AARON JACOB MARCUS

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Inhibition of platelet recruitment by endothelial cell CD39/ecto-ADPase: significance for occlusive vascular diseases
    A J Marcus
    Department of Medicine, VA New York Harbor Healthcare System and Weill Medical College of Cornell University, NY 10010, USA
    Ital Heart J 2:824-30. 2001
  2. ncbi request reprint Role of extracellular ATP metabolism in regulation of platelet reactivity
    Alex V Birk
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Lab Clin Med 140:166-75. 2002
  3. pmc CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia
    Dianne Pulte
    Research Service, Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
    J Transl Med 5:23. 2007
  4. ncbi request reprint Thromboregulation by endothelial cells: significance for occlusive vascular diseases
    A Marcus
    VA New York Harbor Healthcare System and Weill Medical College of Cornell University, New York, NY 10010, USA
    Arterioscler Thromb Vasc Biol 21:178-82. 2001
  5. ncbi request reprint Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection
    Aaron J Marcus
    Weill Medical College of Cornell University, 423 East 23rd Street, New York, NY 10010, USA
    Semin Thromb Hemost 31:234-46. 2005
  6. ncbi request reprint Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1)
    A J Marcus
    Department of Medicine, Weill Medical College of Cornell University, and Medical Service Hematology Oncology, VA New York Harbor Healthcare System, New York, NY 10010, USA
    J Thromb Haemost 1:2497-509. 2003
  7. ncbi request reprint Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases
    Aaron J Marcus
    Department of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10010, USA
    J Pharmacol Exp Ther 305:9-16. 2003
  8. pmc The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
    A J Marcus
    Department of Medicine, Veterans Affairs Medical Center, New York 10010 5050, USA
    J Clin Invest 99:1351-60. 1997
  9. pmc Human solCD39 inhibits injury-induced development of neointimal hyperplasia
    J H F Drosopoulos
    Thrombosis Research Laboratory, Room 13026W, VA New York Harbor Healthcare System, 423 East 23rd Street, New York, N Y 10010 5050, USA
    Thromb Haemost 103:426-34. 2010
  10. ncbi request reprint Site-directed mutagenesis of human endothelial cell ecto-ADPase/soluble CD39: requirement of glutamate 174 and serine 218 for enzyme activity and inhibition of platelet recruitment
    J H Drosopoulos
    Department of Medicine, Division of Hematology and Medical Oncology, VA New York Harbor Healthcare System, New York, New York 10010 5050, USA
    Biochemistry 39:6936-43. 2000

Research Grants

  1. CELL-CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 2003
  2. VASCULAR CONTROL OF BLOOD CELL REACTIVITY IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 2005
  3. CELL-CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 2007
  4. CELL-CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 1993
  5. CELL/CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 1999
  6. Thromboregulation in Occlusive Vascular Diseases
    AARON JACOB MARCUS; Fiscal Year: 2010

Collaborators

  • Joan H F Drosopoulos
  • R B Gayle
  • R Levi
  • K A Hajjar
  • M A Schoenborn
  • R Kraemer
  • R K Upmacis
  • A Lago
  • David J Pinsky
  • Hazel Szeto
  • Shahin Rafii
  • N S Kleiman
  • Jorge R Kizer
  • TERENCE KIRLEY
  • E Sander Connolly
  • M Johan Broekman
  • Naziba Islam
  • Casilde Sesti
  • E Dianne Pulte
  • Kim E Olson
  • Alex V Birk
  • Takuji Machida
  • M Teresa Santos
  • Juana Valles
  • Ulrich Schaefer
  • Dianne Pulte
  • Hans Georg Kopp
  • John M Buergler
  • Magdi M El-Omar
  • Marta Piñón
  • Justo Aznar
  • Antonio Moscardo
  • Emily Wood
  • Hugh D Robertson
  • Harold S Ballard
  • Richard R Furman
  • Ashley E Olson
  • Fan Zhang
  • Scott T Avecilla
  • Juan Cosin
  • Paul Bornstein
  • Isabelle Petit
  • Carlos A Ramos
  • Min Luo
  • Andrea T Hooper
  • Till Milde
  • Tabitha Kopp
  • Elena Sanchez
  • David K Jin
  • Steven P Sedlis
  • Charles R Maliszewski
  • Alicia C Reid
  • Randi B Silver
  • Donald C Roa
  • Ulrich Schäfer
  • Grzegorz L Kaluza
  • Daryl G Schulz
  • Nadir M Ali
  • Jeffrey D Lorin
  • Paul M Heerdt
  • Albert E Raizner
  • Motohiro Koyama
  • Eva M Gladek
  • Joshua I Park
  • Arleen B Rifkind
  • Silvia Diani-Moore
  • Darya Bubman
  • Marcial Martínez
  • Michelle Tickner

Detail Information

Publications24

  1. ncbi request reprint Inhibition of platelet recruitment by endothelial cell CD39/ecto-ADPase: significance for occlusive vascular diseases
    A J Marcus
    Department of Medicine, VA New York Harbor Healthcare System and Weill Medical College of Cornell University, NY 10010, USA
    Ital Heart J 2:824-30. 2001
    ..In this review, we summarize our recent research results with CD39 and solCD39, and discuss our viewpoints on its present and future possibilities as a novel treatment for thrombosis...
  2. ncbi request reprint Role of extracellular ATP metabolism in regulation of platelet reactivity
    Alex V Birk
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Lab Clin Med 140:166-75. 2002
    ..The presence of both endothelial CD39 and plasma nucleotidase appears to be important in the maintenance of normal hemostasis and prevention of excessive platelet responsiveness...
  3. pmc CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia
    Dianne Pulte
    Research Service, Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
    J Transl Med 5:23. 2007
    ....
  4. ncbi request reprint Thromboregulation by endothelial cells: significance for occlusive vascular diseases
    A Marcus
    VA New York Harbor Healthcare System and Weill Medical College of Cornell University, New York, NY 10010, USA
    Arterioscler Thromb Vasc Biol 21:178-82. 2001
    ....
  5. ncbi request reprint Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection
    Aaron J Marcus
    Weill Medical College of Cornell University, 423 East 23rd Street, New York, NY 10010, USA
    Semin Thromb Hemost 31:234-46. 2005
    ..Thus, CD39 represents the next generation of cardioprotective and cerebroprotective molecules. This article focuses on our interpretations of recent data and their implications for therapeutics...
  6. ncbi request reprint Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1)
    A J Marcus
    Department of Medicine, Weill Medical College of Cornell University, and Medical Service Hematology Oncology, VA New York Harbor Healthcare System, New York, NY 10010, USA
    J Thromb Haemost 1:2497-509. 2003
    ..This reduction can prevent fatal arrhythmia. Moreover, solCD39 ameliorated the sequelae of stroke in CD39 null mice. CD39 represents the next generation of cardioprotective and cerebroprotective molecules...
  7. ncbi request reprint Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases
    Aaron J Marcus
    Department of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10010, USA
    J Pharmacol Exp Ther 305:9-16. 2003
    ..quot;Reconstitution" of CD39 null mice with solCD39 reversed these changes. We hypothesize that solCD39 has potential as a novel therapeutic agent for thrombotic diatheses...
  8. pmc The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
    A J Marcus
    Department of Medicine, Veterans Affairs Medical Center, New York 10010 5050, USA
    J Clin Invest 99:1351-60. 1997
    ..The identification of HUVEC ADPase/CD39 as a constitutively expressed potent inhibitor of platelet reactivity offers new prospects for antithrombotic therapeusis...
  9. pmc Human solCD39 inhibits injury-induced development of neointimal hyperplasia
    J H F Drosopoulos
    Thrombosis Research Laboratory, Room 13026W, VA New York Harbor Healthcare System, 423 East 23rd Street, New York, N Y 10010 5050, USA
    Thromb Haemost 103:426-34. 2010
    ..56 +/- 0.34 at 19 days). Thus, systemic administration of solCD39 profoundly affects injury-induced cellular responses, minimising platelet deposition and leukocyte recruitment, and suppressing neointimal hyperplasia...
  10. ncbi request reprint Site-directed mutagenesis of human endothelial cell ecto-ADPase/soluble CD39: requirement of glutamate 174 and serine 218 for enzyme activity and inhibition of platelet recruitment
    J H Drosopoulos
    Department of Medicine, Division of Hematology and Medical Oncology, VA New York Harbor Healthcare System, New York, New York 10010 5050, USA
    Biochemistry 39:6936-43. 2000
    ..Thus, glutamate 174 and serine 218 are essential for both the enzymatic and biological activity of solCD39...
  11. pmc Aspirin therapy for inhibition of platelet reactivity in the presence of erythrocytes in patients with vascular disease
    M Teresa Santos
    Research Center, Hospital Universitario La Fe, Valencia, Spain
    J Lab Clin Med 147:220-7. 2006
    ....
  12. ncbi request reprint EctoNucleotidase in cardiac sympathetic nerve endings modulates ATP-mediated feedback of norepinephrine release
    Casilde Sesti
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Pharmacol Exp Ther 300:605-11. 2002
    ..We propose that ectonucleotidase control of norepinephrine release should provide cardiac protection in hyperadrenergic states such as myocardial ischemia...
  13. ncbi request reprint Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology
    Alex V Birk
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Lab Clin Med 139:116-24. 2002
    ....
  14. pmc Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain
    David J Pinsky
    Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, Presbyterial Hospital 10 Stem, 630 W 168th Street, New York, NY 10032, USA
    J Clin Invest 109:1031-40. 2002
    ..solCD39 reconstituted these mice, restoring postischemic cerebral perfusion and rescuing them from cerebral injury. These data demonstrate that CD39 exerts a protective thromboregulatory function in stroke...
  15. ncbi request reprint Targeted deletion of ectonucleoside triphosphate diphosphohydrolase 1/CD39 leads to desensitization of pre- and postsynaptic purinergic P2 receptors
    Ulrich Schaefer
    Department of Pharmacology, Weill Cornell Medical College, 1300 York Ave, New York, NY, USA
    J Pharmacol Exp Ther 322:1269-77. 2007
    ..Moreover, by virtue of its antithrombotic action CD39 can potentially prevent the transition from myocardial ischemia to infarction...
  16. ncbi request reprint Effects of SolCD39, a novel inhibitor of Platelet Aggregation, on Platelet Deposition and Aggregation after PTCA in a Porcine Model
    John M Buergler
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, The Methodist DeBakey Heart Center, Houston, TX 77030, USA
    J Thromb Thrombolysis 19:115-22. 2005
    ..CD39 (E-NTPDase1), is the endothelial ecto-ADPase inhibiting platelet function via hydrolysis of released platelet ADP...
  17. pmc Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization
    Hans Georg Kopp
    Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Invest 116:3277-91. 2006
    ..As such, interference with the release of cellular stores of TSPs may be clinically effective in augmenting neoangiogenesis...
  18. pmc CD39/NTPDase-1 activity and expression in normal leukocytes
    E Dianne Pulte
    Research Service, Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, United States
    Thromb Res 121:309-17. 2007
    ..CD39 is expressed on numerous different types of normal leukocytes, but details of its expression have not been determined previously...
  19. ncbi request reprint The ratio of ADP- to ATP-ectonucleotidase activity is reduced in patients with coronary artery disease
    Magdi M El-Omar
    Department of Medicine Cardiology, New York University Medical School, New York, NY, USA
    Thromb Res 116:199-206. 2005
    ..Based on data in animal models and in vitro, CD39 constitutes a new therapeutic modality for vascular disease with a novel and unique mode of action...
  20. ncbi request reprint Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis
    Takuji Machida
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Pharmacol Exp Ther 313:570-7. 2005
    ..By curtailing NE release, in addition to its effects as an antithrombotic agent, soluble CD39 may constitute a novel therapeutic approach to ischemic complications in the myocardium...
  21. ncbi request reprint Platelet-erythrocyte interactions enhance alpha(IIb)beta(3) integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo
    Juana Valles
    Research Center and Department of Clinical Pathology, University Hospital La Fe, Valencia, Spain
    Blood 99:3978-84. 2002
    ..We conclude that by these mechanisms, erythrocytes can actively contribute to platelet-driven thrombogenesis and microvascular occlusion...
  22. ncbi request reprint Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Emily Wood
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Arch Biochem Biophys 407:49-62. 2002
    ..It is likely that such differences are important for cell-specific susceptibility to extracellular nucleotide toxicity and responses to purinergic signaling...
  23. ncbi request reprint COX inhibitors and thromboregulation
    Aaron J Marcus
    Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
    N Engl J Med 347:1025-6. 2002
  24. ncbi request reprint Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia
    Casilde Sesti
    Department of Pharmacology, Room LC419, 1300 York Ave, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Pharmacol Exp Ther 306:238-44. 2003
    ..Because excessive NE release is an established cause of dysfunction in ischemic heart disease, solCD39 may offer a novel therapeutic approach to myocardial ischemia and its consequences...

Research Grants22

  1. CELL-CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 2003
    ....
  2. VASCULAR CONTROL OF BLOOD CELL REACTIVITY IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 2005
    ..This collaboration, based on compelling feasibility data and historical collaborative success, will advance the understanding of CD39 thromboregulation, and lead to a novel therapeutic agent for thrombotic diathesis. ..
  3. CELL-CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 2007
    ..abstract_text> ..
  4. CELL-CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 1993
    ..Established experimental methods include: Separate measurement of platelet activation and recruitment, tissue culture, TLC, HPLC, GC/MS, aggregometry and radioimmunoassay...
  5. CELL/CELL INTERACTIONS IN THROMBOSIS
    Aaron Marcus; Fiscal Year: 1999
    ..Experiments proposed in this application will furnish information for future development of rational and effective forms of antithrombotic therapy which will act at the very earliest stages of thrombus formation. ..
  6. Thromboregulation in Occlusive Vascular Diseases
    AARON JACOB MARCUS; Fiscal Year: 2010
    ..We anticipate that the research proposed herein will lead to formulation of a clinical trial of a human soluble apyrase such as solCD39. ..