Carl F Nathan


Affiliation: Cornell University
Country: USA


  1. Sula Karreci E, Fan H, Uehara M, Mihali A, Singh P, Kurdi A, et al. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc Natl Acad Sci U S A. 2016;113:E8425-E8432 pubmed publisher
  2. Ballinger E, Mosior J, Hartman T, Burns Huang K, Gold B, Morris R, et al. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science. 2019;363: pubmed publisher
    ..Our PptT-inhibitor cocrystal structure may aid further development of antimycobacterial agents against this long-sought target. The opposing reactions of PptT and PptH uncover a regulatory pathway in CoA physiology. ..
  3. Yu H, Lupoli T, Kovach A, Meng X, Zhao G, Nathan C, et al. ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB. Proc Natl Acad Sci U S A. 2018;115:E9560-E9569 pubmed publisher
    ..However, whereas Hsp104's two NBDs move in opposing directions during one step of peptide translocation, in Mtb ClpB the two NBDs move only in the direction of translocation. ..
  4. McAulay K, Saito K, Warrier T, Walsh K, Mathurin L, Royal Mardi G, et al. Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment. MBio. 2018;9: pubmed publisher
    ..tuberculosis cells or enrich their representation among the surviving bacteria, and this may contribute to the need for prolonged treatment with those agents in order to achieve durable cures. ..
  5. Nathan C. Secretory products of macrophages: twenty-five years on. J Clin Invest. 2012;122:1189-90 pubmed
    ..quot; Last fall's Nobel Prizes honored two of the few scientists who studied macrophages three decades ago. Now perhaps thousands do, and the subtypes they describe reflect ongoing discoveries of macrophages' extraordinary plasticity. ..
  6. Maksymiuk C, Balakrishnan A, Bryk R, Rhee K, Nathan C. E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress. Proc Natl Acad Sci U S A. 2015;112:E5834-43 pubmed publisher
    ..Identification of these systems leads us to suggest that Mtb can recruit components of its CCM for reactive nitrogen defense using central carbon metabolites. ..
  7. Nathan C, Ding A. Nonresolving inflammation. Cell. 2010;140:871-82 pubmed publisher
    ..This greatly complicates the development of anti-inflammatory therapies. The problem calls for conceptual, organizational, and statistical innovations. ..
  8. Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, et al. Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinb). 2015;95:689-694 pubmed publisher
    ..These observations offer a cautionary lesson about the strength of inference from complementation and sequence analysis, and commend consideration of more complex phenomena than usually contemplated in Mtb, such as epigenetic control. ..
  9. Warrier T, Kapilashrami K, Argyrou A, Ioerger T, Little D, Murphy K, et al. N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016;113:E4523-30 pubmed publisher
    ..Thus, 14 joins a growing list of DprE1 inhibitors that are potently mycobactericidal. Bacterial methylation of an antibacterial agent, 14, catalyzed by Rv0560c of Mtb, is a previously unreported mechanism of AMR. ..

More Information


  1. Lupoli T, Fay A, Adura C, Glickman M, Nathan C. Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proc Natl Acad Sci U S A. 2016;113:E7947-E7956 pubmed
    ..These studies lay the groundwork for strategies to target essential chaperone-protein interactions in Mtb, the leading cause of death from a bacterial infection. ..
  2. Saito K, Warrier T, Somersan Karakaya S, Kaminski L, Mi J, Jiang X, et al. Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proc Natl Acad Sci U S A. 2017;114:E4832-E4840 pubmed publisher
    ..In contrast, thioridazine did not generate DD Mtb from starved cells but killed those generated by rifampin. ..
  3. Shen C, Nathan C. Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. Mol Med. 2002;8:95-102 pubmed
    ..The substantial resistance of human cells to hydroperoxides may result in part from the additive action of multiple Prxs. ..
  4. Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, et al. Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells. Cell Host Microbe. 2015;17:178-90 pubmed publisher
    ..Treatment of tuberculosis might be assisted by drugs that cripple the pathway by which Mtb buffers, sequesters, and asymmetrically distributes IOPs. ..
  5. Nathan C. Macrophages' Choice: Take It In or Keep It Out. Immunity. 2016;45:710-711 pubmed publisher
    ..Interference with the function of E-cadherin in macrophages disorganized the granulomas and protected the fish, introducing new ideas and questions about macrophage function and granulomatous diseases. ..
  6. Nathan C. Kunkel Lecture: Fundamental immunodeficiency and its correction. J Exp Med. 2017;214:2175-2191 pubmed publisher
    ..Immunologists can aid the development of sorely needed antimicrobial agents, and the study of antimicrobial agents can help immunologists discover targets and mechanisms of host immunity. ..