W A Muller

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Migration of leukocytes across endothelial junctions: some concepts and controversies
    W A Muller
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Microcirculation 8:181-93. 2001
  2. ncbi request reprint Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response
    William A Muller
    Department of Pathology, and Laboratory Medicine, Graduate Program in Immunology, Weill Medical College, 1300 York Avenue, New York, NY 10021, USA
    Trends Immunol 24:327-34. 2003
  3. pmc A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:6924-9. 1998
  4. ncbi request reprint Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C 420, New York, NY 10021, USA
    Science 282:480-3. 1998
  5. ncbi request reprint Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion
    J Ali
    Department of Cell Physiology and Immunology, Rockefeller University, New York, USA
    Microcirculation 4:267-77. 1997
  6. pmc Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1
    Y Xie
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 90:5569-73. 1993
  7. ncbi request reprint Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes
    W A Muller
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Leukoc Biol 66:698-704. 1999
  8. ncbi request reprint Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro
    G J Randolph
    Department of Pathology, Cornell University Medical College, New York, NY, USA
    Blood 92:4167-77. 1998
  9. ncbi request reprint Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
    G J Randolph
    Department of Pathology, Weill Medical College of Cornell University, New York, USA
    Immunity 11:753-61. 1999
  10. ncbi request reprint The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response
    Alan R Schenkel
    Weill Cornell Medical College, Department of Pathology and Laboratory Medicine, New York, NY, USA
    Cell Commun Adhes 14:227-37. 2007

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Migration of leukocytes across endothelial junctions: some concepts and controversies
    W A Muller
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Microcirculation 8:181-93. 2001
    ..These are all active (and some controversial) areas of investigation. I have tried to objectively present both sides of any controversies, while stating at the end the general consensus of the field...
  2. ncbi request reprint Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response
    William A Muller
    Department of Pathology, and Laboratory Medicine, Graduate Program in Immunology, Weill Medical College, 1300 York Avenue, New York, NY 10021, USA
    Trends Immunol 24:327-34. 2003
    ..In addition, this Review introduces a new and unified nomenclature for the junctional adhesion molecule (JAM) family...
  3. pmc A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:6924-9. 1998
    ....
  4. ncbi request reprint Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C 420, New York, NY 10021, USA
    Science 282:480-3. 1998
    ..Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration...
  5. ncbi request reprint Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion
    J Ali
    Department of Cell Physiology and Immunology, Rockefeller University, New York, USA
    Microcirculation 4:267-77. 1997
    ..We characterized and cloned the antigen to study its functional properties...
  6. pmc Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1
    Y Xie
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 90:5569-73. 1993
    ..Stable L-cell transfectants aggregate with each other in a PECAM-dependent, homophilic manner...
  7. ncbi request reprint Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes
    W A Muller
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Leukoc Biol 66:698-704. 1999
    ..We postulate that a major source of DC in lymph nodes is cells derived from monocytes that enter a tissue via the blood and leave several days later via afferent lymphatic channels...
  8. ncbi request reprint Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro
    G J Randolph
    Department of Pathology, Cornell University Medical College, New York, NY, USA
    Blood 92:4167-77. 1998
    ..This binding was blocked by anti-TF MoAb, suggesting that endothelial cells bear a receptor for TF. These data suggest that mononuclear phagocytes use TF, perhaps as an adhesive protein, to exit sites of inflammation...
  9. ncbi request reprint Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
    G J Randolph
    Department of Pathology, Weill Medical College of Cornell University, New York, USA
    Immunity 11:753-61. 1999
    ..Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs...
  10. ncbi request reprint The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response
    Alan R Schenkel
    Weill Cornell Medical College, Department of Pathology and Laboratory Medicine, New York, NY, USA
    Cell Commun Adhes 14:227-37. 2007
    ..Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo...
  11. pmc Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment
    Zahra Mamdouh
    Department of Pathology and Laboratory Medicine and the Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10021, USA
    J Exp Med 205:951-66. 2008
    ..Furthermore, these data provide the first demonstration of a role for endothelial microtubules and kinesins in promoting diapedesis, and a mechanism to explain targeted recycling...
  12. ncbi request reprint CD99 plays a major role in the migration of monocytes through endothelial junctions
    Alan R Schenkel
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:143-50. 2002
    ..Therefore, diapedesis, the forward migration of leukocytes through endothelial junctions, is regulated sequentially by two distinct molecules, PECAM-1 and CD99...
  13. ncbi request reprint Leukocyte-endothelial cell interactions in the inflammatory response
    William A Muller
    Department of Pathology and Graduate Program in Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Lab Invest 82:521-33. 2002
  14. ncbi request reprint Locomotion of monocytes on endothelium is a critical step during extravasation
    Alan R Schenkel
    Department of Pathology, Weill Medical College of Cornell University, Room C320, 1300 York Avenue, New York, New York 10021, USA
    Nat Immunol 5:393-400. 2004
    ..The blocked monocytes spun in circles as if they were unable to direct their movement despite being able to adhere and polarize normally. This step fills a gap in the paradigm of extravasation as a multistep process...
  15. doi request reprint CD99 is essential for leukocyte diapedesis in vivo
    Eric M Dufour
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA
    Cell Commun Adhes 15:351-63. 2008
    ..Microscopy showed that this blocking occurred at the luminal surface of venules. The authors conclude that CD99 plays a major role in the emigration of leukocytes in vivo...
  16. pmc Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment
    Zahra Mamdouh
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Exp Med 206:2795-808. 2009
    ..Similar to their effects on paracellular transmigration, antibodies against PECAM or CD99, but not JAM-A, block transcellular migration. We conclude that similar molecular mechanisms promote both para- and transcellular migration...
  17. ncbi request reprint CD99 is a key mediator of the transendothelial migration of neutrophils
    Olivia Lou
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 178:1136-43. 2007
    ..Taken together, the evidence demonstrates that PECAM and CD99 regulate distinct, sequential steps in the transendothelial migration of neutrophils during inflammation...
  18. ncbi request reprint Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis
    Zahra Mamdouh
    Department of Pathology and Laboratory Medicine, Weill Medical College, 1300 York Avenue, New York, New York 10021, USA
    Nature 421:748-53. 2003
    ..In addition, blockade of TEM with antibodies against PECAM specifically blocks the recruitment of this membrane to the zones of leukocyte migration, without affecting the constitutive membrane trafficking...
  19. pmc Endothelial Src kinase regulates membrane recycling from the lateral border recycling compartment during leukocyte transendothelial migration
    Bidisha Dasgupta
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Eur J Immunol 38:3499-507. 2008
    ....
  20. ncbi request reprint The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes
    D F Robbiani
    Department of Pathology and Immunology Program Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY 10029, USA
    Cell 103:757-68. 2000
    ..Thus, MRP-1 regulates DC migration to lymph nodes, apparently by transporting LTC(4), which in turn promotes chemotaxis to CCL19 and mobilization of DCs from the epidermis...
  21. ncbi request reprint The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo
    W A Muller
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA
    J Leukoc Biol 57:523-8. 1995
    ..Thus, PECAM-1 has a distinct role in the transendothelial migration phase of leukocyte emigration, independent of the adhesion events on the apical surface...
  22. pmc Assays of transendothelial migration in vitro
    William A Muller
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Methods Enzymol 443:155-76. 2008
    ....
  23. pmc PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2
    Michael A Seidman
    Department of Pathology, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 4:e4316. 2009
    ....
  24. pmc Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils
    Hyunsil Han
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Exp Med 202:353-61. 2005
    ..Thus, TNF turns on phox through a Ca2+-triggered, sAC-dependent process that may involve activation of Rap1A. This pathway may offer opportunities to suppress oxidative damage during inflammation without blocking antimicrobial function...
  25. pmc A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration
    Bidisha Dasgupta
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 182:5041-51. 2009
    ..These data define a novel role for tyrosine 663 and suggest that it is part of a recognition motif for trafficking to and/or from the LBRC...
  26. pmc Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
    Guido Ferlazzo
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:16606-11. 2004
    ..These results identify secondary lymphoid organs as a potential DC/NK cell interaction site and identify the distinct roles for DC-derived IL-12 and IL-15 in NK cell activation...
  27. ncbi request reprint Transendothelial migration of monocytes: the underlying molecular mechanisms and consequences of HIV-1 infection
    Clare L V Maslin
    AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    Curr HIV Res 3:303-17. 2005
    ..This review provides insights into the most recent studies on the process of monocyte migration across the vascular endothelium, and changes in migration that can occur during HIV-infection...
  28. ncbi request reprint Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains
    Alan R Schenkel
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 173:6403-8. 2004
    ..Murine models of inflammatory disease that have been studied using C57BL/6 mice should be re-evaluated using FVB/n or other mouse strains to determine whether PECAM plays a role in those models...
  29. pmc Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms
    Emily K Reinke
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    J Neuroimmunol 186:86-93. 2007
    ..Our data suggest that short-term treatment of diseases like MS with sPECAM-Fc has therapeutic potential...
  30. ncbi request reprint The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection
    Suzanne Crowe
    AIDS Pathogenesis and Clinical Research Programme, The Macfarlane Burnet Institute for Medical Research nad Public Health, Melbourne, Australia
    J Leukoc Biol 74:635-41. 2003
    ..This review provides an evaluation of the contribution of monocytes to HIV-1 persistence and the HIV-1 reservoir, essential for the effective design of therapeutic eradication strategies...

Research Grants1

  1. Beyond PECAM: Mechanisms of Transendothelial Migration
    William Muller; Fiscal Year: 2007
    ..We will thus learn more about the regulation of both forms of transendothelial migration. ..