DONNA MUSCARELLA

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines
    Donna E Muscarella
    Department of Microbiology and Immunology, C4 101 VMC, Cornell University, Ithaca, New York 14853, USA
    Toxicol Sci 68:82-92. 2002
  2. ncbi Cross-linking of surface IgM in the Burkitt's lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways
    Donna E Muscarella
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 278:4358-67. 2003
  3. ncbi The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses
    Donna E Muscarella
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Toxicol Appl Pharmacol 228:93-104. 2008
  4. ncbi Potentiation of apoptosis by heat stress plus pesticide exposure in stress resistant human B-lymphoma cells and its attenuation through interaction with follicular dendritic cells: role for c-Jun N-terminal kinase signaling
    Stephen E Bloom
    Department of Microbiology and Immunology, Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    Toxicol Sci 89:214-23. 2006
  5. ncbi Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor
    Donna E Muscarella
    Department of Microbiology, Institute for Comparative Toxicology, Cornell University, Ithaca, New York 14853, USA
    Toxicol Sci 74:66-73. 2003

Research Grants

  1. Arsenite Effects on CD40 Signaling and B-Cell Apoptosis
    DONNA MUSCARELLA; Fiscal Year: 2007
  2. MAP KINASE REGULATION OF B-LYMPHOCYTE APOPTOSIS
    DONNA MUSCARELLA; Fiscal Year: 2003

Collaborators

Detail Information

Publications5

  1. ncbi Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines
    Donna E Muscarella
    Department of Microbiology and Immunology, C4 101 VMC, Cornell University, Ithaca, New York 14853, USA
    Toxicol Sci 68:82-92. 2002
    ..Significantly, the sensitization of resistant cells is characterized by a lowering of the threshold concentration of arsenite required to activate the JNK pathway and induce apoptosis...
  2. ncbi Cross-linking of surface IgM in the Burkitt's lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways
    Donna E Muscarella
    Department of Microbiology and Immunology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 278:4358-67. 2003
    ..This investigation demonstrates, for the first time, that specific signals transduced by activation of the B-cell receptor protect cells at a common point of regulation in the apoptotic pathways for diverse stresses...
  3. ncbi The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses
    Donna E Muscarella
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    Toxicol Appl Pharmacol 228:93-104. 2008
    ..These results reveal two stress-activated pathways, one JNK-dependent and another JNK-independent, either of which can bypass Bcl-2 mediated resistance, resulting in cell death...
  4. ncbi Potentiation of apoptosis by heat stress plus pesticide exposure in stress resistant human B-lymphoma cells and its attenuation through interaction with follicular dendritic cells: role for c-Jun N-terminal kinase signaling
    Stephen E Bloom
    Department of Microbiology and Immunology, Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA
    Toxicol Sci 89:214-23. 2006
    ..These results reveal cell stress scenarios that can greatly augment apoptosis in stress-resistant human B-cells and a germinal center interaction that selectively attenuates pesticide-induced apoptosis...
  5. ncbi Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor
    Donna E Muscarella
    Department of Microbiology, Institute for Comparative Toxicology, Cornell University, Ithaca, New York 14853, USA
    Toxicol Sci 74:66-73. 2003
    ..These results show significant drug-mediated alteration of cell sensitivity and JNK pathway activation to environmental chemicals and mitochondrial toxicants, following ligation of the mBzR...

Research Grants8

  1. Arsenite Effects on CD40 Signaling and B-Cell Apoptosis
    DONNA MUSCARELLA; Fiscal Year: 2007
    ..abstract_text> ..
  2. MAP KINASE REGULATION OF B-LYMPHOCYTE APOPTOSIS
    DONNA MUSCARELLA; Fiscal Year: 2003
    ..abstract_text> ..