HENING contact LIN

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme
    Yang Zhang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 465:891-6. 2010
  2. pmc SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
    Hong Jiang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 496:110-3. 2013
  3. pmc A fluorogenic assay for screening Sirt6 modulators
    Jing Hu
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA
    Org Biomol Chem 11:5213-6. 2013
  4. pmc Protein lysine acylation and cysteine succination by intermediates of energy metabolism
    Hening Lin
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    ACS Chem Biol 7:947-60. 2012
  5. ncbi request reprint Nicotinamide adenine dinucleotide: beyond a redox coenzyme
    Hening Lin
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    Org Biomol Chem 5:2541-54. 2007
  6. pmc S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?
    Hening Lin
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, United States
    Bioorg Chem 39:161-70. 2011
  7. doi request reprint Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD
    Jintang Du
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 48:2878-90. 2009
  8. pmc Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis
    Xuling Zhu
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biosyst 7:74-81. 2011
  9. pmc Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases
    Hong Jiang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850, USA
    J Am Chem Soc 132:9363-72. 2010
  10. pmc Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
    Qun Liu
    MacCHESS, Cornell High Energy Synchrotron Source, CornellUniversity, Ithaca, New York 14853, USA
    J Biol Chem 284:27637-45. 2009

Research Grants

  1. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2010
  2. Diphthamide biosynthesis
    HENING contact LIN; Fiscal Year: 2010
  3. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2011

Collaborators

  • HON C LEE
  • Jing Hu
  • WILLIAM L KRAUS
  • Christopher Walsh
  • Hong Jiang
  • Qun Liu
  • Xuling Zhu
  • Yang Zhang
  • Jintang Du
  • Quan Hao
  • Boris Dzikovski
  • Steven E Ealick
  • Andrew T Torelli
  • Richard Graeff
  • Irina A Kriksunov
  • Minkui Luo
  • Haiyan Tao
  • Carlos Sebastian
  • Bin He
  • Guillaume Charron
  • Eva Ge
  • Raul Mostoslavsky
  • Saba Khan
  • Howard C Hang
  • Ray Kim
  • Yi Wang
  • Jack H Freed
  • Xiaoyang Su
  • Eileen Wang
  • Carsten Krebs
  • Kristine M Frizzell
  • Michael Lee
  • Rachel M Koralewski
  • Jack Freed
  • Jun Hyun Kim
  • Norman Oppenheimer
  • Barry V L Potter
  • Bo Zhang
  • Virginia W Cornish
  • Michael A Fischbach
  • David R Liu
  • John T Groves
  • Pamela Peralta-Yahya

Detail Information

Publications14

  1. pmc Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme
    Yang Zhang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 465:891-6. 2010
    ..Our results suggest that P. horikoshii Dph2 represents a previously unknown, SAM-dependent, [4Fe-4S]-containing enzyme that catalyses unprecedented chemistry...
  2. pmc SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
    Hong Jiang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 496:110-3. 2013
    ..The discovery of SIRT6 as an enzyme that controls protein lysine fatty acylation provides new opportunities to investigate the physiological function of a protein post-translational modification that has been little studied until now...
  3. pmc A fluorogenic assay for screening Sirt6 modulators
    Jing Hu
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA
    Org Biomol Chem 11:5213-6. 2013
    ..Sirt6 modulators will be useful in investigating the function of Sirt6 and protein lysine fatty acylation. ..
  4. pmc Protein lysine acylation and cysteine succination by intermediates of energy metabolism
    Hening Lin
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    ACS Chem Biol 7:947-60. 2012
    ..These new modifications reveal interesting connections between metabolism and protein post-translational modifications and raise many questions for future investigations...
  5. ncbi request reprint Nicotinamide adenine dinucleotide: beyond a redox coenzyme
    Hening Lin
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    Org Biomol Chem 5:2541-54. 2007
    ..Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions...
  6. pmc S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?
    Hening Lin
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, United States
    Bioorg Chem 39:161-70. 2011
    ..These reactions include SAM-dependent cyclopropane fatty acid synthesis, DNA cytosine methylation, RNA adenosine C2 and C8 methylation, and 3-amino-3-carboxypropylation involved in diphthamide biosynthesis and wybutosine biosynthesis...
  7. doi request reprint Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD
    Jintang Du
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 48:2878-90. 2009
    ....
  8. pmc Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis
    Xuling Zhu
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biosyst 7:74-81. 2011
    ..Furthermore, our data suggest that the chemistry requires only one [4Fe-4S] cluster to be present in the PhDph2 dimer...
  9. pmc Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases
    Hong Jiang
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850, USA
    J Am Chem Soc 132:9363-72. 2010
    ..These results demonstrate that the clickable NAD analogue is useful for labeling, in-gel detection, isolation, and identification of the substrate proteins of PARPs and will help to understand the biological functions of PARPs...
  10. pmc Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
    Qun Liu
    MacCHESS, Cornell High Energy Synchrotron Source, CornellUniversity, Ithaca, New York 14853, USA
    J Biol Chem 284:27637-45. 2009
    ..The comprehensive structural comparison of CD38 and APDRC presented in this study thus provides insights into the structural determinants for the functional evolution from a cyclase to a hydrolase...
  11. pmc Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38
    Qun Liu
    MacCHESS, Cornell High Energy Synchrotron Source, Department of Chemistry and Chemical Biology, School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Chem Biol 15:1068-78. 2008
    ....
  12. ncbi request reprint Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation
    Haiyan Tao
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Bioorg Med Chem 14:6940-53. 2006
    ..These optimized chemical dimerizer substrates should allow the potential of chemical complementation for the directed evolution of glycosynthases with diverse substrate specificities and improved properties to be fully realized...
  13. ncbi request reprint Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition
    Minkui Luo
    ACS Chem Biol 1:29-32. 2006
    ..These results suggest that IroB and IroE enhance the ability of Ent-producing pathogens to acquire iron in membrane-rich microenvironments...
  14. ncbi request reprint Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase
    Hening Lin
    Department of Biological Chemistry, and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Chem Biol 11:1635-42. 2004
    ..The cyclic glycopeptides retained antibiotic activity as membrane perturbants in MIC assays, opening the possibility for library construction of cyclic glycopeptides by enzymatic macrocyclization...

Research Grants5

  1. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2010
    ..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
  2. Diphthamide biosynthesis
    HENING contact LIN; Fiscal Year: 2010
    ....
  3. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2011
    ..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..