Shahin Rafii

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    Bi Sen Ding
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 468:310-5. 2010
  2. pmc Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance
    Jennifer Pasquier
    Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha PO 24144, Qatar
    J Transl Med 11:94. 2013
  3. ncbi request reprint Vaccination against tumor neovascularization: Promise and reality
    Shahin Rafii
    Cornell University Medical College, Division of Hematology Oncology, 1300 York Avenue, Room D601, New York, NY 10021, USA
    Cancer Cell 2:429-31. 2002
  4. ncbi request reprint Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  5. ncbi request reprint Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    Shahin Rafii
    Department of Hematology Oncology and Genetic Medicine, Cornell University Medical College, New York, New York, 10021 USA
    Nat Med 9:702-12. 2003
  6. ncbi request reprint Tumor vasculature address book: identification of stage-specific tumor vessel zip codes by phage display
    Shahin Rafii
    Department of Genetic Medicine, Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cancer Cell 4:331-3. 2003
  7. pmc Cancer. A few to flip the angiogenic switch
    Shahin Rafii
    Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Science 319:163-4. 2008
  8. pmc Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
    David K Jin
    Department of Genetic Medicine, Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 12:557-67. 2006
  9. pmc Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene
    Marco Seandel
    Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:19288-93. 2008
  10. pmc Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization
    Hans Georg Kopp
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Invest 116:3277-91. 2006

Detail Information

Publications95

  1. pmc Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
    Bi Sen Ding
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Nature 468:310-5. 2010
    ..Therapeutic co-transplantation of inductive VEGFR2(+)Id1(+)Wnt2(+)HGF(+) LSECs with hepatocytes provides an effective strategy to achieve durable liver regeneration...
  2. pmc Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance
    Jennifer Pasquier
    Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha PO 24144, Qatar
    J Transl Med 11:94. 2013
    ..This supports another role of the endothelium in the constitution of the metastatic niche...
  3. ncbi request reprint Vaccination against tumor neovascularization: Promise and reality
    Shahin Rafii
    Cornell University Medical College, Division of Hematology Oncology, 1300 York Avenue, Room D601, New York, NY 10021, USA
    Cancer Cell 2:429-31. 2002
    ....
  4. ncbi request reprint Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  5. ncbi request reprint Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    Shahin Rafii
    Department of Hematology Oncology and Genetic Medicine, Cornell University Medical College, New York, New York, 10021 USA
    Nat Med 9:702-12. 2003
    ..In this review, we discuss the clinical potential of vascular progenitor and stem cells to restore long-lasting organ vascularization and function...
  6. ncbi request reprint Tumor vasculature address book: identification of stage-specific tumor vessel zip codes by phage display
    Shahin Rafii
    Department of Genetic Medicine, Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cancer Cell 4:331-3. 2003
    ....
  7. pmc Cancer. A few to flip the angiogenic switch
    Shahin Rafii
    Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Science 319:163-4. 2008
  8. pmc Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
    David K Jin
    Department of Genetic Medicine, Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 12:557-67. 2006
    ..Delivery of SDF-1 may be effective in restoring angiogenesis in individuals with vasculopathies...
  9. pmc Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene
    Marco Seandel
    Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:19288-93. 2008
    ....
  10. pmc Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization
    Hans Georg Kopp
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Invest 116:3277-91. 2006
    ..As such, interference with the release of cellular stores of TSPs may be clinically effective in augmenting neoangiogenesis...
  11. ncbi request reprint Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells Dev 14:505-16. 2005
    ....
  12. ncbi request reprint Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue
    Sergey V Shmelkov
    Weill Medical College of Cornell University, Division of Hematology Oncology, New York, NY 10021, USA
    Circulation 111:1175-83. 2005
    ..Because human fetal liver is a rich source of CD133+ cells, we sought to identify the growth factors that promote codifferentiation of these cells into angiogenic and myogenic cells...
  13. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
    ..These findings demonstrate a requirement for VEGFR1+ haematopoietic progenitors in the regulation of metastasis, and suggest that expression patterns of fibronectin and VEGFR1+VLA-4+ clusters dictate organ-specific tumour spread...
  14. pmc Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells
    Andrea T Hooper
    Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Stem Cell 4:263-74. 2009
    ..Therefore, regeneration of SECs via VEGFR2 signaling is essential for engraftment of HSPCs and restoration of hematopoiesis...
  15. pmc Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis
    Andrea T Hooper
    Howard Hughes Medical Institute, Weill Cornell Medical College, 1300 York Ave, Room A 863, New York, NY 10021, USA
    Circ Res 105:201-8. 2009
    ..These results demonstrate that the vascular-specific marker AGM modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A...
  16. pmc Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
    Hideki Kobayashi
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Nat Cell Biol 12:1046-56. 2010
    ....
  17. pmc Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
    Loic Vincent
    Department of Genetic Medicine and Division of Hematology and Oncology, Howard Hughes Medical Institute, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 115:2992-3006. 2005
    ....
  18. pmc Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors
    Pouneh Kermani
    Division of Hematology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 115:653-63. 2005
    ....
  19. ncbi request reprint Contribution of marrow-derived progenitors to vascular and cardiac regeneration
    Shahin Rafii
    Cornell University Medical College, New York, USA
    Semin Cell Dev Biol 13:61-7. 2002
    ....
  20. doi request reprint Surrogate markers predict angiogenic potential and survival in patients with glioblastoma multiforme
    Jeffrey P Greenfield
    Department of Neurological Surgery, NewYork Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USA
    Neurosurgery 64:819-26; discussion 826-7. 2009
    ..In addition, we report on a novel in vitro assay to assess the proangiogenic activity within the plasma samples obtained from glioma patients...
  21. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    ..Release of sKitL by MMP-9 enables BM repopulating cells to translocate to a permissive vascular niche favoring differentiation and reconstitution of the stem/progenitor cell pool...
  22. pmc Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
    Jason M Butler
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Stem Cell 6:251-64. 2010
    ..Gfp(+) LT-HSCs. ECs establish an instructive vascular niche for clinical-scale expansion of LT-HSCs and a cellular platform to identify stem cell-active trophogens...
  23. ncbi request reprint Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment
    Shahin Rafii
    Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 996:49-60. 2003
    ..PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative microenvironment within the BM, favoring differentiation, mobilization, and reconstitution of hematopoiesis...
  24. ncbi request reprint Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    Scott T Avecilla
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nat Med 10:64-71. 2004
    ..Progenitor-active chemokines offer a new strategy to restore hematopoiesis in a clinical setting...
  25. pmc Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways
    Fan Zhang
    Department of Genetic Medicine, Belfer Gene Therapy Core Facility of Weill Medical of Cornell University, New York, NY 10021, USA
    Circ Res 96:950-7. 2005
    ..Taken together, these results suggest that AdE4+ may play an important role in the regulation of Cx expression in ECs, and that these effects are mediated by both the PKA/CREB and PI3K signaling pathways...
  26. pmc In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma
    Agata D Agostino Mutlu
    Laboratory of Viral Oncogenesis, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Cell 11:245-58. 2007
    ..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS...
  27. pmc CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    Sergey V Shmelkov
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:2111-20. 2008
    ....
  28. pmc A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization
    Marco Seandel
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Cell 13:181-3. 2008
    ..likely mirroring the complexity of the real tumor microenvironment and the intricacy of roles of different BMDC populations in mediating tumor neoangiogenesis...
  29. ncbi request reprint Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathway
    Fan Zhang
    Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:11760-6. 2004
    ..Taken together, these results suggest that activation of the VE-cadherin/Akt pathway is critical for AdE4(+)-mediated survival of ECs and angiogenic potential...
  30. pmc Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance
    Zhongwei Cao
    Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Cell 25:350-65. 2014
    ..Thus, targeting the angiocrine FGF4-FGFR1/Jag1-Notch2 loop inhibits LC aggressiveness and enhances chemosensitivity. ..
  31. ncbi request reprint The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma
    Yan Wu
    Department of Experimental Therapeutics, ImClone Systems Incorporated, New York, New York 10014, USA
    Int J Cancer 119:1519-29. 2006
    ..The results suggest that VEGF receptors may not only modulate angiogenesis, but also directly influence the growth of VEGF receptor expressing tumors...
  32. ncbi request reprint Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR
    Carlos Bais
    Laboratory of Viral Oncogenesis, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cancer Cell 3:131-43. 2003
    ..We conclude that vGPCR can cause an oncogenic immortalizing event and recapitulate aspects of the KS angiogenic phenotype in human endothelial cells, pointing to this gene as a pathogenic determinant of KSHV...
  33. ncbi request reprint Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer
    Rakhi P Naik
    Department of Medicine, Division of Hematology Oncology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Breast Cancer Res Treat 107:133-8. 2008
    ..01). These results suggest that circulating EPCs may serve as a potential tumor biomarker in breast cancer and that EPCs may represent a plausible target for future therapeutic intervention...
  34. ncbi request reprint Fetal stromal-dependent paracrine and intracrine vascular endothelial growth factor-a/vascular endothelial growth factor receptor-1 signaling promotes proliferation and motility of human primary myeloma cells
    Loic Vincent
    Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cancer Res 65:3185-92. 2005
    ....
  35. ncbi request reprint Thrombopoietin gene transfer-mediated enhancement of angiogenic responses to acute ischemia
    Hideki Amano
    Department of Genetic Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Circ Res 97:337-45. 2005
    ....
  36. ncbi request reprint PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
    Rosa Bernardi
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 442:779-85. 2006
    ..Thus, our findings identify PML as a novel suppressor of mTOR and neoangiogenesis...
  37. pmc Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity
    Matthew S Walters
    Department of Genetic Medicine, Weill Cornell Medical College, New York NY, USA
    Respir Res 14:135. 2013
    ..Cultured primary BC divide a limited number of times before entering a state of replicative senescence, preventing the establishment of long-term replicating cultures of airway BC that maintain their original phenotype...
  38. ncbi request reprint Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion
    Petri Salven
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    FASEB J 16:1471-3. 2002
    ..This novel mechanism of IL-1alpha-action may enhance the shift to angiogenic phenotype in various conditions designated by excessive angiogenesis...
  39. ncbi request reprint Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
    Marianna B Ruzinova
    Program of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 4:277-89. 2003
    ..Inhibition of these factors phenocopies loss of Id in in vivo angiogenesis assays...
  40. pmc Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17
    Thorsten Maretzky
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College, Cornell University, New York, New York 10021, USA
    Nat Commun 2:229. 2011
    ..Based on these findings, ADAM17 emerges as a central component in a triple membrane-spanning pathway between FGFR2b or VEGFR2 and EGFR/ERK1/2 that is required for cell migration in keratinocytes and presumably also in endothelial cells...
  41. pmc Niche players: spermatogonial progenitors marked by GPR125
    Marco Seandel
    Ansary Center for Stem Cell Therapeutics, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA
    Cell Cycle 7:135-40. 2008
    ..Thus, GPR125 represents a novel target for purifying adult stem and progenitors from tissues, with the goal of developing autologous multipotent cell lines...
  42. pmc CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells
    Jiyeon Kim
    Department of Genetic Medicine, Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, Weill Medical College of Cornell University, New York, New York 10065, USA
    Stem Cells 26:2516-22. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  43. pmc Functional heterogeneity of the bone marrow vascular niche
    Hans Georg Kopp
    Department of Genetic Medicine, Ansary Stem Cell Institute, Weill Cornell Medical College, New York, New York, USA
    Ann N Y Acad Sci 1176:47-54. 2009
    ..Novel, high-efficiency VEGF-binding drugs in combination with chemotherapeutic agents may lead to cases of prolonged cytopenia...
  44. pmc Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue
    Hans Georg Kopp
    Department of Genetic Medicine, Howard Hughes Medical Institute, Weill Medical College of Cornell University, New York 10021, USA
    Curr Opin Hematol 13:175-81. 2006
    ..In the light of recent findings, we may have to redefine our thinking of endothelial cells as well as of perivascular mural cells...
  45. pmc Tie2 activation contributes to hemangiogenic regeneration after myelosuppression
    Hans Georg Kopp
    Department of Genetic Medicine and Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Ave, Room D601, New York, NY 10021, USA
    Blood 106:505-13. 2005
    ..Angiopoietins may be clinically useful to accelerate hemangiogenic recovery after myelosuppression...
  46. pmc Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis
    April S Chan
    Department of Pediatrics, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 4:e7955. 2009
    ..The close proximity of these cells naturally suggests that they interact with one another, but these interactions are just beginning to be characterized...
  47. pmc Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
    Bi Sen Ding
    1 Ansary Stem Cell Institute, Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA 2
    Nature 505:97-102. 2014
    ..These results provide a therapeutic roadmap to achieve hepatic regeneration without provoking fibrosis. ..
  48. ncbi request reprint VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells
    Petri Salven
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Blood 101:168-72. 2003
    ....
  49. ncbi request reprint Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells
    Fan Zhang
    Division of Hematology Oncology and Genetic Medicine, Weill Medical College of Cornell University, 1300 York Ave, Rm D601, New York, NY 10021, USA
    Blood 102:2115-21. 2003
    ..Identification of the molecular partners that interact with GFP will increase our understanding of the vascular-specific factors that regulate stress angiogenesis and hemostasis...
  50. pmc Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration
    Daniel J Nolan
    Department of Genetic Medicine, Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Dev Cell 26:204-19. 2013
    ..These factors could be exploited therapeutically to engineer tissue-specific ECs for regeneration. ..
  51. pmc VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
    Steven Swendeman
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circ Res 103:916-8. 2008
    ..Targeting the sheddases of VEGFR2 or NRP-1 might offer new opportunities to modulate VEGF-A signaling, an already-established target for treatment of pathological neovascularization...
  52. ncbi request reprint Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma
    Jia Ruan
    Center for Lymphoma and Myeloma, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 12:5622-31. 2006
    ..Here, we investigated whether stromal incorporation of CD68(+) hemangiogenic cells and alpha-smooth muscle actin(+) (alpha-SMA(+)) stromal cells correlates with neoangiogenesis and progression in human non-Hodgkin's lymphoma subtypes...
  53. pmc p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow
    Anxo Vidal
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:6890-5. 2005
    ..This article documents the role of these molecules in angiogenesis and further suggests that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events...
  54. doi request reprint Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition
    Shahin Rafii
    Department of Genetic Medicine, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Blood 121:770-80. 2013
    ....
  55. pmc Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells
    Giacomo Curradi
    Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Mol Life Sci 69:2217-31. 2012
    ..These data demonstrate novel VEGFA-mediated cross-talk between airway basal cells and endothelium, the purpose of which is to modulate endothelial activation and in turn stimulate and sustain basal cell growth...
  56. pmc Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization
    Bi Sen Ding
    Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cell 147:539-53. 2011
    ..VEGFR2 and FGFR1 activation in PCECs therefore increases MMP14-dependent bioavailability of EGFR ligands to initiate and sustain alveologenesis...
  57. pmc c-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis
    Yuki Kimura
    Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 6:e26918. 2011
    ..This c-Kit-mediated cellular adhesion was essential for long-term maintenance and expansion of HSPCs. These results lay the foundation for delivering KL within specific niches to maintain and restore hematopoiesis...
  58. ncbi request reprint Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes
    Munira Xaymardan
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circ Res 94:E39-45. 2004
    ..Strategies based on the synergistic interactions of PDGF-AB and endogenous stem cells will need to maintain cellular patterning in order to promote the restoration of cardiac function after acute coronary occlusion...
  59. ncbi request reprint Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF)
    Giuseppe Pintucci
    The Seymour Cohn Cardiovascular Surgical Research Laboratory, Division of Cardiothoracic Surgery, New York University Medical Center, New York, NY 10016, USA
    Thromb Haemost 88:834-42. 2002
    ..Since FGF-2 and VEGF are potent angiogenic factors and known endothelial cell survival factors, their release by platelets provides a plausible mechanism for the platelet support of vascular endothelium...
  60. pmc Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    Koichi Hattori
    Department of Medicine, Cornell University Medical College, New York, New York, USA
    Nat Med 8:841-9. 2002
    ..Thus, PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative BM microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis...
  61. ncbi request reprint Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133
    Sergey V Shmelkov
    Weill Medical College of Cornell University, Division of Hematology Oncology, 1300 York Ave, MED HEM ONC, C 606, New York, NY 10021, USA
    Blood 103:2055-61. 2004
    ..Identification of tissue-specific AC133 promoters may provide a novel method to isolate tissue-specific stem and progenitor cells...
  62. ncbi request reprint VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
    Sergio Dias
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Blood 99:2532-40. 2002
    ..In summary, we demonstrate that Hsp90 mediates antiapoptotic and survival-promoting effects of VEGF, which may contribute to the survival advantage of VEGFR(+) cells such as subsets of leukemias...
  63. pmc Preparing the "soil": the premetastatic niche
    Rosandra N Kaplan
    Department of Pediatrics, Weill College of Medicine at Cornell University, New York, NY 10021, USA
    Cancer Res 66:11089-93. 2006
    ..Focus on the early cellular and molecular events in cancer dissemination and selectivity will likely lead to new approaches to detect and prevent metastasis at its earliest inception...
  64. doi request reprint Generation of a vascular niche for studying stem cell homeostasis
    Jason M Butler
    Weill Cornell Medical College and the Howard Hughes Medical Institute, Cornell University, New York, NY, USA
    Methods Mol Biol 904:221-33. 2012
    ..This unbiased system described here can serve as a platform to identify EC-derived growth and to model treatment of a wide variety of hematological and malignant conditions...
  65. ncbi request reprint Simulated microgravity impairs leukemic cell survival through altering VEGFR-2/VEGF-A signaling pathway
    Loic Vincent
    Department of Genetic Medicine, Cornell University Medical College, New York, NY, USA
    Ann Biomed Eng 33:1405-10. 2005
    ....
  66. pmc Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency
    Lin Chen
    Department of Physiology, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 284:27409-15. 2009
    ..Hence, Galpha(13) is haploinsufficient for adult angiogenesis in both the female reproductive system and tumor angiogenesis...
  67. ncbi request reprint The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1
    Koichi Hattori
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, Room D601 New York, NY 10021, USA
    Leuk Lymphoma 44:575-82. 2003
    ..These studies lay the foundation for using SDF-1 to induce mobilization of progenitor cells in a BM transplantation setting...
  68. pmc The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death
    Isabelle Petit
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, Department of Genetic Medicine, Division of Hematology Oncology, Weill Cornell Medical College, New York, NY 10021, USA
    Blood 111:1951-61. 2008
    ..As such, CA4P provides for an effective means to treat refractory organ-infiltrating leukemias...
  69. ncbi request reprint The bone marrow vascular niche: home of HSC differentiation and mobilization
    Hans Georg Kopp
    Weill Medical College of Cornell University, New York, New York, USA
    Physiology (Bethesda) 20:349-56. 2005
    ....
  70. pmc Sept4/ARTS is required for stem cell apoptosis and tumor suppression
    Maria Garcia-Fernandez
    Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 24:2282-93. 2010
    ..These phenotypes are partially suppressed by inactivation of XIAP. Our results suggest that apoptosis plays an important role as a frontline defense against cancer by restricting the number of normal stem cells...
  71. pmc New dimensions in vascular engineering: opportunities for cancer biology
    Sina Y Rabbany
    Department of Genetic Medicine, Weill Cornell Medical College, Howard Hughes Medical Institute, New York, New York 10065, USA
    Tissue Eng Part A 16:2157-9. 2010
    ..In this article, we discuss how novel tissue engineering platforms provide a framework for the study of tumorigenesis under pathophysiologically relevant in vitro culture conditions...
  72. ncbi request reprint Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand
    Pierre Feugier
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 101, New York, NY 10021, USA
    J Hematother Stem Cell Res 11:127-38. 2002
    ....
  73. pmc Generation of stable co-cultures of vascular cells in a honeycomb alginate scaffold
    Masaya Yamamoto
    Department of Genetics Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Tissue Eng Part A 16:299-308. 2010
    ..These studies demonstrate that alginate scaffolds provide a suitable matrix for establishing durable angiogenic modules that may ultimately enhance organ revascularization...
  74. pmc Generation of functional multipotent adult stem cells from GPR125+ germline progenitors
    Marco Seandel
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York 10065, USA
    Nature 449:346-50. 2007
    ....
  75. ncbi request reprint Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function
    Jay M Edelberg
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Circ Res 90:E89-93. 2002
    ..05). These results may offer a foundation for the development of novel therapies for the prevention and treatment of cardiovascular disease associated with aging...
  76. ncbi request reprint Adult cardiac stem cells--where do we go from here?
    Jay M Edelberg
    Department of Medicine, Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Sci Aging Knowledge Environ 2003:PE17. 2003
    ....
  77. doi request reprint Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing
    Sina Y Rabbany
    Bioengineering Program, Hofstra University, Hempstead, NY, USA
    Cell Transplant 19:399-408. 2010
    ..none in controls) with very little evidence of scarring. These data suggest that patch-mediated SDF-1 delivery may ultimately provide a novel therapy for accelerating healing and reducing scarring in clinical wounds...
  78. ncbi request reprint AC133/CD133/Prominin-1
    Sergey V Shmelkov
    Weill Medical College of Cornell University, Department of Genetic Medicine, 1300 York Avenue, New York, NY 10021, USA
    Int J Biochem Cell Biol 37:715-9. 2005
    ..Although the biological function of Prominin-1 is not well understood, the AC133 epitope currently serves as a useful marker for the isolation of hematopoietic and endothelial progenitor cells...
  79. pmc Platelets, petechiae, and preservation of the vascular wall
    Ralph L Nachman
    Weill Cornell Medical College, New York, NY 10065, USA
    N Engl J Med 359:1261-70. 2008
  80. pmc The role of progenitor cells in the development of intimal hyperplasia
    SHIRLING TSAI
    Department of Surgery, Division of Vascular Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, NY 10021, USA
    J Vasc Surg 49:502-10. 2009
    ....
  81. ncbi request reprint Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy
    Sergio Dias
    Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Blood 99:2179-84. 2002
    ..These results identify the VEGF-C/FLT-4 pathway as a novel therapeutic target for the treatment of subsets of acute leukemia...
  82. ncbi request reprint Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Exp Neurol 205:74-81. 2007
    ..This study provides new mechanism and suggests that MMP inhibitors may offer a new therapeutic strategy for ALS...
  83. pmc Migratory neighbors and distant invaders: tumor-associated niche cells
    Jared Wels
    Department of Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA
    Genes Dev 22:559-74. 2008
    ..Investigations of the tumor-stromal and stromal-stromal cross-talk involved in cellular migration in cancer may lead to the design of novel therapeutic strategies...
  84. pmc Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section
    Michael L Cher
    Department of Urology, Wayne State University School of Medicine, 4160 John R, Suite 1017, Detroit, MI 48201, USA
    Am J Pathol 168:1405-12. 2006
  85. ncbi request reprint Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity
    Errol S Wijelath
    Department of Molecular Biology, The Hope Heart Institute, Seattle, Wash, USA
    Circ Res 91:25-31. 2002
    ..This study demonstrates that FN is potentially a physiological cofactor for VEGF and provides insights into mechanisms by which growth factor receptors and integrins cooperate to influence cellular behavior...
  86. pmc S100 chemokines mediate bookmarking of premetastatic niches
    Shahin Rafii
    Nat Cell Biol 8:1321-3. 2006
  87. pmc Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization
    Beate Heissig
    Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    J Exp Med 202:739-50. 2005
    ..These data show a novel mechanism of neovascularization and suggest that low-dose irradiation may be used for therapeutic angiogenesis to augment vasculogenesis in ischemic tissues...
  88. ncbi request reprint A role for niches in hematopoietic cell development
    Beate Heissig
    Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Hematology 10:247-53. 2005
    ..This review summarizes the recent developments in our understanding of the stem cell niche with particular focus on the HSC niche...
  89. pmc Hitting the mother lode of tumor angiogenesis
    Daylon James
    Nat Biotechnol 26:769-70. 2008
  90. pmc Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas
    Robert S Kerbel
    Proc Natl Acad Sci U S A 105:E54; author reply E55. 2008
  91. ncbi request reprint Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization
    Sina Y Rabbany
    Bioengineering Program, Hofstra University, Hempstead, NY 11549, USA
    Trends Mol Med 9:109-17. 2003
    ....
  92. ncbi request reprint Tumor response to radiotherapy regulated by endothelial cell apoptosis
    Monica Garcia-Barros
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 300:1155-9. 2003
    ..These studies indicate that microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range...
  93. ncbi request reprint Endostatin's endpoints-Deciphering the endostatin antiangiogenic pathway
    Robert Benezra
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA
    Cancer Cell 5:205-6. 2004
    ..This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect the molecular pathways involved in endostatin's selective tumor antiangiogenic effects...
  94. ncbi request reprint Tumor necrosis factor alpha-stimulated endothelium: an inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells
    Anja Moldenhauer
    Institute for Transfusion Medicine, Charite, Universitätsmedizen Berlin, Berlin, Germany
    Stem Cells 22:144-57. 2004
    ..We conclude that, via the action of TNF-alpha, inflamed human endothelium can induce CD34+ and leukemic cells to differentiate into dendritic cells...
  95. ncbi request reprint Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases
    Beate Heissig
    Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York, USA
    Curr Opin Hematol 10:136-41. 2003
    ....

Research Grants13

  1. Contribution of the vascular niche to the hematopoietic reconstitution.
    Shahin Rafii; Fiscal Year: 2010
    ....
  2. Contribution of the vascular niche to the hematopoietic reconstitution.
    Shahin Rafii; Fiscal Year: 2009
    ....
  3. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2005
    ..These studies will lay the foundation for using BM-marrow derived cells for therapeutic cell therapy to enhance organ (i.e. lung, marrow) revascularization. ..
  4. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2004
    ..These studies will lay the foundation for using BM-marrow derived cells for therapeutic cell therapy to enhance organ (i.e. lung, marrow) revascularization. ..
  5. Vascular Heterogeneity Determination /Marrow Progenitors
    Shahin Rafii; Fiscal Year: 2003
    ..These studies will lay the foundation for using BM-marrow derived cells for therapeutic cell therapy to enhance organ (i.e. lung, marrow) revascularization. ..
  6. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  7. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2001
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  8. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2001
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  9. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 1999
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  10. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2000
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  11. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2006
    ..These studies will lay the foundation for using BM-marrow derived cells for therapeutic cell therapy to enhance organ (i.e. lung, marrow) revascularization. ..
  12. Therapy of thrombocytopenic disorders by chemokines
    Shahin Rafii; Fiscal Year: 2007
    ..CGS3135) that are currently being evaluated in phase I clinical trials, would provide the platform for assessing the role of these agents in amelioration and rapid restoration of thrombocytopenia Induced by chemotherapy and irradiation ..