Research Topics
| Jeffrey M PerlmanSummaryAffiliation: Cornell University Country: USA Publications
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Detail Information
Publications
Hemorrhagic-ischemic cerebral injury in the preterm infant: current conceptsLina Shalak
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas TX 75390-9063, USA
Clin Perinatol 29:745-63. 2002..This reinforces the concept of a more diffuse injury to brain in sick premature infants than is apparent from the appearance of current neuroimaging techniques...
Attitudes of neonatologists toward delivery room management of confirmed trisomy 18: potential factors influencing a changing dynamicMelanie P McGraw
Division of Newborn Medicine, Weill Cornell School of Medicine, New York Presbyterian Hospital, 525 East 68th St, Suite N 506, New York, NY 10021, USA
Pediatrics 121:1106-10. 2008..The objective of this study was to determine the attitude of neonatal providers toward delivery room resuscitation of an infant with confirmed trisomy 18 with known congenital heart disease at >/=36 weeks of gestation...- Newborn mortality and fresh stillbirth rates in Tanzania after helping babies breathe trainingGeorgina Msemo
MB, CHB, Weill Cornell Medical College, 525 East 68th St, Suite N 506, New York, NY 10065
Pediatrics 131:e353-60. 2013..Helping Babies Breathe (HBB), a novel educational program using basic interventions to enhance delivery room stabilization/resuscitation, has been developed to reduce the number of these deaths... - The 3:1 is superior to a 15:2 ratio in a newborn manikin model in terms of quality of chest compressions and number of ventilationsRae Jean Hemway
Division of Newborn Nursing, New York Presbyterian Hospital, New York, New York, USA
Arch Dis Child Fetal Neonatal Ed 98:F42-5. 2013..Experimental evidence supports an important role for ventilation during asphyxial arrest. The optimal compression: ventilation (CV) ratio remains unclear and recommendations for newborns have varied from 3:1, 5:1 and 15:2... - Cellular biology of end organ injury and strategies for prevention of injuryJeffrey M Perlman
Division of Newborn Medicine, Department of Pediatrics, Weill Cornell Medical College, 525 East 68th Street, Suite N 506, New York, NY 10065, USA Electronic address
Clin Perinatol 39:785-802. 2012..Specifically, the focus should include the judicious use of supplemental oxygen, avoidance of hypoglycemia and elevated temperature in the delivery room, and the early administration of therapeutic hypothermia to high-risk infants... - Neonatal resuscitation: in pursuit of evidence gaps in knowledgeJeffrey Perlman
Neonatal ILCOR Task Force, America Heart Association, American Academy of Pediatrics, Division of Newborn Medicine, New York Presbyterian Hospital Weill Cornell Medical College, NY, USA
Resuscitation 83:545-50. 2012..The current document is based on the "gaps in knowledge" summary for neonatal resuscitation that was created at the conclusion of the 2005-2010 ILCOR cycle... - Intervention strategies for neonatal hypoxic-ischemic cerebral injuryJeffrey M Perlman
Weill Medical College of Cornell University, New York, New York 10021, USA
Clin Ther 28:1353-65. 2006..It is during this recovery period that the potential for neuroprotection exists... - Summary proceedings from the neurology group on hypoxic-ischemic encephalopathyJeffrey M Perlman
Department of Pediatrics, Weill Cornell Medical College, 525 E 68th St, N 506, New York, New York 10021, USA
Pediatrics 117:S28-33. 2006.... - Morphine, hypotension, and intraventricular hemorrhage in the ventilated premature infantJeffrey M Perlman
Department of Pediatrics, Weill Cornell Medical Center, New York, NY 10021, USA
Pediatrics 115:1416-8. 2005 - The relationship between systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage--a historical perspectiveJeffrey M Perlman
Division of Newborn Medicine, Department of Pediatrics, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10065, USA
Semin Pediatr Neurol 16:191-9. 2009..Early postnatal administration of indomethacin has been associated with a reduction in PV-IVH, although this has not translated into long-term neurocognitive benefits... - Interruption of placental blood flow during labor: potential systemic and cerebral organ consequencesJeffrey M Perlman
Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA
J Pediatr 158:e1-4. 2011..Long-term neurological outcome has been well categorized, whereas the systemic consequences remain unclear... - Brain injury in the term infantJeffrey M Perlman
Division of Neonatology, Department of Pediatrics, Joan and Sanford I Weill Medical College and Graduate School of Medical Sciences at Cornell University, New York, NY 10021, USA
Semin Perinatol 28:415-24. 2004..Modest hypothermia is one such therapy that has been studied in high-risk newborn infants with some initial success. Future studies need to focus on additional neuroprotective strategies... - Intrapartum asphyxia and cerebral palsy: is there a link?Jeffrey M Perlman
Department of Pediatrics, Weill Cornell Medical Center, New York, NY 10021, USA
Clin Perinatol 33:335-53. 2006.... - Delivery room resuscitation past, present, and the futureJeffrey M Perlman
New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10021, USA
Clin Perinatol 33:1-9, v. 2006..Despite difficulties in conducting research in the delivery room, several large randomized studies have been undertaken over the past two decades that have provided a scientific basis for some of the new guidelines... - Hyperthermia in the delivery: potential impact on neonatal mortality and morbidityJeffrey M Perlman
New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10021, USA
Clin Perinatol 33:55-63, vi. 2006..Neonatal experimental studies are limited, and the data are conflicting. This article addresses the available evidence concerning the potential impact of hyperthermia in the delivery on neonatal mortality and morbidity... - Amplitude-integrated electroencephalography coupled with an early neurologic examination enhances prediction of term infants at risk for persistent encephalopathyLina F Shalak
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9063, USA
Pediatrics 111:351-7. 2003.... - Depression at birth in term infants exposed to maternal chorioamnionitis: does neonatal fever play a role?Lina F Shalak
Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX, USA
J Perinatol 25:447-52. 2005.... - Use of volume expansion during delivery room resuscitation in near-term and term infantsMyra H Wyckoff
Division of Neonatology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Pediatrics 115:950-5. 2005.... - Chorioamnionitis and neonatal encephalopathy in term infants with fetal acidemia: histopathologic correlationsLina Shalak
Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
Pediatr Neurol 33:162-5. 2005..However, the presence of histologic chorioamnionitis had a poor predictive value and did not confer additional risk for the subsequent development of neonatal encephalopathy... - Severe fetal acidemia and subsequent neonatal encephalopathy in the larger premature infantWalid A Salhab
Department of Pediatrics, University of Texas Southwestern Medical Center, Neonatal-Perinatal Medicine, Dallas, Texas, USA
Pediatr Neurol 32:25-9. 2005..0003). We conclude that the larger depressed preterm infant is at increased risk for moderate to severe encephalopathy. Such infants could also be considered potential candidates for neuroprotective strategies... - Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemiaWalid A Salhab
University of Texas Southwestern Medical Center at Dallas, Department of Pediatrics, Neonatal-Perinatal Medicine, Dallas, Texas, USA
Pediatrics 114:361-6. 2004..It remains unclear, however, whether earlier detection of hypoglycemia, such as in the delivery room, in this population could modify subsequent neurologic outcome... - Hypoxic-ischemic brain injury in the term infant-current conceptsLina Shalak
Department of Pediatrics, Southwestern Medical Center, University of Texas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Early Hum Dev 80:125-41. 2004.... - Clinical chorioamnionitis, elevated cytokines, and brain injury in term infantsLina F Shalak
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9063, USA
Pediatrics 110:673-80. 2002..CONCLUSIONS: There was a significant association between abnormalities in the neurologic examination and cytokine concentrations, with the highest cytokines concentrations observed in infants who developed HIE/seizures... - Changing pattern of perinatal brain injury in term infants in recent yearsToshiki Takenouchi
Division of Pediatric Neurology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, USA
Pediatr Neurol 46:106-10. 2012..Most cases attributable to perinatal brain injury, except for evolving hypoxic-ischemic encephalopathy, are not identified according to any perinatal characteristics until the onset of signs, limiting opportunities for prevention... - Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathyToshiki Takenouchi
Department of Pediatrics, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10021, USA
J Pediatr 159:232-7. 2011..To determine whether hypothermia modulates acquisition of sleep-wake cycling in term neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE) and the relationship to outcome... - Glucose management during and after intensive delivery room resuscitationJane E McGowan
Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Clin Perinatol 33:183-96, x. 2006..The evidence regarding the role of glucose in modifying post-asphyxia brain injury and resuscitation was reviewed to better define optimal glucose management after perinatal asphyxia and resuscitation... - Necrotizing enterocolitis and neurodevelopmental outcome in extremely low birth weight infants <1000 gWalid A Salhab
Department of Pediatrics, Division of Neonatal-Perinatal Medicine University of Texas Southwestern Medical Center Dallas, TX, USA
J Perinatol 24:534-40. 2004..05). A logistic model identified NEC and chronic lung disease as predictors for abnormal PDI and MDI, respectively. CONCLUSIONS: NEC and its comorbidities are associated with severe neurodevelopmental and growth delay in ELBW infants... - Stimulus-induced seizure in sick neonates--novel observations with potential clinical implicationsToshiki Takenouchi
Division of Pediatric Neurology, Department of Pediatrics, NewYork Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA
Epilepsia 51:308-11. 2010..These observations stress the usefulness of vEEG monitoring and importance of care to avoid unnecessary stimuli in at-risk neonates... - Seizures are common in term infants undergoing head coolingVivien Yap
Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA
Pediatr Neurol 41:327-31. 2009..Magnesium was at </=1.2 mg/dL (n = 9). Electrographic seizures were very frequent, and often lacked a clinical correlate. Electroencephalography monitoring during cooling should be considered to detect subclinical seizures... - Neonatal cord blood subsets and cytokine response to bacterial antigensJohn Denton Peoples
Department of Pediatrics, Host Defenses Program, Cornell University Weill Medical College, New York, New York 10021, USA
Am J Perinatol 26:647-57. 2009..These differences rather than intrinsic functional deficiency may account for neonatal cytokine responses to bacteria... - Chain of Brain Preservation--a concept to facilitate early identification and initiation of hypothermia to infants at high risk for brain injuryToshiki Takenouchi
Department of Pediatrics, Division of Pediatric Neurology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, United States
Resuscitation 81:1637-41. 2010..However, in the three major studies the time to initiate cooling was at approximately 4.5 postnatal hours... - Role of nutrients in the development of neonatal immune responseSusanna Cunningham-Rundles
Division of Hematology Oncology, Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USA
Nutr Rev 67:S152-63. 2009.... - The two-thumb technique using an elevated surface is preferable for teaching infant cardiopulmonary resuscitationTrang K Huynh
Department of Pediatrics, Weill Cornell Medical College, New York, NY 10065, USA
J Pediatr 161:658-61. 2012.... - Partial or complete antenatal steroids treatment and neonatal outcome in extremely low birth weight infants < or =1000 g: is there a dose-dependent effect?Walid A Salhab
Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Perinatol 23:668-72. 2003..To assess the outcome of extremely low birth weight (ELBW) infants < or =1000 g as it relates to antenatal steroids (ANS) therapy... - Apoptosis and white matter injury in preterm infantsSangkae Chamnanvanakij
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA
Pediatr Dev Pathol 5:184-9. 2002..Strategies aimed at preventing the white matter injury will need to incorporate methods of inhibiting the ongoing process of apoptosis... - Restricted diffusion in the corpus callosum in hypoxic-ischemic encephalopathyToshiki Takenouchi
Division of Pediatric Neurology, Department of Pediatrics, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 10021, USA
Pediatr Neurol 43:190-6. 2010.... - Amplitude-integrated electroencephalography in the NICU: frequent artifacts in premature infants may limit its utility as a monitoring deviceDebbie Suk
Department of Pediatrics, Weill Cornell Medical College of Cornell University, 525 E 68th St, Suite N 506, New York, NY 10065, USA
Pediatrics 123:e328-32. 2009..Newer units have the additional feature of visualizing the raw electroencephalogram, which has resulted in the identification of frequent artifacts... - The two-thumb is superior to the two-finger method for administering chest compressions in a manikin model of neonatal resuscitationCatherine Christman
Department of Pediatrics, Weill Cornell Medical College, 525 E 68th Street, New York, NY 10065, USA
Arch Dis Child Fetal Neonatal Ed 96:F99-F101. 2011..Current neonatal guidelines endorse both the two-thumb and the two-finger techniques for performing chest compressions. It remains unclear whether one method is superior to the other in achieving consistent depth... - Physical growth and cognitive abilities in concordant versus discordant birth weight twins at three years oldGail S Ross
Division of Newborn Medicine, Department of Pediatrics, Weill Cornell Medical College, USA
Early Hum Dev 88:753-6. 2012..Discordant birth weight twins have been shown to have high rates of adverse perinatal outcomes, but little is known about their growth and development... - Infection markers and early signs of neonatal encephalopathy in the term infantLina F Shalak
Department of Pediatrics, UT Southwestern Medical School, Dallas, Texas 75235-9063, USA
Ment Retard Dev Disabil Res Rev 8:14-9. 2002..The characteristics of the perinatal inflammatory response, the potential mechanisms of brain injury associated with infection, and the clinical characteristics of neonatal encephalopathy will be discussed... - Use of high-dose epinephrine and sodium bicarbonate during neonatal resuscitation: is there proven benefit?Myra H Wyckoff
Department of Pediatrics, Division of Neonatal Perinatal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9063, USA
Clin Perinatol 33:141-51, viii-ix. 2006..The use of sodium bicarbonate infusion should be discouraged during brief CPR. Whether sodium bicarbonate is beneficial for infants who require prolonged CPR despite adequate ventilation is unknown... - Effective ventilation and temperature control are vital to outborn resuscitationMyra H Wyckoff
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Prehosp Emerg Care 8:191-5. 2004..To determine perinatal clinical characteristics of outborn infants and to examine the early postdelivery management and subsequent clinical outcome of outborns compared with inborns... - Subdural hematoma in term infantsSangkae Chamnanvanakij
Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas 75235-9063, USA
Pediatr Neurol 26:301-4. 2002..The presence of subdural hematoma documented by computed tomography is not necessarily always indicative of birth trauma and may occur as sequelae of an otherwise uncomplicated delivery... - Development of a statewide collaborative to decrease NICU central line-associated bloodstream infectionsJ Schulman
Department of Pediatrics Newborn Medicine, Weill Cornell Medical College, Weill Cornell Medical Center, New York, NY, USA
J Perinatol 29:591-9. 2009.... - Cognitive and behavioral deficits in premature graduates of intensive careJeffrey M Perlman
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
Clin Perinatol 29:779-97. 2002.... - Effects of implementing family-centered rounds (FCRs) in a neonatal intensive care unit (NICU)Kristin C Voos
Division of Newborn Medicine, Department of Pediatrics, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA
J Matern Fetal Neonatal Med 24:1-4. 2011..1) Evaluate impact of FCR on provider satisfaction and collaboration. (2) Evaluate impact of FCR on parent satisfaction with provider communication... - Histologic chorioamnionitis: an occult marker of severe pulmonary hypertension in the term newbornMesfin Woldesenbet
Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390-9063, USA
J Perinatol 25:189-92. 2005..The mechanism/s contributing to these findings are unclear... - Resuscitation--air versus 100% oxygenJeffrey M Perlman
Pediatrics 109:347-9. 2002 - Hypothermia as a therapeutic intervention in term infants with neonatal encephalopathy: is it ready for prime time?Jeffrey M Perlman
Resuscitation 78:1-2. 2008 - Modest hypothermia as a neuroprotective strategy in high-risk term infantsMichael Speer
Department of Neonatology, Texas Children's Hospital, Houston, TX 77030, USA
Clin Perinatol 33:169-82, ix. 2006..Further clinical trials are needed to determine which infants would benefit most and which method of cooling would be most effective... - Predicting cerebral white matter injury in preterm infantsJeffrey M Perlman
Obstet Gynecol 107:546-8. 2006 - Extensive brain injury in a premature infant following a relatively minor maternal motor vehicle accident with airbag deploymentPrameela Karimi
Departments of Pediatrics, Obstetrics and Gynecology and Pediatric Patholog, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Perinatol 24:454-7. 2004..We report a case of extensive neurological injury of a premature infant with minimal maternal trauma associated with deployment of an airbag following a minor motor vehicle accident...