R N Pearse

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Age matters:  Young T lymphocytes offer better protection from myeloma proliferation
    Alexander F Glick
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Immun Ageing 10:5. 2013
  2. ncbi request reprint New strategies for the treatment of metastatic bone disease
    Roger N Pearse
    Department of Medicine, Division of Hematology Medical Oncology, Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Clin Breast Cancer 8:S35-45. 2007
  3. pmc Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    R N Pearse
    Laboratories of Molecular Genetics and Immunology, and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:11581-6. 2001
  4. ncbi request reprint Wnt antagonism in multiple myeloma: a potential cause of uncoupled bone remodeling
    Roger N Pearse
    Division of Hematology Oncology, Cornell University Medical College, New York, New York 10021, USA
    Clin Cancer Res 12:6274s-6278s. 2006
  5. ncbi request reprint A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    Roger N Pearse
    Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
    Blood 105:4429-36. 2005
  6. ncbi request reprint BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma
    Ruben Niesvizky
    Center of Excellence for Lymphoma and Myeloma, Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital Cornell Medical Center, New York, NY 10021, USA
    Blood 111:1101-9. 2008
  7. pmc Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma
    Tomer Mark
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital Cornell Medical Center, New York, New York 10021, USA
    Biol Blood Marrow Transplant 14:795-8. 2008
  8. pmc Atypical serum immunofixation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma
    Tomer Mark
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Lymphoma and Myeloma, Weill Medical College of Cornell University, New York Presbyterian Hospital Cornell Medical Center, New York, NY 10021, USA
    Br J Haematol 143:654-60. 2008
  9. ncbi request reprint Lenalidomide-induced myelosuppression is associated with renal dysfunction: adverse events evaluation of treatment-naïve patients undergoing front-line lenalidomide and dexamethasone therapy
    Ruben Niesvizky
    Center of Excellence for Lymphoma and Myeloma, Division of Hematology and Medical Oncology, Weill Medical College of Cornell University, New York Presbytarian Hospital Cornell Medical Center, New York, NY 10021, USA
    Br J Haematol 138:640-3. 2007
  10. pmc Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference
    Allan Lipton
    Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA, and Department of Oncology, Norwegian Radium Hospital, Oslo, Norway
    Clin Cancer Res 12:6209s-6212s. 2006

Research Grants

  1. Neurotrophin Signaling in Multiple Myeloma
    Roger N Pearse; Fiscal Year: 2010
  2. Neurotrophin Signaling in Multiple Myeloma
    Roger Pearse; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. pmc Age matters:  Young T lymphocytes offer better protection from myeloma proliferation
    Alexander F Glick
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Immun Ageing 10:5. 2013
    ..The incidence and growth of cancer has been reported to increase with age and/or impaired T lymphocyte function...
  2. ncbi request reprint New strategies for the treatment of metastatic bone disease
    Roger N Pearse
    Department of Medicine, Division of Hematology Medical Oncology, Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Clin Breast Cancer 8:S35-45. 2007
    ....
  3. pmc Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    R N Pearse
    Laboratories of Molecular Genetics and Immunology, and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:11581-6. 2001
    ..Our data identify TRANCE and OPG as key cytokines whose deregulation promotes bone destruction and supports myeloma growth...
  4. ncbi request reprint Wnt antagonism in multiple myeloma: a potential cause of uncoupled bone remodeling
    Roger N Pearse
    Division of Hematology Oncology, Cornell University Medical College, New York, New York 10021, USA
    Clin Cancer Res 12:6274s-6278s. 2006
    ..Inhibition of bone formation may result from the ability of MM to inhibit the function of Wnts, secreted glycoproteins critical to osteoblast development. Recent studies show how these processes may be linked...
  5. ncbi request reprint A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    Roger N Pearse
    Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
    Blood 105:4429-36. 2005
    ..Finally, BDNF is expressed by malignant plasma cells isolated from a subset of patients with MM, as well as by most HMCLs, suggesting a potential role for this neurotrophin axis in autocrine as well as paracrine support of MM...
  6. ncbi request reprint BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma
    Ruben Niesvizky
    Center of Excellence for Lymphoma and Myeloma, Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital Cornell Medical Center, New York, NY 10021, USA
    Blood 111:1101-9. 2008
    ..BiRD is an effective regimen with manageable side effects in the treatment of symptomatic, newly diagnosed multiple myeloma. This trial was registered at www.clinicaltrials.gov as #NCT00151203...
  7. pmc Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma
    Tomer Mark
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital Cornell Medical Center, New York, New York 10021, USA
    Biol Blood Marrow Transplant 14:795-8. 2008
    ..91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide...
  8. pmc Atypical serum immunofixation patterns frequently emerge in immunomodulatory therapy and are associated with a high degree of response in multiple myeloma
    Tomer Mark
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Lymphoma and Myeloma, Weill Medical College of Cornell University, New York Presbyterian Hospital Cornell Medical Center, New York, NY 10021, USA
    Br J Haematol 143:654-60. 2008
    ..This is the first time this phenomenon has been seen with regularity in non-myeloablative therapy for MM. Analogous to the ASCT experience, ASIPs do not signal incipient disease progression, but rather herald robust response...
  9. ncbi request reprint Lenalidomide-induced myelosuppression is associated with renal dysfunction: adverse events evaluation of treatment-naïve patients undergoing front-line lenalidomide and dexamethasone therapy
    Ruben Niesvizky
    Center of Excellence for Lymphoma and Myeloma, Division of Hematology and Medical Oncology, Weill Medical College of Cornell University, New York Presbytarian Hospital Cornell Medical Center, New York, NY 10021, USA
    Br J Haematol 138:640-3. 2007
    ..Caution should be exercised when lenalidomide therapy is commenced and CrCl should be incorporated as a determinant of the initial dosing of lenalidomide in MM patients...
  10. pmc Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference
    Allan Lipton
    Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA, and Department of Oncology, Norwegian Radium Hospital, Oslo, Norway
    Clin Cancer Res 12:6209s-6212s. 2006
    ..The conclusions reached during the 2-day meeting are summarized in this article and presented in more detail in the individual articles and accompanying discussion sessions that comprise the conference proceedings...
  11. ncbi request reprint Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
    Shmuel Yaccoby
    Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Br J Haematol 116:278-90. 2002
    ..Breaking this loop may help control myeloma...

Research Grants5

  1. Neurotrophin Signaling in Multiple Myeloma
    Roger N Pearse; Fiscal Year: 2010
    ....
  2. Neurotrophin Signaling in Multiple Myeloma
    Roger Pearse; Fiscal Year: 2007
    ....