Research Topics
| Peter M OkinSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Effect of changing heart rate during treatment of hypertension on incidence of heart failurePeter M Okin
Division of Cardiology, Weill Cornell Medical College, New York, New York, USA
Am J Cardiol 109:699-704. 2012..These findings support serial HR assessment to improve the risk stratification of patients with hypertension...
The relationship of electrocardiographic left ventricular hypertrophy to decreased serum potassiumPeter M Okin
Division of Cardiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA
Blood Press 21:146-52. 2012..Although lower serum K is associated with cardiac hypertrophy in animal models, the relationship of low serum K to the presence and severity of electrocardiographic left ventricular hypertrophy (LVH) is unclear...
Racial differences in sudden cardiac death among hypertensive patients during antihypertensive therapy: the LIFE studyPeter M Okin
Division of Cardiology, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA
Heart Rhythm 9:531-7. 2012..In the general population, blacks appear to have a higher risk of sudden cardiac death (SCD)...
Impact of lower achieved blood pressure on outcomes in hypertensive patientsPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York 10065, USA
J Hypertens 30:802-10; discussion 810. 2012..Although tighter control of systolic blood pressure (SBP) has been associated with a lower rate of ECG LVH, whether tighter vs. standard control of SBP is associated with greater reduction of cardiovascular risk is unclear...
Usefulness of quantitative assessment of electrocardiographic ST depression for predicting new-onset heart failure in American Indians (from the Strong Heart Study)Peter M Okin
Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
Am J Cardiol 100:94-8. 2007..32 per 10-muV increment in STD; p <0.001). In conclusion, increasing STD in lateral precordial leads is strongly associated with increased risk of developing heart failure independent of other risk factors for new heart failure...
Incidence of atrial fibrillation in relation to changing heart rate over time in hypertensive patients: the LIFE studyPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10065, USA
Circ Arrhythm Electrophysiol 1:337-43. 2008..Although losartan therapy and decreasing ECG left ventricular hypertrophy are associated with decreased AF incidence, the relationship of HR changes over time to development of AF has not been examined...
Electrocardiographic strain pattern and prediction of new-onset congestive heart failure in hypertensive patients: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) studyPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Circulation 113:67-73. 2006..However, whether ECG strain is an independent predictor of new-onset congestive heart failure (CHF) in the setting of aggressive antihypertensive therapy in unclear...
Incidence of heart failure in relation to QRS duration during antihypertensive therapy: the LIFE studyPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York 10021, USA
J Hypertens 27:2271-7. 2009....
Repolarization abnormality for prediction of all-cause and cardiovascular mortality in American Indians: the Strong Heart StudyPeter M Okin
Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Cardiovasc Electrophysiol 16:945-51. 2005..However, whether these T-wave descriptors provide prognostic information beyond QTc and the PCA ratio has not been examined...
Regression of electrocardiographic left ventricular hypertrophy and decreased incidence of new-onset atrial fibrillation in patients with hypertensionPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
JAMA 296:1242-8. 2006..Although the presence and severity of electrocardiographic left ventricular hypertrophy (LVH) appear to predict development of AF, whether regression of electrocardiographic LVH is associated with a decreased incidence of AF is unclear...
Serial evaluation of electrocardiographic left ventricular hypertrophy for prediction of risk in hypertensive patientsPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10021, USA
J Electrocardiol 42:584-8. 2009....
Relationship of left atrial enlargement to persistence or development of ECG left ventricular hypertrophy in hypertensive patients: implications for the development of new atrial fibrillationPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York 10065, USA
J Hypertens 28:1534-40. 2010..We postulated that this association might be in part mediated via greater left atrial enlargement (LAE) in patients with new and persistent ECG LVH...
Regression of electrocardiographic left ventricular hypertrophy is associated with less hospitalization for heart failure in hypertensive patientsPeter M Okin
Weill Medical College of Cornell University, New York, New York 10021, USA
Ann Intern Med 147:311-9. 2007..However, whether reduction of electrocardiographic LVH is associated with decreased heart failure is unclear...
In-treatment resolution or absence of electrocardiographic left ventricular hypertrophy is associated with decreased incidence of new-onset diabetes mellitus in hypertensive patients: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE)Peter M Okin
Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY 10021, USA
Hypertension 50:984-90. 2007....
Combination of the electrocardiographic strain pattern and albuminuria for the prediction of new-onset heart failure in hypertensive patients: the LIFE studyPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, New York, USA
Am J Hypertens 21:273-9. 2008..Although albuminuria and the electrocardiographic (ECG) strain pattern each predict development of heart failure (HF), whether combining albuminuria and strain improves prediction of new HF is unclear...
Gender differences in regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapyPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10021, USA
Hypertension 52:100-6. 2008....
C-reactive protein and electrocardiographic ST-segment depression additively predict mortality: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
J Am Coll Cardiol 45:1787-93. 2005....
Greater regression of electrocardiographic left ventricular hypertrophy during hydrochlorothiazide therapy in hypertensive patientsPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, USA
Am J Hypertens 23:786-93. 2010....
Impact of diabetes mellitus on regression of electrocardiographic left ventricular hypertrophy and the prediction of outcome during antihypertensive therapy: the Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, NY 10021, USA
Circulation 113:1588-96. 2006....
Ethnic differences in electrocardiographic criteria for left ventricular hypertrophy: the LIFE study. Losartan Intervention For EndpointPeter M Okin
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Hypertens 15:663-71. 2002..However, the high mortality associated with LVH in African American patients makes more accurate ECG detection of LVH in these patients a clinical priority...
Quantitative assessment of electrocardiographic strain predicts increased left ventricular mass: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
J Am Coll Cardiol 40:1395-400. 2002..This study was designed to examine the relation of computer-measured ST depression (STdep) in the lateral precordial leads to the presence of left ventricular hypertrophy (LVH)...
Principal component analysis of the T wave and prediction of cardiovascular mortality in American Indians: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, New York, NY 10021, USA
Circulation 105:714-9. 2002..However, principal component analysis (PCA) of the T-wave vector loop may more accurately represent repolarization abnormalities than QTd...
Racial differences in incident heart failure during antihypertensive therapyPeter M Okin
Division of Cardiology, Weill Cornell Medical College, New York, NY 10065, USA
Circ Cardiovasc Qual Outcomes 4:157-64. 2011..Although HF incidence is significantly higher in blacks during long-term follow-up of young adults, the relationship of incident HF to race in hypertensive patients undergoing treatment is unclear...
Electrocardiographic repolarization complexity and abnormality predict all-cause and cardiovascular mortality in diabetes: the strong heart studyPeter M Okin
Department of Medicine, Division of Cardiology, Cornell Medical Center, New York, New York, USA
Diabetes 53:434-40. 2004..32-3.12) predicted all-cause mortality. Computerized ECG measures of repolarization abnormality and complexity predict CV and all-cause mortality in type 2 diabetes, supporting their use to identify high-risk individuals with diabetes...
Combined echocardiographic left ventricular hypertrophy and electrocardiographic ST depression improve prediction of mortality in American Indians: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
Hypertension 43:769-74. 2004..These findings support the value of combining Echo-LVH and ECG-STD to improve risk stratification. These findings require verification in other populations...
Serial assessment of the electrocardiographic strain pattern for prediction of new-onset heart failure during antihypertensive treatment: the LIFE studyPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA
Eur J Heart Fail 13:384-91. 2011..persistence vs. development of new ECG strain to subsequent HF is unclear...
All-cause and cardiovascular mortality in relation to changing heart rate during treatment of hypertensive patients with electrocardiographic left ventricular hypertrophyPeter M Okin
Division of Cardiology, Weill Cornell Medical College of Cornell University, 525 East 68th Street, New York, NY 10065, USA
Eur Heart J 31:2271-9. 2010....
Electrocardiographic strain pattern and prediction of cardiovascular morbidity and mortality in hypertensive patientsPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
Hypertension 44:48-54. 2004..33, 95% CI 1.11 to 1.59). Thus, ECG strain is a marker of increased CV risk in hypertensive patients in the setting of aggressive blood pressure lowering, independent of baseline severity of ECG LVH...
Prognostic value of changes in the electrocardiographic strain pattern during antihypertensive treatment: the Losartan Intervention for End-Point Reduction in Hypertension Study (LIFE)Peter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10065, USA
Circulation 119:1883-91. 2009....
QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension StudyLasse Oikarinen
Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
Hypertension 43:1029-34. 2004....
Relation of QT interval and QT dispersion to regression of echocardiographic and electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan Intervention For Endpoint Reduction (LIFE) studyLasse Oikarinen
Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Am Heart J 145:919-25. 2003..Experimentally, regression of LVH normalizes ventricular electrophysiology...
Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular eventsPeter M Okin
Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY 10021, USA
JAMA 292:2343-9. 2004..However, the predictive value of changes in the magnitude of electrocardiographic LVH criteria during antihypertensive therapy remains unclear...
Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The Losartan Intervention for Endpoint reduction in Hypertension (LIFE) StudyPeter M Okin
Department of Medicine, Cornell University Medical Center, 525 East 68th St, New York, NY 10021, USA
Circulation 108:684-90. 2003..However, uncertainty persists as to how best to regress ECG LVH...
Stress-induced ST-segment deviation in relation to the presence and severity of coronary artery disease in patients with normal myocardial perfusion imagingJonathan W Weinsaft
Greenberg Cardiology Division, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
Coron Artery Dis 20:41-9. 2009....
Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart StudyMary J Roman
Division of Cardiology, Weill Cornell Medical College, New York 10021, USA
J Hypertens 28:384-8. 2010..Data regarding the relative impacts of central and brachial pressures on left ventricular hypertrophy and geometry are limited...
QRS duration predicts sudden cardiac death in hypertensive patients undergoing intensive medical therapy: the LIFE studyDaniel P Morin
Division of Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA
Eur Heart J 30:2908-14. 2009..To determine whether QRS duration predicts sudden cardiac death (SCD) in patients with left ventricular hypertrophy and treated hypertension...
Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortalityJames K Min
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
J Am Coll Cardiol 50:1161-70. 2007..The purpose of this study was to examine the association of all-cause death with the coronary computed tomographic angiography (CCTA)-defined extent and severity of coronary artery disease (CAD)...
Electrocardiographic and echocardiographic detection of myocardial infarction in patients with left-ventricular hypertrophy. The LIFE StudySilvana Cicala
Division of Cardiology, Weill Medical College of Cornell University, New York, NewYork 10021, USA
Am J Hypertens 20:771-6. 2007..Thus, we compared the accuracy of 2D echocardiography with Minnesota-code ECG criteria in detecting incident MI, adjudicated during serial evaluation in patients with hypertension and LVH...
Electrocardiographic characteristics and metabolic risk factors associated with inappropriately high left ventricular mass in patients with electrocardiographic left ventricular hypertrophy: the LIFE StudyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 25:1079-85. 2007....
Left bundle branch block and cardiovascular morbidity and mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension studyZhibin Li
Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA
J Hypertens 26:1244-9. 2008..Whether left bundle branch block is associated with cardiovascular events in hypertension with electrocardiographic left ventricular hypertrophy is unknown...
Electrocardiographic strain pattern and left ventricular diastolic function in hypertensive patients with left ventricular hypertrophy: the LIFE studyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 24:2079-84. 2006....
Relation of plaque characteristics defined by coronary computed tomographic angiography to ST-segment depression and impaired functional capacity during exercise treadmill testing in patients suspected of having coronary heart diseaseFay Y Lin
Weill Medical College of Cornell University and The New York Presbyterian Hospital, New York, New York, USA
Am J Cardiol 103:50-8. 2009..30, 95% CI 1.05 to 1.61). In conclusion, measures of plaque on CCTA identify patients more likely to have STD and higher risk DTS, while providing incremental diagnostic yield for the detection of obstructive CAD beyond ETT...
High central pulse pressure is independently associated with adverse cardiovascular outcome the strong heart studyMary J Roman
Weill Cornell Medical College, New York, New York 10021, USA
J Am Coll Cardiol 54:1730-4. 2009..This study was designed to facilitate clinical use of central pulse pressure (PP). We sought to determine a value that might predict adverse outcome and thereby provide a target for assessment of intervention strategies...
Multidetector computed tomography coronary artery plaque predictors of stress-induced myocardial ischemia by SPECTFay Lin
The Greenberg Division of Cardiology, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, NY 10021, United States
Atherosclerosis 197:700-9. 2008..We sought to determine whether anatomic measures of plaque by MDCT predict functional measures of CHD by SPECT and thus, serve as measures of adverse cardiovascular prognosis...
Prognostic value of multiple biomarkers in American Indians free of clinically overt cardiovascular disease (from the Strong Heart Study)Jorge R Kizer
Department of Medicine, Weill Cornell Medical Center, New York, NY, USA
Am J Cardiol 104:247-53. 2009..Risk stratification of these populations with multimarker models could enhance selection for aggressive medical or surgical approaches to prevention...
Echocardiographic wall motion abnormalities in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE StudyVittorio Palmieri
Cornell Medical Center, New York, New York, USA
Hypertension 41:75-82. 2003..No significant differences were found between patients with global or segmental wall motion abnormalities...
Electrocardiographic left ventricular hypertrophy predicts arrhythmia and mortality in patients with ischemic cardiomyopathySeth R Bender
Greenberg Division of Cardiology, Weill Cornell Medical College, 525 East 68 St, New York, NY 10065, USA
J Interv Card Electrophysiol 34:237-45. 2012..The aim of this study is to examine if electrocardiographic LVH predicts mortality and incident ventricular arrhythmia in patients with ICM...
Anatomic distribution of myocardial ischemia as a determinant of exercise-induced ST-segment depressionJonathan W Weinsaft
Department of Medicine, Greenberg Division of Cardiology, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY, USA
Am J Cardiol 96:1356-60. 2005....
Diagnostic performance of a computer-based ECG rhythm algorithmKimble Poon
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University and the Cornell Center of The New York-Presbyterian Hospital, New York, NY 10021, USA
J Electrocardiol 38:235-8. 2005..1% of other rhythms, including sinus. Computer diagnosis of paced rhythms remains problematic, and physician overreading to correct computer-based electrocardiogram rhythm diagnoses remains mandatory...
Prevalence and clinical implications of improper filter settings in routine electrocardiographyPaul Kligfield
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
Am J Cardiol 99:711-3. 2007..This problem should be resolvable by targeted educational efforts to reinforce technical standards in electrocardiography...
Diagnostic impact of SPECT image display on assessment of obstructive coronary artery diseaseJonathan W Weinsaft
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
J Nucl Cardiol 14:659-68. 2007..Although various image displays are available for single photon emission computed tomography (SPECT) interpretation, the effects of display differences on SPECT interpretation remain undetermined...
Effects of papillary muscles and trabeculae on left ventricular quantification: increased impact of methodological variability in patients with left ventricular hypertrophyMatthew Janik
Greenberg Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York 10021, USA
J Hypertens 26:1677-85. 2008..This study investigated the contribution of papillary muscles and trabeculae to left ventricular quantification in relation to the presence and pattern of hypertrophy...
The diagnostic value of heart rate during exercise electrocardiographyJoy M Kaplan
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, and New York-Presbyterian Hospiotal, 525 East 68th Street, New York, NY 10021, USA
J Cardiopulm Rehabil 25:127-34. 2005
Improved electrocardiographic detection of left ventricular hypertrophyRobert A Warner
Inovise Medical, Inc, Newberg, OR 97132, USA
J Electrocardiol 35:111-5. 2002....
Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE studyKristian Wachtell
Department of Medicine, Glostrup University Hospital, Glostrup, Denmark
Ann Intern Med 139:901-6. 2003..The partition values for urine albumin-creatinine ratio (UACR) used to identify microalbuminuria have been based on studies that predicted risk in diabetic patients...
QT interval prolongation and prognosis: further validation of the quantitative approach to electrocardiographyPeter M Okin
J Am Coll Cardiol 43:572-5. 2004
Microalbuminuria in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE studyKristian Wachtell
Copenhagen County University Hospital, Glostrup, Denmark
J Hypertens 20:405-12. 2002....
Prevalence of hypertrophic cardiomyopathy in a population-based sample of American Indians aged 51 to 77 years (the Strong Heart Study)Barry J Maron
Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota 55407, USA
Am J Cardiol 93:1510-4. 2004..This prevalence was similar to that reported in other general populations comprised of younger subjects of other races, offering evidence that HC is a relatively common genetic disease with widespread occurrence within the United States...
Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE studyMichael H Olsen
Glostrup University Hospital, Denmark
J Hypertens 24:775-81. 2006..We wanted to investigate whether these prognostic improvements were independent...
Effects of losartan in women with hypertension and left ventricular hypertrophy: results from the Losartan Intervention for Endpoint Reduction in Hypertension StudyIngrid Os
Department of Nephrology, Ullevaal University Hospital, 0407 Oslo, Norway
Hypertension 51:1103-8. 2008....
Electrocardiography in women: taking the initiativePeter M Okin
Circulation 113:464-6. 2006
Mechanism of angiotensin II type 1 receptor blocker action in the regression of left ventricular hypertrophySverre E Kjeldsen
Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
J Clin Hypertens (Greenwich) 8:487-92. 2006..In conclusion, these agents are efficacious in antihypertensive therapy and can play an important role in the prevention or regression of left ventricular hypertrophy due to hypertension...
Regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapy and reduction in sudden cardiac death: the LIFE StudyKristian Wachtell
Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
Circulation 116:700-5. 2007..Sudden cardiac death (SCD) occurs more often in patients with ECG left ventricular (LV) hypertrophy. However, whether LV hypertrophy regression is associated with a reduced risk of SCD remains unclear...
Gender differences in left ventricular structure and function during antihypertensive treatment: the Losartan Intervention for Endpoint Reduction in Hypertension StudyEva Gerdts
Institute of Medicine, University of Bergen, Haukeland University Hospital, N 5021 Bergen, Norway
Hypertension 51:1109-14. 2008..07; P<0.01). Hypertensive women in this study retained higher left ventricular ejection fraction and stress-corrected midwall shortening in spite of less hypertrophy regression during long-term antihypertensive treatment...
Significance of QT dispersionPaul Kligfield
Am J Cardiol 91:1291. 2003
A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methodsBarbara V Howard
MedStar Research Institute, Washington, DC, USA
Int J Circumpolar Health 64:206-21. 2005..Data from this study will contribute to the delivery of health-care and prevention of CVD in Alaska Eskimos and other populations...
