Research Topics
| P M OkinSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Prognostic value of changes in the electrocardiographic strain pattern during antihypertensive treatment: the Losartan Intervention for End-Point Reduction in Hypertension Study (LIFE)Peter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10065, USA
Circulation 119:1883-91. 2009....
Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular eventsPeter M Okin
Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY 10021, USA
JAMA 292:2343-9. 2004..However, the predictive value of changes in the magnitude of electrocardiographic LVH criteria during antihypertensive therapy remains unclear...
Electrocardiographic strain pattern and prediction of cardiovascular morbidity and mortality in hypertensive patientsPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
Hypertension 44:48-54. 2004..33, 95% CI 1.11 to 1.59). Thus, ECG strain is a marker of increased CV risk in hypertensive patients in the setting of aggressive blood pressure lowering, independent of baseline severity of ECG LVH...
Regression of electrocardiographic left ventricular hypertrophy predicts regression of echocardiographic left ventricular mass: the LIFE studyP M Okin
Department of Medicine, Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
J Hum Hypertens 18:403-9. 2004..Compared with progression of ECG LVH, regression of the Cornell product ECG LVH is associated with greater reduction in LV mass and a greater likelihood of regression of anatomic LVH...
Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The Losartan Intervention for Endpoint reduction in Hypertension (LIFE) StudyPeter M Okin
Department of Medicine, Cornell University Medical Center, 525 East 68th St, New York, NY 10021, USA
Circulation 108:684-90. 2003..However, uncertainty persists as to how best to regress ECG LVH...
Relationship of the electrocardiographic strain pattern to left ventricular structure and function in hypertensive patients: the LIFE study. Losartan Intervention For End pointP M Okin
Department of Medicine, Cornell University Medical Center, New York, New York 10021, USA
J Am Coll Cardiol 38:514-20. 2001..This study was designed to assess the relation of electrocardiographic (ECG) strain to increased left ventricular (LV) mass, independent of its relation to coronary heart disease (CHD)...
Relation of echocardiographic left ventricular mass and hypertrophy to persistent electrocardiographic left ventricular hypertrophy in hypertensive patients: the LIFE StudyP M Okin
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Hypertens 14:775-82. 2001..Because of regression to the mean, not all patients who met screening criteria had persistent ECG LVH on the ECG performed at study baseline...
Computerized ST depression analysis improves prediction of all-cause and cardiovascular mortality: the strong heart studyP M Okin
Department of Medicine, Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
Ann Noninvasive Electrocardiol 6:107-16. 2001..Although computer analysis has been applied to digital ECGs for MC, the prognostic value of computerized MC and computerized ST depression analyses have not been examined in relation to standard visual MC...
Baseline characteristics in relation to electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan intervention for endpoint reduction (LIFE) in hypertension study. The Life Study InvestigatorsP M Okin
Department of Medicine, Division of Cardiology, Weill Medical College of Cornell University, New York, NY, USA
Hypertension 36:766-73. 2000..Thus, hypertensive patients who meet Cornell product and Sokolow-Lyon voltage criteria are associated with different, but potentially equally adverse, risk factor profiles...
Chronotropic response to exercise. Improved performance of ST-segment depression criteria after adjustment for heart rate reserveP M Okin
Division of Cardiology, New York Hospital Cornell Medical Center, New York 10021, USA
Circulation 94:3226-31. 1996..In addition, an attenuated HR response to exercise, a manifestation of chronotropic incompetence, may have independent diagnostic value for CAD...
Association of carotid atherosclerosis with electrocardiographic myocardial ischemia and left ventricular hypertrophyP M Okin
Department of Medicine, New York Hospital Cornell Medical Center, NY 10021, USA
Hypertension 28:3-7. 1996..These findings suggest that the associations of ischemia and left ventricular hypertrophy with carotid atherosclerosis may contribute to the increased incidence of coronary events in patients with carotid atherosclerosis...
Time-voltage QRS area of the 12-lead electrocardiogram: detection of left ventricular hypertrophyP M Okin
Department of Medicine, The New York Hospital Cornell Medical Center, New York 10021, USA
Hypertension 31:937-42. 1998..Further study of this approach is needed to identify optimal criteria for LVH based on the time-voltage area measurements from the 12-lead ECG...
Heart rate adjustment of exercise-induced ST-segment depression identifies men who benefit from a risk factor reduction programP M Okin
Department of Medicine, The New York Hospital Cornell Medical Center, New York 10021, USA
Circulation 96:2899-904. 1997..Whether subjects identified as being at increased risk of coronary heart disease (CHD) death by heart rate adjustment of exercise-induced ST-segment depression will benefit from therapy aimed at reducing risk factors has not been examined...
Effect of obesity on electrocardiographic left ventricular hypertrophy in hypertensive patients : the losartan intervention for endpoint (LIFE) reduction in hypertension studyP M Okin
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
Hypertension 35:13-8. 2000..Thus, Sokolow-Lyon voltage criteria underestimate the prevalence of anatomic LVH in the presence of obesity, whereas Cornell product criteria for ECG LVH appear to provide a more accurate measure of LVH in obese and overweight patients...
Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians: The Strong Heart StudyP M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, New York, NY 10021, USA
Circulation 101:61-6. 2000..Both a prolonged QT interval and increased QT interval dispersion (QTD) have been proposed as surface ECG markers of vulnerability to ventricular arrhythmias and potential predictors of mortality...
Relation of exercise-induced myocardial ischemia to cardiac and carotid structureP M Okin
Department of Medicine, The New York Hospital Cornell Medical Center, New York 10021, USA
Hypertension 30:1382-8. 1997....
Left ventricular wall stresses and wall stress-mass-heart rate products in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. Losartan Intervention For Endpoint reduction in hypertensionR B Devereux
Department of Medicine, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, USA
J Hypertens 18:1129-38. 2000..Left ventricular (LV) hypertrophy on echocardiogram (ECG) strongly predicts coronary heart disease events, but the mechanisms linking increased LV mass to ischemic vascular events is uncertain...
Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients. The LIFE study. The Losartan Intervention For Endpoint ReductionL Oikarinen
Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
J Hypertens 19:1883-91. 2001..We assessed the relation of QT intervals and QT dispersion to echocardiographically determined left ventricular (LV) mass and geometry in a large population of hypertensive patients with ECG evidence of LVH...
Association of left bundle branch block with left ventricular structure and function in hypertensive patients with left ventricular hypertrophy: the LIFE studyZ B Li
Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
J Hum Hypertens 18:397-402. 2004..Among hypertensive patients at high risk because of ECG LVH, the presence of LBBB identifies individuals with worse global and regional LV systolic function and impaired LV relaxation without more severe LVH by echocardiography...
Echocardiographic left ventricular geometry in hypertensive patients with electrocardiographic left ventricular hypertrophy: The LIFE StudyR B Devereux
Department of Medicine, The New York Hospital Cornell Medical Center, NY, USA
Blood Press 10:74-82. 2001....
Prognostic implications of left ventricular hypertrophyB A Vakili
Department of Medicine (Cardiovascular Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA
Am Heart J 141:334-41. 2001..These results clarify the strong relation between LVH and adverse outcome and emphasize the clinical importance of its detection...
QT dispersion, T-wave projection, and heterogeneity of repolarization in patients with coronary artery diseaseK W Lee
Department of Medicine, New York-Weill-Cornell Center of New York-Presbyterian Hospital, New York 10021, USA
Am J Cardiol 87:148-51. 2001..Therefore, QT interval dispersion is not equivalent to heterogeneity of repolarization...
Spontaneous interpolated atrial premature complex detected by 12-lead ambulatory monitoringS C Hao
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York-Weill-Cornell Center of New York-Presbyterian Hospital, New York, New York 10021, USA
Am J Cardiol 88:199-200, A7. 2001....
Electrocardiographic and echocardiographic detection of myocardial infarction in patients with left-ventricular hypertrophy. The LIFE StudySilvana Cicala
Division of Cardiology, Weill Medical College of Cornell University, New York, NewYork 10021, USA
Am J Hypertens 20:771-6. 2007..Thus, we compared the accuracy of 2D echocardiography with Minnesota-code ECG criteria in detecting incident MI, adjudicated during serial evaluation in patients with hypertension and LVH...
Electrocardiographic characteristics and metabolic risk factors associated with inappropriately high left ventricular mass in patients with electrocardiographic left ventricular hypertrophy: the LIFE StudyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 25:1079-85. 2007....
Regression of electrocardiographic left ventricular hypertrophy and decreased incidence of new-onset atrial fibrillation in patients with hypertensionPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
JAMA 296:1242-8. 2006..Although the presence and severity of electrocardiographic left ventricular hypertrophy (LVH) appear to predict development of AF, whether regression of electrocardiographic LVH is associated with a decreased incidence of AF is unclear...
Electrocardiographic strain pattern and left ventricular diastolic function in hypertensive patients with left ventricular hypertrophy: the LIFE studyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 24:2079-84. 2006....
Mechanism of angiotensin II type 1 receptor blocker action in the regression of left ventricular hypertrophySverre E Kjeldsen
Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
J Clin Hypertens (Greenwich) 8:487-92. 2006..In conclusion, these agents are efficacious in antihypertensive therapy and can play an important role in the prevention or regression of left ventricular hypertrophy due to hypertension...
Impact of diabetes mellitus on regression of electrocardiographic left ventricular hypertrophy and the prediction of outcome during antihypertensive therapy: the Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, NY 10021, USA
Circulation 113:1588-96. 2006....
Usefulness of quantitative assessment of electrocardiographic ST depression for predicting new-onset heart failure in American Indians (from the Strong Heart Study)Peter M Okin
Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
Am J Cardiol 100:94-8. 2007..32 per 10-muV increment in STD; p <0.001). In conclusion, increasing STD in lateral precordial leads is strongly associated with increased risk of developing heart failure independent of other risk factors for new heart failure...
Regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapy and reduction in sudden cardiac death: the LIFE StudyKristian Wachtell
Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
Circulation 116:700-5. 2007..Sudden cardiac death (SCD) occurs more often in patients with ECG left ventricular (LV) hypertrophy. However, whether LV hypertrophy regression is associated with a reduced risk of SCD remains unclear...
Prevalence and clinical implications of improper filter settings in routine electrocardiographyPaul Kligfield
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
Am J Cardiol 99:711-3. 2007..This problem should be resolvable by targeted educational efforts to reinforce technical standards in electrocardiography...
Gender differences in regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapyPeter M Okin
Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10021, USA
Hypertension 52:100-6. 2008....
Left bundle branch block and cardiovascular morbidity and mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension studyZhibin Li
Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA
J Hypertens 26:1244-9. 2008..Whether left bundle branch block is associated with cardiovascular events in hypertension with electrocardiographic left ventricular hypertrophy is unknown...
Effects of losartan in women with hypertension and left ventricular hypertrophy: results from the Losartan Intervention for Endpoint Reduction in Hypertension StudyIngrid Os
Department of Nephrology, Ullevaal University Hospital, 0407 Oslo, Norway
Hypertension 51:1103-8. 2008....
Gender differences in left ventricular structure and function during antihypertensive treatment: the Losartan Intervention for Endpoint Reduction in Hypertension StudyEva Gerdts
Institute of Medicine, University of Bergen, Haukeland University Hospital, N 5021 Bergen, Norway
Hypertension 51:1109-14. 2008..07; P<0.01). Hypertensive women in this study retained higher left ventricular ejection fraction and stress-corrected midwall shortening in spite of less hypertrophy regression during long-term antihypertensive treatment...
Combination of the electrocardiographic strain pattern and albuminuria for the prediction of new-onset heart failure in hypertensive patients: the LIFE studyPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, New York, USA
Am J Hypertens 21:273-9. 2008..Although albuminuria and the electrocardiographic (ECG) strain pattern each predict development of heart failure (HF), whether combining albuminuria and strain improves prediction of new HF is unclear...
In-treatment resolution or absence of electrocardiographic left ventricular hypertrophy is associated with decreased incidence of new-onset diabetes mellitus in hypertensive patients: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE)Peter M Okin
Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY 10021, USA
Hypertension 50:984-90. 2007....
Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortalityJames K Min
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
J Am Coll Cardiol 50:1161-70. 2007..The purpose of this study was to examine the association of all-cause death with the coronary computed tomographic angiography (CCTA)-defined extent and severity of coronary artery disease (CAD)...
Diagnostic impact of SPECT image display on assessment of obstructive coronary artery diseaseJonathan W Weinsaft
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
J Nucl Cardiol 14:659-68. 2007..Although various image displays are available for single photon emission computed tomography (SPECT) interpretation, the effects of display differences on SPECT interpretation remain undetermined...
Regression of electrocardiographic left ventricular hypertrophy is associated with less hospitalization for heart failure in hypertensive patientsPeter M Okin
Weill Medical College of Cornell University, New York, New York 10021, USA
Ann Intern Med 147:311-9. 2007..However, whether reduction of electrocardiographic LVH is associated with decreased heart failure is unclear...
Multidetector computed tomography coronary artery plaque predictors of stress-induced myocardial ischemia by SPECTFay Lin
The Greenberg Division of Cardiology, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, NY 10021, United States
Atherosclerosis 197:700-9. 2008..We sought to determine whether anatomic measures of plaque by MDCT predict functional measures of CHD by SPECT and thus, serve as measures of adverse cardiovascular prognosis...
Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE studyMichael H Olsen
Glostrup University Hospital, Denmark
J Hypertens 24:775-81. 2006..We wanted to investigate whether these prognostic improvements were independent...
Electrocardiography in women: taking the initiativePeter M Okin
Circulation 113:464-6. 2006
Electrocardiographic strain pattern and prediction of new-onset congestive heart failure in hypertensive patients: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) studyPeter M Okin
Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Circulation 113:67-73. 2006..However, whether ECG strain is an independent predictor of new-onset congestive heart failure (CHF) in the setting of aggressive antihypertensive therapy in unclear...
Electrocardiographic repolarization complexity and abnormality predict all-cause and cardiovascular mortality in diabetes: the strong heart studyPeter M Okin
Department of Medicine, Division of Cardiology, Cornell Medical Center, New York, New York, USA
Diabetes 53:434-40. 2004..32-3.12) predicted all-cause mortality. Computerized ECG measures of repolarization abnormality and complexity predict CV and all-cause mortality in type 2 diabetes, supporting their use to identify high-risk individuals with diabetes...
Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE studyKristian Wachtell
Department of Medicine, Glostrup University Hospital, Glostrup, Denmark
Ann Intern Med 139:901-6. 2003..The partition values for urine albumin-creatinine ratio (UACR) used to identify microalbuminuria have been based on studies that predicted risk in diabetic patients...
Relation of QT interval and QT dispersion to regression of echocardiographic and electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan Intervention For Endpoint Reduction (LIFE) studyLasse Oikarinen
Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Am Heart J 145:919-25. 2003..Experimentally, regression of LVH normalizes ventricular electrophysiology...
Improved electrocardiographic detection of left ventricular hypertrophyRobert A Warner
Inovise Medical, Inc, Newberg, OR 97132, USA
J Electrocardiol 35:111-5. 2002....
Echocardiographic wall motion abnormalities in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE StudyVittorio Palmieri
Cornell Medical Center, New York, New York, USA
Hypertension 41:75-82. 2003..No significant differences were found between patients with global or segmental wall motion abnormalities...
Quantitative assessment of electrocardiographic strain predicts increased left ventricular mass: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
J Am Coll Cardiol 40:1395-400. 2002..This study was designed to examine the relation of computer-measured ST depression (STdep) in the lateral precordial leads to the presence of left ventricular hypertrophy (LVH)...
Ethnic differences in electrocardiographic criteria for left ventricular hypertrophy: the LIFE study. Losartan Intervention For EndpointPeter M Okin
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Hypertens 15:663-71. 2002..However, the high mortality associated with LVH in African American patients makes more accurate ECG detection of LVH in these patients a clinical priority...
Microalbuminuria in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE studyKristian Wachtell
Copenhagen County University Hospital, Glostrup, Denmark
J Hypertens 20:405-12. 2002....
Combined echocardiographic left ventricular hypertrophy and electrocardiographic ST depression improve prediction of mortality in American Indians: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
Hypertension 43:769-74. 2004..These findings support the value of combining Echo-LVH and ECG-STD to improve risk stratification. These findings require verification in other populations...
QT interval prolongation and prognosis: further validation of the quantitative approach to electrocardiographyPeter M Okin
J Am Coll Cardiol 43:572-5. 2004
Anatomic distribution of myocardial ischemia as a determinant of exercise-induced ST-segment depressionJonathan W Weinsaft
Department of Medicine, Greenberg Division of Cardiology, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY, USA
Am J Cardiol 96:1356-60. 2005....
Repolarization abnormality for prediction of all-cause and cardiovascular mortality in American Indians: the Strong Heart StudyPeter M Okin
Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Cardiovasc Electrophysiol 16:945-51. 2005..However, whether these T-wave descriptors provide prognostic information beyond QTc and the PCA ratio has not been examined...
Diagnostic performance of a computer-based ECG rhythm algorithmKimble Poon
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University and the Cornell Center of The New York-Presbyterian Hospital, New York, NY 10021, USA
J Electrocardiol 38:235-8. 2005..1% of other rhythms, including sinus. Computer diagnosis of paced rhythms remains problematic, and physician overreading to correct computer-based electrocardiogram rhythm diagnoses remains mandatory...
C-reactive protein and electrocardiographic ST-segment depression additively predict mortality: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
J Am Coll Cardiol 45:1787-93. 2005....
Prevalence of hypertrophic cardiomyopathy in a population-based sample of American Indians aged 51 to 77 years (the Strong Heart Study)Barry J Maron
Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota 55407, USA
Am J Cardiol 93:1510-4. 2004..This prevalence was similar to that reported in other general populations comprised of younger subjects of other races, offering evidence that HC is a relatively common genetic disease with widespread occurrence within the United States...
QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension StudyLasse Oikarinen
Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
Hypertension 43:1029-34. 2004....
Principal component analysis of the T wave and prediction of cardiovascular mortality in American Indians: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, New York, NY 10021, USA
Circulation 105:714-9. 2002..However, principal component analysis (PCA) of the T-wave vector loop may more accurately represent repolarization abnormalities than QTd...
Significance of QT dispersionPaul Kligfield
Am J Cardiol 91:1291. 2003
The diagnostic value of heart rate during exercise electrocardiographyJoy M Kaplan
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, and New York-Presbyterian Hospiotal, 525 East 68th Street, New York, NY 10021, USA
J Cardiopulm Rehabil 25:127-34. 2005
A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methodsBarbara V Howard
MedStar Research Institute, Washington, DC, USA
Int J Circumpolar Health 64:206-21. 2005..Data from this study will contribute to the delivery of health-care and prevention of CVD in Alaska Eskimos and other populations...
Effects of papillary muscles and trabeculae on left ventricular quantification: increased impact of methodological variability in patients with left ventricular hypertrophyMatthew Janik
Greenberg Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York 10021, USA
J Hypertens 26:1677-85. 2008..This study investigated the contribution of papillary muscles and trabeculae to left ventricular quantification in relation to the presence and pattern of hypertrophy...
