Teresa A Milner


Affiliation: Cornell University
Country: USA


  1. Waters E, Mazid S, Dodos M, Puri R, Janssen W, Morrison J, et al. Effects of estrogen and aging on synaptic morphology and distribution of phosphorylated Tyr1472 NR2B in the female rat hippocampus. Neurobiol Aging. 2019;73:200-210 pubmed publisher
    ..As phosphorylation at Y1472 blocks NR2B endocytosis, reduction of pY1472 by estradiol suggests another mechanism through which estrogen enhances synaptic plasticity by altering localization of NMDAR subunits within synapses. ..
  2. Ryan J, Zhou Y, Contoreggi N, Bshesh F, Gray J, Kogan J, et al. Sex Differences in the Rat Hippocampal Opioid System After Oxycodone Conditioned Place Preference. Neuroscience. 2018;393:236-257 pubmed publisher
  3. Milner T, Lubbers L, Alves S, McEwen B. Nuclear and extranuclear estrogen binding sites in the rat forebrain and autonomic medullary areas. Endocrinology. 2008;149:3306-12 pubmed publisher
    ..The association of (125)I-estradiol binding with pre- and postsynaptic profiles supports a functional role for nonnuclear ERs in brain. ..
  4. McAlinn H, Reich B, Contoreggi N, Kamakura R, Dyer A, McEwen B, et al. Sex Differences in the Subcellular Distribution of Corticotropin-Releasing Factor Receptor 1 in the Rat Hippocampus following Chronic Immobilization Stress. Neuroscience. 2018;383:98-113 pubmed publisher
    ..These sex differences in CRFR1 distribution and trafficking in the hippocampus may contribute to reported sex differences in hippocampus-dependent learning processes in baseline conditions and following chronic stress. ..
  5. Milner T, Mitterling K, Iadecola C, Waters E. Ultrastructural localization of extranuclear progestin receptors relative to C1 neurons in the rostral ventrolateral medulla. Neurosci Lett. 2008;431:167-72 pubmed
    ..Moreover, they suggest that PR activation may contribute to progestin's effects on arterial blood pressure during pregnancy as well as to sex differences in central cardiovascular regulation. ..
  6. Milner T, Drake C, Lessard A, Waters E, Torres Reveron A, Graustein B, et al. Angiotensin II-induced hypertension differentially affects estrogen and progestin receptors in central autonomic regulatory areas of female rats. Exp Neurol. 2008;212:393-406 pubmed publisher
    ..Considering that ERalpha counteracts the central and peripheral effects of AngII, these receptor changes may underlie adaptive responses that protect females from the deleterious effects of hypertension. ..
  7. Milner T, Waters E, Robinson D, Pierce J. Degenerating processes identified by electron microscopic immunocytochemical methods. Methods Mol Biol. 2011;793:23-59 pubmed publisher
    ..The information obtained can be further refined through the use of dual immunolabeling, which can provide additional data on the phenotype of the degenerating process and inputs to the process. ..
  8. Almey A, Milner T, Brake W. Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females. Horm Behav. 2015;74:125-38 pubmed publisher
  9. Almey A, Milner T, Brake W. Estrogen receptor ? and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum. Neurosci Lett. 2016;622:118-23 pubmed publisher
    ..Binding at membrane-associated ER? and GPER1 could account for rapid estrogen-induced decreases in GABA transmission in the striatum, which, in turn, could affect dopamine transmission in this region. ..

More Information


  1. Milner T, Thompson L, Wang G, Kievits J, MARTIN E, Zhou P, et al. Distribution of estrogen receptor ? containing cells in the brains of bacterial artificial chromosome transgenic mice. Brain Res. 2010;1351:74-96 pubmed publisher
    ..These findings support the utility of Esr2 BAC transgenic reporter mice for future studies understanding the role of ERbeta in CNS function. ..
  2. van Kempen T, Dodos M, Woods C, Marques Lopes J, Justice N, Iadecola C, et al. Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension. Neuroscience. 2015;307:83-97 pubmed publisher
    ..Moreover, these results suggest that sexual dimorphism in AngII-induced hypertension is reflected by NMDA receptor trafficking in presumptive sympathoexcitatory neurons in the RVLM. ..
  3. Rogers S, Kempen T, Pickel V, Milner T. Enkephalin levels and the number of neuropeptide Y-containing interneurons in the hippocampus are decreased in female cannabinoid-receptor 1 knock-out mice. Neurosci Lett. 2016;620:97-103 pubmed publisher