Research Topics
Genomes and Genes | ENRIQUE J RODRIGUEZ BOULANSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Publications
Organization of vesicular trafficking in epitheliaEnrique Rodriguez-Boulan
Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
Nat Rev Mol Cell Biol 6:233-47. 2005..Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking...- Protein sorting in the Golgi complex: shifting paradigmsEnrique Rodriguez-Boulan
Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, LC 300, 1300 York Avenue, New York, NY 10021, USA
Biochim Biophys Acta 1744:455-64. 2005..Several adaptors are candidates to sort apical and basolateral proteins but only AP1B and AP4 are currently involved. Progress is fast and future work should elucidate many of the open questions... - Epithelial trafficking: new routes to familiar placesEnrique Rodriguez-Boulan
Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10021, USA
Curr Opin Cell Biol 16:436-42. 2004..A promising area of research is the study of trafficking functions of novel polarity genes identified in Drosophila and Caenorhabditis elegans... - Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cellsFanny Jaulin
Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
Dev Cell 13:511-22. 2007..Our results demonstrate that apical protein transport depends on selective microtubule motors and that epithelial cells switch kinesins for post-Golgi transport during acquisition of polarity... - The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membraneYunbo Gan
Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
Nat Cell Biol 4:605-9. 2002..Targeting and recycling assays in LLC-PK1 cells, before and after transfection with mu 1B, and in MDCK cells, which express mu 1B constitutively, suggest that AP1B sorts basolateral proteins post-endocytically... - Clathrin is a key regulator of basolateral polaritySylvie Deborde
Department of Ophthalmology, Dyson Vision Research Institute, LC 300, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
Nature 452:719-23. 2008..Our results demonstrate a broad requirement for clathrin in basolateral protein trafficking in epithelial cells... - AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cellsDiego Gravotta
Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:1564-9. 2007..TfR utilizes a direct route from Golgi to basolateral membrane that is established as the epithelial monolayer matures... - LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi networkSusana B Salvarezza
Margaret Dyson Vision Research Institute and Department of Cell and Developmental Biology, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY 10065, USA
Mol Biol Cell 20:438-51. 2009.... - Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cellsDavid Cohen
Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:13792-7. 2004..To our knowledge, Par-1 is the first gene assigned to this task in epithelial morphogenesis... - Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cellsFernando Diaz
Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
Proc Natl Acad Sci U S A 106:11143-8. 2009.... - Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cellsAnne Müsch
M Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
Mol Biol Cell 13:158-68. 2002..These data suggest that Mlgl contributes to apico-basolateral polarity by regulating basolateral exocytosis... - The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epitheliumAmi A Deora
Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
Mol Biol Cell 15:4148-65. 2004..This unusual basolateral sorting signal will be useful in unraveling the specialized sorting machinery of RPE cells... - Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cellsGeri Kreitzer
Margaret M Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
Nat Cell Biol 5:126-36. 2003.... - Itinerant exosomes: emerging roles in cell and tissue polarityAparna Lakkaraju
Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
Trends Cell Biol 18:199-209. 2008..In this review, we discuss new evidence suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues... - Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsinTing Yu Yeh
Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Traffic 7:1495-502. 2006..Taken together, these results suggest that the dynein complex disassembles to release cargo due to the specific phosphorylation of Tctex-1 at the S82 residue and that this process is critical for the apical delivery of membrane cargoes... - Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesisJeffrey P Greenfield
Fisher Center for Research on Alzheimer s Disease and Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
J Biol Chem 277:12128-36. 2002..These results suggest a novel mechanism through which 17beta-E2 may act in estrogen-responsive tissues and illustrate how altering the kinetics of the transport of a protein can influence its metabolic fate... - The absence of a clathrin adapter confers unique polarity essential to proximal tubule functionRyan Schreiner
Department of Ophthalmology, Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, New York, USA
Kidney Int 78:382-8. 2010..Hence, our results show that differential expression of AP1B contributes to normal kidney function and illustrates possible roles of this adapter protein in kidney development, physiology, and pathology... - Efficient electroporation of DNA and protein into confluent and differentiated epithelial cells in cultureAmi A Deora
Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
Traffic 8:1304-12. 2007..We report here the development of a simple procedure that uses available commercial equipment and works efficiently and reproducibly for a variety of epithelial cell lines in culture... - It takes two to tango to the melanosomeAparna Lakkaraju
Margaret M Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, NY 10065, USA
J Cell Biol 187:161-3. 2009..1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis...
Research Grants
- RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPEEnrique Rodriguez Boulan; Fiscal Year: 2009..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSEnrique Rodriguez Boulan; Fiscal Year: 2002..The experiments proposed will provide novel information on the molecular bases of normal and abnormal function of epithelial organs, such as kidney, liver, intestine, lung and glands. ..
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSEnrique Rodriguez Boulan; Fiscal Year: 2006..The experiments proposed will provide novel information on the molecular bases of normal and abnormal function of epithelial organs, such as kidney, liver, intestine, lung and exocrine / endocrine glands. ..
- RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPEEnrique Rodriguez Boulan; Fiscal Year: 2005..The information obtained should help understand the role of RPE in a variety of blinding diseases, such as age-related macular degeneration and diabetic retinopathy. ..
- RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPEENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010....
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSEnrique Rodriguez Boulan; Fiscal Year: 2009....
- RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPEEnrique Rodriguez Boulan; Fiscal Year: 2007..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
- RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPEEnrique Rodriguez Boulan; Fiscal Year: 2007..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
- Tri-Institutional Training in Vision ResearchEnrique Rodriguez Boulan; Fiscal Year: 2007..The request for NIH support of a proposed Tri-Institutional Training Program in Vision Research builds on major commitments by the participating institutions of faculty, funds and research space devoted to vision research. ..
- RETINA: REVERSED MEMBRANE POLARITY IN RPEEnrique Rodriguez Boulan; Fiscal Year: 1993
- RETINA--REVERSED POLARITY IN RPEEnrique Rodriguez Boulan; Fiscal Year: 2000..It is expected that these studies will contribute key information on the cell biology of RPE that may help to elucidate its role in eye diseases. ..
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSEnrique Rodriguez Boulan; Fiscal Year: 1993..It is expected that these studies will contribute fundamental information to the process of epithelial cell organization and differentiation...
- SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLSEnrique Rodriguez Boulan; Fiscal Year: 1990..Furthermore, since epithelia are usually the first barriers to viruses, they may also provide insights on how viral disease spreads in the organism...