novel mechanism through which 17beta-E2 may act in estrogen-responsive tissues and illustrate how altering the kinetics of the transport of a protein can influence its metabolic fate...
  17. pmc The absence of a clathrin adapter confers unique polarity essential to proximal tubule function
    Ryan Schreiner
    Department of Ophthalmology, Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, New York, USA
    Kidney Int 78:382-8. 2010
    ..Hence, our results show that differential expression of AP1B contributes to normal kidney function and illustrates possible roles of this adapter protein in kidney development, physiology, and pathology...
  18. ncbi request reprint Efficient electroporation of DNA and protein into confluent and differentiated epithelial cells in culture
    Ami A Deora
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Traffic 8:1304-12. 2007
    ..We report here the development of a simple procedure that uses available commercial equipment and works efficiently and reproducibly for a variety of epithelial cell lines in culture...
  19. pmc It takes two to tango to the melanosome
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, NY 10065, USA
    J Cell Biol 187:161-3. 2009
    ..1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis...

Research Grants55

  1. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2009
    ..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
  2. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2002
    ..The experiments proposed will provide novel information on the molecular bases of normal and abnormal function of epithelial organs, such as kidney, liver, intestine, lung and glands. ..
  3. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2006
    ..The experiments proposed will provide novel information on the molecular bases of normal and abnormal function of epithelial organs, such as kidney, liver, intestine, lung and exocrine / endocrine glands. ..
  4. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2005
    ..The information obtained should help understand the role of RPE in a variety of blinding diseases, such as age-related macular degeneration and diabetic retinopathy. ..
  5. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
    ..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
  6. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
    ....
  7. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2009
    ....
  8. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2007
    ..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
  9. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2007
    ..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
  10. Tri-Institutional Training in Vision Research
    Enrique Rodriguez Boulan; Fiscal Year: 2007
    ..The request for NIH support of a proposed Tri-Institutional Training Program in Vision Research builds on major commitments by the participating institutions of faculty, funds and research space devoted to vision research. ..
  11. RETINA: REVERSED MEMBRANE POLARITY IN RPE
    Enrique Rodriguez Boulan; Fiscal Year: 1993
  12. RETINA--REVERSED POLARITY IN RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2000
    ..It is expected that these studies will contribute key information on the cell biology of RPE that may help to elucidate its role in eye diseases. ..
  13. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 1993
    ..It is expected that these studies will contribute fundamental information to the process of epithelial cell organization and differentiation...
  14. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 1990
    ..Furthermore, since epithelia are usually the first barriers to viruses, they may also provide insights on how viral disease spreads in the organism...