Colin Parrish

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Host range relationships and the evolution of canine parvovirus
    C R Parrish
    James A Baker Institute, College of Veterinary Medicine, Cornell University Ithaca, NY 14853, USA
    Vet Microbiol 69:29-40. 1999
  2. pmc Presence and role of cytosine methylation in DNA viruses of animals
    Karin Hoelzer
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Nucleic Acids Res 36:2825-37. 2008
  3. pmc Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs
    Jason T Kaelber
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS Pathog 8:e1002666. 2012
  4. pmc The emergence of parvoviruses of carnivores
    Karin Hoelzer
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA
    Vet Res 41:39. 2010
  5. pmc Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges
    Laura M Palermo
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA
    J Virol 80:8482-92. 2006
  6. pmc Detecting small changes and additional peptides in the canine parvovirus capsid structure
    Christian D S Nelson
    Department of Microbiology and Immunology, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 82:10397-407. 2008
  7. pmc Cross-species virus transmission and the emergence of new epidemic diseases
    Colin R Parrish
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Microbiol Mol Biol Rev 72:457-70. 2008
  8. doi request reprint Structures and functions of parvovirus capsids and the process of cell infection
    Colin R Parrish
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
    Curr Top Microbiol Immunol 343:149-76. 2010
  9. pmc Role of multiple hosts in the cross-species transmission and emergence of a pandemic parvovirus
    Andrew B Allison
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
    J Virol 86:865-72. 2012
  10. pmc The role of evolutionary intermediates in the host adaptation of canine parvovirus
    Karla M Stucker
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    J Virol 86:1514-21. 2012

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Host range relationships and the evolution of canine parvovirus
    C R Parrish
    James A Baker Institute, College of Veterinary Medicine, Cornell University Ithaca, NY 14853, USA
    Vet Microbiol 69:29-40. 1999
    ....
  2. pmc Presence and role of cytosine methylation in DNA viruses of animals
    Karin Hoelzer
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Nucleic Acids Res 36:2825-37. 2008
    ..Here we briefly introduce cytosine methylation before reviewing what is currently known about CpG methylation in DNA viruses...
  3. pmc Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs
    Jason T Kaelber
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS Pathog 8:e1002666. 2012
    ..This alters our understanding of this well-known example of viral emergence by indicating that canine parvovirus emergence likely resulted from the re-adaptation of a parvovirus to the resistant receptor of a former host...
  4. pmc The emergence of parvoviruses of carnivores
    Karin Hoelzer
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA
    Vet Res 41:39. 2010
    ..CPV represents a valuable model for understanding disease emergence through cross-species transmission, while MEV provides an interesting comparison...
  5. pmc Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges
    Laura M Palermo
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA
    J Virol 80:8482-92. 2006
    ..The purified feline TfR inhibited FPV and CPV-2 binding and infection of feline cells but not CPV-2b, indicating that the receptor binding may be able to prevent the attachment to the same receptor on cells...
  6. pmc Detecting small changes and additional peptides in the canine parvovirus capsid structure
    Christian D S Nelson
    Department of Microbiology and Immunology, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 82:10397-407. 2008
    ..Exposure of viral DNA to the external environment started above 50 degrees C. Some negative stains showed increased permeability of empty capsids at higher temperatures, but no effects were seen after EGTA treatment...
  7. pmc Cross-species virus transmission and the emergence of new epidemic diseases
    Colin R Parrish
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Microbiol Mol Biol Rev 72:457-70. 2008
    ....
  8. doi request reprint Structures and functions of parvovirus capsids and the process of cell infection
    Colin R Parrish
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
    Curr Top Microbiol Immunol 343:149-76. 2010
    ..Those processes control the infection, pathogenesis, and host ranges of the autonomous viruses and determine the effectiveness of gene therapy using AAV capsids...
  9. pmc Role of multiple hosts in the cross-species transmission and emergence of a pandemic parvovirus
    Andrew B Allison
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
    J Virol 86:865-72. 2012
    ..This highlights the potential role of alternative hosts in viral emergence...
  10. pmc The role of evolutionary intermediates in the host adaptation of canine parvovirus
    Karla M Stucker
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    J Virol 86:1514-21. 2012
    ..Notably, most intermediate viral genotypes containing different combinations of the four key amino acids possessed markedly lower fitness than the wild-type viruses...
  11. ncbi request reprint The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses
    Colin R Parrish
    J A Baker Institute, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Microbiol 59:553-86. 2005
    ..The canine adaptation of the parvoviruses involved capsid protein changes altering the recognition of the host transferrin receptors, allowing canine transferrin receptor binding and its use as a receptor for cell infection...
  12. pmc Early steps in cell infection by parvoviruses: host-specific differences in cell receptor binding but similar endosomal trafficking
    Carole E Harbison
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 83:10504-14. 2009
    ..Constitutively active or dominant negative Rab mutants changed the intracellular distribution of capsids and affected the infectivity of virus in cells...
  13. ncbi request reprint Polymerase chain reaction (PCR) amplification of parvoviral DNA from the brains of dogs and cats with cerebellar hypoplasia
    Scott J Schatzberg
    Department of Clinical Sciences, Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853 6401, USA
    J Vet Intern Med 17:538-44. 2003
    ..This study shows that parvoviral DNA can be amplified from feline and canine archival brain tissue and that cerebellar hypoplasia in dogs might be associated with in utero parvovirus infection...
  14. pmc The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor
    Karsten Hueffer
    James A Baker Institute, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 77:1718-26. 2003
    ....
  15. pmc The VP1 N-terminal sequence of canine parvovirus affects nuclear transport of capsids and efficient cell infection
    Maija Vihinen-Ranta
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 76:1884-91. 2002
    ..To examine the role of the VP1 N terminus in infection, we altered that sequence in CPV, and some of those changes made the capsids inefficient at cell infection...
  16. ncbi request reprint [Evolution and host variation of the canine parvovirus: molecular basis for the development of a new virus]
    Karsten Hueffer
    J A Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University Ithaca, New York, USA
    Berl Munch Tierarztl Wochenschr 117:130-5. 2004
    ..These residues are located on a raised region of the capsid at the three-fold axis of symmetry. Interestingly, adaption of the new virus to the new host appears to correlate with an improved binding to the Tfr receptor...
  17. pmc Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection
    Laura B Goodman
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA
    J Virol 84:4969-78. 2010
    ....
  18. pmc Within-host genetic diversity of endemic and emerging parvoviruses of dogs and cats
    Karin Hoelzer
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 82:11096-105. 2008
    ..These included residues with evidence of positive selection at the population level, which is compatible with a role of this protein in host adaptation...
  19. pmc Combinations of two capsid regions controlling canine host range determine canine transferrin receptor binding by canine and feline parvoviruses
    Karsten Hueffer
    James A Baker Institute, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 77:10099-105. 2003
    ..This shows that both CPV-specific changes control canine TfR binding but that binding is not always sufficient to mediate infection...
  20. pmc Phylogenetic analysis reveals the emergence, evolution and dispersal of carnivore parvoviruses
    Karin Hoelzer
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Gen Virol 89:2280-9. 2008
    ..Such limited viral migration contrasts with the global spread of the virus observed during the early phase of the CPV pandemic, but corresponds to the more endemic nature of current CPV infections...
  21. pmc Residues in the apical domain of the feline and canine transferrin receptors control host-specific binding and cell infection of canine and feline parvoviruses
    Laura M Palermo
    James A Baker Institute, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 77:8915-23. 2003
    ..In some cases, binding of capsids to mutant receptors did not result in infection, suggesting a structural role for the receptor in cell infection by the viruses...
  22. pmc Different mechanisms of antibody-mediated neutralization of parvoviruses revealed using the Fab fragments of monoclonal antibodies
    Christian D S Nelson
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Virology 361:283-93. 2007
    ..All partially prevented binding and uptake of capsids by feline TfR on cells. The virus appears adapted to allow some infectivity in the presence of at least low levels of antibodies...
  23. pmc Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains
    Karsten Hueffer
    James A Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 78:5601-11. 2004
    ..These chimeric receptors bound CPV capsids and mediated uptake but did not result in cell infection. Adding soluble feline TfR ectodomain to the virus during that uptake did not allow infection...
  24. pmc Intrahost evolutionary dynamics of canine influenza virus in naive and partially immune dogs
    Karin Hoelzer
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
    J Virol 84:5329-35. 2010
    ..Potentially advantageous mutations arise readily during the course of single infections and may give rise to antigenic escape or host range variants...
  25. pmc Evaluation of a vectored equine herpesvirus type 1 (EHV-1) vaccine expressing H3 haemagglutinin in the protection of dogs against canine influenza
    Cristina Rosas
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vaccine 26:2335-43. 2008
    ..We concluded that the EHV-1/H3 recombinant vector can be a valuable alternative for protection of dogs against clinical disease induced by CIV and can significantly reduce virus spread...
  26. ncbi request reprint The canine minute virus (minute virus of canines) is a distinct parvovirus that is most similar to bovine parvovirus
    Daniel Schwartz
    James A Baker Institute and Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Virology 302:219-23. 2002
    ..Spliced messages of the NS1 gene transcripts were detected by RT-PCR. VP1 and VP2 proteins were detected in purified capsids, as were modified versions of each protein, and VP3 was also found in full capsids...
  27. ncbi request reprint Parvovirus host range, cell tropism and evolution
    Karsten Hueffer
    JA Baker Institute for Animal Health, Department of Microbiology Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Curr Opin Microbiol 6:392-8. 2003
    ..The cell and tissue tropisms of different adeno-associated virus serotypes were demonstrated to be due, in part, to specific receptor binding...
  28. doi request reprint The parvovirus capsid odyssey: from the cell surface to the nucleus
    Carole E Harbison
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Trends Microbiol 16:208-14. 2008
    ..Here, we define the previously unresolved issues that are now better understood for the infection pathways of these viruses, and outline some of the areas that remain to be clarified in future studies...
  29. pmc Asymmetric binding of transferrin receptor to parvovirus capsids
    Susan Hafenstein
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Proc Natl Acad Sci U S A 104:6585-9. 2007
    ....
  30. pmc Evolutionary dynamics of viral attenuation
    Marty R Badgett
    Section of Integrative Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712 1023, USA
    J Virol 76:10524-9. 2002
    ..Thirteen of the changes observed were identical to or at the same positions as changes observed in other isolates of CPV or feline panleukopenia virus...
  31. pmc Virologic and serologic identification of minute virus of canines (canine parvovirus type 1) from dogs in Japan
    Masami Mochizuki
    Laboratory of Clinical Microbiology Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation, Chiyoda ku, Tokyo 102 0073, Japan
    J Clin Microbiol 40:3993-8. 2002
    ..From this study and several recent European reports describing MVC field cases, it is evident that MVC is distributed among domestic dogs worldwide...
  32. pmc High rate of viral evolution associated with the emergence of carnivore parvovirus
    Laura A Shackelton
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 102:379-84. 2005
    ..Strikingly, although these single-stranded viruses have a DNA genome and use cellular replication machinery, their rate of nucleotide substitution is closer to that of RNA viruses than to that of double-stranded DNA viruses...
  33. ncbi request reprint The structure of porcine parvovirus: comparison with related viruses
    Alan A Simpson
    Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    J Mol Biol 315:1189-98. 2002
    ..These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions...
  34. pmc Minute virus of mice, a parvovirus, in complex with the Fab fragment of a neutralizing monoclonal antibody
    Bärbel Kaufmann
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Virol 81:9851-8. 2007
    ..This finding suggests that the interaction of B7 with three symmetry-related viral subunits at each spike hinders structural transitions in the viral capsid essential during viral entry...
  35. pmc Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants
    Lakshmanan Govindasamy
    Department of Biochemistry and Molecular Biology, Center for Structural Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Virol 77:12211-21. 2003
    ..This emphasizes the complex nature of capsid alterations that change the virus-cell interaction to allow infection of cells from different hosts...
  36. ncbi request reprint Microbiology. A binding contract for anthrax
    James J Bull
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Science 297:201-2. 2002
  37. pmc Pathways of cell infection by parvoviruses and adeno-associated viruses
    Maija Vihinen-Ranta
    Department of Biological and Environmental Science, University of Jyvaskyla, P O Box 35, FIN 40500 Jyväskylä, Finland
    J Virol 78:6709-14. 2004
  38. ncbi request reprint Evolutionary basis of codon usage and nucleotide composition bias in vertebrate DNA viruses
    Laura A Shackelton
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Mol Evol 62:551-63. 2006
    ....
  39. pmc Comparative analysis reveals frequent recombination in the parvoviruses
    Laura A Shackelton
    Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
    J Gen Virol 88:3294-301. 2007
    ..Further, the rodent parvoviruses show complex evolutionary histories for separate genomic regions, suggesting recombination at the interspecies level...
  40. pmc From structure of the complex to understanding of the biology
    Michael G Rossmann
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Acta Crystallogr D Biol Crystallogr 63:9-16. 2007
    ....

Research Grants39

  1. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2007
    ..abstract_text> ..
  2. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2001
    ..Genetic transfer methods will also be used to screen cDNA libraries or genome DNA for the presence of genes that can render cells susceptible to infection - some of which may encode virus receptors or possibly co-receptors. ..
  3. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2002
    ..Genetic transfer methods will also be used to screen cDNA libraries or genome DNA for the presence of genes that can render cells susceptible to infection - some of which may encode virus receptors or possibly co-receptors. ..
  4. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 2002
    ..Irnmuno-electron microscopy will be used to locate the capsids within the cell, around the nuclear pore, and within the nucleus. ..
  5. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2003
    ..abstract_text> ..
  6. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2004
    ..abstract_text> ..
  7. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 2004
    ..Irnmuno-electron microscopy will be used to locate the capsids within the cell, around the nuclear pore, and within the nucleus. ..
  8. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 2005
    ..Irnmuno-electron microscopy will be used to locate the capsids within the cell, around the nuclear pore, and within the nucleus. ..
  9. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2006
    ..abstract_text> ..
  10. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 2007
    ..We would seek to complement endosomal escape mutants in trans by adding adenovirus capsids, competent wild type parvovirus, or transferrin-PEI conjugates to the cells along with the parvoviruses. ..
  11. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 2009
    ..We would seek to complement endosomal escape mutants in trans by adding adenovirus capsids, competent wild type parvovirus, or transferrin-PEI conjugates to the cells along with the parvoviruses. ..
  12. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin R Parrish; Fiscal Year: 2010
    ..We would seek to complement endosomal escape mutants in trans by adding adenovirus capsids, competent wild type parvovirus, or transferrin-PEI conjugates to the cells along with the parvoviruses. ..
  13. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin R Parrish; Fiscal Year: 2011
    ..We would seek to complement endosomal escape mutants in trans by adding adenovirus capsids, competent wild type parvovirus, or transferrin-PEI conjugates to the cells along with the parvoviruses. ..
  14. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY AND RECEPTORS
    Colin Parrish; Fiscal Year: 1993
    ..Finally, a variety of techniques will be used to identify and clone the cellular receptor for parvoviruses. The receptor will then also be studies by genetic and structural methods...
  15. PARVOVIRUS STRUCTURE, FUNCTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 1992
    ..In the case of CPV such a variation resulted in the virus gaining the ability to infect the Family Canidae amongst the Canivora, and so these studies are relevant to many important areas of viral biology and human and animal health...
  16. PARVOVIRUS STRUCTURE, FUNCTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 1991
    ..In the case of CPV such a variation resulted in the virus gaining the ability to infect the Family Canidae amongst the Canivora, and so these studies are relevant to many important areas of viral biology and human and animal health...
  17. PARVOVIRUS STRUCTURE, FUNCTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 1990
    ..In the case of CPV such a variation resulted in the virus gaining the ability to infect the Family Canidae amongst the Canivora, and so these studies are relevant to many important areas of viral biology and human and animal health...
  18. TRAINING IN MOLECULAR VIROLOGY AND PATHOGENESIS
    Colin Parrish; Fiscal Year: 2007
    ....
  19. Antigenic structure of adeno-associated virus capsids and antibody escape mutants
    Colin Parrish; Fiscal Year: 2007
    ..In this study we seek to define the antigenic structures if the viruses so that the adverse effects of antibodies on gene therapy trials can be better understood, and perhaps avoided in the future. ..
  20. PARVOVIRUS STRUCTURE, FUNCTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 1993
    ..In the case of CPV such a variation resulted in the virus gaining the ability to infect the Family Canidae amongst the Canivora, and so these studies are relevant to many important areas of viral biology and human and animal health...
  21. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2000
    ..Genetic transfer methods will also be used to screen cDNA libraries or genome DNA for the presence of genes that can render cells susceptible to infection - some of which may encode virus receptors or possibly co-receptors. ..
  22. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 2001
    ..Irnmuno-electron microscopy will be used to locate the capsids within the cell, around the nuclear pore, and within the nucleus. ..
  23. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 1999
    ..Genetic transfer methods will also be used to screen cDNA libraries or genome DNA for the presence of genes that can render cells susceptible to infection - some of which may encode virus receptors or possibly co-receptors. ..
  24. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 1999
    ..FPV susceptible canine cells in the thymus or bone marrow will also be identified by examination of surface markers and by in vitro culture. ..
  25. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin Parrish; Fiscal Year: 2003
    ..Irnmuno-electron microscopy will be used to locate the capsids within the cell, around the nuclear pore, and within the nucleus. ..
  26. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2005
    ..abstract_text> ..
  27. Structural controls of functional receptor and antibody binding to viral capsids
    Colin R Parrish; Fiscal Year: 2011
    ....