Research Topics
| K OktaySummaryAffiliation: Cornell University Country: USA Publications
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Publications
In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservationKutluk Oktay
Department of Obstetrics and Gynecology, Center for Reproductive Medicine and Infertility, Weill Medical College, Cornell University, New York, New York 10021, USA
Fertil Steril 89:228.e19-22. 2008..To report a novel approach to fertility preservation by in vitro maturation and embryo cryopreservation after LH surge and ovulation...
Fertility preservation for breast cancer patientsOzgur Oktem
Department of Obstetrics and Gynecology, Laboratory of Molecular Reproduction and Fertility Preservation, New York Medical College, Valhalla, New York 10595, USA
Semin Reprod Med 27:486-92. 2009..Ovarian tissue freezing could also be an option in breast cancer patients who do not wish or have a time for an in vitro fertilization cycle, which requires 10 to 14 days of ovarian stimulation...
The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouseAykut Bayrak
Department of Anatomy and Cell Biology, State University of New York Health Science Center, Brooklyn, NY, USA
Reprod Biol Endocrinol 1:41. 2003..Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs)...- A technique for transplantation of ovarian cortical strips to the forearmKutluk Oktay
The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
Fertil Steril 80:193-8. 2003..To describe a forearm heterotopic ovarian transplantation technique... - Ovarian tissue banking for cancer patients: fertility preservation, not just ovarian cryopreservationKutluk Oktay
The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
Hum Reprod 19:477-80. 2004..Fertility preservation should be an integral part of improving the quality of life in cancer survivors; however, it is neither possible nor ethical to recommend the same recipe for every cancer patient... - Embryo development after heterotopic transplantation of cryopreserved ovarian tissueKutluk Oktay
Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
Lancet 363:837-40. 2004..One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue... - Immunohistochemical analysis of tyrosine phosphorylation and AP-1 transcription factors c-Jun, Jun D, and Fos family during early ovarian follicle development in the mouseKutluk H Oktay
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
Appl Immunohistochem Mol Morphol 12:364-9. 2004..Collectively, these data indicate that phosphotyrosine signaling and AP-1 transcription factors are intimately involved in early stages of ovarian follicle growth... - Fertility preservation: an emerging discipline in the care of young patients with cancerKutluk Oktay
Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT-340, New York, NY 10021, USA
Lancet Oncol 6:192-3. 2005 - Fertility preservation in breast cancer patients: a prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservationKutluk Oktay
The Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, 505 E 70th St, HT 340, New York, NY 10021, USA
J Clin Oncol 23:4347-53. 2005..To develop safe ovarian stimulation methods to perform in vitro fertilization (IVF) in breast cancer patients who wish to preserve their fertility via embryo cryopreservation before chemotherapy... - An individualized approach to fertility preservation in women with cancerKutluk Oktay
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
J Support Oncol 4:181-2, 184. 2006 - Efficiency of oocyte cryopreservation: a meta-analysisKutluk Oktay
Fertility Preservation Program at Center for Reproductive Medicine and Infertility, New York, New York, USA
Fertil Steril 86:70-80. 2006..To determine the efficiency of oocyte cryopreservation relative to IVF with unfrozen oocytes... - Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapyKutluk Oktay
Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 East 70th Street, Suite HT300, New York, NY 10021, USA
J Clin Endocrinol Metab 91:3885-90. 2006..Women with breast cancer are not typically offered embryo or oocyte cryopreservation to preserve their fertility before chemotherapy because of the potential risks associated with high estrogen levels arising from ovarian stimulation... - Ovarian transplantation in humans: indications, techniques and the risk of reseeding cancerKutluk Oktay
Center for Reproductive Medicine and Fertility, Weill Medical College, Cornell University, 505 E 70th Street, New York, NY 10021, USA
Eur J Obstet Gynecol Reprod Biol 113:S45-7. 2004..However, the major improvement in the efficiency of ovarian transplantation is anticipated to come from research exploring the revascularization process... - Fertility preservation in breast cancer patients: IVF and embryo cryopreservation after ovarian stimulation with tamoxifenK Oktay
The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
Hum Reprod 18:90-5. 2003..Because increased estrogen levels are thought to be potentially risky in breast cancer patients, natural cycle IVF (NCIVF) has been used to preserve fertility and treat infertility in these women... - The potential of ovarian tissue transplant to preserve fertilityKutluk Oktay
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY10021, USA
Expert Opin Biol Ther 2:361-70. 2002..However, the major improvement in the efficiency of ovarian transplantation is anticipated to come from research exploring the revascularisation process... - Recent progress in oocyte and ovarian tissue cryopreservation and transplantationK Oktay
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
Curr Opin Obstet Gynecol 13:263-8. 2001..Ovarian tissue and oocyte freezing can now be recommended in a carefully selected group of patients, provided that these options are offered under protocols that are approved by an institutional review board... - Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patientsK Oktay
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
Hum Reprod Update 7:526-34. 2001..With the addition of promising data from humans, ovarian tissue cryopreservation from selected patients before cancer treatment, and in those requiring oophorectomy for benign causes, is now advocated... - Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearmK Oktay
Center for Reproductive Medicine and Infertility and Institute for Reproductive Medicine, Weill Medical College, Cornell University, 505 E 70th St, HT340, New York, NY 10021, USA
JAMA 286:1490-3. 2001..In addition, a significant number of women experience early menopause due to oophorectomy performed for benign indications... - Relative potencies of anastrozole and letrozole to suppress estradiol in breast cancer patients undergoing ovarian stimulation before in vitro fertilizationAmr A Azim
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
J Clin Endocrinol Metab 92:2197-200. 2007..Breast cancer patients undergoing controlled ovarian hyperstimulation (COH) for embryo or oocyte cryopreservation should be induced by the method that leads to the least increase in estradiol (E(2)) levels... - Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experienceKutluk Oktay
Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York and Institute for Fertility Preservation, Center for Human Reproduction, New York, New York 10021, USA
Fertil Steril 93:762-8. 2010..To assess the indications, safety, utilization, and success of ovarian tissue freezing and transplantation... - A technique for laparoscopic transplantation of frozen-banked ovarian tissueK Oktay
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021
Fertil Steril 75:1212-6. 2001..To describe a laparoscopic technique for transplanting frozen-banked ovarian tissue... - Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled studyAmr A Azim
Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
J Clin Oncol 26:2630-5. 2008.... - Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinomaAmr Azim
Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
Fertil Steril 88:657-64. 2007..To reduce estrogen exposure in women with endometrial cancer undergoing in vitro fertilization using an aromatase inhibitor... - Absence of conclusive evidence for the safety and efficacy of gonadotropin-releasing hormone analogue treatment in protecting against chemotherapy-induced gonadal injuryKutluk Oktay
Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, New York 10021, USA
Oncologist 12:1055-66. 2007..In this manuscript, we debate the rationale for the effectiveness of GnRH analogue coadministration in preservation of fertility by reviewing the literature, and provide preliminary data to support our views... - Fertility preservation in young women undergoing breast cancer therapyMurat Sonmezer
Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York, USA
Oncologist 11:422-34. 2006..The benefit of ovarian protection by gonadotropin-releasing hormone analogues is unproven and unlikely, and thus this treatment should not be offered as the sole method of fertility preservation... - Cryopreservation of immature human oocytes and ovarian tissue: an emerging technology?K Oktay
Department of Obstetrics and Gynecology, Cornell University Medical College, New York, USA
Fertil Steril 69:1-7. 1998..To review the potential for cryopreserving immature follicles either in situ or after isolation from ovarian stroma and to consider the options for fertility by transplantation or in vitro follicle growth... 
Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risksKutluk Oktay
Institute for Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
J Clin Oncol 28:240-4. 2010..Because infertility is associated with breast and ovarian cancer risks, we hypothesized that the mutations in the BRCA gene may be associated with low response to fertility treatments...- Restoration of ovarian endocrine function by ovarian transplantationMunire Akar
The Center for Reproductive Medicine and Infertility, Joan and Sanford I. Weill Medical College of Cornell University, 505 East 70(th) Street, HT-340, New York, New York 10021, USA
Trends Endocrinol Metab 16:374-80. 2005..As survival rates for young cancer patients improve, protection against iatrogenic infertility caused by chemotherapy or radiotherapy assumes a higher priority... - Preservation of menstrual function in adolescent and young femalesOzgur Oktem
Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
Ann N Y Acad Sci 1135:237-43. 2008..In this review, we discuss and outline the current strategies and the future directions of fertility preservation and ovarian cryopreservation and transplantation in adolescents and young females... - Impact of breast cancer chemotherapy on ovarian reserve: a prospective observational analysis by menstrual history and ovarian reserve markersAndrea Reh
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA
Fertil Steril 90:1635-9. 2008..To determine whether addition of taxanes to anthracycline and cyclophosphamide regimens impact ovarian function as assessed by menstrual history and ovarian reserve markers... - Who is the best candidate for oocyte cryopreservation research?Kutluk Oktay
Department of Obstetrics and Gynecology, New York Medical College, Valhhala, New York, USA
Fertil Steril 93:13-5. 2010..This article discusses the controversial aspects of selecting candidates for oocyte cryopreservation research... - Stem cells: a perspective on oocytesOzgur Oktem
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New York Medical College, Munger Pavilion Room 617, Valhalla, NY 10595, USA
Ann N Y Acad Sci 1127:20-6. 2008..We place special emphasis on studies that challenge the current dogma in reproductive biology that female mammals are born with a set number of nonrenewable germ cells in the ovary by showing germ cell renewal in the adult ovary... - Ovarian tissue cryopreservation: benefits and risksMurat Sonmezer
The Center for Reproductive Medicine and Infertility, The Weill Medical College of Cornell University, New York, NY 10021, USA
Cell Tissue Res 322:125-32. 2005..The objective of this manuscript is to review the indications, risks and benefits of ovarian tissue cryopreservation... - GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor/FSH stimulationKutluk Oktay
Department of Obstetrics and Gynecology, Division of Reproductive Medicine and Institute for Fertility Preservation, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Reprod Biomed Online 20:783-8. 2010..GnRHa trigger improves outcomes by increasing the yield of mature oocytes and embryos in aromatase inhibitor cycles and also decreases the post-trigger oestradiol exposure as well as OHSS risks in women with breast cancer... - Spontaneous conceptions and live birth after heterotopic ovarian transplantation: is there a germline stem cell connection?Kutluk Oktay
Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
Hum Reprod 21:1345-8. 2006.... - Fertility preservation in female patientsMurat Sonmezer
Ankara University School of Medicine, Ankara, Turkey and The Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I. Weill Medical College of Cornell University, New York, NY 10021, USA
Hum Reprod Update 10:251-66. 2004..All current, emerging, experimental as well as controversial approaches are reviewed. A comprehensive algorithm to manage fertility preservation through an individualized approach is presented... - The ovary: anatomy and function throughout human lifeOzgur Oktem
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New York Medical College, Munger Pavilion Room 617, Valhalla, NY 10595, USA
Ann N Y Acad Sci 1127:1-9. 2008..Therefore, the objective of this review article is to provide brief and updated information on the molecular basis of the events that control gonadal development, germ cell formation, folliculogenesis, and ovulation... - Is the immunological noise of abnormal autoimmunity an independent risk factor for premature ovarian aging?Norbert Gleicher
Center for Human Reproduction New York and the Foundation for Reproductive Medicine, New York, NY, USA
Menopause 16:760-4. 2009..To what degree milder forms of premature ovarian aging are also associated with these two etiologies is, however, unknown... - Chemotherapy and amenorrhea: risks and treatment optionsKutluk Oktay
Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
Curr Opin Obstet Gynecol 20:408-15. 2008..The purpose of this study is to review the impact of chemotherapy on fertility and to update the reader on the current state of fertility preservation techniques... - A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserveOzgur Oktem
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
Cancer Res 67:10159-62. 2007..Human ovarian xenografting is a promising model to characterize the gonadotoxic effects of current and emerging cancer drugs without a need for lengthy clinical studies... - Fertility preservation by ovarian stimulation and oocyte cryopreservation in a 14-year-old adolescent with Turner syndrome mosaicism and impending premature ovarian failureKutluk Oktay
Institute for Fertility Preservation, Department of Obstetrics and Gynecology, NY Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Fertil Steril 94:753.e15-9. 2010..To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation... - Interaction of extracellular matrix and activin-A in the initiation of follicle growth in the mouse ovaryK Oktay
Departments of Obstetrics and Gynecology, Cornell University, Weill Medical College and New York Methodist Hospital, Brooklyn, New York 11215 9008, USA
Biol Reprod 63:457-61. 2000..These results strongly suggest that extracellular matrix components and activin-A interact with each other, and that they regulate follicle growth initiation and multilayer follicle development... - Fertility issues and options in young women with cancerK Oktay
Department of Obstetrics and Gynecology, Joan and Sanford I. Weill Medical College of Cornell University, New York, NY 10021, USA
Recent Results Cancer Res 178:203-24. 2008 - Correlation of triple repeats on the FMR1 (fragile X) gene to ovarian reserve: a new infertility test?Norbert Gleicher
The Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA
Acta Obstet Gynecol Scand 88:1024-30. 2009..To determine to what degree the number of triple Cytosine/Guanine/Guanine (CGG) repeats on the FMR1 (fragile X) gene correlate with specific ovarian reserve parameters, and potentially facilitate infertility diagnosis... - Relevance of triple CGG repeats in the FMR1 gene to ovarian reserveNorbert Gleicher
Center for Human Reproduction, New York, USA
Reprod Biomed Online 19:385-90. 2009..001). Approximately 29-30 CGG repeats appear reflective of normal ovarian reserve, with higher and lower counts denoting similar risks towards premature ovarian senescence... - Can the FMR1 (fragile X) gene serve as predictor of response to ovarian stimulation?Norbert Gleicher
Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA
Reprod Sci 16:462-7. 2009..03). This supports FMR1 testing as useful in fertility practice and suggests why response rates to increasing stimulation with gonadotropins may vary... - Oocyte and ovarian tissue cryopreservation: indications, techniques, and applicationsMousa Issa Shamonki
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York, USA
Semin Reprod Med 23:266-76. 2005..The objective of this manuscript is to review the basic aspects of oocyte and ovarian tissue cryopreservation, and to discuss the current and future applications of these technologies in fertility preservation... - Current knowledge in the renewal capability of germ cells in the adult ovaryOzgur Oktem
Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York 10595, USA
Birth Defects Res C Embryo Today 87:90-5. 2009.... - Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal functionOzgur Oktem
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York 10021, USA
Cancer 110:2222-9. 2007..The aim was to quantify the impact of chemotherapy on primordial follicle reserve and stromal function in human ovary with a prospective controlled quantitative histologic and in vitro study... - The role of extracellular matrix and activin-A in in vitro growth and survival of murine preantral folliclesOzgur Oktem
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA
Reprod Sci 14:358-66. 2007..These data may suggest that 3-dimensional culture with extracellular matrix and activin-A provides a better milieu for in vitro growth and survival of preantral follicles in immature mice... - Do etiologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)?Norbert Gleicher
Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA
Hum Reprod 24:2395-400. 2009..It is unknown whether etiologies differ between milder forms of premature ovarian senescence (the acronym given here 'premature ovarian aging, POA'), and premature ovarian failure (POF)... - Normal female phenotype and ovarian development despite the ovarian expression of the sex-determining region of Y chromosome (SRY) in a 46,XX/69,XXY diploid/triploid mosaic child conceived after in vitro fertilization-intracytoplasmic sperm injectionOzgur Oktem
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, 505 East 70th Street, Suite HT300, New York, New York 10021, USA
J Clin Endocrinol Metab 92:1008-14. 2007..All phenotypic females with diploid/triploid mosaic reported so far had 46,XX/69,XXX karyotype... - Fertility preservation medicine: a new field in the care of young cancer survivorsKutluk Oktay
Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
Pediatr Blood Cancer 53:267-73. 2009..For adult survivors of childhood cancer who experienced reproductive failure, third party reproduction techniques are highly successful... - Fertility preservation in gynecologic cancersKutluk Oktay
Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
Curr Opin Oncol 19:506-11. 2007..This review focuses on the current options for fertility preservation in young women facing the risk of premature ovarian failure and infertility as a sequel to the treatment of gynecologic cancer... - Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomasMaja H Oktay
Department of Pathology, Montefiore Medical Center and Albert Einstein College of Medicine, New York, NY 10467, USA
Hum Pathol 34:240-5. 2003..We conclude that FAK overexpression is not restricted to invasive phenotype, but rather appears to be a marker for malignant transformation... - Options for preservation of fertility in womenKutluk H Oktay
N Engl J Med 353:1418-20; author reply 1418-20. 2005 - Preliminary experience with orthotopic and heterotopic transplantation of ovarian cortical stripsKutluk H Oktay
Department of Reproductive Medicine, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York 10021, USA
Semin Reprod Med 20:63-74. 2002..Synchronization between the laboratory and the operating room will be detailed to provide guidance for clinicians who are contemplating ovarian transplantation with previously frozen ovarian tissue...
Research Grants
- Role of integrins and activin in granulosa cell growthKutluk Oktay; Fiscal Year: 2007..Cell proliferation and survival will be determined before and after transfection with the dominant-negative mutants. ..