Stephan Menne

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 76:1769-80. 2002
  2. pmc Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, New York 14853, USA
    Antimicrob Agents Chemother 49:2720-8. 2005
  3. ncbi request reprint The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection
    Stephan Menne
    Department of Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, Cornell University, Ithaca, NY 14853, USA
    World J Gastroenterol 13:104-24. 2007
  4. ncbi request reprint Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hepatology 45:614-22. 2007
  5. pmc Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, NY 14853, USA
    Antimicrob Agents Chemother 51:3177-84. 2007
  6. pmc Chemoimmunotherapy of chronic hepatitis B virus infection in the woodchuck model overcomes immunologic tolerance and restores T-cell responses to pre-S and S regions of the viral envelope protein
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, New York 14853, USA
    J Virol 81:10614-24. 2007
  7. pmc Antiviral effects of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate administered orally alone and in combination to woodchucks with chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Antimicrob Agents Chemother 52:3617-32. 2008
  8. ncbi request reprint Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Intervirology 45:237-50. 2002
  9. ncbi request reprint Real-time polymerase chain reaction assays for leukocyte CD and cytokine mRNAs of the Eastern woodchuck (Marmota monax)
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C2 005 VMC, Cornell University, Ithaca, NY 14853, USA
    Vet Immunol Immunopathol 87:97-105. 2002
  10. pmc Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 76:5305-14. 2002

Collaborators

Detail Information

Publications19

  1. pmc Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 76:1769-80. 2002
    ..By analogy, these results suggest that the onset of chronic hepatitis B virus (HBV) infection in humans may be associated with deficiencies in the primary T-cell response to acute HBV infection...
  2. pmc Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, New York 14853, USA
    Antimicrob Agents Chemother 49:2720-8. 2005
    ..Following drug withdrawal there was prompt recrudescence of WHV viremia to pretreatment levels. It was concluded that oral administration of TDF for 4 weeks was safe and effective in the woodchuck model of chronic HBV infection...
  3. ncbi request reprint The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection
    Stephan Menne
    Department of Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, Cornell University, Ithaca, NY 14853, USA
    World J Gastroenterol 13:104-24. 2007
    ....
  4. ncbi request reprint Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hepatology 45:614-22. 2007
    ..CONCLUSION: These experimental observations demonstrate the potential of immunosuppression to reactivate HBV after resolution of infection...
  5. pmc Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, NY 14853, USA
    Antimicrob Agents Chemother 51:3177-84. 2007
    ..Therefore, oral administration of APD for 4 weeks was safe in the woodchuck model of chronic HBV infection, and the effect on serum WHV viremia was dose dependent...
  6. pmc Chemoimmunotherapy of chronic hepatitis B virus infection in the woodchuck model overcomes immunologic tolerance and restores T-cell responses to pre-S and S regions of the viral envelope protein
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, New York 14853, USA
    J Virol 81:10614-24. 2007
    ..The results have implications for mechanisms of immunological tolerance operating in chronic HBV infection and suggest that such combined chemoimmunotherapy may be useful for treatment of humans with chronic HBV infection...
  7. pmc Antiviral effects of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate administered orally alone and in combination to woodchucks with chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Antimicrob Agents Chemother 52:3617-32. 2008
    ..In conclusion, the oral administration of 3TC, FTC, ADV, and TDF alone and in combination was safe and effective in the woodchuck model of HBV infection...
  8. ncbi request reprint Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Intervirology 45:237-50. 2002
    ....
  9. ncbi request reprint Real-time polymerase chain reaction assays for leukocyte CD and cytokine mRNAs of the Eastern woodchuck (Marmota monax)
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C2 005 VMC, Cornell University, Ithaca, NY 14853, USA
    Vet Immunol Immunopathol 87:97-105. 2002
    ..These assays will enable the high-throughput analyses of mRNA markers during WHV infection, and thereby facilitate continued modelling of the immunopathogenesis and immunotherapy of human hepatitis B virus (HBV) infection...
  10. pmc Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection
    Stephan Menne
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 76:5305-14. 2002
    ..Such combination therapy represents a potentially useful approach to the control of chronic hepatitis B virus infection in humans...
  11. ncbi request reprint Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection
    Bud C Tennant
    Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14953, USA
    Gastroenterology 127:S283-93. 2004
    ....
  12. pmc Electroporation enhances immunogenicity of a DNA vaccine expressing woodchuck hepatitis virus surface antigen in woodchucks
    Katherine H Liu
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Virol 85:4853-62. 2011
    ....
  13. ncbi request reprint Measurement of cell-mediated immune response in woodchucks
    Stephan Menne
    Gstrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Methods Mol Med 96:27-36. 2004
  14. ncbi request reprint Woodchuck dendritic cells generated from peripheral blood mononuclear cells and transduced with recombinant human adenovirus serotype 5 induce antigen-specific cellular immune responses
    Laura Ochoa-Callejero
    Laboratory of Gene Therapy of Viral Hepatitis, Division of Gene Therapy and Hepatology, Center for Applied Medical Research CIMA, Pamplona, Navarra, Spain
    J Med Virol 79:522-9. 2007
    ..Following transfection with a recombinant adenovirus wDCs can be used as a feasible and effective tool for eliciting WHV-specific T-cell responses indicating their potential to serve as prophylactic and therapeutic vaccines...
  15. ncbi request reprint Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model
    Mengji Lu
    Institut fur Virologie, Universitatsklinikum Essen, Essen, Germany
    Expert Opin Investig Drugs 16:787-801. 2007
    ..It is now generally accepted that a combination of antiviral treatment and immunization will be necessary to achieve successful immunomodulation with a long-term control of chronic hepatitis B virus infection...
  16. ncbi request reprint Kinetics of viremia and acute liver injury in relation to outcome of neonatal woodchuck hepatitis virus infection
    Yun Wang
    Division of Molecular Virology and Immunology, Department of Microbiology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20852, USA
    J Med Virol 72:406-15. 2004
    ..Thus, chronicity as an outcome of neonatal WHV infection develops relatively early during the acute phase of infection due to reduced immune-mediated clearance of infected hepatocytes by both cytolytic and non-cytolytic processes...
  17. ncbi request reprint Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens
    Mengji Lu
    Institut fur Virologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Hepatol 39:405-13. 2003
    ..Here we investigated the induction of antibody responses to hepadnaviral surface antigens in the woodchuck model, with emphasis on the vaccination of woodchucks chronically infected with woodchuck hepatitis virus (WHV)...
  18. ncbi request reprint Role of type 1 versus type 2 immune responses in liver during the onset of chronic woodchuck hepatitis virus infection
    Yun Wang
    Division of Molecular Virology and Immunology, Department of Microbiology and Immunology, Georgetown University Medical Center, Rockville, MD 20850, USA
    Hepatology 37:771-80. 2003
    ..This has relevant implications for future treatment of chronic hepatitis B virus (HBV) infection in humans...
  19. ncbi request reprint Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection
    Brent E Korba
    Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, MD, USA
    Antivir Ther 9:937-52. 2004
    ..This study demonstrates enhanced benefits of combination chemo-immunotherapy against viral load and disease progression in chronic hepadnaviral infection, and provides a platform for further development of such treatment regimens...