DAVID POSNETT

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. doi request reprint Development of effective vaccines for old mice in a tumor model
    David N Posnett
    Dep of Medicine, Weill Medical College of Cornell University, New York, NY 10021, United States
    Vaccine 27:1093-100. 2009
  2. ncbi request reprint Sleeping with the enemy--endogenous superantigens in humans
    D N Posnett
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 15:503-6. 2001
  3. ncbi request reprint Herpesviruses and autoimmunity
    David N Posnett
    Weill Medical College of Cornell University, Department of Medicine, Division of Hematology Oncology, 1300 York Avwnue, New York, NY 10021, USA
    Curr Opin Investig Drugs 9:505-14. 2008
  4. ncbi request reprint Oligoclonal expansions of antigen-specific CD8+ T cells in aged mice
    David N Posnett
    Weill Medical College, Cornell University, Immunology Program, Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 987:274-9. 2003
  5. pmc The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
    A J Marcus
    Department of Medicine, Veterans Affairs Medical Center, New York 10010 5050, USA
    J Clin Invest 99:1351-60. 1997
  6. pmc Lack of muco-cutaneous signs of toxic shock syndrome when T cells are absent: S. aureus shock in immunodeficient adults with multiple myeloma
    N S Kamel
    Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Clin Exp Immunol 128:131-9. 2002
  7. ncbi request reprint Polyclonal lymphocytosis of T-cells associated with human T-cell leukemia virus I
    D N Posnett
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    Cancer Res 48:2585-9. 1988
  8. ncbi request reprint Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome
    Sanil J Manavalan
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:187-98. 2004
  9. pmc Antiviral T cell responses: phalanx or multipronged attack?
    David N Posnett
    Department of Medicine, Division of Hematology Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Exp Med 201:1881-4. 2005
  10. ncbi request reprint Apoptosis of T cells in peripheral blood and cerebrospinal fluid is associated with disease activity of multiple sclerosis
    Yoshinobu Okuda
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neuroimmunol 171:163-70. 2006

Research Grants

  1. HIV-1-ASSOCIATED SUPERANTIGEN
    DAVID POSNETT; Fiscal Year: 1993
  2. HIV-1 ASSOCIATED SUPERANTIGEN
    DAVID POSNETT; Fiscal Year: 2001

Collaborators

Detail Information

Publications16

  1. doi request reprint Development of effective vaccines for old mice in a tumor model
    David N Posnett
    Dep of Medicine, Weill Medical College of Cornell University, New York, NY 10021, United States
    Vaccine 27:1093-100. 2009
    ..However, fusion constructs with Vp22 gave a strong CD4 response to B16 melanoma and the OmpA response is MHC-II dependent. Both adjuvant fusion constructs stimulated CD4 and CD8 responses otherwise diminished in old mice...
  2. ncbi request reprint Sleeping with the enemy--endogenous superantigens in humans
    D N Posnett
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 15:503-6. 2001
    ..Now, based on two papers in this issue of Immunity, it seems that we all have SAg genes within us, lying dormant and waiting to be activated under special circumstances...
  3. ncbi request reprint Herpesviruses and autoimmunity
    David N Posnett
    Weill Medical College of Cornell University, Department of Medicine, Division of Hematology Oncology, 1300 York Avwnue, New York, NY 10021, USA
    Curr Opin Investig Drugs 9:505-14. 2008
    ....
  4. ncbi request reprint Oligoclonal expansions of antigen-specific CD8+ T cells in aged mice
    David N Posnett
    Weill Medical College, Cornell University, Immunology Program, Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 987:274-9. 2003
    ..The TCE appear to be inefficient as they are often anergic. As a result an occasional peritoneal or splenic tumor may arise in old mice...
  5. pmc The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
    A J Marcus
    Department of Medicine, Veterans Affairs Medical Center, New York 10010 5050, USA
    J Clin Invest 99:1351-60. 1997
    ..The identification of HUVEC ADPase/CD39 as a constitutively expressed potent inhibitor of platelet reactivity offers new prospects for antithrombotic therapeusis...
  6. pmc Lack of muco-cutaneous signs of toxic shock syndrome when T cells are absent: S. aureus shock in immunodeficient adults with multiple myeloma
    N S Kamel
    Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Clin Exp Immunol 128:131-9. 2002
    ..Thus, S. aureus sepsis/shock can be clinically distinguished from typical TSS, and we suggest that mucocutaneous manifestations of TSS are the most telling signs of massive T-cell-dependent cytokine release...
  7. ncbi request reprint Polyclonal lymphocytosis of T-cells associated with human T-cell leukemia virus I
    D N Posnett
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    Cancer Res 48:2585-9. 1988
    ..Polyclonal T-cell infection by human T-cell leukemia virus type I may represent an infrequently observed stage of leukemogenesis...
  8. ncbi request reprint Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome
    Sanil J Manavalan
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:187-98. 2004
    ..g., due to genomic deletion) has functional significance. We examined this question in relation to a known 21.6-kb insertion/deletion-related polymorphism (IDRP) in the human BV locus...
  9. pmc Antiviral T cell responses: phalanx or multipronged attack?
    David N Posnett
    Department of Medicine, Division of Hematology Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Exp Med 201:1881-4. 2005
    ..Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach to combatting pathogens or tumors?..
  10. ncbi request reprint Apoptosis of T cells in peripheral blood and cerebrospinal fluid is associated with disease activity of multiple sclerosis
    Yoshinobu Okuda
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neuroimmunol 171:163-70. 2006
    ..These results indicate that the resistance of T cells to Fas-mediated apoptosis is involved in exacerbation of MS and/or that Fas-mediated apoptosis of T cells is associated with remission of MS...
  11. ncbi request reprint Tumor antigen drives a persistent oligoclonal expansion of CD8+ T cells in aged mice
    Fang Li
    Immunology Program, Graduate School of Medical Sciences, Weil Medical College of Cornell University, New York, NY 10021, USA
    Eur J Immunol 32:1650-8. 2002
    ..This induced tumor antigen-specific response may represent a model for the spontaneous TCE observed with aging and demonstrates that the CD8 response to a defined peptide/MHC antigen is indeed more oligoclonal in old mice...
  12. ncbi request reprint Staphylococcus aureus express unique superantigens depending on the tissue source
    Michael C Banks
    Immunology Program, Graduate School of Medical Sciences, Weill Medical College, Cornell University, New York, New York 10021, USA
    J Infect Dis 187:77-86. 2003
    ..Together, the data suggest a role for SEG/SEI or closely linked genes in the adaptation of S. aureus to the genital mucosa environment...
  13. pmc Amplification of autoimmune disease by infection
    David N Posnett
    Immunology Program, Graduate School of Medical Sciences, Weill Medical College, Cornell University, Ithaca, NY, USA
    Arthritis Res Ther 7:74-84. 2005
    ..We suggest that patients with autoimmune disorders receiving immunosuppressing drugs should benefit from preventive antiviral therapy...
  14. ncbi request reprint The activation of memory CD4(+) T cells and CD8(+) T cells in patients with multiple sclerosis
    Yoshinobu Okuda
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neurol Sci 235:11-7. 2005
    ..Transient as well as continuous activation of T cells by recall antigens may be involved in the disease course of MS...
  15. doi request reprint Mechanisms of immunization against cancer using chimeric antigens
    Manuel E Engelhorn
    The Swim Across America Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Ther 16:773-81. 2008
    ..Therefore large fusion vector panels such as those presented here can provide information to promote the successful advancement of gene-based vaccines...
  16. ncbi request reprint A mouse herpesvirus induces relapse of experimental autoimmune arthritis by infection of the inflammatory target tissue
    Dmitry A Yarilin
    Immunology Program, Graduate School of Medical Sciences, Division of Hematology Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Immunol 173:5238-46. 2004
    ..We conclude that herpesviruses may play an ancillary pathogenic role in autoimmune arthritis by infection of the inflammatory target tissue...

Research Grants8

  1. HIV-1-ASSOCIATED SUPERANTIGEN
    DAVID POSNETT; Fiscal Year: 1993
    ..7a transgenic mice. They suggest that blocking the effects of an HIV-1 SA in vivo could represent a novel therapeutic approach to AIDS...
  2. HIV-1 ASSOCIATED SUPERANTIGEN
    DAVID POSNETT; Fiscal Year: 2001
    ..Another aim is to investigate whether the SAG enhances CMV infection or reactivation. Finally a potential role of the CMV SAG in enhancing HIV infection will be explored. ..