Jordi Magrane

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. doi request reprint Isolation and culture of neurons and astrocytes from the mouse brain cortex
    Hyun Jeong Kim
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA
    Methods Mol Biol 793:63-75. 2011
  2. pmc Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis
    Jordi Magrane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    Antioxid Redox Signal 11:1615-26. 2009
  3. pmc A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo
    Virginia Fonte
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Mol Neurodegener 6:61. 2011
  4. pmc The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis
    Hyun Jeong Kim
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th St, A 505, New York, NY 10065, USA
    Brain 135:2865-74. 2012
  5. pmc Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons
    Jordi Magrane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 32:229-42. 2012
  6. pmc Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities
    Jordi Magrane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 18:4552-64. 2009
  7. pmc In vivo pathogenic role of mutant SOD1 localized in the mitochondrial intermembrane space
    Anissa Igoudjil
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 31:15826-37. 2011
  8. pmc PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    Cristofol Vives-Bauza
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:378-83. 2010
  9. pmc Novel role of ATPase subunit C targeting peptides beyond mitochondrial protein import
    Cristofol Vives-Bauza
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Biol Cell 21:131-9. 2010
  10. pmc Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria
    Hibiki Kawamata
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 283:28321-8. 2008

Collaborators

Detail Information

Publications15

  1. doi request reprint Isolation and culture of neurons and astrocytes from the mouse brain cortex
    Hyun Jeong Kim
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA
    Methods Mol Biol 793:63-75. 2011
    ..Here, we describe a method to isolate and culture neurons and astrocytes from the mouse cerebral cortex, and we also present a practical application for transfection and subsequent immunofluorescence...
  2. pmc Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis
    Jordi Magrane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    Antioxid Redox Signal 11:1615-26. 2009
    ..Here we review the current knowledge on mitochondrial transport and its role in ALS...
  3. pmc A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo
    Virginia Fonte
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Mol Neurodegener 6:61. 2011
    ..abstract:..
  4. pmc The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis
    Hyun Jeong Kim
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th St, A 505, New York, NY 10065, USA
    Brain 135:2865-74. 2012
    ..Such a protective mechanism may contribute to the lower incidence and later onset of amyotrophic lateral sclerosis, and perhaps other chronic neurodegenerative diseases, in females...
  5. pmc Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons
    Jordi Magrane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 32:229-42. 2012
    ..Together, these results suggest that impaired mitochondrial dynamics may contribute to the selective degeneration of motor neurons in SOD1-FALS...
  6. pmc Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities
    Jordi Magrane
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 18:4552-64. 2009
    ..Our findings demonstrate that mutant SOD1 localized in the IMS is sufficient to determine mitochondrial abnormalities and neuronal toxicity, and contributes to ALS pathogenesis...
  7. pmc In vivo pathogenic role of mutant SOD1 localized in the mitochondrial intermembrane space
    Anissa Igoudjil
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 31:15826-37. 2011
    ....
  8. pmc PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    Cristofol Vives-Bauza
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:378-83. 2010
    ..Thus by impairing this process, mutations in either Parkin or PINK1 may alter mitochondrial turnover which, in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in Parkinson's disease...
  9. pmc Novel role of ATPase subunit C targeting peptides beyond mitochondrial protein import
    Cristofol Vives-Bauza
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Biol Cell 21:131-9. 2010
    ....
  10. pmc Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria
    Hibiki Kawamata
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 283:28321-8. 2008
    ..mitoKARS is the first described member of a group of mitochondrial proteins whose interaction with mutant SOD1 contributes to mitochondrial dysfunction in ALS...
  11. pmc α-Synuclein is localized to mitochondria-associated ER membranes
    Cristina Guardia-Laguarta
    Departments of Pathology, Neurology, and Genetics and Development, and Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, Institut fur Biochemie und Molekularbiologie, Universität 53115 Bonn, Germany, and Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065
    J Neurosci 34:249-59. 2014
    ..We believe that our results have far-reaching implications for both our understanding of α-syn biology and the treatment of synucleinopathies. ..
  12. pmc adPEO mutations in ANT1 impair ADP-ATP translocation in muscle mitochondria
    Hibiki Kawamata
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 20:2964-74. 2011
    ....
  13. pmc PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease
    Wencheng Liu
    Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA
    PLoS ONE 4:e4597. 2009
    ..Our results indicate that it will be important to delineate the relationship between mitochondrial functional deficits, proteasome dysfunction and alpha-synclein aggregation...
  14. pmc Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models
    Jordi Magrane
    Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 23:1413-24. 2014
    ..At the same time, differences in the temporal and spatial manifestation of mitochondrial abnormalities between the two mouse models of familial ALS imply that different molecular mechanisms may be involved. ..
  15. pmc The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells
    Cristofol Vives-Bauza
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 283:24770-80. 2008
    ..They suggest that synergy of sub-toxic lysosomal and mitochondrial changes in RPE cells with age may cause RPE dysfunction that is known to contribute to human retinal diseases like age-related macular degeneration...