Research Topics
| Alan NixonSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Detail Information
Publications
Cell- and gene-based approaches to tendon regenerationAlan J Nixon
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Shoulder Elbow Surg 21:278-94. 2012..This review summarizes cell- and gene-enhanced cell research for tendon repair and provides future directions for rotator cuff repair using biologic composites...
Differentiated cellular function in fetal chondrocytes cultured with insulin-like growth factor-I and transforming growth factor-betaA J Nixon
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Orthop Res 16:531-41. 1998....- Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin compositesA J Nixon
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Orthop Res 17:475-87. 1999..However, none of the biochemical or morphologic features were consistent with those of normal articular cartilage... - Molecular cloning of equine transforming growth factor-beta1 reveals equine-specific amino acid substitutions in the mature peptide sequenceA J Nixon
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Mol Endocrinol 24:261-72. 2000..Expression of TGF-beta was particularly evident in spleen and kidney, and showed an age-related increase in expression in cartilage as the animals approached maturity and then a decline with progressive aging... - Exogenous insulin-like growth factor-I stimulates an autoinductive IGF-I autocrine/paracrine response in chondrocytesA J Nixon
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Orthop Res 19:26-32. 2001.... - Gene therapy in musculoskeletal repairAlan J Nixon
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Ann N Y Acad Sci 1117:310-27. 2007..Combining existing cell transplant technology to deliver differentiated cells in a minimally invasive way, with genes that improve matrix formation, provides a manageable protocol for a persisting anabolic impact... 
Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis modelAshlee E Watts
Department of Clinical Sciences, Comparative Orthopaedics Laboratory at Cornell University, Ithaca, NY, 14850 USA
Stem Cell Res Ther 2:4. 2011..We report the use of intra-lesional injection of male, fetal derived embryonic-like stem cells (fdESC) that express Oct-4, Nanog, SSEA4, Tra 1-60, Tra 1-81 and telomerase...- Autologous chondrocyte implantation drives early chondrogenesis and organized repair in extensive full- and partial-thickness cartilage defects in an equine modelAlan J Nixon
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
J Orthop Res 29:1121-30. 2011..The equine model of cartilage healing closely resembles cartilage repair in man, and results of this study confirm cell persistence and improved early cartilage healing events after ACI... - Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7Chisa Hidaka
Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, NY 10021, USA
J Orthop Res 21:573-83. 2003..This study shows the feasibility of using genetically modified chondrocytes to accelerate cartilage healing... - Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendonsLauren V Schnabel
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, C3 187 Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Orthop Res 27:1392-8. 2009..Both MSC and AdIGF-MSC injection resulted in significantly improved tendon histological scores. These findings indicate a benefit to the use of MSCs and AdIGF-MSCs for the treatment of tendinitis... - A technique for internal fixation of scapulohumeral luxation using scapulohumeral tension sutures in three alpacas and one miniature steerAshlee E Watts
Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
Vet Surg 37:161-5. 2008..To report a technique for open reduction and internal fixation of scapulohumeral joint luxation in large animals, and outcome... - New surgical treatments for osteochondritis dissecans and subchondral bone cystsLisa A Fortier
Department of Clinical Sciences, Veterinary Medical College, C3 181, Cornell University, Ithaca, NY 14853, USA
Vet Clin North Am Equine Pract 21:673-90, vii. 2005..Methods for improving cartilage repair (ie, restoration of damaged cartilage)or regeneration (ie, reformation or recreation of new articular cartilage) in select cases of OCD and SBCs are discussed... - Arthroscopic removal of palmar/plantar osteochondral fragments from the proximal interphalangeal joint in four horsesRolfe M Radcliffe
New York State College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Surg 37:733-40. 2008..To describe anatomic considerations and arthroscopic technique in horses for arthroscopic removal of palmar/plantar osteochondral fragments from the proximal interphalangeal (PIP) joint... - Biochemical and biomechanical properties of lesion and adjacent articular cartilage after chondral defect repair in an equine modelEric J Strauss
Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, New York 10021, USA
Am J Sports Med 33:1647-53. 2005..Chondral defects may lead to degradative changes in the surrounding cartilage, predisposing patients to developing osteoarthritis... - Medical treatment of osteoarthritis in the horse - a reviewLaurie R Goodrich
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
Vet J 171:51-69. 2006..Data are also given on disease modifying OA drugs such as glucosamine and chondroitin sulphate that have more recently become available to the equine practitioner... - Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture modelJennifer L Haupt
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, C3-176 Veterinary Medical Center, Ithaca, NY 14853, USA
J Orthop Res 23:118-26. 2005.... - Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine modelLisa A Fortier
Departments of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
J Bone Joint Surg Am 92:1927-37. 2010.... - A technique for laser-facilitated equine pastern arthrodesis using parallel screws inserted in lag fashionAshlee E Watts
Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
Vet Surg 39:244-53. 2010..To report a technique for laser-facilitated, minimally invasive proximal interphalangeal joint (PIJ) arthrodesis in horses... - Insulin-like growth factor-I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitisLinda A Dahlgren
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Veterinary Medical Center, Ithaca, NY 14853, USA
J Orthop Res 20:910-9. 2002..Considered together with the decreased soft tissue swelling and improved sonographic healing, these data support the potential use of intralesional IGF-I for treatment of debilitating tendon injuries... - Continuous peripheral neural blockade to alleviate signs of experimentally induced severe forelimb pain in horsesAshlee E Watts
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Am Vet Med Assoc 238:1032-9. 2011.... - Cloning and expression of type III collagen in normal and injured tendons of horsesLinda A Dahlgren
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 66:266-70. 2005..The role of type III collagen in tendon healing is not fully elucidated... - Biomechanical evaluation of the relation between number of suture anchors and strength of the bone-tendon interface in a goat rotator cuff modelStephen Fealy
Department of Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY 10021, USA
Arthroscopy 22:595-602. 2006..The purpose of this study was to test whether the strength of a healed bone-tendon interface is related to the amount of tendon that is in contact with bone at the time of repair... - Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1Lisa A Fortier
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 63:301-5. 2002..These results suggest that application of such composites for in vivo use during cartilage grafting procedures should provide an anabolic effect on the grafted cells... - Exostoses of the caudal perimeter of the radial physis as a cause of carpal synovial sheath tenosynovitis and lameness in horses: 10 cases (1999-2003)Alan J Nixon
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Am Vet Med Assoc 224:264-70. 2004.... - Temporal expression of growth factors and matrix molecules in healing tendon lesionsLinda A Dahlgren
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, C3-187 Veterinary Medical Ctr, Ithaca, NY 14853, USA
J Orthop Res 23:84-92. 2005.... - Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine modelMarkus M Wilke
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, C3 187, Ithaca, New York 14853, USA
J Orthop Res 25:913-25. 2007..Mesenchymal stem cell grafts improved the early healing response, but did not significantly enhance the long-term histologic appearance or biochemical composition of full-thickness cartilage lesions... - Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitisAlan J Nixon
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
Am J Vet Res 69:928-37. 2008..To assess the potential of adipose-derived nucleated cell (ADNC) fractions to improve tendon repair in horses with collagenase-induced tendinitis... - Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopyLaurie R Goodrich
Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
Vet Surg 31:232-9. 2002.... - Parathyroid hormone-related peptide and indian hedgehog expression patterns in naturally acquired equine osteochondrosisStacy A Semevolos
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, C3-187 Veterinary Medical Ctr, Ithaca, NY 14853, USA
J Orthop Res 20:1290-7. 2002..More evidence is necessary to determine the role of Ihh in articular cartilage and if a similar feedback cycle exists as previously described for the growth plate... - Tenoscopic release of the equine carpal canalJamie A Textor
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Surg 32:278-84. 2003..CLINICAL RELEVANCE: Tensocopic release of the carpal flexor retinaculum is a safe alternative to open division of the retinaculum to decompress the carpal canal in horses with carpal canal syndrome... - Expression of insulin-like growth factor binding proteins in healing tendon lesionsLinda A Dahlgren
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
J Orthop Res 24:183-92. 2006.... - Nucleotide structure of equine platelet-derived growth factor-A and -B and expression in horses with induced acute tendinitisBrandon P Donnelly
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 67:1218-25. 2006..Serial exogenous treatment with either PDGF isoform within the first 2 to 4 weeks after tendon injury may bolster the meager PDGF paracrine-autocrine intrinsic response to injury... - Prevalence and response to surgical treatment of lateral palmar intercarpal ligament avulsion in horses: 37 cases (1990-2001)Christopher P Beinlich
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Am Vet Med Assoc 226:760-6. 2005..Prognosis for return to work of horses with avulsion of the LPICL is good... - A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopyBerit L Fischer
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Anaesth Analg 36:67-76. 2009..To compare the analgesic efficacy of buprenorphine plus detomidine with that of morphine plus detomidine when administered epidurally in horses undergoing bilateral stifle arthroscopy... - Expression of bone morphogenetic protein-6 and -2 and a bone morphogenetic protein antagonist in horses with naturally acquired osteochondrosisStacy A Semevolos
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 65:110-5. 2004..CONCLUSIONS AND CLINICAL RELEVANCE: Although these signaling peptides may play important roles in cartilage differentiation, results did not provide evidence to suggest that they are involved in the disease process of osteochondrosis... - Comparison of arthroscopic approaches and accessible anatomic structures during arthroscopy of the caudal pouches of equine femorotibial jointsAshlee E Watts
Cornell University, Veterinary Medical Center, College of Veterinary Medicine, Ithaca, NY 14853, USA
Vet Surg 35:219-26. 2006.... - Arthroscopic approaches to the palmar aspect of the equine carpusJonathan Cheetham
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Surg 35:227-31. 2006..CLINICAL RELEVANCE: Arthroscopic approaches to the palmar aspect of the carpus could be used to remove fracture fragments, and to assess the medial palmar intercarpal ligaments... - Age-related expression of molecular regulators of hypertrophy and maturation in articular cartilageStacy A Semevolos
Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
J Orthop Res 24:1773-81. 2006..The increased expression of hedgehog receptor and transcription factors during puberty may indicate maturation of the deep articular layer during this time period... - Biomechanical evaluation of a rotator cuff defect model augmented with a bioresorbable scaffold in goatsJohn D MacGillivray
Department of Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY, USA
J Shoulder Elbow Surg 15:639-44. 2006..A cellular fibrous tissue occupied the patch at 6 weeks, which over time matured into a dense, homogeneous fibrous tissue with alignment of collagen between the scaffold bundles... - Effects of platelet-derived growth factor-BB on the metabolic function and morphologic features of equine tendon in explant cultureJennifer L Haupt
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 67:1595-600. 2006..Positive autoinductive effects of PDGF-BB in equine SDFT explants were detected early following culture medium supplementation, but these diminished with time... - Cloning and expression of equine insulin-like growth factor binding proteins in normal equine tendonLinda A Dahlgren
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
Am J Vet Res 66:300-6. 2005..To define a portion of the nucleotide sequences of each of the 6 insulin-like growth factor (IGF) binding proteins (IGFBPs) in horses and describe patterns of messenger RNA (mRNA) and protein expression for IGFBPs in normal equine tendons... - Radiographic and pathologic characterization of lateral palmar intercarpal ligament avulsion fractures in the horseChristopher P Beinlich
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Radiol Ultrasound 45:532-7. 2004.... - Expression patterns of hedgehog signaling peptides in naturally acquired equine osteochondrosisStacy A Semevolos
Comparative Orthopaedics Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Orthop Res 23:1152-9. 2005..The disparity between increased Ihh expression and decreased Gli1 expression in OC cartilage suggests a different primary transcription factor for Ihh or the presence of an elevated Ihh inhibitor in these tissues... - Protein functionalized micro hydrogel features for cell-surface interactionParijat Bhatnagar
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
Biomed Microdevices 10:567-71. 2008..Interaction of mesenchymal stem cells with transforming growth factor-beta 1 (TGF-beta1) functionalized muhf was studied, and TGF-beta1 was found to retain its tumor suppression activity... - Stem cell therapy in bone repair and regenerationNeeha Zaidi
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Ann N Y Acad Sci 1117:62-72. 2007..This finding has a considerable array of therapeutic implications. For example, administered EPCs can localize to sites of osteogenesis where they increase blood vessel formation; this may be useful in enhancing fracture repair... - IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defectsSophie Morisset
Orthopaedic Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80524, USA
Clin Orthop Relat Res 462:221-8. 2007..These data suggest in vivo gene therapy can improve biologic processes associated with chondral defect repair... - Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilageKenneth R Gratz
Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093-0412, USA
J Biomech 39:138-46. 2006..This represents the first quantitative biomechanical investigation of the tensile properties of repair tissue and its integration strength in an in vivo joint defect environment...
Research Grants
- Adeno-associated virus for IGF-I cartilage gene therapyAlan Nixon; Fiscal Year: 2003..abstract_text> ..
- Gene enhanced cartilage repair in a cytokine permissive environmentAlan Nixon; Fiscal Year: 2009..Insulin-like growth factor-I (IGF-I) enhances cartilage repair and this grant tests long-term growth factor expression in joints where degradation is controlled by RNA interference. ..
- Gene enhanced cartilage repair in a cytokine permissive environmentAlan J Nixon; Fiscal Year: 2010..Insulin-like growth factor-I (IGF-I) enhances cartilage repair and this grant tests long-term growth factor expression in joints where degradation is controlled by RNA interference. ..