Anne Müsch

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network
    A Musch
    Dyson Institute of Vision Research, Departments of Biochemistry and Cell Biology, Joan and Sanford Weill Medical College of Cornell University, New York, NY 10021, USA
    EMBO J 20:2171-9. 2001
  2. ncbi Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells
    Anne Müsch
    M Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 13:158-68. 2002
  3. ncbi Microtubule organization and function in epithelial cells
    Anne Müsch
    Dyson Institute of Vision Research Weill Medical College of Cornell University, New York, 10021, USA
    Traffic 5:1-9. 2004
  4. ncbi PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells
    Maya Elbert
    Margaret M Dyson Vision Research Institute and Graduate Program in Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Mol Biol Cell 17:3345-55. 2006
  5. ncbi Protein sorting in the Golgi complex: shifting paradigms
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, LC 300, 1300 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1744:455-64. 2005
  6. ncbi Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells
    David Cohen
    Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13792-7. 2004
  7. ncbi Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling
    David Cohen
    The Margaret Dyson Institute of Vision Research, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 18:2203-15. 2007
  8. ncbi Organization of vesicular trafficking in epithelia
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 6:233-47. 2005
  9. ncbi Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton
    David Cohen
    Margaret M. Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, Box 233, New York, NY 10021, USA
    J Cell Biol 164:717-27. 2004
  10. ncbi Epithelial trafficking: new routes to familiar places
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10021, USA
    Curr Opin Cell Biol 16:436-42. 2004

Research Grants

  1. EMK1 in kidney and hepatic epithelial cell polarity
    ANNE MUESCH; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. ncbi cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network
    A Musch
    Dyson Institute of Vision Research, Departments of Biochemistry and Cell Biology, Joan and Sanford Weill Medical College of Cornell University, New York, NY 10021, USA
    EMBO J 20:2171-9. 2001
    ..This regulation may result from modulation of the actin cytoskeleton, as GTPase-deficient cdc42 depleted a perinuclear actin pool that rapidly exchanges with exogenous fluorescent actin...
  2. ncbi Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells
    Anne Müsch
    M Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 13:158-68. 2002
    ..These data suggest that Mlgl contributes to apico-basolateral polarity by regulating basolateral exocytosis...
  3. ncbi Microtubule organization and function in epithelial cells
    Anne Müsch
    Dyson Institute of Vision Research Weill Medical College of Cornell University, New York, 10021, USA
    Traffic 5:1-9. 2004
    ..Novel findings suggest, moreover, that microtubule-based transport promotes protein sorting, and even the generation of transport carriers in the endo- and exocytic pathways...
  4. ncbi PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells
    Maya Elbert
    Margaret M Dyson Vision Research Institute and Graduate Program in Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Mol Biol Cell 17:3345-55. 2006
    ..Instead, our data suggest that both proteins function antagonistically to regulate the assembly of functional E-cadherin-dependent adhesion complexes...
  5. ncbi Protein sorting in the Golgi complex: shifting paradigms
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, LC 300, 1300 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1744:455-64. 2005
    ..Several adaptors are candidates to sort apical and basolateral proteins but only AP1B and AP4 are currently involved. Progress is fast and future work should elucidate many of the open questions...
  6. ncbi Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells
    David Cohen
    Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13792-7. 2004
    ..To our knowledge, Par-1 is the first gene assigned to this task in epithelial morphogenesis...
  7. ncbi Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling
    David Cohen
    The Margaret Dyson Institute of Vision Research, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Biol Cell 18:2203-15. 2007
    ..E-cadherin depletion also reverted the hepatic-type intracellular luminal compartment in Par1b-MDCK cells to VACs characteristic of control MDCK cells, indicating a novel link between E-cadherin and luminal protein targeting...
  8. ncbi Organization of vesicular trafficking in epithelia
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 6:233-47. 2005
    ..Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking...
  9. ncbi Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton
    David Cohen
    Margaret M. Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, Box 233, New York, NY 10021, USA
    J Cell Biol 164:717-27. 2004
    ..Our experiments suggest that EMK1 primarily promotes reorganization of the MT network, consistent with the MT-regulating role of this gene product in other systems, which in turn controls lumen formation and position...
  10. ncbi Epithelial trafficking: new routes to familiar places
    Enrique Rodriguez-Boulan
    Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10021, USA
    Curr Opin Cell Biol 16:436-42. 2004
    ..A promising area of research is the study of trafficking functions of novel polarity genes identified in Drosophila and Caenorhabditis elegans...
  11. ncbi Apical surface formation in MDCK cells: regulation by the serine/threonine kinase EMK1
    David Cohen
    M. Dyson Institute of Vision Research, Weill Medical College of Cornell University, New York, NY 10021, USA
    Methods 30:269-76. 2003
    ..The assays allowed us to characterize the Caenorhabditis elegans PAR-1 homologue EMK1 as a novel regulator of apical surface formation in epithelial cells...

Research Grants7

  1. EMK1 in kidney and hepatic epithelial cell polarity
    ANNE MUESCH; Fiscal Year: 2010
    ..to elucidate the EMK1 -mediated differences in the apical protein trafficking pathways that contribute to different lumen polarity in kidney epithelia and hepatocytes. ..