Alan Nixon

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. doi request reprint Cell- and gene-based approaches to tendon regeneration
    Alan J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Shoulder Elbow Surg 21:278-94. 2012
  2. ncbi request reprint Differentiated cellular function in fetal chondrocytes cultured with insulin-like growth factor-I and transforming growth factor-beta
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 16:531-41. 1998
  3. ncbi request reprint Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 17:475-87. 1999
  4. ncbi request reprint Molecular cloning of equine transforming growth factor-beta1 reveals equine-specific amino acid substitutions in the mature peptide sequence
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Mol Endocrinol 24:261-72. 2000
  5. ncbi request reprint Exogenous insulin-like growth factor-I stimulates an autoinductive IGF-I autocrine/paracrine response in chondrocytes
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Orthop Res 19:26-32. 2001
  6. ncbi request reprint Gene therapy in musculoskeletal repair
    Alan J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Ann N Y Acad Sci 1117:310-27. 2007
  7. pmc Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model
    Ashlee E Watts
    Department of Clinical Sciences, Comparative Orthopaedics Laboratory at Cornell University, Ithaca, NY, 14850 USA
    Stem Cell Res Ther 2:4. 2011
  8. doi request reprint Autologous chondrocyte implantation drives early chondrogenesis and organized repair in extensive full- and partial-thickness cartilage defects in an equine model
    Alan J Nixon
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    J Orthop Res 29:1121-30. 2011
  9. ncbi request reprint Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7
    Chisa Hidaka
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, NY 10021, USA
    J Orthop Res 21:573-83. 2003
  10. doi request reprint Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons
    Lauren V Schnabel
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, C3 187 Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 27:1392-8. 2009

Collaborators

Detail Information

Publications47

  1. doi request reprint Cell- and gene-based approaches to tendon regeneration
    Alan J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Shoulder Elbow Surg 21:278-94. 2012
    ..This review summarizes cell- and gene-enhanced cell research for tendon repair and provides future directions for rotator cuff repair using biologic composites...
  2. ncbi request reprint Differentiated cellular function in fetal chondrocytes cultured with insulin-like growth factor-I and transforming growth factor-beta
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 16:531-41. 1998
    ....
  3. ncbi request reprint Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 17:475-87. 1999
    ..However, none of the biochemical or morphologic features were consistent with those of normal articular cartilage...
  4. ncbi request reprint Molecular cloning of equine transforming growth factor-beta1 reveals equine-specific amino acid substitutions in the mature peptide sequence
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Mol Endocrinol 24:261-72. 2000
    ..Expression of TGF-beta was particularly evident in spleen and kidney, and showed an age-related increase in expression in cartilage as the animals approached maturity and then a decline with progressive aging...
  5. ncbi request reprint Exogenous insulin-like growth factor-I stimulates an autoinductive IGF-I autocrine/paracrine response in chondrocytes
    A J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Orthop Res 19:26-32. 2001
    ....
  6. ncbi request reprint Gene therapy in musculoskeletal repair
    Alan J Nixon
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Ann N Y Acad Sci 1117:310-27. 2007
    ..Combining existing cell transplant technology to deliver differentiated cells in a minimally invasive way, with genes that improve matrix formation, provides a manageable protocol for a persisting anabolic impact...
  7. pmc Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model
    Ashlee E Watts
    Department of Clinical Sciences, Comparative Orthopaedics Laboratory at Cornell University, Ithaca, NY, 14850 USA
    Stem Cell Res Ther 2:4. 2011
    ..We report the use of intra-lesional injection of male, fetal derived embryonic-like stem cells (fdESC) that express Oct-4, Nanog, SSEA4, Tra 1-60, Tra 1-81 and telomerase...
  8. doi request reprint Autologous chondrocyte implantation drives early chondrogenesis and organized repair in extensive full- and partial-thickness cartilage defects in an equine model
    Alan J Nixon
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    J Orthop Res 29:1121-30. 2011
    ..The equine model of cartilage healing closely resembles cartilage repair in man, and results of this study confirm cell persistence and improved early cartilage healing events after ACI...
  9. ncbi request reprint Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7
    Chisa Hidaka
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, NY 10021, USA
    J Orthop Res 21:573-83. 2003
    ..In this context we hypothesized that implantation of genetically modified chondrocytes expressing BMP-7 would accelerate the formation of hyaline-like repair tissue in an equine model of cartilage defect repair...
  10. doi request reprint Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons
    Lauren V Schnabel
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, C3 187 Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 27:1392-8. 2009
    ..Both MSC and AdIGF-MSC injection resulted in significantly improved tendon histological scores. These findings indicate a benefit to the use of MSCs and AdIGF-MSCs for the treatment of tendinitis...
  11. doi request reprint A technique for internal fixation of scapulohumeral luxation using scapulohumeral tension sutures in three alpacas and one miniature steer
    Ashlee E Watts
    Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 37:161-5. 2008
    ..To report a technique for open reduction and internal fixation of scapulohumeral joint luxation in large animals, and outcome...
  12. ncbi request reprint New surgical treatments for osteochondritis dissecans and subchondral bone cysts
    Lisa A Fortier
    Department of Clinical Sciences, Veterinary Medical College, C3 181, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 21:673-90, vii. 2005
    ..Methods for improving cartilage repair (ie, restoration of damaged cartilage)or regeneration (ie, reformation or recreation of new articular cartilage) in select cases of OCD and SBCs are discussed...
  13. doi request reprint Arthroscopic removal of palmar/plantar osteochondral fragments from the proximal interphalangeal joint in four horses
    Rolfe M Radcliffe
    New York State College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Vet Surg 37:733-40. 2008
    ..To describe anatomic considerations and arthroscopic technique in horses for arthroscopic removal of palmar/plantar osteochondral fragments from the proximal interphalangeal (PIP) joint...
  14. ncbi request reprint Biochemical and biomechanical properties of lesion and adjacent articular cartilage after chondral defect repair in an equine model
    Eric J Strauss
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, New York 10021, USA
    Am J Sports Med 33:1647-53. 2005
    ..Chondral defects may lead to degradative changes in the surrounding cartilage, predisposing patients to developing osteoarthritis...
  15. ncbi request reprint Medical treatment of osteoarthritis in the horse - a review
    Laurie R Goodrich
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Vet J 171:51-69. 2006
    ..Data are also given on disease modifying OA drugs such as glucosamine and chondroitin sulphate that have more recently become available to the equine practitioner...
  16. ncbi request reprint Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model
    Jennifer L Haupt
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, C3 176 Veterinary Medical Center, Ithaca, NY 14853, USA
    J Orthop Res 23:118-26. 2005
    ....
  17. doi request reprint Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model
    Lisa A Fortier
    Departments of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    J Bone Joint Surg Am 92:1927-37. 2010
    ....
  18. doi request reprint A technique for laser-facilitated equine pastern arthrodesis using parallel screws inserted in lag fashion
    Ashlee E Watts
    Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 39:244-53. 2010
    ..To report a technique for laser-facilitated, minimally invasive proximal interphalangeal joint (PIJ) arthrodesis in horses...
  19. ncbi request reprint Insulin-like growth factor-I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis
    Linda A Dahlgren
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Veterinary Medical Center, Ithaca, NY 14853, USA
    J Orthop Res 20:910-9. 2002
    ..Considered together with the decreased soft tissue swelling and improved sonographic healing, these data support the potential use of intralesional IGF-I for treatment of debilitating tendon injuries...
  20. doi request reprint Continuous peripheral neural blockade to alleviate signs of experimentally induced severe forelimb pain in horses
    Ashlee E Watts
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 238:1032-9. 2011
    ....
  21. ncbi request reprint Cloning and expression of type III collagen in normal and injured tendons of horses
    Linda A Dahlgren
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 66:266-70. 2005
    ..To clone the 5' end of type III collagen and describe its pattern of mRNA and protein expression in normal and healing tendons in horses...
  22. ncbi request reprint Biomechanical evaluation of the relation between number of suture anchors and strength of the bone-tendon interface in a goat rotator cuff model
    Stephen Fealy
    Department of Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY 10021, USA
    Arthroscopy 22:595-602. 2006
    ..The purpose of this study was to test whether the strength of a healed bone-tendon interface is related to the amount of tendon that is in contact with bone at the time of repair...
  23. ncbi request reprint Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1
    Lisa A Fortier
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 63:301-5. 2002
    ..To assess the effects of supraphysiologic concentrations of insulin-like growth factor-1 (IGF-1) on morphologic and phenotypic responses of chondrocytes...
  24. ncbi request reprint Exostoses of the caudal perimeter of the radial physis as a cause of carpal synovial sheath tenosynovitis and lameness in horses: 10 cases (1999-2003)
    Alan J Nixon
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 224:264-70. 2004
    ....
  25. ncbi request reprint Temporal expression of growth factors and matrix molecules in healing tendon lesions
    Linda A Dahlgren
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, C3 187 Veterinary Medical Ctr, Ithaca, NY 14853, USA
    J Orthop Res 23:84-92. 2005
    ....
  26. ncbi request reprint Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model
    Markus M Wilke
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, C3 187, Ithaca, New York 14853, USA
    J Orthop Res 25:913-25. 2007
    ..Mesenchymal stem cell grafts improved the early healing response, but did not significantly enhance the long-term histologic appearance or biochemical composition of full-thickness cartilage lesions...
  27. doi request reprint Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis
    Alan J Nixon
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Am J Vet Res 69:928-37. 2008
    ..To assess the potential of adipose-derived nucleated cell (ADNC) fractions to improve tendon repair in horses with collagenase-induced tendinitis...
  28. ncbi request reprint Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy
    Laurie R Goodrich
    Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
    Vet Surg 31:232-9. 2002
    ..To determine whether preoperative epidural administration of morphine and detomidine would decrease postoperative lameness after bilateral stifle arthroscopy in horses...
  29. ncbi request reprint Parathyroid hormone-related peptide and indian hedgehog expression patterns in naturally acquired equine osteochondrosis
    Stacy A Semevolos
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, C3 187 Veterinary Medical Ctr, Ithaca, NY 14853, USA
    J Orthop Res 20:1290-7. 2002
    ..More evidence is necessary to determine the role of Ihh in articular cartilage and if a similar feedback cycle exists as previously described for the growth plate...
  30. ncbi request reprint Tenoscopic release of the equine carpal canal
    Jamie A Textor
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 32:278-84. 2003
    ..To develop a tenoscopic method to divide the carpal flexor retinaculum and decompress the carpal canal...
  31. ncbi request reprint Expression of insulin-like growth factor binding proteins in healing tendon lesions
    Linda A Dahlgren
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    J Orthop Res 24:183-92. 2006
    ....
  32. ncbi request reprint Nucleotide structure of equine platelet-derived growth factor-A and -B and expression in horses with induced acute tendinitis
    Brandon P Donnelly
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 67:1218-25. 2006
    ..To characterize the nucleotide sequence of equine platelet-derived growth factor (PDGF)-A and -B and analyze temporal expression of these genes in equine tendon after induced tendinitis injury. Animals-18 mature horses...
  33. ncbi request reprint Prevalence and response to surgical treatment of lateral palmar intercarpal ligament avulsion in horses: 37 cases (1990-2001)
    Christopher P Beinlich
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 226:760-6. 2005
    ....
  34. doi request reprint A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy
    Berit L Fischer
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Vet Anaesth Analg 36:67-76. 2009
    ..To compare the analgesic efficacy of buprenorphine plus detomidine with that of morphine plus detomidine when administered epidurally in horses undergoing bilateral stifle arthroscopy...
  35. ncbi request reprint Expression of bone morphogenetic protein-6 and -2 and a bone morphogenetic protein antagonist in horses with naturally acquired osteochondrosis
    Stacy A Semevolos
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 65:110-5. 2004
    ..To determine the mRNA expression of bone morphogenetic protein (BMP)-6 and -2 and a BMP antagonist (Noggin) in horses with osteochondrosis...
  36. ncbi request reprint Comparison of arthroscopic approaches and accessible anatomic structures during arthroscopy of the caudal pouches of equine femorotibial joints
    Ashlee E Watts
    Cornell University, Veterinary Medical Center, College of Veterinary Medicine, Ithaca, NY 14853, USA
    Vet Surg 35:219-26. 2006
    ..To (1) describe a caudal approach to equine medial and lateral femorotibial (FT) joints and (2) illustrate the complex anatomic detail of the caudal compartments of the lateral FT joint...
  37. ncbi request reprint Arthroscopic approaches to the palmar aspect of the equine carpus
    Jonathan Cheetham
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 35:227-31. 2006
    ..To identify sites for arthroscopic access to the palmar aspects of the antebrachiocarpal (AC) and middle carpal (MC) joints, and describe visible carpal bone surfaces for each approach...
  38. ncbi request reprint Age-related expression of molecular regulators of hypertrophy and maturation in articular cartilage
    Stacy A Semevolos
    Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
    J Orthop Res 24:1773-81. 2006
    ..The increased expression of hedgehog receptor and transcription factors during puberty may indicate maturation of the deep articular layer during this time period...
  39. ncbi request reprint Biomechanical evaluation of a rotator cuff defect model augmented with a bioresorbable scaffold in goats
    John D MacGillivray
    Department of Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY, USA
    J Shoulder Elbow Surg 15:639-44. 2006
    ..A cellular fibrous tissue occupied the patch at 6 weeks, which over time matured into a dense, homogeneous fibrous tissue with alignment of collagen between the scaffold bundles...
  40. ncbi request reprint Effects of platelet-derived growth factor-BB on the metabolic function and morphologic features of equine tendon in explant culture
    Jennifer L Haupt
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 67:1595-600. 2006
    ..Animals-6 euthanized horses (2 to 5 years old)...
  41. ncbi request reprint Cloning and expression of equine insulin-like growth factor binding proteins in normal equine tendon
    Linda A Dahlgren
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Am J Vet Res 66:300-6. 2005
    ..To define a portion of the nucleotide sequences of each of the 6 insulin-like growth factor (IGF) binding proteins (IGFBPs) in horses and describe patterns of messenger RNA (mRNA) and protein expression for IGFBPs in normal equine tendons...
  42. ncbi request reprint Radiographic and pathologic characterization of lateral palmar intercarpal ligament avulsion fractures in the horse
    Christopher P Beinlich
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Radiol Ultrasound 45:532-7. 2004
    ....
  43. ncbi request reprint Expression patterns of hedgehog signaling peptides in naturally acquired equine osteochondrosis
    Stacy A Semevolos
    Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Orthop Res 23:1152-9. 2005
    ..The disparity between increased Ihh expression and decreased Gli1 expression in OC cartilage suggests a different primary transcription factor for Ihh or the presence of an elevated Ihh inhibitor in these tissues...
  44. doi request reprint Protein functionalized micro hydrogel features for cell-surface interaction
    Parijat Bhatnagar
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Biomed Microdevices 10:567-71. 2008
    ..Interaction of mesenchymal stem cells with transforming growth factor-beta 1 (TGF-beta1) functionalized muhf was studied, and TGF-beta1 was found to retain its tumor suppression activity...
  45. ncbi request reprint Stem cell therapy in bone repair and regeneration
    Neeha Zaidi
    Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Ann N Y Acad Sci 1117:62-72. 2007
    ..This finding has a considerable array of therapeutic implications. For example, administered EPCs can localize to sites of osteogenesis where they increase blood vessel formation; this may be useful in enhancing fracture repair...
  46. ncbi request reprint IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects
    Sophie Morisset
    Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80524, USA
    Clin Orthop Relat Res 462:221-8. 2007
    ..These data suggest in vivo gene therapy can improve biologic processes associated with chondral defect repair...
  47. ncbi request reprint Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage
    Kenneth R Gratz
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093 0412, USA
    J Biomech 39:138-46. 2006
    ..This represents the first quantitative biomechanical investigation of the tensile properties of repair tissue and its integration strength in an in vivo joint defect environment...

Research Grants4

  1. Adeno-associated virus for IGF-I cartilage gene therapy
    Alan Nixon; Fiscal Year: 2003
    ..abstract_text> ..
  2. Gene enhanced cartilage repair in a cytokine permissive environment
    Alan Nixon; Fiscal Year: 2009
    ..Insulin-like growth factor-I (IGF-I) enhances cartilage repair and this grant tests long-term growth factor expression in joints where degradation is controlled by RNA interference. ..
  3. Gene enhanced cartilage repair in a cytokine permissive environment
    Alan J Nixon; Fiscal Year: 2010
    ..Insulin-like growth factor-I (IGF-I) enhances cartilage repair and this grant tests long-term growth factor expression in joints where degradation is controlled by RNA interference. ..