G J Randolph
Affiliation: Cornell University
- A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vesselsG J Randolph
Department of Pathology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 95:6924-9. 1998....
- Differentiation of monocytes into dendritic cells in a model of transendothelial traffickingG J Randolph
Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C 420, New York, NY 10021, USA
Science 282:480-3. 1998..Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration...
- The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodesD F Robbiani
Department of Pathology and Immunology Program Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY 10029, USA
Cell 103:757-68. 2000..Thus, MRP-1 regulates DC migration to lymph nodes, apparently by transporting LTC(4), which in turn promotes chemotaxis to CCL19 and mobilization of DCs from the epidermis...
- Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytesW A Muller
Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
J Leukoc Biol 66:698-704. 1999..We postulate that a major source of DC in lymph nodes is cells derived from monocytes that enter a tissue via the blood and leave several days later via afferent lymphatic channels...
- Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitroG J Randolph
Department of Pathology, Cornell University Medical College, New York, NY, USA
Blood 92:4167-77. 1998..This binding was blocked by anti-TF MoAb, suggesting that endothelial cells bear a receptor for TF. These data suggest that mononuclear phagocytes use TF, perhaps as an adhesive protein, to exit sites of inflammation...
- Differentiation of phagocytic monocytes into lymph node dendritic cells in vivoG J Randolph
Department of Pathology, Weill Medical College of Cornell University, New York, USA
Immunity 11:753-61. 1999..Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs...
- Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediatorsG J Randolph
Institute for Gene Therapy and Molecular Medicine, Mt Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, NY 10029, USA
Semin Immunol 13:267-74. 2001..Indeed, MRP1 and the related multidrug resistance protein 1 (MDR1, p-glycoprotein, ABCB1) may control the intracellular and extracellular accumulation of key signaling lipids that regulate dendritic cell migration...
- The fate of monocytes in atherosclerosisG J Randolph
Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Thromb Haemost 7:28-30. 2009..All of these points of intervention will be briefly discussed in this article...