Affiliation: Cornell University
- Leon A, Mallinckrodt C, Chuang Stein C, Archibald D, Archer G, Chartier K. Attrition in randomized controlled clinical trials: methodological issues in psychopharmacology. Biol Psychiatry. 2006;59:1001-5 pubmed..This information can be used to eliminate some of the very obstacles that lead to attrition, and can be incorporated in data analyses to reduce bias, but it will not eliminate all attrition bias. ..
- Leon A, Davis L, Kraemer H. The role and interpretation of pilot studies in clinical research. J Psychiatr Res. 2011;45:626-9 pubmed publisher..Investigators should be forthright in stating these objectives of a pilot study. Grant reviewers and other stakeholders should expect no more. ..
- Leon A. Evolution of psychopharmacology trial design and analysis: six decades in the making. J Clin Psychiatry. 2011;72:331-40 pubmed publisher..Despite the progress in randomized controlled trial (RCT) design, the discovery of new mechanisms of action and blockbuster interventions has slowed during the past decade. ..