Research Topics
| Stephan MenneSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculationStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Virol 76:1769-80. 2002..By analogy, these results suggest that the onset of chronic hepatitis B virus (HBV) infection in humans may be associated with deficiencies in the primary T-cell response to acute HBV infection...- Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infectionStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, New York 14853, USA
Antimicrob Agents Chemother 49:2720-8. 2005..Following drug withdrawal there was prompt recrudescence of WHV viremia to pretreatment levels. It was concluded that oral administration of TDF for 4 weeks was safe and effective in the woodchuck model of chronic HBV infection... 
The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infectionStephan Menne
Department of Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, Cornell University, Ithaca, NY 14853, USA
World J Gastroenterol 13:104-24. 2007....- Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infectionStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Hepatology 45:614-22. 2007..CONCLUSION: These experimental observations demonstrate the potential of immunosuppression to reactivate HBV after resolution of infection... - Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infectionStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, NY 14853, USA
Antimicrob Agents Chemother 51:3177-84. 2007..Therefore, oral administration of APD for 4 weeks was safe in the woodchuck model of chronic HBV infection, and the effect on serum WHV viremia was dose dependent... - Chemoimmunotherapy of chronic hepatitis B virus infection in the woodchuck model overcomes immunologic tolerance and restores T-cell responses to pre-S and S regions of the viral envelope proteinStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C 2005 VMC, Cornell University, Ithaca, New York 14853, USA
J Virol 81:10614-24. 2007..The results have implications for mechanisms of immunological tolerance operating in chronic HBV infection and suggest that such combined chemoimmunotherapy may be useful for treatment of humans with chronic HBV infection... - Antiviral effects of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate administered orally alone and in combination to woodchucks with chronic woodchuck hepatitis virus infectionStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Antimicrob Agents Chemother 52:3617-32. 2008..In conclusion, the oral administration of 3TC, FTC, ADV, and TDF alone and in combination was safe and effective in the woodchuck model of HBV infection... - Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infectionStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Intervirology 45:237-50. 2002.... - Real-time polymerase chain reaction assays for leukocyte CD and cytokine mRNAs of the Eastern woodchuck (Marmota monax)Stephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Room C2 005 VMC, Cornell University, Ithaca, NY 14853, USA
Vet Immunol Immunopathol 87:97-105. 2002..These assays will enable the high-throughput analyses of mRNA markers during WHV infection, and thereby facilitate continued modelling of the immunopathogenesis and immunotherapy of human hepatitis B virus (HBV) infection... - Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infectionStephan Menne
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Virol 76:5305-14. 2002..Such combination therapy represents a potentially useful approach to the control of chronic hepatitis B virus infection in humans... - Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infectionBud C Tennant
Gastrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14953, USA
Gastroenterology 127:S283-93. 2004.... - Electroporation enhances immunogenicity of a DNA vaccine expressing woodchuck hepatitis virus surface antigen in woodchucksKatherine H Liu
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Virol 85:4853-62. 2011.... - Measurement of cell-mediated immune response in woodchucksStephan Menne
Gstrointestinal Unit, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Methods Mol Med 96:27-36. 2004 - Woodchuck dendritic cells generated from peripheral blood mononuclear cells and transduced with recombinant human adenovirus serotype 5 induce antigen-specific cellular immune responsesLaura Ochoa Callejero
Laboratory of Gene Therapy of Viral Hepatitis, Division of Gene Therapy and Hepatology, Center for Applied Medical Research CIMA, Pamplona, Navarra, Spain
J Med Virol 79:522-9. 2007..Following transfection with a recombinant adenovirus wDCs can be used as a feasible and effective tool for eliciting WHV-specific T-cell responses indicating their potential to serve as prophylactic and therapeutic vaccines... - Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck modelMengji Lu
Institut fur Virologie, Universitatsklinikum Essen, Essen, Germany
Expert Opin Investig Drugs 16:787-801. 2007..It is now generally accepted that a combination of antiviral treatment and immunization will be necessary to achieve successful immunomodulation with a long-term control of chronic hepatitis B virus infection... - Kinetics of viremia and acute liver injury in relation to outcome of neonatal woodchuck hepatitis virus infectionYun Wang
Division of Molecular Virology and Immunology, Department of Microbiology and Immunology, Georgetown University Medical Center, Rockville, Maryland 20852, USA
J Med Virol 72:406-15. 2004..Thus, chronicity as an outcome of neonatal WHV infection develops relatively early during the acute phase of infection due to reduced immune-mediated clearance of infected hepatocytes by both cytolytic and non-cytolytic processes... - Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigensMengji Lu
Institut fur Virologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany
J Hepatol 39:405-13. 2003..Here we investigated the induction of antibody responses to hepadnaviral surface antigens in the woodchuck model, with emphasis on the vaccination of woodchucks chronically infected with woodchuck hepatitis virus (WHV)... - Role of type 1 versus type 2 immune responses in liver during the onset of chronic woodchuck hepatitis virus infectionYun Wang
Division of Molecular Virology and Immunology, Department of Microbiology and Immunology, Georgetown University Medical Center, Rockville, MD 20850, USA
Hepatology 37:771-80. 2003..This has relevant implications for future treatment of chronic hepatitis B virus (HBV) infection in humans... - Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infectionBrent E Korba
Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, MD, USA
Antivir Ther 9:937-52. 2004..This study demonstrates enhanced benefits of combination chemo-immunotherapy against viral load and disease progression in chronic hepadnaviral infection, and provides a platform for further development of such treatment regimens...