David N Posnett

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Tumor antigen drives a persistent oligoclonal expansion of CD8+ T cells in aged mice
    Fang Li
    Immunology Program, Graduate School of Medical Sciences, Weil Medical College of Cornell University, New York, NY 10021, USA
    Eur J Immunol 32:1650-8. 2002
  2. ncbi Antiviral T cell responses: phalanx or multipronged attack?
    David N Posnett
    Department of Medicine, Division of Hematology Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Exp Med 201:1881-4. 2005
  3. ncbi Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome
    Sanil J Manavalan
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:187-98. 2004
  4. ncbi Development of effective vaccines for old mice in a tumor model
    David N Posnett
    Dep of Medicine, Weill Medical College of Cornell University, New York, NY 10021, United States
    Vaccine 27:1093-100. 2009
  5. ncbi Apoptosis of T cells in peripheral blood and cerebrospinal fluid is associated with disease activity of multiple sclerosis
    Yoshinobu Okuda
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neuroimmunol 171:163-70. 2006
  6. ncbi Mechanisms of immunization against cancer using chimeric antigens
    Manuel E Engelhorn
    The Swim Across America Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Ther 16:773-81. 2008
  7. ncbi Amplification of autoimmune disease by infection
    David N Posnett
    Immunology Program, Graduate School of Medical Sciences, Weill Medical College, Cornell University, Ithaca, NY, USA
    Arthritis Res Ther 7:74-84. 2005
  8. ncbi Herpesviruses and autoimmunity
    David N Posnett
    Weill Medical College of Cornell University, Department of Medicine, Division of Hematology Oncology, 1300 York Avwnue, New York, NY 10021, USA
    Curr Opin Investig Drugs 9:505-14. 2008
  9. ncbi The activation of memory CD4(+) T cells and CD8(+) T cells in patients with multiple sclerosis
    Yoshinobu Okuda
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neurol Sci 235:11-7. 2005
  10. ncbi Oligoclonal expansions of antigen-specific CD8+ T cells in aged mice
    David N Posnett
    Weill Medical College, Cornell University, Immunology Program, Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 987:274-9. 2003

Collaborators

Detail Information

Publications12

  1. ncbi Tumor antigen drives a persistent oligoclonal expansion of CD8+ T cells in aged mice
    Fang Li
    Immunology Program, Graduate School of Medical Sciences, Weil Medical College of Cornell University, New York, NY 10021, USA
    Eur J Immunol 32:1650-8. 2002
    ..This induced tumor antigen-specific response may represent a model for the spontaneous TCE observed with aging and demonstrates that the CD8 response to a defined peptide/MHC antigen is indeed more oligoclonal in old mice...
  2. ncbi Antiviral T cell responses: phalanx or multipronged attack?
    David N Posnett
    Department of Medicine, Division of Hematology Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Exp Med 201:1881-4. 2005
    ..Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach to combatting pathogens or tumors?..
  3. ncbi Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome
    Sanil J Manavalan
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:187-98. 2004
    ..g., due to genomic deletion) has functional significance. We examined this question in relation to a known 21.6-kb insertion/deletion-related polymorphism (IDRP) in the human BV locus...
  4. ncbi Development of effective vaccines for old mice in a tumor model
    David N Posnett
    Dep of Medicine, Weill Medical College of Cornell University, New York, NY 10021, United States
    Vaccine 27:1093-100. 2009
    ..However, fusion constructs with Vp22 gave a strong CD4 response to B16 melanoma and the OmpA response is MHC-II dependent. Both adjuvant fusion constructs stimulated CD4 and CD8 responses otherwise diminished in old mice...
  5. ncbi Apoptosis of T cells in peripheral blood and cerebrospinal fluid is associated with disease activity of multiple sclerosis
    Yoshinobu Okuda
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neuroimmunol 171:163-70. 2006
    ..These results indicate that the resistance of T cells to Fas-mediated apoptosis is involved in exacerbation of MS and/or that Fas-mediated apoptosis of T cells is associated with remission of MS...
  6. ncbi Mechanisms of immunization against cancer using chimeric antigens
    Manuel E Engelhorn
    The Swim Across America Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Ther 16:773-81. 2008
    ..Therefore large fusion vector panels such as those presented here can provide information to promote the successful advancement of gene-based vaccines...
  7. ncbi Amplification of autoimmune disease by infection
    David N Posnett
    Immunology Program, Graduate School of Medical Sciences, Weill Medical College, Cornell University, Ithaca, NY, USA
    Arthritis Res Ther 7:74-84. 2005
    ..We suggest that patients with autoimmune disorders receiving immunosuppressing drugs should benefit from preventive antiviral therapy...
  8. ncbi Herpesviruses and autoimmunity
    David N Posnett
    Weill Medical College of Cornell University, Department of Medicine, Division of Hematology Oncology, 1300 York Avwnue, New York, NY 10021, USA
    Curr Opin Investig Drugs 9:505-14. 2008
    ....
  9. ncbi The activation of memory CD4(+) T cells and CD8(+) T cells in patients with multiple sclerosis
    Yoshinobu Okuda
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Neurol Sci 235:11-7. 2005
    ..Transient as well as continuous activation of T cells by recall antigens may be involved in the disease course of MS...
  10. ncbi Oligoclonal expansions of antigen-specific CD8+ T cells in aged mice
    David N Posnett
    Weill Medical College, Cornell University, Immunology Program, Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 987:274-9. 2003
    ..The TCE appear to be inefficient as they are often anergic. As a result an occasional peritoneal or splenic tumor may arise in old mice...
  11. ncbi A mouse herpesvirus induces relapse of experimental autoimmune arthritis by infection of the inflammatory target tissue
    Dmitry A Yarilin
    Immunology Program, Graduate School of Medical Sciences, Division of Hematology-Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Immunol 173:5238-46. 2004
    ..We conclude that herpesviruses may play an ancillary pathogenic role in autoimmune arthritis by infection of the inflammatory target tissue...
  12. ncbi Staphylococcus aureus express unique superantigens depending on the tissue source
    Michael C Banks
    Immunology Program, Graduate School of Medical Sciences, Weill Medical College, Cornell University, New York, New York 10021, USA
    J Infect Dis 187:77-86. 2003
    ..Together, the data suggest a role for SEG/SEI or closely linked genes in the adaptation of S. aureus to the genital mucosa environment...