ANDREW LEON

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Statistical strategies for randomized controlled clinical trials to detect differential onset of action
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA
    Psychopharmacol Bull 42:39-46. 2009
  2. doi Performance of a propensity score adjustment in longitudinal studies with covariate-dependent representation
    Andrew C Leon
    Weill Cornell Medical College, New York City, NY 10065, USA
    Stat Med 31:2262-74. 2012
  3. pmc Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, USA
    Am J Psychiatry 169:285-91. 2012
  4. ncbi Independent data and safety monitoring in psychiatric intervention research
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th St, New York, NY 10065, USA
    J Clin Psychiatry 73:e257-63. 2012
  5. doi Challenges in designing comparative-effectiveness trials for antidepressants
    A C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA
    Clin Pharmacol Ther 91:165-7. 2012
  6. ncbi A comparison of mixed-effects quantile stratification propensity adjustment strategies for longitudinal treatment effectiveness analyses of continuous outcomes
    Andrew C Leon
    Department of Psychiatry, Cornell University, New York, NY, USA
    Stat Med 26:2650-65. 2007
  7. pmc Enhancing clinical trial design of interventions for posttraumatic stress disorder
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    J Trauma Stress 22:603-11. 2009
  8. ncbi A mixed-effects quintile-stratified propensity adjustment for effectiveness analyses of ordered categorical doses
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Stat Med 24:647-58. 2005
  9. ncbi Paroxetine, other antidepressants, and youth suicide in New York City: 1993 through 1998
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY10021, USA
    J Clin Psychiatry 65:915-8. 2004
  10. ncbi A comparison of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, New York 10021, USA
    J Biopharm Stat 15:839-55. 2005

Research Grants

Detail Information

Publications82

  1. ncbi Statistical strategies for randomized controlled clinical trials to detect differential onset of action
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA
    Psychopharmacol Bull 42:39-46. 2009
    ..The applicability of mixed-effects models and the cure model to challenges in the study of onset of action is described...
  2. doi Performance of a propensity score adjustment in longitudinal studies with covariate-dependent representation
    Andrew C Leon
    Weill Cornell Medical College, New York City, NY 10065, USA
    Stat Med 31:2262-74. 2012
    ..The simulations found that estimates were adversely affected by underrepresentation when there was lower ICC among repeated doses and among repeated outcomes...
  3. pmc Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, USA
    Am J Psychiatry 169:285-91. 2012
    ..The present study examines the hypothesis that the three antiepileptics approved for bipolar disorder (carbamazepine, lamotrigine, and valproate) are associated with an elevated risk of suicide attempts and suicides...
  4. ncbi Independent data and safety monitoring in psychiatric intervention research
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th St, New York, NY 10065, USA
    J Clin Psychiatry 73:e257-63. 2012
    ..Ultimately, a DSMB's responsibilities are broader than that of the trial being monitored. It will protect potential study participants and eventually could affect patients seeking clinical treatment for the disorder being studied...
  5. doi Challenges in designing comparative-effectiveness trials for antidepressants
    A C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA
    Clin Pharmacol Ther 91:165-7. 2012
    ..NI hypothesis testing, on the other hand, requires an a priori NI margin and evidence of trial assay sensitivity. Either design demands unusually large samples, which could render such trials infeasible...
  6. ncbi A comparison of mixed-effects quantile stratification propensity adjustment strategies for longitudinal treatment effectiveness analyses of continuous outcomes
    Andrew C Leon
    Department of Psychiatry, Cornell University, New York, NY, USA
    Stat Med 26:2650-65. 2007
    ..The approach is illustrated in an evaluation of the effectiveness of somatic treatments for major depression in a longitudinal, observational study of affective disorders...
  7. pmc Enhancing clinical trial design of interventions for posttraumatic stress disorder
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    J Trauma Stress 22:603-11. 2009
    ..Fundamental goals of RCT design are described. Strategies in design and analysis that contribute to the goals of an RCT and thereby enhance the likelihood of signal detection are considered...
  8. ncbi A mixed-effects quintile-stratified propensity adjustment for effectiveness analyses of ordered categorical doses
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Stat Med 24:647-58. 2005
    ..This approach is a useful strategy for observational studies of treatment effectiveness. It is capable of adjusting for selection bias, incorporating multiple observations per subject, and comparing effectiveness of ordinal doses...
  9. ncbi Paroxetine, other antidepressants, and youth suicide in New York City: 1993 through 1998
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY10021, USA
    J Clin Psychiatry 65:915-8. 2004
    ....
  10. ncbi A comparison of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, New York 10021, USA
    J Biopharm Stat 15:839-55. 2005
    ..Analyses of data from a randomized controlled clinical trial of treatments for mania in bipolar disorder are used to illustrate the application of the multiplicity adjustments...
  11. ncbi The revised black box warning for antidepressants sets a public health experiment in motion
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
    J Clin Psychiatry 68:1139-41. 2007
  12. ncbi Bias reduction in effectiveness analyses of longitudinal ordinal doses with a mixed-effects propensity adjustment
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Stat Med 26:110-23. 2007
    ..In addition, type I error rate and statistical power are examined. The approach is illustrated by applying it to a longitudinal, observational study of maintenance treatment of major depression...
  13. pmc Implications of clinical trial design on sample size requirements
    Andrew C Leon
    Weill Medical College of Cornell University, New York, NY 10065, USA
    Schizophr Bull 34:664-9. 2008
    ..The objective of this article is to consider strategies that overcome the problems of unreliability and multiplicity...
  14. ncbi Statistical power of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, Box 140, 525 East 68th Street, New York, NY 10021, USA
    Stat Med 26:1712-23. 2007
    ..50; whereas the James procedure provides more statistical power with higher rho, the common correlation among the multiple outcomes. A study of gender differences in New York City homicides is used to illustrate the approaches...
  15. ncbi Antidepressants and youth suicide in New York City, 1999-2002
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Am Acad Child Adolesc Psychiatry 45:1054-8. 2006
    ..To determine the proportion of youth suicides in New York City from 1999 to 2002 in which antidepressants were detected at autopsy...
  16. ncbi The revised warning for antidepressants and suicidality: unveiling the black box of statistical analyses
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Psychiatry 164:1786-9. 2007
  17. ncbi Bias reduction with an adjustment for participants' intent to dropout of a randomized controlled clinical trial
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Clin Trials 4:540-7. 2007
    ..Although likelihood-based statistical models such as mixed-effects models can accommodate incomplete data, the assumption of ignorable attrition is usually required for valid inferences...
  18. ncbi Antidepressants in adult suicides in New York City: 2001-2004
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 68:1399-403. 2007
    ..Nearly all suicidality in those trials was nonfatal suicide attempts and ideation. Here, we consider whether antidepressants are linked with adult suicide deaths...
  19. ncbi Attrition in randomized controlled clinical trials: methodological issues in psychopharmacology
    Andrew C Leon
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    Biol Psychiatry 59:1001-5. 2006
    ..This information can be used to eliminate some of the very obstacles that lead to attrition, and can be incorporated in data analyses to reduce bias, but it will not eliminate all attrition bias...
  20. ncbi Multiplicity-adjusted sample size requirements: a strategy to maintain statistical power with Bonferroni adjustments
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 65:1511-4. 2004
    ..Here, a simple strategy is described that adjusts alpha for multiple primary efficacy measures, yet maintains statistical power for each test...
  21. pmc Evolution of psychopharmacology trial design and analysis: six decades in the making
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th St, New York, NY 10065, USA
    J Clin Psychiatry 72:331-40. 2011
    ..The evolution of trial design and analysis during the lifespan of psychopharmacology is examined...
  22. doi Comparative effectiveness clinical trials in psychiatry: superiority, noninferiority, and the role of active comparators
    Andrew C Leon
    Weill Cornell Medical College, Departments of Psychiatry and Public Health, New York, NY 10065, USA
    J Clin Psychiatry 72:1344-9. 2011
    ..As a result, trials with active comparators are more costly, require longer recruitment duration, and expose more participants to the risks of an experiment than do trials in which the only comparator is placebo...
  23. pmc Evaluation of psychiatric interventions in an observational study: issues in design and analysis
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th Street, New York, NY 10065, USA
    Dialogues Clin Neurosci 13:191-8. 2011
    ..Evaluations presented here examine acute and maintenance antidepressant effectiveness and demonstrate effectiveness of the higher categorical doses...
  24. ncbi False positive results: a challenge for psychiatric screening in primary care
    A C Leon
    Department of Psychiatry, Cornell University Medical College, NY 10021, USA
    Am J Psychiatry 154:1462-4. 1997
    ..The goal of this study was to characterize primary care patients with false positive results on screens for mental disorders...
  25. pmc Antidepressants and risks of suicide and suicide attempts: a 27-year observational study
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    J Clin Psychiatry 72:580-6. 2011
    ..The objective of this study was to examine the association of antidepressants with suicide attempts and with suicide deaths...
  26. pmc The role and interpretation of pilot studies in clinical research
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th Street, New York, NY 10065, USA
    J Psychiatr Res 45:626-9. 2011
    ..Investigators should be forthright in stating these objectives of a pilot study. Grant reviewers and other stakeholders should expect no more...
  27. ncbi Are two antidepressant mechanisms better than one? Issues in clinical trial design and analysis
    Andrew C Leon
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 65:31-6. 2004
    ..equivalence trial), and others are somewhat more discretionary (e.g., assessment tools, statistical procedures). Issues in the design and analysis of clinical trials comparing dual- and single-action antidepressants are discussed...
  28. doi Two clinical trial designs to examine personalized treatments for psychiatric disorders
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    J Clin Psychiatry 72:593-7. 2011
    ..When resources are abundant, the 2 × 2 design is the preferable approach for identifying personalized interventions because it directly tests the differential treatment effect, but its demand on research funds is extraordinary...
  29. pmc A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia
    Donald C Goff
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 33:465-72. 2008
    ..CX516 was not effective for cognition or for symptoms of schizophrenia when added to clozapine, olanzapine, or risperidone...
  30. ncbi The long-term natural history of the weekly symptomatic status of bipolar I disorder
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 59:530-7. 2002
    ..To our knowledge, this is the first prospective natural history study of weekly symptomatic status of patients with bipolar I disorder (BP-I) during long-term follow-up...
  31. ncbi Toward rapproachment in the placebo control debate. A calculated compromise of power
    Andrew C Leon
    Weill Medical College of Cornell University, USA
    Eval Health Prof 26:404-14. 2003
    ....
  32. ncbi A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 60:261-9. 2003
    ..This is the first prospective longitudinal study, to our knowledge, of the natural history of the weekly symptomatic status of bipolar II disorder (BP-II)...
  33. ncbi Expanding the black box - depression, antidepressants, and the risk of suicide
    Richard A Friedman
    Psychopharmacology Clinic, Weill Cornell Medical College, New York, USA
    N Engl J Med 356:2343-6. 2007
  34. ncbi Antidepressant treatment patterns in a novel methadone maintenance clinic targeting young adults an observational study
    David W Galarneau
    Weill Medical College of Cornell University, New York, NY 10021, USA
    J Addict Dis 25:47-52. 2006
    ..e., general outpatient vs. methadone maintenance)...
  35. doi Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 65:386-94. 2008
    ..Both bipolar disorder type I and type II are characterized by frequent affective episode relapse and/or recurrence. An increasingly important goal of therapy is reducing chronicity by preventing or delaying additional episodes...
  36. ncbi Sample-size requirements for comparisons of two groups on repeated observations of a binary outcome
    Andrew C Leon
    Weill Medical College of Cornell University, USA
    Eval Health Prof 27:34-44. 2004
    ....
  37. pmc Drugs and firearm deaths in New York City, 1990-1998
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, New York 10029, USA
    J Urban Health 79:70-86. 2002
    ..These results suggest a complex role of drugs in firearm-related deaths...
  38. ncbi Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, 401 Parnassus Avenue, PO Box 0984 F, San Francisco, CA 94143, USA
    J Clin Psychiatry 66:1409-14. 2005
    ..We examined the frequency and severity of residual depressive symptoms in 2 studies comparing the selective serotonin reuptake inhibitor (SSRI) fluoxetine with the norepinephrine reuptake inhibitor (NRI) reboxetine...
  39. pmc Manic/hypomanic symptom burden and cardiovascular mortality in bipolar disorder
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Psychosom Med 71:598-606. 2009
    ..To compare the risk for cardiovascular mortality between bipolar I and bipolar II subtypes and determine correlates of cardiovascular mortality. Bipolar disorder conveys an increased risk of cardiovascular mortality...
  40. ncbi Antidepressant use in elderly suicide victims in New York city: an analysis of 255 cases
    Robert C Abrams
    Department of Psychiatry, Weill Cornell Medical College, New York, N Y 10021, USA
    J Clin Psychiatry 70:312-7. 2009
    ..We examined postmortem evidence of antidepressant, analgesic, and anxiolytic-hypnotic drugs in suicide victims aged 65 years and older...
  41. doi Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and design
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Trials 6:637-48. 2009
    ..Recent data indicate that lithium use for bipolar disorder has declined over the last decade and that lithium largely has been replaced with alternate, commercially promoted medications that may or may not result in better outcomes...
  42. pmc "Gray murder": characteristics of elderly compared with nonelderly homicide victims in New York City
    Robert C Abrams
    Department of Psychiatry, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10021, USA
    Am J Public Health 97:1666-70. 2007
    ....
  43. ncbi Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, N Y, USA
    J Clin Psychiatry 70:354-61. 2009
    ..We hypothesized that patient preference at baseline would interact with treatment group to differentially affect treatment outcome...
  44. pmc A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  45. pmc Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Gen Psychiatry 66:1178-88. 2009
    ..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
  46. doi Statistical power and sample size requirements for three level hierarchical cluster randomized trials
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, New York 10605, USA
    Biometrics 64:1256-62. 2008
    ..Recommendations at the design stage of a cluster-RCT are discussed...
  47. ncbi A randomized trial of depression assessment intervention in home health care
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, New York, USA
    J Am Geriatr Soc 55:1793-800. 2007
    ..To determine whether an educational intervention would improve depression assessment and appropriate referral. Secondary analyses tested whether referral led to depression improvement...
  48. pmc The NimStim set of facial expressions: judgments from untrained research participants
    Nim Tottenham
    Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10021, USA
    Psychiatry Res 168:242-9. 2009
    ..The results lend empirical support for the validity and reliability of this set of facial expressions as determined by accurate identification of expressions and high intra-participant agreement across two testing sessions, respectively...
  49. doi A new scale for assessing the quality of randomized clinical trials of psychotherapy
    James H Kocsis
    Weill Cornell Medical College, New York, NY 10065, USA
    Compr Psychiatry 51:319-24. 2010
    ..In 2004, the American Psychiatric Association's Committee on Research on Psychiatric Treatments appointed a subcommittee to investigate the status of empirical evidence with regard to psychodynamic psychotherapy...
  50. ncbi Do comorbid personality disorders moderate panic-focused psychotherapy? An exploratory examination of the American Psychiatric Association practice guideline
    Barbara L Milrod
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 68:885-91. 2007
    ..No data underlie this recommendation. This exploratory study assessed the moderating effect of personality disorder on psychodynamic and non-psychodynamic psychotherapy outcome...
  51. ncbi A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder
    Barbara Milrod
    Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
    Am J Psychiatry 164:265-72. 2007
    ..To the authors' knowledge, this is the first efficacy randomized controlled clinical trial of panic-focused psychodynamic psychotherapy, a manualized psychoanalytical psychotherapy for patients with DSM-IV panic disorder...
  52. ncbi Performance of a mixed effects logistic regression model for binary outcomes with unequal cluster size
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Biopharm Stat 15:513-26. 2005
    ..This is illustrated using data from the Prevention Of Suicide in Primary care Elderly: Collaborative Trial (PROSPECT) study...
  53. ncbi Are there differences in the symptoms that respond to a selective serotonin or norepinephrine reuptake inhibitor?
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, San Francisco, California 94143, USA
    Biol Psychiatry 57:1535-42. 2005
    ....
  54. ncbi Comparison of statistical methods for analysis of clustered binary observations
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, Westchester Division, White Plains, NY 10605, USA
    Stat Med 24:911-23. 2005
    ....
  55. ncbi The face behind the mask: a developmental study
    Nim Tottenham
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
    Dev Sci 9:288-94. 2006
    ....
  56. pmc Preference for fall from height as a method of suicide by elderly residents of New York City
    Robert C Abrams
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
    Am J Public Health 95:1000-2. 2005
    ..Among persons who died by fall from height, those 65 or older were more likely than others to have fallen from buildings where they lived...
  57. ncbi A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness
    Andrew C Leon
    NIMH Collaborative Program on the Psychobiology of Depression, USA
    Am J Psychiatry 160:727-33. 2003
    ..This observational study examined the effectiveness of somatic antidepressant treatments as administered in the community...
  58. ncbi Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 62:1322-30. 2005
    ..Evidence of psychosocial disability in bipolar disorder is based primarily on bipolar I disorder (BP-I) and does not relate disability to affective symptom severity and polarity or to bipolar II disorder (BP-II)...
  59. ncbi Suicide among New York City police officers, 1977-1996
    Peter M Marzuk
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Psychiatry 159:2069-71. 2002
    ..The authors assessed the suicide rates of New York City police officers during a recent period...
  60. ncbi Assessment of outcome in depression
    J Craig Nelson
    Department of Psychiatry, University of California, San Francisco, CA, USA
    J Psychopharmacol 20:47-53. 2006
    ..And we review studies that have identified 'core' symptoms of depression and compare these findings to the magnitude of individual symptom change we found in five studies of selective serotonergic or nonadrenergic antidepressants...
  61. pmc Sample size requirements to detect an intervention by time interaction in longitudinal cluster randomized clinical trials
    Moonseong Heo
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Stat Med 28:1017-27. 2009
    ..A simulation study confirmed that theoretical power estimates based on the derived formulae are nearly identical to empirical estimates...
  62. ncbi Psychopathology of panic attacks in panic disorder
    E H Uhlenhuth
    Department of Psychiatry, MSC09 5030, 1 University of New Mexico, Albuquerque, 87131 0001, USA
    J Affect Disord 92:55-62. 2006
    ..limited symptom; spontaneous vs. situational) and between these subtypes, panic disorder subtypes, and other characteristics of panic disorder, especially agoraphobia...
  63. ncbi Unipolar mania over the course of a 20-year follow-up study
    David A Solomon
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, at Mood Disorders Program, Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence RI 02903 4970, USA
    Am J Psychiatry 160:2049-51. 2003
    ..Using data from a longitudinal study of the mood disorders, the investigators address the phenomenon of unipolar mania...
  64. ncbi ACNP Task Force report on SSRIs and suicidal behavior in youth
    J John Mann
    Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:473-92. 2006
    ....
  65. pmc Empirical typology of bipolar I mood episodes
    David A Solomon
    Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence, Rhode Island 02903 4970, USA
    Br J Psychiatry 195:525-30. 2009
    ..Much remains unknown about the phenomenology of bipolar I disorder...
  66. ncbi Assessment and treatment of depression in disability claimants: a cost-benefit simulation study
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, New York 10021, USA
    J Nerv Ment Dis 190:3-9. 2002
    ..The economic and public health benefits both point toward the value of such an intervention for disability claimants...
  67. ncbi The prospectively observed course of illness among depressed patients who commit suicide
    William Coryell
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Acta Psychiatr Scand 105:218-23. 2002
    ..These analyses were conducted to describe the course of illness among patients with major affective disorders who commit suicide...
  68. ncbi Symptoms of late-life depression: frequency and change during treatment
    J Craig Nelson
    Dept of Psychiatry, University of California at San Francisco, 401 Parnassus Ave, Box 0984 F, San Francisco, CA 94143, USA
    Am J Geriatr Psychiatry 13:520-6. 2005
    ....
  69. ncbi Role of antidepressants in murder and suicide
    Kenneth Tardiff
    Am J Psychiatry 159:1248-9. 2002
  70. pmc Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop
    Alan S Bellack
    University of Maryland School of Medicine, 737 West Lombard Street, Suite 551, Baltimore, MD 21201, USA
    Schizophr Bull 33:805-22. 2007
    ..This criterion is problematic because different observers and constituencies often have different opinions about what types of change are clinically important and how much change is significant...
  71. pmc Predicting recovery from episodes of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02903 4970, United States
    J Affect Disord 107:285-91. 2008
    ..This study examined psychosocial functioning as a predictor of recovery from episodes of unipolar major depression...
  72. ncbi Income distribution and risk of fatal drug overdose in New York City neighborhoods
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York 10024, USA
    Drug Alcohol Depend 70:139-48. 2003
    ..Disinvestment in social and economic resources in unequal neighborhoods may explain this association. Public health interventions related to overdose risk should pay particular attention to highly unequal neighborhoods...
  73. ncbi The long-term course of rapid-cycling bipolar disorder
    William Coryell
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:914-20. 2003
    ..To our knowledge, no prospective study has, as yet, described the course of this phenomenon beyond 5 years...
  74. ncbi The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
    ..Because treatment-seeking behavior is known to be associated with a worse prognosis, 23 weeks probably represents a lower-limit approximation of the median duration of an untreated depressive episode...
  75. ncbi The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
    ..Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns...
  76. ncbi Psychosocial impairment and recurrence of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Compr Psychiatry 45:423-30. 2004
    ..In patients who have recovered from an episode of major depression, the presence of psychosocial impairment may help identify who is at increased risk of recurrence...
  77. ncbi Distinguishing bipolar major depression from unipolar major depression with the screening assessment of depression-polarity (SAD-P)
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    J Clin Psychiatry 67:434-42. 2006
    ..The goal of this study was to develop and validate a brief instrument to screen for bipolar disorder in patients actively ill with major depression...
  78. ncbi Tachyphylaxis in unipolar major depressive disorder
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Clin Psychiatry 66:283-90. 2005
    ..This study describes recurrence of major depression despite maintenance pharmacotherapy, termed tachyphylaxis...
  79. ncbi A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia
    Robert W Buchanan
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 31:5-19. 2005
    ....
  80. ncbi Can interpersonal loss precipitate panic disorder?
    Barbara Milrod
    Am J Psychiatry 161:758-9. 2004
  81. ncbi Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990-98
    Phillip O Coffin
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York 10029, USA
    Addiction 98:739-47. 2003
    ..Multi-drug use has been documented as a key risk factor in overdose and overdose mortality in several studies. This study investigated the contribution of multiple drug combinations to overdose mortality trends...
  82. ncbi Prevention of missing data in clinical research studies
    Stephen R Wisniewski
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 59:997-1000. 2006
    ..Despite efforts devoted to areas, no study is without missing data. Once the study is completed, it is essential to assess the pattern of missing data and apply the appropriate statistical analysis...

Research Grants7

  1. DYNAMIC TECHNIQUES FOR TREATMENT EFFECTIVENESS ANALYSES
    ANDREW LEON; Fiscal Year: 2003
    ..Its use could preclude the need for both endpoint and completer analyses. The performance of the proposed methodology will be evaluated and compared to standard procedures in a Simulation Study (Aim 4). ..
  2. DYNAMIC TECHNIQUES FOR TREATMENT EFFECTIVENESS ANALYSES
    ANDREW LEON; Fiscal Year: 2007
    ..In summary, this interdisciplinary project will inform methodologists about the proposed data analytic strategy and inform clinicians about effectiveness of treatments for PD, BDD, and bipolar depression. ..