Nikolaus Osterrieder

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. doi request reprint Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression
    Christine L Wimer
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Immunol Immunopathol 140:266-74. 2011
  2. pmc Effective treatment of respiratory alphaherpesvirus infection using RNA interference
    Amy Fulton
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 4:e4118. 2009
  3. pmc A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis
    Sascha Trapp
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    J Exp Med 203:1307-17. 2006
  4. ncbi request reprint [Establishment and use of infectious bacterial artificial chromosome (BAC) DNA clones of animal herpesviruses]
    Nikolaus Osterrieder
    Department of Microbiology und Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Berl Munch Tierarztl Wochenschr 116:373-80. 2003
  5. ncbi request reprint Marek's disease virus: from miasma to model
    Nikolaus Osterrieder
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Microbiol 4:283-94. 2006
  6. doi request reprint A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virus
    Gerlinde R Van De Walle
    The Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vaccine 28:1048-55. 2010
  7. ncbi request reprint In vitro and in vivo characterization of equine herpesvirus type 1 (EHV-1) mutants devoid of the viral chemokine-binding glycoprotein G (gG)
    Jens von Einem
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Virology 362:151-62. 2007
  8. ncbi request reprint Evaluation of the vaccine potential of an equine herpesvirus type 1 vector expressing bovine viral diarrhea virus structural proteins
    Cristina T Rosas
    Department of Microbiology and Immunology, Ithaca, NY 14853, USA
    J Gen Virol 88:748-57. 2007
  9. doi request reprint A single-nucleotide polymorphism in a herpesvirus DNA polymerase is sufficient to cause lethal neurological disease
    Gerlinde R Van De Walle
    Department of Microbiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Infect Dis 200:20-5. 2009
  10. ncbi request reprint Live-attenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV)
    Cristina T Rosas
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Virus Res 125:69-78. 2007

Research Grants

  1. VZV BACs: New Tools for Pathogenesis Research
    Nikolaus Osterrieder; Fiscal Year: 2005
  2. A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUS
    Nikolaus Osterrieder; Fiscal Year: 2006
  3. Herpesvirus-induced telomerase dysregulation and tumor formation
    Nikolaus Osterrieder; Fiscal Year: 2007

Collaborators

Detail Information

Publications71

  1. doi request reprint Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression
    Christine L Wimer
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Immunol Immunopathol 140:266-74. 2011
    ..The data also implies that different EHV-1 strains have varying effects on all five chemokines, with the nuropathogenic strain, Ab4, having the greatest suppressive potential...
  2. pmc Effective treatment of respiratory alphaherpesvirus infection using RNA interference
    Amy Fulton
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 4:e4118. 2009
    ..siRNA therapy in vivo significantly reduced viral replication and clinical signs. Intranasal treatment did not require a transport vehicle and proved effective when given up to 12 h before or after infection...
  3. pmc A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis
    Sascha Trapp
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    J Exp Med 203:1307-17. 2006
    ..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model...
  4. ncbi request reprint [Establishment and use of infectious bacterial artificial chromosome (BAC) DNA clones of animal herpesviruses]
    Nikolaus Osterrieder
    Department of Microbiology und Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Berl Munch Tierarztl Wochenschr 116:373-80. 2003
    ..Special emphasis is put on the exploitation of herpesviral BAC's for the analysis of virus replication und vaccine developments...
  5. ncbi request reprint Marek's disease virus: from miasma to model
    Nikolaus Osterrieder
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Microbiol 4:283-94. 2006
    ..Furthermore, the door is now open for rational and efficient engineering of new vaccines against one of the most important and widespread infectious diseases in chickens...
  6. doi request reprint A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virus
    Gerlinde R Van De Walle
    The Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vaccine 28:1048-55. 2010
    ....
  7. ncbi request reprint In vitro and in vivo characterization of equine herpesvirus type 1 (EHV-1) mutants devoid of the viral chemokine-binding glycoprotein G (gG)
    Jens von Einem
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Virology 362:151-62. 2007
    ..Therefore we concluded that deletion of gG in EHV-1 seems to lead to an exacerbation of respiratory disease in the mouse...
  8. ncbi request reprint Evaluation of the vaccine potential of an equine herpesvirus type 1 vector expressing bovine viral diarrhea virus structural proteins
    Cristina T Rosas
    Department of Microbiology and Immunology, Ithaca, NY 14853, USA
    J Gen Virol 88:748-57. 2007
    ..Immunized animals presented with reduced viraemia levels and decreased nasal virus shedding, and maintained higher leukocyte counts than mock-vaccinated controls...
  9. doi request reprint A single-nucleotide polymorphism in a herpesvirus DNA polymerase is sufficient to cause lethal neurological disease
    Gerlinde R Van De Walle
    Department of Microbiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Infect Dis 200:20-5. 2009
    ....
  10. ncbi request reprint Live-attenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV)
    Cristina T Rosas
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Virus Res 125:69-78. 2007
    ..From the results, we concluded that the EHV-1 vectored virus is able to express the WNV structural proteins and that vaccination of horses results in the induction of WNV E-protein-specific IgG(T), IgGb, and neutralizing antibodies...
  11. pmc vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus
    Jeremy P Kamil
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 79:6984-96. 2005
    ..Therefore, it is suggested that this particular example of lipase homology may represent the repurposing of an alpha/beta hydrolase fold toward a nonenzymatic role, possibly in lipid bonding...
  12. ncbi request reprint Analysis of the herpesvirus chemokine-binding glycoprotein G residues essential for chemokine binding and biological activity
    Gerlinde R Van De Walle
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 284:5968-76. 2009
    ..Taking these results together, this report is the first to provide insight into the functional residues of an alphaherpesviral vCKBP...
  13. pmc Horizontal transmission of Marek's disease virus requires US2, the UL13 protein kinase, and gC
    Keith W Jarosinski
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 81:10575-87. 2007
    ..The experiments clearly showed that US2, UL13, and gC in combination are essential for horizontal transmission of MDV and that none of the genes alone is able to restore this phenotype...
  14. ncbi request reprint Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli
    B Karsten Tischer
    Cornell University, Ithaca, NY, USA
    Biotechniques 40:191-7. 2006
    ....
  15. pmc Expression of the full-length form of gp2 of equine herpesvirus 1 (EHV-1) completely restores respiratory virulence to the attenuated EHV-1 strain KyA in CBA mice
    Patrick M Smith
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Virol 79:5105-15. 2005
    ....
  16. pmc Fluorescently tagged pUL47 of Marek's disease virus reveals differential tissue expression of the tegument protein in vivo
    Keith W Jarosinski
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    J Virol 86:2428-36. 2012
    ....
  17. ncbi request reprint Investigation of the prevalence of neurologic equine herpes virus type 1 (EHV-1) in a 23-year retrospective analysis (1984-2007)
    Gillian A Perkins
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Microbiol 139:375-8. 2009
    ....
  18. pmc A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9
    B Karsten Tischer
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 81:13200-8. 2007
    ..The essential nature of ORF9 for VZV replication was ultimately confirmed by restoration of the growth of the ORF9-deficient mutant virus using trans-complementation via baculovirus-mediated gene transfer...
  19. pmc Enzymatically inactive U(S)3 protein kinase of Marek's disease virus (MDV) is capable of depolymerizing F-actin but results in accumulation of virions in perinuclear invaginations and reduced virus growth
    Daniel Schumacher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Virology 375:37-47. 2008
    ..The unaltered disruption of F-actin by the K220A pU(S)3 mutant suggests that F-actin disassembly is unrelated to MDV growth restrictions in the absence of the unique-short protein kinase...
  20. pmc Evaluation of a vectored equine herpesvirus type 1 (EHV-1) vaccine expressing H3 haemagglutinin in the protection of dogs against canine influenza
    Cristina Rosas
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vaccine 26:2335-43. 2008
    ..We concluded that the EHV-1/H3 recombinant vector can be a valuable alternative for protection of dogs against clinical disease induced by CIV and can significantly reduce virus spread...
  21. doi request reprint The effect of siRNA treatment on experimental equine herpesvirus type 1 (EHV-1) infection in horses
    Margaret M Brosnahan
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Virus Res 147:176-81. 2010
    ....
  22. ncbi request reprint Herpesvirus chemokine-binding glycoprotein G (gG) efficiently inhibits neutrophil chemotaxis in vitro and in vivo
    Gerlinde R Van De Walle
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 179:4161-9. 2007
    ..In summary, we demonstrate for the first time that EHV-1 gG not only binds to chemokines but is also capable of inhibiting their chemotactic function both in vitro and in vivo, thereby contributing to viral pathogenesis and virulence...
  23. pmc A point mutation in a herpesvirus polymerase determines neuropathogenicity
    Laura B Goodman
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America
    PLoS Pathog 3:e160. 2007
    ....
  24. pmc Potential of equine herpesvirus 1 as a vector for immunization
    Sascha Trapp
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 79:5445-54. 2005
    ....
  25. doi request reprint Down-regulation of MHC class I by the Marek's disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion
    Keith W Jarosinski
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Virology 405:457-63. 2010
    ..We concluded that the pathogenic effect of MHC class I down-regulation mediated by pUL49.5 is small because virus immune evasion possibly requires more than one viral protein...
  26. pmc Herpesvirus telomerase RNA (vTR) with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis
    Benedikt B Kaufer
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS Pathog 7:e1002333. 2011
    ....
  27. pmc Intrahost evolutionary dynamics of canine influenza virus in naive and partially immune dogs
    Karin Hoelzer
    Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
    J Virol 84:5329-35. 2010
    ..Potentially advantageous mutations arise readily during the course of single infections and may give rise to antigenic escape or host range variants...
  28. ncbi request reprint Protection of mice by equine herpesvirus type 1 based experimental vaccine against lethal Venezuelan equine encephalitis virus infection in the absence of neutralizing antibodies
    Cristina T Rosas
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Am J Trop Med Hyg 78:83-92. 2008
    ....
  29. pmc The truncated form of glycoprotein gp2 of equine herpesvirus 1 (EHV-1) vaccine strain KyA is not functionally equivalent to full-length gp2 encoded by EHV-1 wild-type strain RacL11
    Jens von Einem
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 78:3003-13. 2004
    ..From the results we conclude that full-length and truncated EHV-1 gp2 are not functionally equivalent and cannot compensate for the action of their homologues in allogeneic virus backgrounds...
  30. ncbi request reprint Cytokine profiles and long-term virus-specific antibodies following immunization of CBA mice with equine herpesvirus 1 and viral glycoprotein D
    Yunfei Zhang
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Viral Immunol 16:307-20. 2003
    ..Overall, the data indicate that immunization with infectious KyA or rgD induces significant levels of cytokines, virus-specific ASC in the lungs and spleen, and long-term virus specific B-cell responses...
  31. ncbi request reprint Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1 (EHV-1)
    Laura B Goodman
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vaccine 24:3636-45. 2006
    ....
  32. pmc The alpha-TIF (VP16) homologue (ETIF) of equine herpesvirus 1 is essential for secondary envelopment and virus egress
    Jens von Einem
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 80:2609-20. 2006
    ..Taken together, our results demonstrate that ETIF has an essential function in the replication cycle of EHV-1, and its main role appears to be in secondary envelopment...
  33. doi request reprint Evaluation of metaphylactic RNA interference to prevent equine herpesvirus type 1 infection in experimental herpesvirus myeloencephalopathy in horses
    Gillian A Perkins
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 74:248-56. 2013
    ....
  34. pmc Attenuation of Marek's disease virus by deletion of open reading frame RLORF4 but not RLORF5a
    Keith W Jarosinski
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 79:11647-59. 2005
    ..i.; however, two chickens had tumors at the termination of the experiment. The data indicate that RLORF4 is involved in attenuation of MDV, although the function of RLORF4 is still unknown...
  35. ncbi request reprint Marek's disease virus: lytic replication, oncogenesis and control
    Keith W Jarosinski
    Cornell University, Department of Microbiology and Immunology, College of Veterinary Medicine, Ithaca, NY 14853, USA
    Expert Rev Vaccines 5:761-72. 2006
    ....
  36. pmc Marek's disease virus expresses multiple UL44 (gC) variants through mRNA splicing that are all required for efficient horizontal transmission
    Keith W Jarosinski
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    J Virol 86:7896-906. 2012
    ....
  37. pmc CCL3 and viral chemokine-binding protein gg modulate pulmonary inflammation and virus replication during equine herpesvirus 1 infection
    Gerlinde R Van De Walle
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 82:1714-22. 2008
    ..The immunomodulatory activity of CCL3 is balanced by the expression of viral gG, whose chemokine-binding activity is mitigated in secondary infections by the production of anti-gG antibodies...
  38. pmc High-level expression of Marek's disease virus glycoprotein C is detrimental to virus growth in vitro
    B Karsten Tischer
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 79:5889-99. 2005
    ....
  39. pmc A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation
    Keith Jarosinski
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 104:20025-30. 2007
    ..The herpesvirus USP thus appears to be required not only to maintain a foothold in the immunocompetent host, but also to contribute to malignant outgrowths...
  40. pmc Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential
    Keith W Jarosinski
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 84:7911-6. 2010
    ..In contrast, the absence of gC expression or mutating the invariant lysine essential for U(L)13 kinase activity abolished horizontal spread of MDV between chickens...
  41. pmc Equine herpesvirus 1 entry via endocytosis is facilitated by alphaV integrins and an RSD motif in glycoprotein D
    Gerlinde R Van De Walle
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 82:11859-68. 2008
    ....
  42. pmc Herpesvirus telomerase RNA(vTR)-dependent lymphoma formation does not require interaction of vTR with telomerase reverse transcriptase (TERT)
    Benedikt B Kaufer
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS Pathog 6:e1001073. 2010
    ..Our study provides the first evidence that expression of TR, in this case encoded by a herpesvirus, is pro-oncogenic in the absence of telomerase activity...
  43. pmc The protein encoded by the US3 orthologue of Marek's disease virus is required for efficient de-envelopment of perinuclear virions and involved in actin stress fiber breakdown
    Daniel Schumacher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 79:3987-97. 2005
    ....
  44. pmc Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation
    Benedikt B Kaufer
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Exp Med 208:605-15. 2011
    ..This finding is of particular importance as reactivation is critical for virus spread between susceptible individuals and is necessary for continued herpesvirus evolution and survival...
  45. pmc Equine herpesvirus type 1 infection induces procoagulant activity in equine monocytes
    Wee Ming Yeo
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Vet Res 44:16. 2013
    ..Our results indicate that EHV-1 rapidly stimulates procoagulant activity in equine monocytes in vitro. The EHV-1-induced procoagulant activity in monocytes may contribute to clinical thrombosis in horses with EHV-1 infection...
  46. ncbi request reprint Contribution of gene products encoded within the unique short segment of equine herpesvirus 1 to virulence in a murine model
    Arthur R Frampton
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Virus Res 90:287-301. 2002
    ..These findings show that gI, and/or gI and gE restore a virulent phenotype to the EHV-1 KyA strain, and indicate that virulence factors, in addition to gI and gE, contribute to the pathogenesis of the RacL11 strain...
  47. ncbi request reprint Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains
    Bettina Wagner
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Vet Immunol Immunopathol 143:116-24. 2011
    ..The ability of this EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4...
  48. pmc Alphaherpesviruses and chemokines: pas de deux not yet brought to perfection
    Gerlinde R Van De Walle
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Virol 82:6090-7. 2008
  49. ncbi request reprint Equine herpesvirus type 1 modified live virus vaccines: quo vaditis?
    Cristina T Rosas
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Expert Rev Vaccines 5:119-31. 2006
    ..The improvement of modified live virus vaccines will likely be a major focus of research in the future, and will hopefully help to more completely protect horses against one of the most important and devastating viral diseases...
  50. ncbi request reprint Generation and characterization of an EICP0 null mutant of equine herpesvirus 1
    Haijun Yao
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, 1501 Kings Highway, P O Box 33932, Shreveport, LA 71130 3932, USA
    Virus Res 98:163-72. 2003
    ....
  51. pmc Delivery of foreign antigens by engineered outer membrane vesicle vaccines
    David J Chen
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 107:3099-104. 2010
    ....
  52. ncbi request reprint The equine herpesvirus 1 UL34 gene product is involved in an early step in virus egress and can be efficiently replaced by a UL34-GFP fusion protein
    Antonie Neubauer
    Institute for Medical Microbiology, Infectious and Epidemic Diseases, Ludwig Maximilians Universitat Munchen, Veterinarstrasse 13, D 80539, Munich, Germany
    Virology 300:189-204. 2002
    ..It was concluded that the EHV-1 UL34 product is essential for an early step in virus egress, i.e., release of capsids from infected-cell nuclei...
  53. ncbi request reprint A DNA vaccine containing an infectious Marek's disease virus genome can confer protection against tumorigenic Marek's disease in chickens
    B Karsten Tischer
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D 17498 Insel Riems, Germany
    J Gen Virol 83:2367-76. 2002
    ..The results suggested that an MDV BAC DNA vaccine has potential to protect chickens against MD, but that in vivo reconstitution of vaccine virus is a prerequisite for protection...
  54. ncbi request reprint Generation of a permanent cell line that supports efficient growth of Marek's disease virus (MDV) by constitutive expression of MDV glycoprotein E
    Daniel Schumacher
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D 17498 Insel Riems, Germany
    J Gen Virol 83:1987-92. 2002
    ....
  55. ncbi request reprint Meningoencephalitis in mice infected with an equine herpesvirus 1 strain KyA recombinant expressing glycoprotein I and glycoprotein E
    Arthur R Frampton
    Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Virus Genes 29:9-17. 2004
    ..We propose that gI and gE are neurovirulence factors for EHV-1, and that the CBA mouse model can be extended to study neurologic sequelae resulting after EHV-1 infection...
  56. ncbi request reprint The products of the UL10 (gM) and the UL49.5 genes of Marek's disease virus serotype 1 are essential for virus growth in cultured cells
    B Karsten Tischer
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D 17498 Insel Riems, Germany
    J Gen Virol 83:997-1003. 2002
    ..Thus, MDV-1 represents the first example of a member of the family Herpesviridae for which the highly conserved membrane proteins are indispensable for cell-to-cell spread...
  57. ncbi request reprint Equine herpesvirus type 1 devoid of gM and gp2 is severely impaired in virus egress but not direct cell-to-cell spread
    Jens Rudolph
    Institute of Molecular Biology, Federal Research Centre for Virus Diseases of Animals, D 17498 Insel Riems, Germany
    Virology 293:356-67. 2002
    ..From the results it was concluded that the simultaneous absence of gM and gp2 had an additive effect on egress but not secondary envelopment or cell-to-cell spread of EHV-1...
  58. pmc The gene 10 (UL49.5) product of equine herpesvirus 1 is necessary and sufficient for functional processing of glycoprotein M
    Jens Rudolph
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17498 Insel Riems, Germany
    J Virol 76:2952-63. 2002
    ..5 product. Taken together, our results demonstrate that the expression of the EHV-1 UL49.5 product is necessary and sufficient for gM processing and that it is required for efficient virus replication...
  59. pmc Characterization of Marek's disease virus serotype 1 (MDV-1) deletion mutants that lack UL46 to UL49 genes: MDV-1 UL49, encoding VP22, is indispensable for virus growth
    Fabien Dorange
    Laboratoire de Virologie Moleculaire, Station de Pathologie Aviaire et de Parasitologie, Institut National de la Recherche Agronomique de Tours, 37380 Nouzilly, France
    J Virol 76:1959-70. 2002
    ..These results demonstrate for the first time that an alphaherpesvirus UL49-homologous gene is essential for virus growth in cell culture...
  60. ncbi request reprint Mutagenesis of a bovine herpesvirus type 1 genome cloned as an infectious bacterial artificial chromosome: analysis of glycoprotein E and G double deletion mutants
    Sascha Trapp
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, D 17498 Insel Riems, Germany
    J Gen Virol 84:301-6. 2003
    ..Our results suggested that gE and gG function independently from each other in cell-to-cell spread, because an additive effect on plaque formation was observed in the gE/gG double deletion mutant...
  61. ncbi request reprint A full UL13 open reading frame in Marek's disease virus (MDV) is dispensable for tumor formation and feather follicle tropism and cannot restore horizontal virus transmission of rRB-1B in vivo
    Caroline Blondeau
    INRA, Laboratoire Virologie Moléculaire, UR1282, Infectiologie Animale et Sante Publique, IASP, 37380 Nouzilly, France
    Vet Res 38:419-33. 2007
    ..This finding also shows for the first time that a full UL13 ORF is dispensable for MDV tumor formation and feather follicle tropism...
  62. pmc Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor
    Arthur R Frampton
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Virol 79:3169-73. 2005
    ..As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans...
  63. pmc Varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cells
    Angela Erazo
    Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Virol 82:7653-65. 2008
    ..Thus, the unique short region VZV kinase has important cell-type-specific functions that are separate from those affecting IE62 and apoptosis...
  64. pmc Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP
    Danijela Koppers-Lalic
    Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Pathog 4:e1000080. 2008
    ..5. Taken together, these results classify the UL 49.5 gene products of BHV-1, PRV, EHV-1, and EHV-4 as members of a novel family of viral immune evasion proteins, inhibiting TAP through a variety of mechanisms...
  65. ncbi request reprint Clustering of mutations within the inverted repeat regions of a serially passaged attenuated gallid herpesvirus type 2 strain
    Stephen J Spatz
    Southeast Poultry Research Laboratory, United States Department of Agriculture, Agricultural Research Service, 934 College Station Rd, Athens, GA 30605, USA
    Virus Genes 37:69-80. 2008
    ..The sequencing of the attenuated strain 584Ap80 and comparison to that of the virulent parent 584A passage 9 (584Ap9) has provided a wealth of information regarding genetic changes which have occurred during the attenuation process...
  66. pmc Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccines
    Lawrence Petherbridge
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom
    J Virol 77:8712-8. 2003
    ....
  67. pmc Detection of Marek's disease virus DNA in chicken but not in human plasma
    Holger Hennig
    Institute of Immunology and Transfusion Medicine, University of Lubeck, D 23538 Lubeck, Germany
    J Clin Microbiol 41:2428-32. 2003
    ..Accordingly, Marek's disease in chickens can be diagnosed by detection of MDV DNA in plasma as well as in leukocytes. Once again, we found no evidence for the spread of MDV to humans...
  68. pmc Oncogenicity of virulent Marek's disease virus cloned as bacterial artificial chromosomes
    Lawrence Petherbridge
    Viral Oncogenesis Group, Institute for Animal Health, High St, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol 78:13376-80. 2004
    ..The generation of the oncogenic BAC clones of MDV is a significant step in unraveling the oncogenic determinants of this virus...
  69. ncbi request reprint Equine herpesvirus type 1 (EHV-1) glycoprotein K is required for efficient cell-to-cell spread and virus egress
    Antonie Neubauer
    Institute for Medical Microbiology, Infectious and Epidemic Diseases, Ludwig Maximilians Universitat Munchen, D 80539 Munich, Germany
    Virology 329:18-32. 2004
    ....
  70. pmc The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virions
    Walter Fuchs
    Institutes of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17498 Insel Riems, Germany
    J Virol 76:364-78. 2002
    ....
  71. ncbi request reprint Molecular characterization of the equine herpesvirus 1 strains RacL11 and Kentucky D
    Yasser M Ghanem
    Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu, Japan
    J Vet Med Sci 69:573-6. 2007
    ..These results indicate that point nucleotide differences in RacL11 and Kentucky D might be responsible for their pathogenicity in rodent models...

Research Grants5

  1. VZV BACs: New Tools for Pathogenesis Research
    Nikolaus Osterrieder; Fiscal Year: 2005
    ..B-scid/beige mice, and infected MeWo or MeWo-9 cells will be used to inoculate the grafts. Virus replication in the implants will be examined by virus titrations, real-time PCR, histopathology and immunohistochemistry. ..
  2. A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUS
    Nikolaus Osterrieder; Fiscal Year: 2006
    ..The tests will include ELISPOT and CTL assays in the context of a human class I allele using HLA-A2.1 transgenic mice. ..
  3. Herpesvirus-induced telomerase dysregulation and tumor formation
    Nikolaus Osterrieder; Fiscal Year: 2007
    ..It will also address the mechanism of herpesvirus integration into the host genome and its importance for latent infection and transformation of lymphocytes. ..