Research Topics
| Nikolaus OsterriederSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expressionChristine L Wimer
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 140:266-74. 2011..The data also implies that different EHV-1 strains have varying effects on all five chemokines, with the nuropathogenic strain, Ab4, having the greatest suppressive potential...
[Establishment and use of infectious bacterial artificial chromosome (BAC) DNA clones of animal herpesviruses]Nikolaus Osterrieder
Department of Microbiology und Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Berl Munch Tierarztl Wochenschr 116:373-80. 2003..Special emphasis is put on the exploitation of herpesviral BAC's for the analysis of virus replication und vaccine developments...- Marek's disease virus: from miasma to modelNikolaus Osterrieder
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Nat Rev Microbiol 4:283-94. 2006..Furthermore, the door is now open for rational and efficient engineering of new vaccines against one of the most important and widespread infectious diseases in chickens... - A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virusGerlinde R Van De Walle
The Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vaccine 28:1048-55. 2010.... 
Effective treatment of respiratory alphaherpesvirus infection using RNA interferenceAmy Fulton
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
PLoS ONE 4:e4118. 2009..CONCLUSIONS/SIGNIFICANCE: siRNA treatment has potential for both prevention and early treatment of EHV-1 infections...- Evaluation of the vaccine potential of an equine herpesvirus type 1 vector expressing bovine viral diarrhea virus structural proteinsCristina T Rosas
Department of Microbiology and Immunology, Ithaca, NY 14853, USA
J Gen Virol 88:748-57. 2007..Immunized animals presented with reduced viraemia levels and decreased nasal virus shedding, and maintained higher leukocyte counts than mock-vaccinated controls... - Horizontal transmission of Marek's disease virus requires US2, the UL13 protein kinase, and gCKeith W Jarosinski
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 81:10575-87. 2007..The experiments clearly showed that US2, UL13, and gC in combination are essential for horizontal transmission of MDV and that none of the genes alone is able to restore this phenotype... - Analysis of the herpesvirus chemokine-binding glycoprotein G residues essential for chemokine binding and biological activityGerlinde R Van De Walle
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 284:5968-76. 2009..Taking these results together, this report is the first to provide insight into the functional residues of an alphaherpesviral vCKBP... - In vitro and in vivo characterization of equine herpesvirus type 1 (EHV-1) mutants devoid of the viral chemokine-binding glycoprotein G (gG)Jens von Einem
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Virology 362:151-62. 2007..Therefore we concluded that deletion of gG in EHV-1 seems to lead to an exacerbation of respiratory disease in the mouse... - Fluorescently tagged pUL47 of Marek's disease virus reveals differential tissue expression of the tegument protein in vivoKeith W Jarosinski
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
J Virol 86:2428-36. 2012.... - A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9B Karsten Tischer
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 81:13200-8. 2007..The essential nature of ORF9 for VZV replication was ultimately confirmed by restoration of the growth of the ORF9-deficient mutant virus using trans-complementation via baculovirus-mediated gene transfer... - A single-nucleotide polymorphism in a herpesvirus DNA polymerase is sufficient to cause lethal neurological diseaseGerlinde R Van De Walle
Department of Microbiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Infect Dis 200:20-5. 2009.... - Investigation of the prevalence of neurologic equine herpes virus type 1 (EHV-1) in a 23-year retrospective analysis (1984-2007)Gillian A Perkins
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Microbiol 139:375-8. 2009.... - Live-attenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV)Cristina T Rosas
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
Virus Res 125:69-78. 2007..From the results, we concluded that the EHV-1 vectored virus is able to express the WNV structural proteins and that vaccination of horses results in the induction of WNV E-protein-specific IgG(T), IgGb, and neutralizing antibodies... - A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesisSascha Trapp
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
J Exp Med 203:1307-17. 2006..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model... - Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coliB Karsten Tischer
Cornell University, Ithaca, NY, USA
Biotechniques 40:191-7. 2006.... - Enzymatically inactive U(S)3 protein kinase of Marek's disease virus (MDV) is capable of depolymerizing F-actin but results in accumulation of virions in perinuclear invaginations and reduced virus growthDaniel Schumacher
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Virology 375:37-47. 2008..The unaltered disruption of F-actin by the K220A pU(S)3 mutant suggests that F-actin disassembly is unrelated to MDV growth restrictions in the absence of the unique-short protein kinase... - Evaluation of a vectored equine herpesvirus type 1 (EHV-1) vaccine expressing H3 haemagglutinin in the protection of dogs against canine influenzaCristina Rosas
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vaccine 26:2335-43. 2008..We concluded that the EHV-1/H3 recombinant vector can be a valuable alternative for protection of dogs against clinical disease induced by CIV and can significantly reduce virus spread... - The effect of siRNA treatment on experimental equine herpesvirus type 1 (EHV-1) infection in horsesMargaret M Brosnahan
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
Virus Res 147:176-81. 2010.... - Herpesvirus telomerase RNA (vTR) with a mutated template sequence abrogates herpesvirus-induced lymphomagenesisBenedikt B Kaufer
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
PLoS Pathog 7:e1002333. 2011.... - Protection of mice by equine herpesvirus type 1 based experimental vaccine against lethal Venezuelan equine encephalitis virus infection in the absence of neutralizing antibodiesCristina T Rosas
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
Am J Trop Med Hyg 78:83-92. 2008.... - Intrahost evolutionary dynamics of canine influenza virus in naive and partially immune dogsKarin Hoelzer
Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
J Virol 84:5329-35. 2010..Potentially advantageous mutations arise readily during the course of single infections and may give rise to antigenic escape or host range variants... - vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virusJeremy P Kamil
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 79:6984-96. 2005..Therefore, it is suggested that this particular example of lipase homology may represent the repurposing of an alpha/beta hydrolase fold toward a nonenzymatic role, possibly in lipid bonding... - Down-regulation of MHC class I by the Marek's disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashionKeith W Jarosinski
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Virology 405:457-63. 2010..We concluded that the pathogenic effect of MHC class I down-regulation mediated by pUL49.5 is small because virus immune evasion possibly requires more than one viral protein... - Herpesvirus chemokine-binding glycoprotein G (gG) efficiently inhibits neutrophil chemotaxis in vitro and in vivoGerlinde R Van De Walle
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunol 179:4161-9. 2007..In summary, we demonstrate for the first time that EHV-1 gG not only binds to chemokines but is also capable of inhibiting their chemotactic function both in vitro and in vivo, thereby contributing to viral pathogenesis and virulence... - Marek's disease virus expresses multiple UL44 (gC) variants through mRNA splicing that are all required for efficient horizontal transmissionKeith W Jarosinski
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
J Virol 86:7896-906. 2012.... - The alpha-TIF (VP16) homologue (ETIF) of equine herpesvirus 1 is essential for secondary envelopment and virus egressJens von Einem
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Virol 80:2609-20. 2006..Taken together, our results demonstrate that ETIF has an essential function in the replication cycle of EHV-1, and its main role appears to be in secondary envelopment... - A point mutation in a herpesvirus polymerase determines neuropathogenicityLaura B Goodman
Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America
PLoS Pathog 3:e160. 2007.... - CCL3 and viral chemokine-binding protein gg modulate pulmonary inflammation and virus replication during equine herpesvirus 1 infectionGerlinde R Van De Walle
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 82:1714-22. 2008..The immunomodulatory activity of CCL3 is balanced by the expression of viral gG, whose chemokine-binding activity is mitigated in secondary infections by the production of anti-gG antibodies... - Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1)Laura B Goodman
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vaccine 24:3636-45. 2006.... - Contribution of gene products encoded within the unique short segment of equine herpesvirus 1 to virulence in a murine modelArthur R Frampton
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA
Virus Res 90:287-301. 2002..These findings show that gI, and/or gI and gE restore a virulent phenotype to the EHV-1 KyA strain, and indicate that virulence factors, in addition to gI and gE, contribute to the pathogenesis of the RacL11 strain... - Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessentialKeith W Jarosinski
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Virol 84:7911-6. 2010..In contrast, the absence of gC expression or mutating the invariant lysine essential for U(L)13 kinase activity abolished horizontal spread of MDV between chickens... - Herpesvirus telomerase RNA(vTR)-dependent lymphoma formation does not require interaction of vTR with telomerase reverse transcriptase (TERT)Benedikt B Kaufer
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
PLoS Pathog 6:e1001073. 2010..Our study provides the first evidence that expression of TR, in this case encoded by a herpesvirus, is pro-oncogenic in the absence of telomerase activity... - Equine herpesvirus 1 entry via endocytosis is facilitated by alphaV integrins and an RSD motif in glycoprotein DGerlinde R Van De Walle
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 82:11859-68. 2008.... - Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1) completely restores respiratory virulence to the attenuated EHV-1 strain KyA in CBA micePatrick M Smith
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
J Virol 79:5105-15. 2005.... - Marek's disease virus: lytic replication, oncogenesis and controlKeith W Jarosinski
Cornell University, Department of Microbiology and Immunology, College of Veterinary Medicine, Ithaca, NY 14853, USA
Expert Rev Vaccines 5:761-72. 2006.... - Attenuation of Marek's disease virus by deletion of open reading frame RLORF4 but not RLORF5aKeith W Jarosinski
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 79:11647-59. 2005..i.; however, two chickens had tumors at the termination of the experiment. The data indicate that RLORF4 is involved in attenuation of MDV, although the function of RLORF4 is still unknown... - A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formationKeith Jarosinski
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 104:20025-30. 2007..The herpesvirus USP thus appears to be required not only to maintain a foothold in the immunocompetent host, but also to contribute to malignant outgrowths... - Potential of equine herpesvirus 1 as a vector for immunizationSascha Trapp
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 79:5445-54. 2005.... - High-level expression of Marek's disease virus glycoprotein C is detrimental to virus growth in vitroB Karsten Tischer
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 79:5889-99. 2005.... - Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivationBenedikt B Kaufer
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Exp Med 208:605-15. 2011..This finding is of particular importance as reactivation is critical for virus spread between susceptible individuals and is necessary for continued herpesvirus evolution and survival... - Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strainsBettina Wagner
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Immunol Immunopathol 143:116-24. 2011..The ability of this EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4... - Equine herpesvirus type 1 modified live virus vaccines: quo vaditis?Cristina T Rosas
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Expert Rev Vaccines 5:119-31. 2006..The improvement of modified live virus vaccines will likely be a major focus of research in the future, and will hopefully help to more completely protect horses against one of the most important and devastating viral diseases... - Alphaherpesviruses and chemokines: pas de deux not yet brought to perfectionGerlinde R Van De Walle
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 82:6090-7. 2008 - Cytokine profiles and long-term virus-specific antibodies following immunization of CBA mice with equine herpesvirus 1 and viral glycoprotein DYunfei Zhang
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, USA
Viral Immunol 16:307-20. 2003..Overall, the data indicate that immunization with infectious KyA or rgD induces significant levels of cytokines, virus-specific ASC in the lungs and spleen, and long-term virus specific B-cell responses... - Evaluation of metaphylactic RNA interference to prevent equine herpesvirus type 1 infection in experimental herpesvirus myeloencephalopathy in horsesGillian A Perkins
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 74:248-56. 2013.... - Delivery of foreign antigens by engineered outer membrane vesicle vaccinesDavid J Chen
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 107:3099-104. 2010.... - The protein encoded by the US3 orthologue of Marek's disease virus is required for efficient de-envelopment of perinuclear virions and involved in actin stress fiber breakdownDaniel Schumacher
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Virol 79:3987-97. 2005.... - The truncated form of glycoprotein gp2 of equine herpesvirus 1 (EHV-1) vaccine strain KyA is not functionally equivalent to full-length gp2 encoded by EHV-1 wild-type strain RacL11Jens von Einem
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Virol 78:3003-13. 2004..From the results we conclude that full-length and truncated EHV-1 gp2 are not functionally equivalent and cannot compensate for the action of their homologues in allogeneic virus backgrounds... - Generation and characterization of an EICP0 null mutant of equine herpesvirus 1Haijun Yao
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USA
Virus Res 98:163-72. 2003.... - Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strainStephen J Spatz
Southeast Poultry Research Laboratory, United States Department of Agriculture, Agricultural Research Service, 934 College Station Rd, Athens, GA 30605, USA
Virus Genes 37:69-80. 2008..The sequencing of the attenuated strain 584Ap80 and comparison to that of the virulent parent 584A passage 9 (584Ap9) has provided a wealth of information regarding genetic changes which have occurred during the attenuation process... - A full UL13 open reading frame in Marek's disease virus (MDV) is dispensable for tumor formation and feather follicle tropism and cannot restore horizontal virus transmission of rRB-1B in vivoCaroline Blondeau
INRA, Laboratoire Virologie Moléculaire, UR1282, Infectiologie Animale et Sante Publique, IASP, 37380 Nouzilly, France
Vet Res 38:419-33. 2007..This finding also shows for the first time that a full UL13 ORF is dispensable for MDV tumor formation and feather follicle tropism... - Characterization of Marek's disease virus serotype 1 (MDV-1) deletion mutants that lack UL46 to UL49 genes: MDV-1 UL49, encoding VP22, is indispensable for virus growthFabien Dorange
, Station de Pathologie Aviaire et de Parasitologie, Institut National de la Recherche Agronomique de Tours, 37380 Nouzilly, France
J Virol 76:1959-70. 2002..These results demonstrate for the first time that an alphaherpesvirus UL49-homologous gene is essential for virus growth in cell culture... - The gene 10 (UL49.5) product of equine herpesvirus 1 is necessary and sufficient for functional processing of glycoprotein MJens Rudolph
Institute of Molecular Biology, Friedrich-Loeffler-Institutes, Federal Research Centre for Virus Diseases of Animals, D-17498 Insel Riems, Germany
J Virol 76:2952-63. 2002..5 product. Taken together, our results demonstrate that the expression of the EHV-1 UL49.5 product is necessary and sufficient for gM processing and that it is required for efficient virus replication... - Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAPDanijela Koppers-Lalic
Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
PLoS Pathog 4:e1000080. 2008..5. Taken together, these results classify the UL 49.5 gene products of BHV-1, PRV, EHV-1, and EHV-4 as members of a novel family of viral immune evasion proteins, inhibiting TAP through a variety of mechanisms... - Equine herpesvirus type 1 devoid of gM and gp2 is severely impaired in virus egress but not direct cell-to-cell spreadJens Rudolph
Institute of Molecular Biology, Federal Research Centre for Virus Diseases of Animals, D-17498 Insel Riems, Germany
Virology 293:356-67. 2002..From the results it was concluded that the simultaneous absence of gM and gp2 had an additive effect on egress but not secondary envelopment or cell-to-cell spread of EHV-1... - Varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cellsAngela Erazo
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Virol 82:7653-65. 2008..Thus, the unique short region VZV kinase has important cell-type-specific functions that are separate from those affecting IE62 and apoptosis... - Meningoencephalitis in mice infected with an equine herpesvirus 1 strain KyA recombinant expressing glycoprotein I and glycoprotein EArthur R Frampton
Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
Virus Genes 29:9-17. 2004..We propose that gI and gE are neurovirulence factors for EHV-1, and that the CBA mouse model can be extended to study neurologic sequelae resulting after EHV-1 infection... - Equine herpesvirus 1 utilizes a novel herpesvirus entry receptorArthur R Frampton
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA
J Virol 79:3169-73. 2005..As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans... - The products of the UL10 (gM) and the UL49.5 genes of Marek's disease virus serotype 1 are essential for virus growth in cultured cellsB Karsten Tischer
Institute of Molecular Biology, Friedrich-Loeffler-Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D-17498 Insel Riems, Germany
J Gen Virol 83:997-1003. 2002..Thus, MDV-1 represents the first example of a member of the family Herpesviridae for which the highly conserved membrane proteins are indispensable for cell-to-cell spread... - Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccinesLawrence Petherbridge
Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom
J Virol 77:8712-8. 2003.... - Detection of Marek's disease virus DNA in chicken but not in human plasmaHolger Hennig
Institute of Immunology and Transfusion Medicine, University of Lubeck, D 23538 Lubeck, Germany
J Clin Microbiol 41:2428-32. 2003..Accordingly, Marek's disease in chickens can be diagnosed by detection of MDV DNA in plasma as well as in leukocytes. Once again, we found no evidence for the spread of MDV to humans... - Mutagenesis of a bovine herpesvirus type 1 genome cloned as an infectious bacterial artificial chromosome: analysis of glycoprotein E and G double deletion mutantsSascha Trapp
Institute of Molecular Biology, Friedrich-Loeffler-Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D-17498 Insel Riems, Germany
J Gen Virol 84:301-6. 2003..Our results suggested that gE and gG function independently from each other in cell-to-cell spread, because an additive effect on plaque formation was observed in the gE/gG double deletion mutant... - The equine herpesvirus 1 UL34 gene product is involved in an early step in virus egress and can be efficiently replaced by a UL34-GFP fusion proteinAntonie Neubauer
Institute for Medical Microbiology, Infectious and Epidemic Diseases, Ludwig Maximilians Universitat Munchen, Veterinarstrasse 13, D 80539, Munich, Germany
Virology 300:189-204. 2002..It was concluded that the EHV-1 UL34 product is essential for an early step in virus egress, i.e., release of capsids from infected-cell nuclei... - A DNA vaccine containing an infectious Marek's disease virus genome can confer protection against tumorigenic Marek's disease in chickensB Karsten Tischer
Institute of Molecular Biology, Friedrich-Loeffler-Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D-17498 Insel Riems, Germany
J Gen Virol 83:2367-76. 2002..The results suggested that an MDV BAC DNA vaccine has potential to protect chickens against MD, but that in vivo reconstitution of vaccine virus is a prerequisite for protection... - Generation of a permanent cell line that supports efficient growth of Marek's disease virus (MDV) by constitutive expression of MDV glycoprotein EDaniel Schumacher
Institute of Molecular Biology, Friedrich-Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D-17498 Insel Riems, Germany
J Gen Virol 83:1987-92. 2002.... - Molecular characterization of the equine herpesvirus 1 strains RacL11 and Kentucky DYasser M Ghanem
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu, Japan
J Vet Med Sci 69:573-6. 2007..These results indicate that point nucleotide differences in RacL11 and Kentucky D might be responsible for their pathogenicity in rodent models... - The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virionsWalter Fuchs
Institutes of Molecular Biology, Friedrich-Loeffler-Institutes, Federal Research Centre for Virus Diseases of Animals, D-17498 Insel Riems, Germany
J Virol 76:364-78. 2002.... - Equine herpesvirus type 1 (EHV-1) glycoprotein K is required for efficient cell-to-cell spread and virus egressAntonie Neubauer
Institute for Medical Microbiology, Infectious and Epidemic Diseases, Ludwig Maximilians Universitat Munchen, D 80539 Munich, Germany
Virology 329:18-32. 2004.... - Oncogenicity of virulent Marek's disease virus cloned as bacterial artificial chromosomesLawrence Petherbridge
Viral Oncogenesis Group, Institute for Animal Health, High St, Compton, Berkshire RG20 7NN, United Kingdom
J Virol 78:13376-80. 2004..The generation of the oncogenic BAC clones of MDV is a significant step in unraveling the oncogenic determinants of this virus...
Research Grants
- VZV BACs: New Tools for Pathogenesis ResearchNikolaus Osterrieder; Fiscal Year: 2005..B-scid/beige mice, and infected MeWo or MeWo-9 cells will be used to inoculate the grafts. Virus replication in the implants will be examined by virus titrations, real-time PCR, histopathology and immunohistochemistry. ..
- A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUSNikolaus Osterrieder; Fiscal Year: 2006..The tests will include ELISPOT and CTL assays in the context of a human class I allele using HLA-A2.1 transgenic mice. ..
- Herpesvirus-induced telomerase dysregulation and tumor formationNikolaus Osterrieder; Fiscal Year: 2007..It will also address the mechanism of herpesvirus integration into the host genome and its importance for latent infection and transformation of lymphocytes. ..